FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9571, 408 aa 1>>>pF1KE9571 408 - 408 aa - 408 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7749+/-0.000306; mu= 18.4572+/- 0.020 mean_var=159.0444+/-36.780, 0's: 0 Z-trim(121.5): 509 B-trim: 1998 in 1/56 Lambda= 0.101699 statistics sampled from 37451 (38137) to 37451 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.764), E-opt: 0.2 (0.447), width: 16 Scan time: 8.430 The best scores are: opt bits E(85289) NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 2812 424.1 3e-118 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 886 141.6 3.9e-33 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 732 118.9 2.2e-26 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 677 110.9 6.3e-24 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 654 107.6 7.2e-23 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 645 106.4 1.9e-22 NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 562 94.1 7.8e-19 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 542 91.1 5.9e-18 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 542 91.1 5.9e-18 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 529 89.1 1.9e-17 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 525 88.5 3e-17 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 525 88.6 3.1e-17 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 525 88.7 3.7e-17 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 519 87.6 5e-17 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 519 87.6 5e-17 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 477 81.4 3.8e-15 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 477 81.5 3.8e-15 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 477 81.5 4e-15 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 477 81.5 4.2e-15 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 472 80.8 7.1e-15 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 471 80.6 7.2e-15 NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 464 79.6 1.6e-14 NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 464 79.7 1.7e-14 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 459 78.9 2.5e-14 XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 458 78.8 3e-14 NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 458 78.8 3e-14 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 448 77.3 8.4e-14 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 443 76.6 1.4e-13 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 440 76.0 1.6e-13 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 440 76.0 1.7e-13 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 440 76.1 1.7e-13 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 440 76.1 1.7e-13 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 440 76.1 1.8e-13 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 440 76.1 1.8e-13 NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 422 73.5 1.2e-12 NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 409 71.6 4.3e-12 XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 409 71.6 4.4e-12 NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 403 70.6 7.3e-12 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 399 69.9 9.7e-12 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 399 69.9 9.8e-12 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 399 69.9 9.9e-12 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 399 70.0 1e-11 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 399 70.0 1.1e-11 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 399 70.0 1.1e-11 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 399 70.1 1.2e-11 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 399 70.1 1.2e-11 >>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa) initn: 2812 init1: 2812 opt: 2812 Z-score: 2243.9 bits: 424.1 E(85289): 3e-118 Smith-Waterman score: 2812; 100.0% identity (100.0% similar) in 408 aa overlap (1-408:1-408) 10 20 30 40 50 60 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL 310 320 330 340 350 360 370 380 390 400 pF1KE9 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS :::::::::::::::::::::::::::::::::::::::::::::::: NP_000 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS 370 380 390 400 >>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa) initn: 829 init1: 625 opt: 886 Z-score: 715.9 bits: 141.6 E(85289): 3.9e-33 Smith-Waterman score: 1283; 52.5% identity (69.6% similar) in 425 aa overlap (2-394:10-424) 10 20 30 pF1KE9 MAPWPHENSSLAPWPDLPT-----LAPNTANTSGLPGV---P------WEAA : : . :: :: :: . :.: . .: :: . : : :. NP_000 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE9 LAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLA . : :.:: :: :.::.::::::: ::::::.::.:. :::.::::::::::: .::.. NP_000 M-GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIV 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 LTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAV . :.: :. ::::::::::::::::::::..:.:::::.:.:.:: .:.:. :: : NP_000 