FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3158, 376 aa 1>>>pF1KE3158 376 - 376 aa - 376 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7510+/-0.000431; mu= 14.8923+/- 0.027 mean_var=104.6922+/-21.492, 0's: 0 Z-trim(112.4): 197 B-trim: 1186 in 2/54 Lambda= 0.125348 statistics sampled from 21130 (21381) to 21130 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.251), width: 16 Scan time: 6.420 The best scores are: opt bits E(85289) NP_078815 (OMIM: 300439) E3 ubiquitin-protein liga ( 402) 1068 204.2 4.2e-52 NP_919445 (OMIM: 300439) E3 ubiquitin-protein liga ( 428) 991 190.3 6.9e-48 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 270 59.8 9.8e-09 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 270 59.8 9.8e-09 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 270 59.8 9.8e-09 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 270 59.8 9.8e-09 NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 270 59.9 1.1e-08 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 270 59.9 1.1e-08 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 270 59.9 1.1e-08 NP_899237 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 264 58.8 2.4e-08 XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 264 58.8 2.4e-08 XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 264 58.8 2.4e-08 XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 264 58.8 2.4e-08 NP_009213 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 264 58.8 2.4e-08 XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 264 58.8 2.4e-08 XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193) 217 50.1 5.3e-06 XP_016861149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 250) 216 50.0 7.2e-06 NP_859061 (OMIM: 612063) E3 ubiquitin-protein liga ( 429) 219 50.7 7.3e-06 XP_016861147 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 XP_005247149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 XP_016861146 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 XP_016861148 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 XP_016861145 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 XP_011510678 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 216 50.0 7.5e-06 NP_115549 (OMIM: 612062) E3 ubiquitin-protein liga ( 836) 220 51.2 1e-05 XP_011528737 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 220 51.2 1.1e-05 XP_011528739 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 220 51.2 1.1e-05 XP_016884479 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 220 51.2 1.1e-05 XP_011528738 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 220 51.2 1.1e-05 XP_011528740 (OMIM: 612062) PREDICTED: E3 ubiquiti ( 841) 220 51.2 1.1e-05 NP_001193927 (OMIM: 612062) E3 ubiquitin-protein l ( 936) 220 51.2 1.1e-05 NP_001292473 (OMIM: 612482,617108) E3 ubiquitin-pr ( 783) 205 48.4 6.6e-05 NP_060233 (OMIM: 612482,617108) E3 ubiquitin-prote ( 783) 205 48.4 6.6e-05 XP_011523257 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 205 48.5 7.1e-05 XP_016880289 (OMIM: 612482,617108) PREDICTED: E3 u ( 869) 205 48.5 7.1e-05 NP_001127809 (OMIM: 612489) RING finger protein 24 ( 148) 192 45.4 0.0001 NP_009150 (OMIM: 612489) RING finger protein 24 is ( 148) 192 45.4 0.0001 NP_001308678 (OMIM: 612489) RING finger protein 24 ( 148) 192 45.4 0.0001 XP_011527448 (OMIM: 612489) PREDICTED: RING finger ( 163) 192 45.5 0.00011 XP_016883109 (OMIM: 612489) PREDICTED: RING finger ( 169) 192 45.5 0.00011 NP_001127810 (OMIM: 612489) RING finger protein 24 ( 169) 192 45.5 0.00011 XP_016883110 (OMIM: 612489) PREDICTED: RING finger ( 169) 192 45.5 0.00011 XP_011527447 (OMIM: 612489) PREDICTED: RING finger ( 169) 192 45.5 0.00011 XP_016877829 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 993) 202 48.0 0.00011 XP_016877830 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 993) 202 48.0 0.00011 >>NP_078815 (OMIM: 300439) E3 ubiquitin-protein ligase R (402 aa) initn: 1036 init1: 628 opt: 1068 Z-score: 1056.3 bits: 204.2 E(85289): 4.2e-52 Smith-Waterman score: 1072; 44.7% identity (74.5% similar) in 380 aa overlap (11-374:5-378) 10 20 30 40 50 pF1KE3 MHLLKVGTWRNNTASSWLMK-FSVLWLVSQNCCRASVVWMAYMNISFHVGNHVLSELGET : .. ::. :. : .. . .. : ..:.: ...:.. : : NP_078 MNQENRSSFFWLLVIFTFLLKITASFSMSAYVTVTYYN---ETSNYTAIETCEC 10 20 30 40 50 60 70 80 90 100 110 pF1KE3 GVFGRSSTLKRVAGVIVPPEGKIQNACNPNTIFSRSKYSETWLALIERGGCTFTQKIKVA ::.: .: . . ::. :... .::. :: :: .: . :.::::::.:::..::..: NP_078 GVYGLASPVANAMGVVGIPKNNNYQACDHNTEFSNTK--KPWIALIERGNCTFSEKIQTA 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 TEKGASGVIIYNVPGTGNQVFPMFHQAFEDVVVVMIGNLKGTEIFHLIKKGVLITAVVEV ...:..:.:::.: ::::.. : . . :.:..::::::::.:.. :..:. .: :.:: NP_078 GRRNADAVVIYNAPETGNQTIQMANFGAVDIVAIMIGNLKGTKILQSIQRGIQVTMVIEV 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 GRKHIIWMNHYL-----VSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTF :.:: :.::: ::: :.:.::..::::: .:: :: :.:. ..: .: .... NP_078 GKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLKADAKKAI 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 GQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKHFFHKNCIDPWILPHGTCP :.::::..:.::.::.:.::::..:.: :::::.::::::.:.:::.:.:::.: : ::: NP_078 GRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWLLEHRTCP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE3 ICKCDILKVLGIQVVVENGTEPLQVLMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEE .:::::::.:::.: ::.:. ::: .:::. .. : ::.. .:.. .: .. : ..: NP_078 MCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYAS-VQGTDE 290 300 310 320 330 340 360 370 pF1KE3 NPT-----SQNNDIQ-----PHSVVEDVHPSP : : :...: .::. :: : NP_078 PPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREIKS 350 360 370 380 390 400 >>NP_919445 (OMIM: 300439) E3 ubiquitin-protein ligase R (428 aa) initn: 1204 init1: 628 opt: 991 Z-score: 980.7 bits: 190.3 E(85289): 6.9e-48 Smith-Waterman score: 1170; 50.1% identity (76.8% similar) in 367 aa overlap (34-374:39-404) 10 20 30 40 50 pF1KE3 LKVGTWRNNTASSWLMKFSVLWLVSQNCCRASVVWMAYMNISF---HVG-NHVLSELGET : .:: ::.:.:. :.: :... ::.: NP_919 VSCRGGCGFSRLLAWCFLLALSPQAPGSRGAEAVWTAYLNVSWRVPHTGVNRTVWELSEE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 GVFGRSSTLKRVAGVIVPPEGK-IQNACNPNTIFSR-----SKYSETWLALIERGG-CTF ::.:..: :. ::::.:::.: :::::.: :. : . .:::::.::: ::: NP_919 GVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNFTVPTVWGSTVQVSWLALIQRGGGCTF 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 TQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFEDVVVVMIGNLKGTEIFHLIKKGVL ..::..: :.::::..:.: ::: :.:.:: : . :.:..::::::::.:.. :..:. NP_919 ADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIVAIMIGNLKGTKILQSIQRGIQ 130 140 150 160 170 180 180 190 200 210 220 pF1KE3 ITAVVEVGRKHIIWMNHYL-----VSFVIVTTATLAYFIFYHIHRLCLARIQNRRWQRLT .: :.:::.:: :.::: ::: :.:.::..::::: .:: :: :.:. ..: NP_919 VTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSARRLRNARAQSRKQRQLK 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 TDLQNTFGQLQLRVVKEGDEEINPNGDSCVICFERYKPNDIVRILTCKHFFHKNCIDPWI .: ....:.::::..:.::.::.:.::::..:.: :::::.::::::.:.:::.:.:::. NP_919 ADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNHIFHKTCVDPWL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 LPHGTCPICKCDILKVLGIQVVVENGTEPLQVLMSNELPETLSPSEEETNNEVSPAGTSD : : :::.:::::::.:::.: ::.:. ::: .:::. .. : ::.. .:.. .: .. NP_919 LEHRTCPMCKCDILKALGIEVDVEDGSVSLQVPVSNEISNSASSHEEDNRSETASSGYAS 310 320 330 340 350 360 350 360 370 pF1KE3 KVIHVEENPT-----SQNNDIQ-----PHSVVEDVHPSP : ..: : : :...: .::. :: : NP_919 -VQGTDEPPLEEHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVREIK 370 380 390 400 410 420 NP_919 S >>NP_001307292 (OMIM: 610431) E3 ubiquitin-protein ligas (315 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.8 bits: 59.8 E(85289): 9.8e-09 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:9-237) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 MDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 10 20 30 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 150 160 170 180 190 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 260 270 280 290 300 310 >>NP_001307294 (OMIM: 610431) E3 ubiquitin-protein ligas (315 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.8 bits: 59.8 E(85289): 9.8e-09 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:9-237) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 MDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 10 20 30 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 150 160 170 180 190 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 260 270 280 290 300 310 >>NP_001307291 (OMIM: 610431) E3 ubiquitin-protein ligas (315 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.8 bits: 59.8 E(85289): 