FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4269, 1129 aa 1>>>pF1KE4269 1129 - 1129 aa - 1129 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 16.7182+/-0.000523; mu= -31.5468+/- 0.033 mean_var=685.3615+/-142.083, 0's: 0 Z-trim(122.8): 110 B-trim: 0 in 0/58 Lambda= 0.048991 statistics sampled from 41283 (41402) to 41283 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.485), width: 16 Scan time: 15.560 The best scores are: opt bits E(85289) NP_060952 (OMIM: 605953) arf-GAP with SH3 domain, (1129) 7507 546.7 3e-154 XP_006716626 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154 XP_005250982 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154 XP_011515354 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154 NP_001234925 (OMIM: 605953) arf-GAP with SH3 domai (1122) 7380 537.7 1.5e-151 XP_006716627 (OMIM: 605953) PREDICTED: arf-GAP wit (1125) 7364 536.6 3.3e-151 XP_011515355 (OMIM: 605953) PREDICTED: arf-GAP wit (1125) 7364 536.6 3.3e-151 XP_016868957 (OMIM: 605953) PREDICTED: arf-GAP wit (1073) 7104 518.2 1.1e-145 XP_016868956 (OMIM: 605953) PREDICTED: arf-GAP wit (1087) 7103 518.1 1.1e-145 XP_006716628 (OMIM: 605953) PREDICTED: arf-GAP wit (1076) 7101 518.0 1.2e-145 XP_016868958 (OMIM: 605953) PREDICTED: arf-GAP wit (1072) 5386 396.7 3.8e-109 XP_006716629 (OMIM: 605953) PREDICTED: arf-GAP wit (1075) 5370 395.6 8.4e-109 NP_003878 (OMIM: 603817) arf-GAP with SH3 domain, (1006) 3494 263.0 6.5e-69 XP_006711961 (OMIM: 603817) PREDICTED: arf-GAP wit (1009) 3465 261.0 2.7e-68 NP_001128663 (OMIM: 603817) arf-GAP with SH3 domai ( 961) 3446 259.6 6.6e-68 XP_006711965 (OMIM: 603817) PREDICTED: arf-GAP wit ( 964) 3411 257.1 3.7e-67 XP_011508706 (OMIM: 603817) PREDICTED: arf-GAP wit (1017) 3295 248.9 1.1e-64 XP_006711964 (OMIM: 603817) PREDICTED: arf-GAP wit ( 970) 3268 247.0 4.1e-64 XP_011508708 (OMIM: 603817) PREDICTED: arf-GAP wit ( 978) 3268 247.0 4.1e-64 XP_011508705 (OMIM: 603817) PREDICTED: arf-GAP wit (1020) 3266 246.9 4.7e-64 XP_011508709 (OMIM: 603817) PREDICTED: arf-GAP wit ( 975) 3212 243.1 6.4e-63 XP_011508710 (OMIM: 603817) PREDICTED: arf-GAP wit ( 959) 3147 238.5 1.5e-61 XP_011508711 (OMIM: 603817) PREDICTED: arf-GAP wit ( 891) 2952 224.7 2e-57 XP_011508707 (OMIM: 603817) PREDICTED: arf-GAP wit ( 995) 2852 217.6 3e-55 XP_016857174 (OMIM: 616594) PREDICTED: arf-GAP wit ( 924) 1956 154.3 3.2e-36 XP_011540057 (OMIM: 616594) PREDICTED: arf-GAP wit ( 926) 1944 153.4 5.8e-36 NP_060177 (OMIM: 616594) arf-GAP with SH3 domain, ( 903) 1909 150.9 3.2e-35 XP_016857175 (OMIM: 616594) PREDICTED: arf-GAP wit ( 905) 1897 150.1 5.7e-35 XP_016857176 (OMIM: 616594) PREDICTED: arf-GAP wit ( 883) 1810 143.9 4e-33 XP_016857177 (OMIM: 616594) PREDICTED: arf-GAP wit ( 793) 1603 129.3 9.2e-29 XP_016857178 (OMIM: 616594) PREDICTED: arf-GAP wit ( 774) 1544 125.1 1.6e-27 NP_001137250 (OMIM: 616594) arf-GAP with SH3 domai ( 894) 1468 119.8 7.6e-26 NP_036419 (OMIM: 607766) arf-GAP with coiled-coil, ( 778) 512 52.2 1.5e-05 XP_011510905 (OMIM: 607766) PREDICTED: arf-GAP wit ( 813) 512 52.2 1.5e-05 XP_016861538 (OMIM: 607766) PREDICTED: arf-GAP wit ( 806) 483 50.1 6.3e-05 XP_016861536 (OMIM: 607766) PREDICTED: arf-GAP wit ( 841) 483 50.1 6.5e-05 NP_055729 (OMIM: 608651) arf-GAP with GTPase, ANK ( 804) 434 46.7 0.00069 XP_005246116 (OMIM: 608651) PREDICTED: arf-GAP wit ( 808) 434 46.7 0.0007 XP_006712298 (OMIM: 608651) PREDICTED: arf-GAP wit ( 882) 435 46.8 0.00071 XP_006712297 (OMIM: 608651) PREDICTED: arf-GAP wit ( 886) 435 46.8 0.00071 NP_001032208 (OMIM: 608651) arf-GAP with GTPase, A ( 857) 434 46.7 0.00073 XP_011508850 (OMIM: 608651) PREDICTED: arf-GAP wit (1098) 435 46.8 0.00085 XP_016858771 (OMIM: 608651) PREDICTED: arf-GAP wit (1106) 435 46.8 0.00086 XP_011508851 (OMIM: 608651) PREDICTED: arf-GAP wit (1073) 434 46.7 0.00088 XP_006712300 (OMIM: 608651) PREDICTED: arf-GAP wit (1147) 435 46.8 0.00088 XP_006712302 (OMIM: 608651) PREDICTED: arf-GAP wit (1151) 435 46.8 0.00089 XP_011508849 (OMIM: 608651) PREDICTED: arf-GAP wit (1126) 434 46.8 0.00091 XP_016867224 (OMIM: 616813) PREDICTED: arf-GAP wit ( 462) 413 45.0 0.0012 XP_016867222 (OMIM: 616813) PREDICTED: arf-GAP wit ( 527) 413 45.1 0.0014 XP_016867223 (OMIM: 616813) PREDICTED: arf-GAP wit ( 580) 413 45.1 0.0015 >>NP_060952 (OMIM: 605953) arf-GAP with SH3 domain, ANK (1129 aa) initn: 7507 init1: 7507 opt: 7507 Z-score: 2890.3 bits: 