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 VLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLL ::..:: ::: ::. .:::. .: ::.::...:.:: :..: :.. :: ::::.:: NP_000 CTVWAISALVSFLPILMHWWRAESD-EARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 VMLFVYARVFVVATRQLRLLRGELGRF-PPEESPPAPSRSLAPAPVGTCAPPEGVP---- .: ::: ::: : .:.. . . :: ::.:: : .::: ::: : : NP_000 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAP----APPPGPPRPAA 240 250 260 270 280 290 280 290 300 310 320 pF1KE9 -------ACGR----RPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL : :: ::.::. :::..:: :::.:::.:::::::::::::..:. : NP_000 AAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRE-L 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE9 VPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAA--RPALF :: :. .::::::::::::.:::::::::.::. ::: :.:: . :. :: NP_000 VPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLC-CARRAARRRHATHGDRPR-- 360 370 380 390 400 410 390 400 pF1KE9 PSGVPAARSSPAQPRLCQRLDGASWGVS :: : . : .: NP_000 ASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPG 420 430 440 450 460 470 >>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa) initn: 1068 init1: 533 opt: 732 Z-score: 594.5 bits: 118.9 E(85289): 2.2e-26 Smith-Waterman score: 1048; 48.2% identity (72.0% similar) in 357 aa overlap (5-361:4-341) 10 20 30 40 50 60 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV : ..:.. :. . ::. :. : : ... : ...: ::: : ::.:::. NP_000 MGQPGNGSAFLLAPNR-SHAPDHDVTQQRDEV-WVVGM-GIVMSLIVLAIVFGNVLVIT 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC ::: ::::.:: :.:::: ::::::: ::: .:. : : .: ::.:::.:::: NP_000 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV :::::::::..:::::.:.:.:..: .:.:: ::. ...::.::. .:: ::. .:.:. NP_000 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG . :: :..: :: : .:. :.. :: ::::.::..:.:::.::: : :::. . NP_000 -THQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDK 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT ::: . .:. . .: . : : . . :.::.:: :::.:::: NP_000 SEGRFHVQ--------NLSQVE------QDGRTGHGLRRSSKFCLKEHKALKTLGIIMGT 240 250 260 270 280 310 320 330 340 350 360 pF1KE9 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL :::::::::..:..... .:. ... :::.::.::.::::::::::::: ::..:: NP_000 FTLCWLPFFIVNIVHVIQD-NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL 290 300 310 320 330 340 370 380 390 400 pF1KE9 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS : NP_000 CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNID 350 360 370 380 390 400 >>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa) initn: 476 init1: 164 opt: 677 Z-score: 550.5 bits: 110.9 E(85289): 6.3e-24 Smith-Waterman score: 677; 33.2% identity (62.9% similar) in 367 aa overlap (39-395:25-378) 10 20 30 40 50 60 pF1KE9 SSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRL :.. .:.: .:.:. :: :: .:. .: NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHL 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 QT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIET .. .:: :: :::..::....::.: :. ..: ::.:. :..:.. :..: :::: . NP_000 RSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 LCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVG----AD ::...:::: :...:.:: .: . : . ..:..:. .:: :.. .: .. .: NP_000 LCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 AEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELG ..: . : . . :.. :: .:::.:. .:. .:.:.. .: .:.: . . : NP_000 GNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI-AALE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 RFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTL : .. . . :: :. ::. .. :: ..: ::..:::.:. NP_000 R-AAVHAKNCQTTTGNGKPV-ECSQPES-------SFKMSFKRETKVLKTLSVIMGVFVC 240 250 260 270 280 310 320 330 340 350 pF1KE9 CWLPFFLANVLRALGG-----PSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRR ::::::. : . . : : . . .: .. :.:.:::..::.:: . :::.:: NP_000 CWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFST 290 300 310 320 330 340 360 370 380 390 400 pF1KE9 LLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS :: : : : : .. .:. : :: .:: NP_000 LLG-CYRLCPATNNAIETVSINNNGA-AMFSSHHEPRGSISKECNLVYLIPHAVGSSEDL 350 360 370 380 390 400 NP_000 KKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT 410 420 430 440 >>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa) initn: 672 init1: 390 opt: 654 Z-score: 531.6 bits: 107.6 E(85289): 7.2e-23 Smith-Waterman score: 745; 37.2% identity (66.5% similar) in 376 aa overlap (6-366:9-373) 10 20 30 40 50 pF1KE9 MAPWPHENSSLAPWPDLPT---LAPN-TANTSGLPGVPWEAALA-GALLALAVLATV :..:. : : .: . .:: :...: :: . :.. : .:. .: .. NP_000 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 GGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCEL ::.:::...: . .:.: :: :...:: :::.... :.: .:.: . :.: :: :.. NP_000 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 WTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAP :..::::: :::: .:::...:::..: :.: .:::.: : :.. :::.:...:..: NP_000 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 