FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4032, 242 aa 1>>>pF1KE4032 242 - 242 aa - 242 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6624+/-0.000356; mu= 3.4009+/- 0.022 mean_var=316.9505+/-64.995, 0's: 0 Z-trim(124.0): 6 B-trim: 0 in 0/57 Lambda= 0.072041 statistics sampled from 44724 (44742) to 44724 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.814), E-opt: 0.2 (0.525), width: 16 Scan time: 8.170 The best scores are: opt bits E(85289) NP_667339 (OMIM: 612061) E3 ubiquitin-protein liga ( 242) 1678 186.7 3.1e-47 NP_115644 (OMIM: 612060) E3 ubiquitin-protein liga ( 227) 609 75.6 8.4e-14 XP_016879282 (OMIM: 612060) PREDICTED: E3 ubiquiti ( 227) 609 75.6 8.4e-14 >>NP_667339 (OMIM: 612061) E3 ubiquitin-protein ligase Z (242 aa) initn: 1678 init1: 1678 opt: 1678 Z-score: 968.9 bits: 186.7 E(85289): 3.1e-47 Smith-Waterman score: 1678; 100.0% identity (100.0% similar) in 242 aa overlap (1-242:1-242) 10 20 30 40 50 60 pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_667 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGANGTAGGGGGARAAAAGRFPAQVPSAHQPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_667 ASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVHSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 PEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_667 PEDGGGGRDRPVGGSPGGPRLVIGSLPAHLSPHMFGGFKCPVCSKFVSSDEMDLHLVMCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 TKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_667 TKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNRSCPEHP 190 200 210 220 230 240 pF1KE4 SD :: NP_667 SD >>NP_115644 (OMIM: 612060) E3 ubiquitin-protein ligase Z (227 aa) initn: 671 init1: 553 opt: 609 Z-score: 368.8 bits: 75.6 E(85289): 8.4e-14 Smith-Waterman score: 664; 45.6% identity (65.3% similar) in 248 aa overlap (1-242:1-227) 10 20 30 40 50 pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGAN--GTAGGGGGARAAAAGRFPAQVPSAHQ ::.::: : . : . : .: ::: : :::: . . . . . . NP_115 MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVH ::..::. : . .: ::. : . . ..:. :..: .. : : :.. NP_115 PSTAGGV------PFGLYTPASRGTGDSERAPGGGGSASDSTYAHGN------GYQET-- 70 80 90 100 120 130 140 150 160 170 pF1KE4 SSPEDGGGGRDRPVGGSPGGPRLVIG-SLPAHLSPHMFG---GFKCPVCSKFVSSDEMDL :::. : : : : .. .:: :..:. :. :::::.::: :.::::.. NP_115 ------GGGHHRD-GMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEM 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 HLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNR :..:::.:::..::.:::.::::::.:::::: ::::::::::::::::.::: :::::: NP_115 HFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR 160 170 180 190 200 210 240 pF1KE4 SCPEHPSD ::::::.: NP_115 SCPEHPAD 220 >>XP_016879282 (OMIM: 612060) PREDICTED: E3 ubiquitin-pr (227 aa) initn: 671 init1: 553 opt: 609 Z-score: 368.8 bits: 75.6 E(85289): 8.4e-14 Smith-Waterman score: 664; 45.6% identity (65.3% similar) in 248 aa overlap (1-242:1-227) 10 20 30 40 50 pF1KE4 MGAKQSGPAAANGRTRAYSGSDLPSSSSGGAN--GTAGGGGGARAAAAGRFPAQVPSAHQ ::.::: : . : . : .: ::: : :::: . . . . . . XP_016 MGGKQSTAARSRGPFPGVSTDDSAVPPPGGAPHFGHYRTGGGAMGLRSRSVSSVAGMGMD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 PSASGGAAAAAAAPAAPAAPRSRSLGGAVGSVASGARAAQSPFSIPNSSSGPYGSQDSVH ::..::. : . .: ::. : . . ..:. :..: .. : : :.. XP_016 PSTAGGV------PFGLYTPASRGTGDSERAPGGGGSASDSTYAHGN------GYQET-- 70 80 90 100 120 130 140 150 160 170 pF1KE4 SSPEDGGGGRDRPVGGSPGGPRLVIG-SLPAHLSPHMFG---GFKCPVCSKFVSSDEMDL :::. : : : : .. .:: :..:. :. :::::.::: :.::::.. XP_016 ------GGGHHRD-GMLYLGSRASLADALPLHIAPRWFSSHSGFKCPICSKSVASDEMEM 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 HLVMCLTKPRITYNEDVLSKDAGECAICLEELQQGDTIARLPCLCIYHKGCIDEWFEVNR :..:::.:::..::.:::.::::::.:::::: ::::::::::::::::.::: :::::: XP_016 HFIMCLSKPRLSYNDDVLTKDAGECVICLEELLQGDTIARLPCLCIYHKSCIDSWFEVNR 160 170 180 190 200 210 240 pF1KE4 SCPEHPSD ::::::.: XP_016 SCPEHPAD 220 242 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:20:52 2016 done: Mon Nov 7 16:20:54 2016 Total Scan time: 8.170 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]