546.7 E(85289): 3e-154 Smith-Waterman score: 7507; 100.0% identity (100.0% similar) in 1129 aa overlap (1-1129:1-1129) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE4 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE4 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE4 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE4 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE4 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KE4 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD ::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1090 1100 1110 1120 >>XP_006716626 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa) initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154 Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1090 1100 1110 1120 1130 >>XP_005250982 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa) initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154 Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1090 1100 1110 1120 1130 >>XP_011515354 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa) initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154 Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 250 260 270 280 290 300 310 320 330 340 350 pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG 550 560 570 580 590 600 600 610 620 630 640 650 pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES 670 680 690 700 710 720 720 730 740 750 760 770 pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS 730 740 750 760 770 780 780 790 800 810 820 830 pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT 790 800 810 820 830 840 840 850 860 870 880 890 pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL 850 860 870 880 890 900 900 910 920 930 940 950 pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP 910 920 930 940 950 960 960 970 980 990 1000 1010 pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV 970 980 990 1000 1010 1020 1020 1030 1040 1050 1060 1070 pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD 1030 1040 1050 1060 1070 1080 1080 1090 1100 1110 1120 pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1090 1100 1110 1120 1130 >>NP_001234925 (OMIM: 605953) arf-GAP with SH3 domain, A (1122 aa) initn: 7379 init1: 7379 opt: 7380 Z-score: 2841.8 bits: 537.7 E(85289): 1.5e-151 Smith-Waterman score: 7380; 99.8% identity (99.8% similar) in 1112 aa overlap (18-1129:13-1122) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL : :::::::::::::::::::::::::::::::::::::::: NP_001 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE4 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE4 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK 480 490 500 510 520 530 550 560 570 580 590 600 pF1KE4 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL 540 550 560 570 580 590 610 620 630 640 650 660 pF1KE4 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK 600 610 620 630 640 650 670 680 690 700 710 720 pF1KE4 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD 660 670 680 690 700 710 730 740 750 760 770 780 pF1KE4 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE4 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD 780 790 800 810 820 830 850 860 870 880 890 900 pF1KE4 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK 840 850 860 870 880 890 910 920 930 940 950 960 pF1KE4 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG 900 910 920 930 940 950 970 980 990 1000 1010 1020 pF1KE4 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK 960 970 980 990 1000 1010 1030 1040 1050 1060 1070 1080 pF1KE4 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA 1020 1030 1040 1050 1060 1070 1090 1100 1110 1120 pF1KE4 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1080 1090 1100 1110 1120 >>XP_006716627 (OMIM: 605953) PREDICTED: arf-GAP with SH (1125 aa) initn: 5582 init1: 5582 opt: 7364 Z-score: 2835.7 bits: 536.6 E(85289): 3.3e-151 Smith-Waterman score: 7364; 99.6% identity (99.6% similar) in 1115 aa overlap (18-1129:13-1125) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL : :::::::::::::::::::::::::::::::::::::::: XP_006 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 240 250 260 270 280 290 310 320 330 340 350 pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT 780 790 800 810 820 830 840 850 860 870 880 890 pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL 840 850 