IMSQWWRVGADAEAQRCHSNPRCCAFASNMP-YVLLSSSVSFYLPLLVMLFVYARVFVVA ... :. : . ..: ... : :.:.:: :::.:: :.: .: ::..:: NP_000 LLG--WKEPAPNDDKECG--------VTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA 190 200 210 220 230 240 250 260 270 280 pF1KE9 TRQLRLLR-GELGRFP--PEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL-RE : . :. : . .. : . :... ... . .: . ..:. . :: NP_000 KRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSS-TKAKGHNPRSSIAVKLFKFSRE 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 HRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIY- ..: :::...: : :::::::.: : .: . : .: .. :::: :: .::.:: NP_000 KKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYP 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE9 CRSPDFRSAFRRLL-CRC---GRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDG : : .:. :: :.: :.: ::: NP_000 CSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDD 350 360 370 380 390 400 >>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa) initn: 693 init1: 414 opt: 645 Z-score: 524.0 bits: 106.4 E(85289): 1.9e-22 Smith-Waterman score: 738; 37.7% identity (64.9% similar) in 382 aa overlap (7-371:64-429) 10 20 30 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPG--VP .: : : : . .. .:... : : NP_000 GAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVS 40 50 60 70 80 90 40 50 60 70 80 90 pF1KE9 WEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPA ... .:..:: .: .:.::::::...: . .:::.:: :...::.:::... :.: . NP_000 AQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFS 100 110 120 130 140 150 100 110 120 130 140 150 pF1KE9 ATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCA ::. . : : .: . :..:..::::: :::: .::...::::..: . :.: :..:.: : NP_000 ATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKA 160 170 180 190 200 210 160 170 180 190 200 210 pF1KE9 RTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFY . ..:.:::. .:: .:... :. . . : :... . :...:: ::: NP_000 AAILALLWVVALVVSVGPLLG--WK-------EPVPPDERFCGITEEAGYAVFSSVCSFY 220 230 240 250 260 220 230 240 250 260 270 pF1KE9 LPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPA ::. :.. .: ::.::: : :.. . : : : : :. . .: : NP_000 LPMAVIVVMYCRVYVVARSTTRSLEAGVKR----ERGKASEVVLRIHCRGAATGADG--A 270 280 290 300 310 280 290 300 310 320 pF1KE9 CGRRPA-----------RLLPL-REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL : : : ::: . ::..: ::....:.:.:::.:::.. : .: :.: NP_000 HGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLF-PQL 320 330 340 350 360 370 330 340 350 360 370 pF1KE9 VPGPA-FLALNWLGYANSAFNPLIY-CRSPDFRSAFRRLL-CRCGRRLPPEPCAAARPAL :. . : .. :::: :: ::::: : : .:. :: ::: :.: :: .: NP_000 KPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHH 380 390 400 410 420 430 380 390 400 pF1KE9 FPSGVPAARSSPAQPRLCQRLDGASWGVS NP_000 WRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREW 440 450 460 470 480 490 >>NP_000612 (OMIM: 103780,164230,181500,182135,606788,60 (471 aa) initn: 524 init1: 201 opt: 562 Z-score: 459.1 bits: 94.1 E(85289): 7.8e-19 Smith-Waterman score: 562; 30.0% identity (58.7% similar) in 387 aa overlap (20-399:61-429) 10 20 30 40 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVL :.:. . : : : :. :.... NP_000 DFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLT----AVVII 40 50 60 70 80 50 60 70 80 90 100 pF1KE9 ATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH-WPLGAT :..::.:::.:.. .::. :: :. ::: ::...:.::.: . : :. ::: . NP_000 LTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSK 90 100 110 120 130 140 110 120 130 140 150 160 pF1KE9 GCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAV : .: .::: :::: :::...:::.:. ::.... . .. : .. ::..:... NP_000 LCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGI 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE9 SFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVF :. :: . . :... . : : .:.. .::..: :::..:: .:...: .. NP_000 SM-PI--PVFGLQDDSKVFKEGS----CLLADDN-FVLIGSFVSFFIPLTIMVITYFLTI 210 220 230 240 250 230 240 250 260 270 280 pF1KE9 VVATRQLRLLRGELGRFPPEESPP-APSRSLAPAPV-GTCAPPEGVPACGRRPARLLPLR .. : ..:: : :. ::. . : ::: . . NP_000 KSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSIS-N 260 270 280 290 300 310 290 300 310 320 330 340 pF1KE9 EHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSL---VPGPAFLALNWLGYANSAFNP :..: .::... :.. : :::..:.. .. : : : . .. :.:: .:: :: NP_000 EQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNP 320 330 340 350 360 370 350 360 370 380 390 400 pF1KE9 LIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDG :.: . .:::: : . .: . .: .. . .:: . .: .. :. NP_000 LVYTLFNKTYRSAFSRYI-QCQYKENKKPLQL----ILVNTIPALAYKSSQLQMGQKKNS 380 390 400 410 420 430 pF1KE9 ASWGVS NP_000 KQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 440 450 460 470 >>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa) initn: 548 init1: 203 opt: 542 Z-score: 443.4 bits: 91.1 E(85289): 5.9e-18 Smith-Waterman score: 542; 32.3% identity (57.7% similar) in 381 aa overlap (10-371:26-393) 10 20 30 40 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTS--GLP-GVPWEAALAG :..: . : ::.. . .: :: ::. NP_001 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALS- 10 20 30 40 50 50 60 70 80 90 100 pF1KE9 ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTG ... .. :.:::.:::.:.. .:.. :: :. ::: ::...::::.: . : NP_001 --IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 H-WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL . ::: : .: :.::: :::: :::...:::.:. ::.... . .. : ... NP_001 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVM ::..: .:: .:: .: : . .: : : .::..: :.:..:: .: NP_001 VWAISIGVS-VPIPV----IGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIM 180 190 200 210 220 230 230 240 250 260 270 pF1KE9 LFVYARVFVVATRQ-LRLLRGELGRFPPEESPP---APSRSLAPAPVGTCAPPEGVPACG ...: .. : :: : ::.:. . :: : .:. : .. : . : NP_001 VITYCLTIYVLRRQALMLLHGHT-EEPPGLSLDFLKCCKRNTAEEE-NSANPNQDQNARR 240 250 260 270 280 280 290 300 310 320 pF1KE9 RRPARLLPL-------REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL :. . : :..: .::... .: . : :::..:.: .: : NP_001 RKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEK 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 ALN---WLGYANSAFNPLIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVP :: :.::. :..:::.: . .: :: : ::. .. .: NP_001 LLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL-RCNYKVEKKPPVRQIPRVAATALS 350 360 370 380 390 400 390 400 pF1KE9 AARSSPAQPRLCQRLDGASWGVS NP_001 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 410 420 430 440 450 >>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa) initn: 548 init1: 203 opt: 542 Z-score: 443.4 bits: 91.1 E(85289): 5.9e-18 Smith-Waterman score: 542; 32.3% identity (57.7% similar) in 381 aa overlap (10-371:26-393) 10 20 30 40 pF1KE9 MAPWPHENSSLAPWPDLPTLAPNTANTS--GLP-GVPWEAALAG :..: . : ::.. . .: :: ::. NP_000 MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALS- 10 20 30 40 50 50 60 70 80 90 100 pF1KE9 ALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTG ... .. :.:::.:::.:.. .:.. :: :. ::: ::...::::.: . : NP_000 --IVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 H-WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL . ::: : .: :.::: :::: :::...:::.:. ::.... . .. : ... NP_000 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAI 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVM ::..: .:: .:: .: : . .: : : .::..: :.:..:: .: NP_000 VWAISIGVS-VPIPV----IGLRDEEKVFVNNTTCVLNDPN--FVLIGSFVAFFIPLTIM 180 190 200 210 220 230 230 240 250 260 270 pF1KE9 LFVYARVFVVATRQ-LRLLRGELGRFPPEESPP---APSRSLAPAPVGTCAPPEGVPACG ...: .. : :: : ::.:. . :: : .:. : .. : . : NP_000 VITYCLTIYVLRRQALMLLHGHT-EEPPGLSLDFLKCCKRNTAEEE-NSANPNQDQNARR 240 250 260 270 280 280 290 300 310 320 pF1KE9 RRPARLLPL-------REHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFL :. . : :..: .::... .: . : :::..:.: .: : NP_000 RKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEK 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 ALN---WLGYANSAFNPLIYCR-SPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVP :: :.::. :..:::.: . .: :: : ::. .. .: NP_000 LLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL-RCNYKVEKKPPVRQIPRVAATALS 350 360 370 380 390 400 390 400 pF1KE9 AARSSPAQPRLCQRLDGASWGVS NP_000 GRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV 410 420 430 440 450 >>XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B adrene (366 aa) initn: 594 init1: 390 opt: 529 Z-score: 434.1 bits: 89.1 E(85289): 1.9e-17 Smith-Waterman score: 620; 36.1% identity (67.3% similar) in 327 aa overlap (6-322:9-324) 10 20 30 40 50 pF1KE9 MAPWPHENSSLAPWPDLPT---LAPN-TANTSGLPGVPWEAALA-GALLALAVLATV :..:. : : .: . .:: :...: :: . :.. : .:. .: .. XP_005 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 GGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCEL ::.:::...: . .:.: :: :...:: :::.... :.: .:.: . :.: :: :.. XP_005 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 WTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAP :..::::: :::: .:::...:::..: :.: .:::.: : :.. :::.:...:..: XP_005 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 IMSQWWRVGADAEAQRCHSNPRCCAFASNMP-YVLLSSSVSFYLPLLVMLFVYARVFVVA ... :. : . ..: ... : :.:.:: :::.:: :.: .: ::..:: XP_005 LLG--WKEPAPNDDKECG--------VTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVA 190 200 210 220 230 240 250 260 270 280 pF1KE9 TRQLRLLR-GELGRFP--PEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPL-RE : . :. : . .. : . :... ... . .: . ..:. . :: XP_005 KRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSS-TKAKGHNPRSSIAVKLFKFSRE 240 250 260 270 280 290 300 310 320 330 340 pF1KE9 HRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYC ..: :::...: : :::::::.: :.. :. :: XP_005 KKAAKTLGIVVGMFILCWLPFFIALPLESKGSLSLKTLNACCKSRKEMNEHNLNLSSLES 290 300 310 320 330 340 350 360 370 380 390 400 pF1KE9 RSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGV XP_005 GHVRDTGATLHHHIIRY 350 360 408 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:09:48 2016 done: Sun Nov 6 16:09:49 2016 Total Scan time: 8.430 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]