9.8e-09 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:9-237) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 MDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 10 20 30 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 150 160 170 180 190 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 260 270 280 290 300 310 >>NP_001307293 (OMIM: 610431) E3 ubiquitin-protein ligas (315 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.8 bits: 59.8 E(85289): 9.8e-09 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:9-237) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 MDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 10 20 30 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 100 110 120 130 140 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 150 160 170 180 190 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 260 270 280 290 300 310 >>NP_001307287 (OMIM: 610431) E3 ubiquitin-protein ligas (350 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.2 bits: 59.9 E(85289): 1.1e-08 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:44-272) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 AVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 20 30 40 50 60 70 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 190 200 210 220 230 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 300 310 320 330 340 350 >>NP_056343 (OMIM: 610431) E3 ubiquitin-protein ligase R (350 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.2 bits: 59.9 E(85289): 1.1e-08 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:44-272) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_056 AVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 20 30 40 50 60 70 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_056 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_056 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_056 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 190 200 210 220 230 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_056 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_056 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 300 310 320 330 340 350 >>NP_001307290 (OMIM: 610431) E3 ubiquitin-protein ligas (350 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.2 bits: 59.9 E(85289): 1.1e-08 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:44-272) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 AVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 20 30 40 50 60 70 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 190 200 210 220 230 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 300 310 320 330 340 350 >>NP_001307289 (OMIM: 610431) E3 ubiquitin-protein ligas (350 aa) initn: 234 init1: 171 opt: 270 Z-score: 277.2 bits: 59.9 E(85289): 1.1e-08 Smith-Waterman score: 288; 27.8% identity (60.9% similar) in 248 aa overlap (61-297:44-272) 40 50 60 70 80 90 pF1KE3 CCRASVVWMAYMNISFHVGNHVLSELGETGVFGRSSTLKRVAGVIVPPEGKIQNACNPNT .:: . . . . : .: :.. .:::.: . NP_001 AVLWGAAPTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLV--EAHPDNACSPIA 20 30 40 50 60 70 100 110 120 130 140 pF1KE3 IFSRSKYSET-WLALIERGGCTFTQKIKVATEKGASGVIIYNVPGTGNQVFPMFHQAFE- . . . ..::..: :.: :. : . : ......:: ..:... : .. : NP_001 PPPPAPVNGSVFIALLRRFDCNFDLKVLNAQKAGYGAAVVHNV--NSNELLNMVWNSEEI 80 90 100 110 120 150 160 170 180 190 200 pF1KE3 --DVVV--VMIGNLKGTEIFHLI---KKGVLITAVVEVGRKHIIWMNHYLVSFV-IVTTA .. . :.::. ...: .. . .::. . : . . . ...::. :. :: NP_001 QQQIWIPSVFIGE-RSSEYLRALFVYEKGARVLLVPD----NTFPLGYYLIPFTGIVGLL 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE3 TLAYFIFYHIHRLCLARIQNRRWQRLTTDLQNTFGQLQLRVVKEGDEEINPNGDSCVICF .::. . : : : ::.:. :: .: . . ::. . : . . . : :.::. NP_001 VLAMGAVM-IAR-C---IQHRK--RLQ---RNRLTKEQLKQIPTHDYQKGDQYDVCAICL 190 200 210 220 230 270 280 290 300 310 pF1KE3 ERYKPNDIVRILTCKHFFHKNCIDPWILP-HGTCPICKCDILKVLGIQVVVENGTEPLQV ..:. .: .:.: : : .:. :.:::. . :::::: NP_001 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEG 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE3 LMSNELPETLSPSEEETNNEVSPAGTSDKVIHVEENPTSQNNDIQPHSVVEDVHPSP NP_001 DEGEPRDHPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 300 310 320 330 340 350 376 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:50:05 2016 done: Sun Nov 6 04:50:06 2016 Total Scan time: 6.420 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]