FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5337, 259 aa 1>>>pF1KE5337 259 - 259 aa - 259 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.4347+/-0.000432; mu= -1.8993+/- 0.027 mean_var=263.6563+/-53.609, 0's: 0 Z-trim(120.0): 32 B-trim: 644 in 1/53 Lambda= 0.078987 statistics sampled from 34727 (34759) to 34727 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.71), E-opt: 0.2 (0.408), width: 16 Scan time: 4.620 The best scores are: opt bits E(85289) NP_003832 (OMIM: 603613) tumor necrosis factor rec ( 259) 1760 213.0 4.5e-55 NP_003831 (OMIM: 603614) tumor necrosis factor rec ( 386) 819 105.9 1.1e-22 NP_003835 (OMIM: 603611) tumor necrosis factor rec ( 468) 644 86.0 1.3e-16 NP_003833 (OMIM: 275355,603612) tumor necrosis fac ( 440) 599 80.9 4.4e-15 NP_671716 (OMIM: 275355,603612) tumor necrosis fac ( 411) 523 72.2 1.7e-12 XP_016869433 (OMIM: 275355,603612) PREDICTED: tumo ( 375) 451 63.9 4.7e-10 >>NP_003832 (OMIM: 603613) tumor necrosis factor recepto (259 aa) initn: 1760 init1: 1760 opt: 1760 Z-score: 1109.8 bits: 213.0 E(85289): 4.5e-55 Smith-Waterman score: 1760; 100.0% identity (100.0% similar) in 259 aa overlap (1-259:1-259) 10 20 30 40 50 60 pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNEN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SPEMCRKCSRCPSGEVQVSNCTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 ETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ETMNTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHY 190 200 210 220 230 240 250 pF1KE5 LSCTIVGIIVLIVLLIVFV ::::::::::::::::::: NP_003 LSCTIVGIIVLIVLLIVFV 250 >>NP_003831 (OMIM: 603614) tumor necrosis factor recepto (386 aa) initn: 937 init1: 680 opt: 819 Z-score: 528.0 bits: 105.9 E(85289): 1.1e-22 Smith-Waterman score: 819; 71.2% identity (85.3% similar) in 170 aa overlap (5-173:35-204) 10 20 30 pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEV :: ::::: :::::::: . ::: ::.:: NP_003 GQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 PQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCKSD :::::::::::.:.: :::::::::::.:::::::::::::: :::: :::. :::::: NP_003 PQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 QKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCVEEF : .::::: ::::::::..:.:...::::::: : . :: : :.::::: .::.: .: NP_003 QTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNES 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 GANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEETM .:..: .:::::::..: : NP_003 AASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGIC 190 200 210 220 230 240 >>NP_003835 (OMIM: 603611) tumor necrosis factor recepto (468 aa) initn: 616 init1: 490 opt: 644 Z-score: 419.1 bits: 86.0 E(85289): 1.3e-16 Smith-Waterman score: 644; 60.0% identity (80.0% similar) in 155 aa overlap (3-156:87-236) 10 20 30 pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE :. ::.::::: .::: :. ::.: . . NP_003 TSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVV--GVLLQVVPSSAATIKLH 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK . :... :: .:: :: :: ::::::: :::: ::::: ::::::: .:.:::.:: NP_003 D---QSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACK 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSR-CPSGEVQVSNCTSWDDIQCVE ::....: :: ::.:.:::: :::::.:: :::::::: :: : :.:..:: :.::.::. NP_003 SDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVH 180 190 200 210 220 230 160 170 180 190 200 210 pF1KE5 EFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAEE . ..: NP_003 KESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGA 240 250 