860 870 880 890 900 910 920 930 940 950 pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1080 1090 1100 1110 1120 >>XP_011515355 (OMIM: 605953) PREDICTED: arf-GAP with SH (1125 aa) initn: 5582 init1: 5582 opt: 7364 Z-score: 2835.7 bits: 536.6 E(85289): 3.3e-151 Smith-Waterman score: 7364; 99.6% identity (99.6% similar) in 1115 aa overlap (18-1129:13-1125) 10 20 30 40 50 60 pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL : :::::::::::::::::::::::::::::::::::::::: XP_011 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD 240 250 260 270 280 290 310 320 330 340 350 pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS ::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL 600 610 620 630 640 650 660 670 680 690 700 710 pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES 660 670 680 690 700 710 720 730 740 750 760 770 pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS 720 730 740 750 760 770 780 790 800 810 820 830 pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT 780 790 800 810 820 830 840 850 860 870 880 890 pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL 840 850 860 870 880 890 900 910 920 930 940 950 pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP 900 910 920 930 940 950 960 970 980 990 1000 1010 pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV 960 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD 1020 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1080 1090 1100 1110 1120 >>XP_016868957 (OMIM: 605953) PREDICTED: arf-GAP with SH (1073 aa) initn: 5582 init1: 5582 opt: 7104 Z-score: 2736.7 bits: 518.2 E(85289): 1.1e-145 Smith-Waterman score: 7104; 99.5% identity (99.6% similar) in 1073 aa overlap (60-1129:1-1073) 30 40 50 60 70 80 pF1KE4 FIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHV .: ::::::::::::::::::::::::::: XP_016 MESALDQDRTALQKVKKSVKAIYNSGQDHV 10 20 30 90 100 110 120 130 140 pF1KE4 QNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDS 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 LLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEK 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 ERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLA 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 ADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEYGSE :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::: XP_016 ADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEYGSE 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE4 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL 400 410 420 430 440 450 510 520 530 540 550 560 pF1KE4 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNE 460 470 480 490 500 510 570 580 590 600 610 620 pF1KE4 LLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQN 520 530 540 550 560 570 630 640 650 660 670 680 pF1KE4 CGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCE 580 590 600 610 620 630 690 700 710 720 730 740 pF1KE4 DLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSIS 640 650 660 670 680 690 750 760 770 780 790 800 pF1KE4 PQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPP 700 710 720 730 740 750 810 820 830 840 850 860 pF1KE4 STLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSS 760 770 780 790 800 810 870 880 890 900 910 920 pF1KE4 SKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQ 820 830 840 850 860 870 930 940 950 960 970 980 pF1KE4 LAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQM 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 pF1KE4 KDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSND 940 950 960 970 980 990 1050 1060 1070 1080 1090 1100 pF1KE4 LTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWI 1000 1010 1020 1030 1040 1050 1110 1120 pF1KE4 GHIEGQPERKGVFPVSFVHILSD ::::::::::::::::::::::: XP_016 GHIEGQPERKGVFPVSFVHILSD 1060 1070 >>XP_016868956 (OMIM: 605953) PREDICTED: arf-GAP with SH (1087 aa) initn: 5582 init1: 5582 opt: 7103 Z-score: 2736.2 bits: 518.1 E(85289): 1.1e-145 Smith-Waterman score: 7103; 99.5% identity (99.5% similar) in 1076 aa overlap (57-1129:14-1087) 30 40 50 60 70 80 pF1KE4 VSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQ ::: ::::::::::::::::::::::::: XP_016 MHCSALPHLRDPPVTL--EALDQDRTALQKVKKSVKAIYNSGQ 10 20 30 40 90 100 110 120 130 140 pF1KE4 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE4 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE4 