FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3288, 740 aa 1>>>pF1KE3288 740 - 740 aa - 740 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8730+/-0.000626; mu= 5.6018+/- 0.039 mean_var=369.7137+/-70.369, 0's: 0 Z-trim(116.8): 351 B-trim: 0 in 0/53 Lambda= 0.066702 statistics sampled from 27942 (28317) to 27942 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.332), width: 16 Scan time: 13.000 The best scores are: opt bits E(85289) NP_689786 (OMIM: 611344) ras and EF-hand domain-co ( 740) 4836 480.7 9.3e-135 XP_005251788 (OMIM: 611344) PREDICTED: ras and EF- ( 611) 3858 386.5 1.8e-106 XP_005251787 (OMIM: 611344) PREDICTED: ras and EF- ( 717) 2680 273.2 2.6e-72 NP_001138430 (OMIM: 614178) EF-hand calcium-bindin ( 731) 581 71.2 1.7e-11 XP_011519339 (OMIM: 614178) PREDICTED: EF-hand cal ( 493) 572 70.1 2.4e-11 XP_011519340 (OMIM: 614178) PREDICTED: EF-hand cal ( 493) 572 70.1 2.4e-11 XP_011519336 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11 XP_006719084 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11 XP_011519338 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11 NP_005361 (OMIM: 165040) ras-related protein Rab-8 ( 207) 520 64.6 4.7e-10 XP_011526322 (OMIM: 165040) PREDICTED: ras-related ( 215) 520 64.6 4.8e-10 NP_057614 (OMIM: 613532) ras-related protein Rab-8 ( 207) 511 63.7 8.5e-10 NP_783865 (OMIM: 609956) ras-related protein Rab-3 ( 216) 494 62.1 2.7e-09 NP_001317400 (OMIM: 609956) ras-related protein Ra ( 196) 487 61.4 4.1e-09 NP_001006639 (OMIM: 609956) ras-related protein Ra ( 223) 487 61.5 4.4e-09 NP_112243 (OMIM: 612565) ras-related protein Rab-1 ( 201) 486 61.3 4.4e-09 NP_001157461 (OMIM: 609956) ras-related protein Ra ( 228) 487 61.5 4.5e-09 NP_057215 (OMIM: 612672) ras-related protein Rab-1 ( 200) 477 60.4 8.1e-09 NP_004152 (OMIM: 179508) ras-related protein Rab-1 ( 205) 477 60.5 8.2e-09 NP_055168 (OMIM: 605455) ras-related protein Rab-2 ( 256) 477 60.6 9.4e-09 NP_001294982 (OMIM: 605455) ras-related protein Ra ( 190) 458 58.6 2.8e-08 NP_001272990 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08 NP_001272988 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08 NP_001272989 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08 NP_055303 (OMIM: 605693) ras-related protein Rab-3 ( 203) 454 58.2 3.8e-08 NP_002861 (OMIM: 602672) ras-related protein Rab-1 ( 203) 450 57.8 4.9e-08 NP_001020471 (OMIM: 616448) ras-related protein Ra ( 244) 436 56.6 1.4e-07 XP_011526466 (OMIM: 179490) PREDICTED: ras-related ( 220) 433 56.3 1.6e-07 NP_002857 (OMIM: 179490) ras-related protein Rab-3 ( 220) 433 56.3 1.6e-07 NP_006852 (OMIM: 604199) ras-related protein Rab-3 ( 201) 432 56.1 1.6e-07 NP_004209 (OMIM: 604198) ras-related protein Rab-1 ( 218) 431 56.1 1.8e-07 NP_004274 (OMIM: 604350) ras-related protein Rab-3 ( 219) 429 55.9 2.1e-07 NP_004654 (OMIM: 605570) ras-related protein Rab-1 ( 216) 428 55.8 2.2e-07 NP_002856 (OMIM: 179509) ras-related protein Rab-2 ( 212) 426 55.6 2.5e-07 XP_016857447 (OMIM: 179510) PREDICTED: ras-related ( 219) 423 55.3 3.1e-07 NP_002858 (OMIM: 179510) ras-related protein Rab-3 ( 219) 423 55.3 3.1e-07 NP_004785 (OMIM: 300333) ras-related protein Rab-3 ( 237) 423 55.3 3.3e-07 NP_116235 (OMIM: 607466) ras-related protein Rab-2 ( 216) 417 54.7 4.6e-07 NP_001304844 (OMIM: 612829) ras-related protein Ra ( 225) 417 54.7 4.7e-07 NP_612462 (OMIM: 612829) ras-related protein Rab-3 ( 227) 415 54.5 5.4e-07 NP_741995 (OMIM: 300774) ras-related protein Rab-3 ( 213) 411 54.1 6.8e-07 NP_065120 (OMIM: 612942) ras-related protein Rab-2 ( 213) 409 53.9 7.8e-07 NP_067075 (OMIM: 602207,614222) ras-related protei ( 206) 405 53.5 1e-06 NP_057406 (OMIM: 612673) ras-related protein Rab-1 ( 215) 401 53.2 1.3e-06 NP_001157462 (OMIM: 609956) ras-related protein Ra ( 186) 398 52.8 1.5e-06 XP_016873867 (OMIM: 612565) PREDICTED: ras-related ( 237) 399 53.0 1.6e-06 NP_004153 (OMIM: 179512) ras-related protein Rab-5 ( 215) 396 52.7 1.9e-06 NP_002860 (OMIM: 179513) ras-related protein Rab-6 ( 208) 393 52.4 2.2e-06 NP_071894 (OMIM: 602206) ras-related protein Rab-1 ( 212) 392 52.3 2.4e-06 NP_112586 (OMIM: 605950,615222) ras-related protei ( 229) 392 52.3 2.5e-06 >>NP_689786 (OMIM: 611344) ras and EF-hand domain-contai (740 aa) initn: 4836 init1: 4836 opt: 4836 Z-score: 2540.3 bits: 480.7 E(85289): 9.3e-135 Smith-Waterman score: 4836; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:1-740) 10 20 30 40 50 60 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE3 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE3 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE3 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_689 