260 270 280 290 >>NP_003833 (OMIM: 275355,603612) tumor necrosis factor (440 aa) initn: 685 init1: 403 opt: 599 Z-score: 391.7 bits: 80.9 E(85289): 4.4e-15 Smith-Waterman score: 599; 52.3% identity (72.7% similar) in 176 aa overlap (3-176:33-206) 10 20 30 pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE :.:::: :.:..:::: : : :: ..:. NP_003 QRGQNAPAASGARKRHGPGPREARGARPGPRVPKTL--VLVVAAVLLLVSAESALITQQD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK .::: .::::.: : . :: : : :: : : : ::.. :. :. :: : NP_003 LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCV- : . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: :.::.:: NP_003 SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 EEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAE .: :.. . :.::.:::...:::::: NP_003 KESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCKSLLWKKV 190 200 210 220 230 240 >>NP_671716 (OMIM: 275355,603612) tumor necrosis factor (411 aa) initn: 497 init1: 403 opt: 523 Z-score: 345.3 bits: 72.2 E(85289): 1.7e-12 Smith-Waterman score: 523; 38.2% identity (59.8% similar) in 246 aa overlap (3-242:33-275) 10 20 30 pF1KE5 MARIPKTLKFVVVIVAVLLPVLAYSATTARQE :.:::: :.:..:::: : : :: ..:. NP_671 QRGQNAPAASGARKRHGPGPREARGARPGPRVPKTL--VLVVAAVLLLVSAESALITQQD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 EVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSCFPCTVCK .::: .::::.: : . :: : : :: : : : ::.. :. :. :: : NP_671 LAPQQRAAPQQKRSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCD 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 SDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSWDDIQCVE : . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: :.::.::. NP_671 SGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVH 130 140 150 160 170 180 160 170 180 190 200 pF1KE5 EFGANATVETPAAEETMNTSPGTPAPAAEETMN-----TSPGTPAPAAEETMTTSPGTPA . .. : :: . . . .... : : : . . ::. NP_671 KESGIIIGVTVAAVVLIVAVFVCKSLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAED 190 200 210 220 230 240 210 220 230 240 250 pF1KE5 PAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV . .: .. : .: .: . :. :.. ..:: NP_671 NVLNEIVSILQPTQVPE-QEMEVQEPAEPTGVNMLSPGESEHLLEPAEAERSQRRRLLVP 250 260 270 280 290 NP_671 ANEGDPTETLRQCFDDFADLVPFDSWEPLMRKLGLMDNEIKVAKAEAAGHRDTLYTMLIK 300 310 320 330 340 350 >>XP_016869433 (OMIM: 275355,603612) PREDICTED: tumor ne (375 aa) initn: 559 init1: 277 opt: 451 Z-score: 301.5 bits: 63.9 E(85289): 4.7e-10 Smith-Waterman score: 451; 52.8% identity (73.2% similar) in 123 aa overlap (56-176:19-141) 30 40 50 60 70 80 pF1KE5 ATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCTEGVDYTNASNNEPSC : : :: : : : ::.. :. : XP_016 MDDVWGMRTIEAPNSTAQGHHISEDGRDCISCKYGQDYSTHWNDLLFC 10 20 30 40 90 100 110 120 130 140 pF1KE5 FPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKC-SRCPSGEVQVSNCTSW . :: : : . . : :: ::.:::::.:::::.:.:::::::: . :: : :.:..:: : XP_016 LRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPW 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE5 DDIQCV-EEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPG .::.:: .: :.. . :.::.:::...:::::: XP_016 SDIECVHKESGTKHSGEVPAVEETVTSSPGTPASPCSLSGIIIGVTVAAVVLIVAVFVCK 110 120 130 140 150 160 210 220 230 240 250 pF1KE5 TPAPAAEETMTTSPGTPAPAAEETMTTSPGTPASSHYLSCTIVGIIVLIVLLIVFV XP_016 SLLWKKVLPYLKGICSGGGGDPERVDRSSQRPGAEDNVLNEIVSILQPTQVPEQEMEVQE 170 180 190 200 210 220 259 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 23:54:15 2016 done: Mon Nov 7 23:54:16 2016 Total Scan time: 4.620 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]