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE4 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEY ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_016 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEY 230 240 250 260 270 280 330 340 350 360 370 380 pF1KE4 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK 290 300 310 320 330 340 390 400 410 420 430 440 pF1KE4 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE 350 360 370 380 390 400 450 460 470 480 490 500 pF1KE4 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE 410 420 430 440 450 460 510 520 530 540 550 560 pF1KE4 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK 470 480 490 500 510 520 570 580 590 600 610 620 pF1KE4 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL 530 540 550 560 570 580 630 640 650 660 670 680 pF1KE4 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT 590 600 610 620 630 640 690 700 710 720 730 740 pF1KE4 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS 650 660 670 680 690 700 750 760 770 780 790 800 pF1KE4 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT 710 720 730 740 750 760 810 820 830 840 850 860 pF1KE4 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP 770 780 790 800 810 820 870 880 890 900 910 920 pF1KE4 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK 830 840 850 860 870 880 930 940 950 960 970 980 pF1KE4 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK 890 900 910 920 930 940 990 1000 1010 1020 1030 1040 pF1KE4 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED 950 960 970 980 990 1000 1050 1060 1070 1080 1090 1100 pF1KE4 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE 1010 1020 1030 1040 1050 1060 1110 1120 pF1KE4 WWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::: XP_016 WWIGHIEGQPERKGVFPVSFVHILSD 1070 1080 >>XP_006716628 (OMIM: 605953) PREDICTED: arf-GAP with SH (1076 aa) initn: 5582 init1: 5582 opt: 7101 Z-score: 2735.5 bits: 518.0 E(85289): 1.2e-145 Smith-Waterman score: 7101; 99.3% identity (99.5% similar) in 1076 aa overlap (57-1129:1-1076) 30 40 50 60 70 80 pF1KE4 VSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQ .:. . :::::::::::::::::::::::: XP_006 MTMYNGALDQDRTALQKVKKSVKAIYNSGQ 10 20 30 90 100 110 120 130 140 pF1KE4 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE4 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE4 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE4 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEY ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::: XP_006 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEY 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE4 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK 280 290 300 310 320 330 390 400 410 420 430 440 pF1KE4 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE 340 350 360 370 380 390 450 460 470 480 490 500 pF1KE4 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE 400 410 420 430 440 450 510 520 530 540 550 560 pF1KE4 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK 460 470 480 490 500 510 570 580 590 600 610 620 pF1KE4 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL 520 530 540 550 560 570 630 640 650 660 670 680 pF1KE4 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT 580 590 600 610 620 630 690 700 710 720 730 740 pF1KE4 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS 640 650 660 670 680 690 750 760 770 780 790 800 pF1KE4 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT 700 710 720 730 740 750 810 820 830 840 850 860 pF1KE4 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP 760 770 780 790 800 810 870 880 890 900 910 920 pF1KE4 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK 820 830 840 850 860 870 930 940 950 960 970 980 pF1KE4 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK 880 890 900 910 920 930 990 1000 1010 1020 1030 1040 pF1KE4 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED 940 950 960 970 980 990 1050 1060 1070 1080 1090 1100 pF1KE4 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE 1000 1010 1020 1030 1040 1050 1110 1120 pF1KE4 WWIGHIEGQPERKGVFPVSFVHILSD :::::::::::::::::::::::::: XP_006 WWIGHIEGQPERKGVFPVSFVHILSD 1060 1070 1129 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:11:14 2016 done: Tue Nov 8 03:11:17 2016 Total Scan time: 15.560 Total Display time: 0.370 Function used was FASTA [36.3.4 Apr, 2011]