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI 670 680 690 700 710 720 730 740 pF1KE3 TNLTGTNSKKSPQMKNCCNG :::::::::::::::::::: NP_689 TNLTGTNSKKSPQMKNCCNG 730 740 >>XP_005251788 (OMIM: 611344) PREDICTED: ras and EF-hand (611 aa) initn: 3858 init1: 3858 opt: 3858 Z-score: 2032.5 bits: 386.5 E(85289): 1.8e-106 Smith-Waterman score: 3858; 100.0% identity (100.0% similar) in 597 aa overlap (144-740:15-611) 120 130 140 150 160 170 pF1KE3 ALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNF :::::::::::::::::::::::::::::: XP_005 MEEGLQTWRPPEPGREEQVSTLYQNINLVEPRLIQPYEHVIKNF 10 20 30 40 180 190 200 210 220 230 pF1KE3 IREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALS 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE3 DLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEA 110 120 130 140 150 160 300 310 320 330 340 350 pF1KE3 QTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSN 170 180 190 200 210 220 360 370 380 390 400 410 pF1KE3 DGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCD 230 240 250 260 270 280 420 430 440 450 460 470 pF1KE3 SLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGG 290 300 310 320 330 340 480 490 500 510 520 530 pF1KE3 DASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNA 350 360 370 380 390 400 540 550 560 570 580 590 pF1KE3 KSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQ 410 420 430 440 450 460 600 610 620 630 640 650 pF1KE3 LWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVG 470 480 490 500 510 520 660 670 680 690 700 710 pF1KE3 NKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTD 530 540 550 560 570 580 720 730 740 pF1KE3 KDDSRSITNLTGTNSKKSPQMKNCCNG ::::::::::::::::::::::::::: XP_005 KDDSRSITNLTGTNSKKSPQMKNCCNG 590 600 610 >>XP_005251787 (OMIM: 611344) PREDICTED: ras and EF-hand (717 aa) initn: 2634 init1: 2634 opt: 2680 Z-score: 1419.1 bits: 273.2 E(85289): 2.6e-72 Smith-Waterman score: 4640; 96.9% identity (96.9% similar) in 740 aa overlap (1-740:1-717) 10 20 30 40 50 60 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL :::::::::::::::::::: ::::::::::::::::: XP_005 QSELDALKSDYADQSLNTER-----------------------TANRKLHDSNDGLRSAL 310 320 330 370 380 390 400 410 420 pF1KE3 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE3 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV 400 410 420 430 440 450 490 500 510 520 530 540 pF1KE3 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK 460 470 480 490 500 510 550 560 570 580 590 600 pF1KE3 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ 520 530 540 550 560 570 610 620 630 640 650 660 pF1KE3 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD 580 590 600 610 620 630 670 680 690 700 710 720 pF1KE3 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI 640 650 660 670 680 690 730 740 pF1KE3 TNLTGTNSKKSPQMKNCCNG :::::::::::::::::::: XP_005 TNLTGTNSKKSPQMKNCCNG 700 710 >>NP_001138430 (OMIM: 614178) EF-hand calcium-binding do (731 aa) initn: 677 init1: 454 opt: 581 Z-score: 327.4 bits: 71.2 E(85289): 1.7e-11 Smith-Waterman score: 859; 27.7% identity (59.5% similar) in 751 aa overlap (2-738:44-730) 10 20 30 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE ...:. : . . : .:::. .: . :. NP_001 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK 20 30 40 50 60 70 40 50 60 70 80 pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP ... : :: . . : ::. :::: .: .: :::. :: . : . ..: : . NP_001 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE . : ..:: :: :: : . : .: ::: . : . : NP_001 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES 140 150 160 170 150 160 170 180 190 200 pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE .:. :. ... ::.:.. .: . .: ... : ..: :.:: ....: NP_001 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ :::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : .. NP_001 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII ..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:. NP_001 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI : . ... .: .:...:. :..:.: : ..: :.. . :. . . NP_001 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW 360 370 380 390 400 390 400 410 420 430 440 pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST .. : . ::. . : ::. .:. . ... : .:.. ... : . . : . NP_001 KKRSGSVIGKYVDSRGILRSQS----EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG- 410 420 430 440 450 450 460 470 480 490 pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL .:. . : ..: .:.:. .:.. : :. .. . : NP_001 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS 460 470 480 490 500 500 510 520 530 540 550 pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF : ::.. :. .. . .: . . : .... . .. .:::..:..::::.:: NP_001 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV : :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....::::::: NP_001 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK ...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::. NP_001 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ 630 640 650 660 670 680 690 700 710 720 730 pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC :: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.: NP_001 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC 680 690 700 710 720 740 pF1KE3 CNG : NP_001 CG 730 >>XP_011519339 (OMIM: 614178) PREDICTED: EF-hand calcium (493 aa) initn: 554 init1: 454 opt: 572 Z-score: 324.6 bits: 70.1 E(85289): 2.4e-11 Smith-Waterman score: 683; 27.7% identity (62.3% similar) in 538 aa overlap (209-738:1-492) 180 190 200 210 220 230 pF1KE3 LQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQ :.:.:.. ... . .. . ..:... XP_011 MEQQIKSEKEQFLLKDTERFQARSQELEQK 10 20 30 240 250 260 270 280 290 pF1KE3 YETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIA . .:. .: ..:: : .. ..: : . :.. ::.. ..: ... .. XP_011 LLCKEQELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQ 40 50 60 70 80 300 310 320 330 340 350 pF1KE3 FLQSELDALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQTANRKLHDSNDG :..:..:... .:. :...:. : . ... .: .:...:. :..:.: : XP_011 DAQQQLESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD- 90 100 110 120 130 140 360 370 380 390 400 410 pF1KE3 LRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSL ..: :.. . :. . . .. : . ::. . : :::.: .:. . . XP_011 ------ICFQK-NKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSSQS---EEEEEVF 150 160 170 180 190 420 430 440 450 460 470 pF1KE3 ALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDA .. : .:.. ... : . . : . .:. . : ..: .:.:. XP_011 GI--P-RRSSLGLSGYPLTEEEPGTG---EPGPGG-----PYPRPLRRIISVEED----- 200 210 220 230 480 490 500 510 520 530 pF1KE3 SDTDVPDIRD---EETFG-LEDVASVLDWKPQGSVSEGSIVS-SSRKPISALSPQTDLVD .:.. : :. .. . : : ::.. :. .. . .: . . : XP_011 ---PLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCK 240 250 260 270 280 290 540 550 560 570 580 590 pF1KE3 DNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERT .... . .. .:::..:..::::.::: :.:...: ...::.:.:...::: ::. .. XP_011 EESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQV 300 310 320 330 340 350 600 610 620 630 640 650 pF1KE3 VLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIM .:::::::::::.: :....:::::::...::.: ..:::..:.:.. .:.:. . ::.. XP_011 ALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVL 360 370 380 390 400 410 660 670 680 690 700 710 pF1KE3 LVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKK :.::: : .: .. :: .::.:: . .: : :: .: : :..::::: .:. XP_011 LLGNKLD------NEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKE 420 430 440 450 460 470 720 730 740 pF1KE3 RTDKDDSRSITNLTGTNSKKSPQMKNCCNG . .: : : .: .:: :.:: XP_011 Q--EDTVREDTIQVGHPAKK----KSCCG 480 490 >>XP_011519340 (OMIM: 614178) PREDICTED: EF-hand calcium (493 aa) initn: 554 init1: 454 opt: 572 Z-score: 324.6 bits: 70.1 E(85289): 2.4e-11 Smith-Waterman score: 683; 27.7% identity (62.3% similar) in 538 aa overlap (209-738:1-492) 180 190 200 210 220 230 pF1KE3 LQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQ :.:.:.. ... . .. . ..:... XP_011 MEQQIKSEKEQFLLKDTERFQARSQELEQK 10 20 30 240 250 260 270 280 290 pF1KE3 YETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIA . .:. .: ..:: : .. ..: : . :.. ::.. ..: ... .. XP_011 LLCKEQELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQ 40 50 60 70 80 300 310 320 330 340 350 pF1KE3 FLQSELDALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQTANRKLHDSNDG :..:..:... .:. :...:. : . ... .: .:...:. :..:.: : XP_011 DAQQQLESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD- 90 100 110 120 130 140 360 370 380 390 400 410 pF1KE3 LRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSL ..: :.. . :. . . .. : . ::. . : :::.: .:. . . XP_011 ------ICFQK-NKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSSQS---EEEEEVF 150 160 170 180 190 420 430 440 450 460 470 pF1KE3 ALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDA .. : .:.. ... : . . : . .:. . : ..: .:.:. XP_011 GI--P-RRSSLGLSGYPLTEEEPGTG---EPGPGG-----PYPRPLRRIISVEED----- 200 210 220 230 480 490 500 510 520 530 pF1KE3 SDTDVPDIRD---EETFG-LEDVASVLDWKPQGSVSEGSIVS-SSRKPISALSPQTDLVD .:.. : :. .. . : : ::.. :. .. . .: . . : XP_011 ---PLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCK 240 250 260 270 280 290 540 550 560 570 580 590 pF1KE3 DNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERT .... . .. .:::..:..::::.::: :.:...: ...::.:.:...::: ::. .. XP_011 EESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQV 300 310 320 330 340 350 600 610 620 630 640 650 pF1KE3 VLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIM .:::::::::::.: :....:::::::...::.: ..:::..:.:.. .:.:. . ::.. XP_011 ALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVL 360 370 380 390 400 410 660 670 680 690 700 710 pF1KE3 LVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKK :.::: : .: .. :: .::.:: . .: : :: .: : :..::::: .:. XP_011 LLGNKLD------NEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKE 420 430 440 450 460 470 720 730 740 pF1KE3 RTDKDDSRSITNLTGTNSKKSPQMKNCCNG . .: : : .: .:: :.:: XP_011 Q--EDTVREDTIQVGHPAKK----KSCCG 480 490 >>XP_011519336 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa) initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11 Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731) 10 20 30 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE ...:. : . . : .:::. .: . :. XP_011 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK 20 30 40 50 60 70 40 50 60 70 80 pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP ... : :: . . : ::. :::: .: .: :::. :: . : . ..: : . XP_011 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE . : ..:: :: :: : . : .: ::: . : . : XP_011 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES 140 150 160 170 150 160 170 180 190 200 pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE .:. :. ... ::.:.. .: . .: ... : ..: :.:: ....: XP_011 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ :::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : .. XP_011 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII ..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:. XP_011 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI : . ... .: .:...:. :..:.: : ..: :.. . :. . . XP_011 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW 360 370 380 390 400 390 400 410 420 430 440 pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST .. : . ::. . : :::.: .:. . ... : .:.. ... : . . : . XP_011 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG- 410 420 430 440 450 450 460 470 480 490 pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL .:. . : ..: .:.:. .:.. : :. .. . : XP_011 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS 460 470 480 490 500 500 510 520 530 540 550 pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF : ::.. :. .. . .: . . : .... . .. .:::..:..::::.:: XP_011 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV : :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....::::::: XP_011 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK ...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::. XP_011 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ 630 640 650 660 670 680 690 700 710 720 730 pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC :: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.: XP_011 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC 680 690 700 710 720 730 740 pF1KE3 CNG : XP_011 CG >>XP_006719084 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa) initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11 Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731) 10 20 30 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE ...:. : . . : .:::. .: . :. XP_006 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK 20 30 40 50 60 70 40 50 60 70 80 pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP ... : :: . . : ::. :::: .: .: :::. :: . : . ..: : . XP_006 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE . : ..:: :: :: : . : .: ::: . : . : XP_006 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES 140 150 160 170 150 160 170 180 190 200 pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE .:. :. ... ::.:.. .: . .: ... : ..: :.:: ....: XP_006 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ :::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : .. XP_006 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII ..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:. XP_006 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI : . ... .: .:...:. :..:.: : ..: :.. . :. . . XP_006 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW 360 370 380 390 400 390 400 410 420 430 440 pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST .. : . ::. . : :::.: .:. . ... : .:.. ... : . . : . XP_006 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG- 410 420 430 440 450 450 460 470 480 490 pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL .:. . : ..: .:.:. .:.. : :. .. . : XP_006 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS 460 470 480 490 500 500 510 520 530 540 550 pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF : ::.. :. .. . .: . . : .... . .. .:::..:..::::.:: XP_006 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV : :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....::::::: XP_006 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK ...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::. XP_006 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ 630 640 650 660 670 680 690 700 710 720 730 pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC :: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.: XP_006 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC 680 690 700 710 720 730 740 pF1KE3 CNG : XP_006 CG >>XP_011519338 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa) initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11 Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731) 10 20 30 pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE ...:. : . . : .:::. .: . :. XP_011 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK 20 30 40 50 60 70 40 50 60 70 80 pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP ... : :: . . : ::. :::: .: .: :::. :: . : . ..: : . XP_011 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE . : ..:: :: :: : . : .: ::: . : . : XP_011 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES 140 150 160 170 150 160 170 180 190 200 pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE .:. :. ... ::.:.. .: . .: ... : ..: :.:: ....: XP_011 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ :::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : .. XP_011 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII ..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:. XP_011 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI : . ... .: .:...:. :..:.: : ..: :.. . :. . . XP_011 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW 360 370 380 390 400 390 400 410 420 430 440 pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST .. : . ::. . : :::.: .:. . ... : .:.. ... : . . : . XP_011 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG- 410 420 430 440 450 450 460 470 480 490 pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL .:. . : ..: .:.:. .:.. : :. .. . : XP_011 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS 460 470 480 490 500 500 510 520 530 540 550 pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF : ::.. :. .. . .: . . : .... . .. .:::..:..::::.:: XP_011 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF 510 520 530 540 550 560 560 570 580 590 600 610 pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV : :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....::::::: XP_011 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV 570 580 590 600 610 620 620 630 640 650 660 670 pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK ...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::. XP_011 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ 630 640 650 660 670 680 690 700 710 720 730 pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC :: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.: XP_011 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC 680 690 700 710 720 730 740 pF1KE3 CNG : XP_011 CG >>NP_005361 (OMIM: 165040) ras-related protein Rab-8A [H (207 aa) initn: 510 init1: 397 opt: 520 Z-score: 301.5 bits: 64.6 E(85289): 4.7e-10 Smith-Waterman score: 520; 45.7% identity (72.8% similar) in 173 aa overlap (542-714:9-175) 520 530 540 550 560 570 pF1KE3 VSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENIS .:..: ::..:::. :.:. .. : .. NP_005 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFI 10 20 30 580 590 600 610 620 630 pF1KE3 ATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLN .:.:.::...:. .::.: ::.::::::::::.:. .:.: : :..:.::.: :::: : NP_005 STIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDN 40 50 60 70 80 90 640 650 660 670 680 690 pF1KE3 IREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSA ::.:. ::. : : :..::: :. : .. : . :::::. :: : :::: NP_005 IRNWIRNIEEHASADVEKMILGNKCDVND------KRQVSKERGEKLALDYGIKFMETSA 100 110 120 130 140 150 700 710 720 730 740 pF1KE3 KDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG : . :. .: . :::..: . :: NP_005 KANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCVLL 160 170 180 190 200 740 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 05:37:31 2016 done: Sun Nov 6 05:37:33 2016 Total Scan time: 13.000 Total Display time: 0.180 Function used was FASTA [36.3.4 Apr, 2011]