FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5332, 290 aa 1>>>pF1KE5332 290 - 290 aa - 290 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2635+/-0.000499; mu= 10.3545+/- 0.031 mean_var=125.0104+/-26.495, 0's: 0 Z-trim(111.0): 215 B-trim: 338 in 2/52 Lambda= 0.114710 statistics sampled from 19195 (19498) to 19195 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.598), E-opt: 0.2 (0.229), width: 16 Scan time: 5.780 The best scores are: opt bits E(85289) NP_054862 (OMIM: 605402) programmed cell death 1 l ( 290) 1903 326.7 3.3e-89 NP_001300958 (OMIM: 605402) programmed cell death ( 245) 1486 257.6 1.7e-68 NP_001254635 (OMIM: 605402) programmed cell death ( 176) 1049 185.1 8.1e-47 NP_079516 (OMIM: 605715) CD276 antigen isoform b p ( 316) 416 80.6 4.2e-15 NP_001316557 (OMIM: 605715) CD276 antigen isoform ( 316) 416 80.6 4.2e-15 NP_001316558 (OMIM: 605715) CD276 antigen isoform ( 388) 412 80.0 7.8e-15 XP_011520397 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15 NP_001019907 (OMIM: 605715) CD276 antigen isoform ( 534) 412 80.2 9.8e-15 XP_011520398 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15 XP_016878127 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15 XP_005254757 (OMIM: 605715) PREDICTED: CD276 antig ( 534) 412 80.2 9.8e-15 NP_079515 (OMIM: 605723) programmed cell death 1 l ( 273) 366 72.3 1.2e-12 XP_005251657 (OMIM: 605723) PREDICTED: programmed ( 283) 366 72.3 1.2e-12 NP_078902 (OMIM: 608162) V-set domain-containing T ( 282) 241 51.6 2e-06 XP_016857824 (OMIM: 608162) PREDICTED: V-set domai ( 287) 241 51.6 2.1e-06 XP_011540445 (OMIM: 608162) PREDICTED: V-set domai ( 332) 241 51.7 2.3e-06 NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 243 52.2 2.5e-06 XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 243 52.3 2.9e-06 NP_008820 (OMIM: 601020) T-lymphocyte activation a ( 323) 202 45.2 0.0002 NP_787058 (OMIM: 601020) T-lymphocyte activation a ( 329) 202 45.2 0.0002 XP_011512570 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026 XP_011512569 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026 XP_006715042 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026 XP_006715044 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026 XP_006715043 (OMIM: 613594) PREDICTED: butyrophili ( 339) 200 44.9 0.00026 NP_001184163 (OMIM: 613590) butyrophilin subfamily ( 330) 199 44.7 0.00028 NP_510961 (OMIM: 613590) butyrophilin subfamily 2 ( 334) 199 44.7 0.00028 NP_008980 (OMIM: 613590) butyrophilin subfamily 2 ( 527) 199 44.9 0.0004 NP_001184167 (OMIM: 613591) butyrophilin subfamily ( 336) 194 43.9 0.00051 XP_016865658 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053 XP_016865657 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053 XP_006715018 (OMIM: 613591) PREDICTED: butyrophili ( 353) 194 43.9 0.00053 NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 194 44.1 0.0007 NP_001184166 (OMIM: 613591) butyrophilin subfamily ( 523) 194 44.1 0.0007 XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007 XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007 XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 194 44.1 0.0007 NP_005182 (OMIM: 112203) T-lymphocyte activation a ( 288) 190 43.2 0.00072 NP_001240778 (OMIM: 608162) V-set domain-containin ( 187) 187 42.5 0.00074 XP_006715045 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092 XP_011512571 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092 XP_016865702 (OMIM: 613594) PREDICTED: butyrophili ( 297) 188 42.9 0.00092 XP_016863009 (OMIM: 112203) PREDICTED: T-lymphocyt ( 249) 186 42.5 0.001 NP_001184177 (OMIM: 613594) butyrophilin subfamily ( 311) 185 42.4 0.0013 XP_005248884 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014 XP_016865700 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014 NP_001184175 (OMIM: 613594) butyrophilin subfamily ( 334) 185 42.4 0.0014 NP_001184176 (OMIM: 613594) butyrophilin subfamily ( 334) 185 42.4 0.0014 XP_016865701 (OMIM: 613594) PREDICTED: butyrophili ( 334) 185 42.4 0.0014 NP_008978 (OMIM: 613594) butyrophilin subfamily 3 ( 334) 185 42.4 0.0014 >>NP_054862 (OMIM: 605402) programmed cell death 1 ligan (290 aa) initn: 1903 init1: 1903 opt: 1903 Z-score: 1722.5 bits: 326.7 E(85289): 3.3e-89 Smith-Waterman score: 1903; 100.0% identity (100.0% similar) in 290 aa overlap (1-290:1-290) 10 20 30 40 50 60 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET :::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET 250 260 270 280 290 >>NP_001300958 (OMIM: 605402) programmed cell death 1 li (245 aa) initn: 1486 init1: 1486 opt: 1486 Z-score: 1350.5 bits: 257.6 E(85289): 1.7e-68 Smith-Waterman score: 1486; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227) 10 20 30 40 50 60 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPGNILNVSIKICLT 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET NP_001 LSPST >>NP_001254635 (OMIM: 605402) programmed cell death 1 li (176 aa) initn: 1049 init1: 1049 opt: 1049 Z-score: 961.5 bits: 185.1 E(85289): 8.1e-47 Smith-Waterman score: 1049; 99.4% identity (100.0% similar) in 161 aa overlap (130-290:16-176) 100 110 120 130 140 150 pF1KE5 QITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEG .::::::::::::::::::::::::::::: NP_001 MRIFAVFIFMTYWHLLNAPYNKINQRILVVDPVTSEHELTCQAEG 10 20 30 40 160 170 180 190 200 210 pF1KE5 YPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEEN 50 60 70 80 90 100 220 230 240 250 260 270 pF1KE5 HTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNS 110 120 130 140 150 160 280 290 pF1KE5 KKQSDTHLEET ::::::::::: NP_001 KKQSDTHLEET 170 >>NP_079516 (OMIM: 605715) CD276 antigen isoform b precu (316 aa) initn: 311 init1: 180 opt: 416 Z-score: 392.1 bits: 80.6 E(85289): 4.2e-15 Smith-Waterman score: 416; 30.2% identity (59.3% similar) in 285 aa overlap (13-288:22-300) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: NP_079 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : NP_079 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: NP_079 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAE ::.: ... :.:..::.. :. ::.: :.::. .: . : : ... . NP_079 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 LVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ- ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... . NP_079 VTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEG 240 250 260 270 280 290 290 pF1KE5 SDTHLEET : : :. NP_079 SKTALQPLKHSDSKEDDGQEIA 300 310 >>NP_001316557 (OMIM: 605715) CD276 antigen isoform b pr (316 aa) initn: 311 init1: 180 opt: 416 Z-score: 392.1 bits: 80.6 E(85289): 4.2e-15 Smith-Waterman score: 416; 30.2% identity (59.3% similar) in 285 aa overlap (13-288:22-300) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: NP_001 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : NP_001 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: NP_001 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAE ::.: ... :.:..::.. :. ::.: :.::. .: . : : ... . NP_001 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDAHGS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 LVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ- ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... . NP_001 VTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGEGEG 240 250 260 270 280 290 290 pF1KE5 SDTHLEET : : :. NP_001 SKTALQPLKHSDSKEDDGQEIA 300 310 >>NP_001316558 (OMIM: 605715) CD276 antigen isoform c [H (388 aa) initn: 312 init1: 180 opt: 412 Z-score: 387.3 bits: 80.0 E(85289): 7.8e-15 Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:100-372) 10 20 30 40 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ : : ::.: :. :.. :..:.: : NP_001 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG 70 80 90 100 110 120 50 60 70 80 90 100 pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ ..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. NP_001 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA 130 140 150 160 170 180 110 120 130 140 150 160 pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY : : . :..: ....: :::.: :. . : :: .::.. .:: NP_001 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY 190 200 210 220 230 240 170 180 190 200 210 220 pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH :.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ... NP_001 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA 250 260 270 280 290 300 230 240 250 260 270 280 pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK . ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... NP_001 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE 310 320 330 340 350 360 290 pF1KE5 KQ-SDTHLEET . : : :. NP_001 GEGSKTALQPLKHSDSKEDDGQEIA 370 380 >>XP_011520397 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa) initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15 Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518) 10 20 30 40 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ : : ::.: :. :.. :..:.: : XP_011 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG 220 230 240 250 260 270 50 60 70 80 90 100 pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ ..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. XP_011 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA 280 290 300 310 320 330 110 120 130 140 150 160 pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY : : . :..: ....: :::.: :. . : :: .::.. .:: XP_011 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY 340 350 360 370 380 170 180 190 200 210 220 pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH :.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ... XP_011 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK . ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... XP_011 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE 450 460 470 480 490 500 290 pF1KE5 KQ-SDTHLEET . : : :. XP_011 GEGSKTALQPLKHSDSKEDDGQEIA 510 520 530 >-- initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13 Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: XP_011 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : XP_011 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: XP_011 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA ::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :.. XP_011 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ . :. XP_011 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV 240 250 260 270 280 290 >>NP_001019907 (OMIM: 605715) CD276 antigen isoform a pr (534 aa) initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15 Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518) 10 20 30 40 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ : : ::.: :. :.. :..:.: : NP_001 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG 220 230 240 250 260 270 50 60 70 80 90 100 pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ ..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. NP_001 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA 280 290 300 310 320 330 110 120 130 140 150 160 pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY : : . :..: ....: :::.: :. . : :: .::.. .:: NP_001 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY 340 350 360 370 380 170 180 190 200 210 220 pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH :.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ... NP_001 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK . ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... NP_001 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE 450 460 470 480 490 500 290 pF1KE5 KQ-SDTHLEET . : : :. NP_001 GEGSKTALQPLKHSDSKEDDGQEIA 510 520 530 >-- initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13 Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: NP_001 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : NP_001 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: NP_001 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA ::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :.. NP_001 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ . :. NP_001 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV 240 250 260 270 280 290 >>XP_011520398 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa) initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15 Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518) 10 20 30 40 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ : : ::.: :. :.. :..:.: : XP_011 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG 220 230 240 250 260 270 50 60 70 80 90 100 pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ ..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. XP_011 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA 280 290 300 310 320 330 110 120 130 140 150 160 pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY : : . :..: ....: :::.: :. . : :: .::.. .:: XP_011 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY 340 350 360 370 380 170 180 190 200 210 220 pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH :.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ... XP_011 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK . ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... XP_011 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE 450 460 470 480 490 500 290 pF1KE5 KQ-SDTHLEET . : : :. XP_011 GEGSKTALQPLKHSDSKEDDGQEIA 510 520 530 >-- initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13 Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: XP_011 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : XP_011 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: XP_011 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA ::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :.. XP_011 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ . :. XP_011 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV 240 250 260 270 280 290 >>XP_016878127 (OMIM: 605715) PREDICTED: CD276 antigen i (534 aa) initn: 443 init1: 180 opt: 412 Z-score: 385.6 bits: 80.2 E(85289): 9.8e-15 Smith-Waterman score: 412; 30.1% identity (59.5% similar) in 279 aa overlap (18-288:246-518) 10 20 30 40 pF1KE5 MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQ : : ::.: :. :.. :..:.: : XP_016 GTYSCLVRNPVLQQDAHSSVTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPG 220 230 240 250 260 270 50 60 70 80 90 100 pF1KE5 LDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQ ..:: : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. XP_016 FSLAQLNLIWQLTDTK--QLVHSFTEGRDQGSAYANRTALFPDLLAQGNASLRLQRVRVA 280 290 300 310 320 330 110 120 130 140 150 160 pF1KE5 DAGVYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGY : : . :..: ....: :::.: :. . : :: .::.. .:: XP_016 DEGSFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYRGY 340 350 360 370 380 170 180 190 200 210 220 pF1KE5 PKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENH :.:::.: ... :.:..::.. :. ::.: :.::. .: . : : ... XP_016 PEAEVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSVLRVVLGANGTYSCLVRNPVLQQDA 390 400 410 420 430 440 230 240 250 260 270 280 pF1KE5 TAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSK . ..: :.. ::. : :.. :. : :::.:. . . . .. : .: ... XP_016 HGSVTITGQPMTFPPEALWVTVGLSVCLIALLVALAFVCWRKIKQSCEEENAGAEDQDGE 450 460 470 480 490 500 290 pF1KE5 KQ-SDTHLEET . : : :. XP_016 GEGSKTALQPLKHSDSKEDDGQEIA 510 520 530 >-- initn: 247 init1: 145 opt: 374 Z-score: 351.6 bits: 73.9 E(85289): 7.6e-13 Smith-Waterman score: 374; 31.6% identity (60.0% similar) in 225 aa overlap (13-228:22-240) 10 20 30 40 50 pF1KE5 MRIFAVFIFMTYWH-LLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDL : : .:. : ::.: :. :.. :. :.: : ..: XP_016 MLRRRGSPGMGVHVGAALGALWFCLTGALEVQVPEDPVVALVGTDATLCCSFSPEPGFSL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE5 AALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAG : : . :.. : . :.::. . . : :.: .:. :. : :. :::.:.. :.. : : XP_016 AQLNLIWQLTDTK--QLVHSFAEGQDQGSAYANRTALFPDLLAQGNASLRLQRVRVADEG 70 80 90 100 110 120 130 140 150 160 pF1KE5 VYRCMISYGGADYKRITVKVNAPYNKI------NQRILVVDPVTSEHELTCQA-EGYPKA . :..: ....: :::.: :. . : :: .::.. .:::.: XP_016 SFTCFVSIRDFGSAAVSLQVAAPYSKPSMTLEPNKDLRPGDTVT----ITCSSYQGYPEA 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE5 EVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRR-LDPEENHTA ::.: ... :.:..::.. :. ::.: : ::. .: . : : . .. :.. XP_016 EVFWQDGQGVPLTGNVTTSQMANEQGLFDVHSILRVVLGANGTYSCLVRNPVLQQDAHSS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE5 ELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQ . :. XP_016 VTITPQRSPTGAVEVQVPEDPVVALVGTDATLRCSFSPEPGFSLAQLNLIWQLTDTKQLV 240 250 260 270 280 290 290 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 23:51:29 2016 done: Mon Nov 7 23:51:30 2016 Total Scan time: 5.780 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]