FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1701, 206 aa 1>>>pF1KE1701 206 - 206 aa - 206 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8958+/-0.000335; mu= 16.2282+/- 0.021 mean_var=68.6373+/-13.538, 0's: 0 Z-trim(116.3): 26 B-trim: 0 in 0/53 Lambda= 0.154808 statistics sampled from 27280 (27302) to 27280 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.32), width: 16 Scan time: 5.030 The best scores are: opt bits E(85289) NP_056279 (OMIM: 609675) sclerostin domain-contain ( 206) 1430 327.8 7.7e-90 XP_016867432 (OMIM: 609675) PREDICTED: sclerostin ( 206) 1430 327.8 7.7e-90 NP_079513 (OMIM: 122860,239100,269500,605740) scle ( 213) 462 111.6 9.5e-25 >>NP_056279 (OMIM: 609675) sclerostin domain-containing (206 aa) initn: 1430 init1: 1430 opt: 1430 Z-score: 1733.9 bits: 327.8 E(85289): 7.7e-90 Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 206 aa overlap (1-206:1-206) 10 20 30 40 50 60 pF1KE1 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE 130 140 150 160 170 180 190 200 pF1KE1 SMSPAKPVQHHRERKRASKSSKHSMS :::::::::::::::::::::::::: NP_056 SMSPAKPVQHHRERKRASKSSKHSMS 190 200 >>XP_016867432 (OMIM: 609675) PREDICTED: sclerostin doma (206 aa) initn: 1430 init1: 1430 opt: 1430 Z-score: 1733.9 bits: 327.8 E(85289): 7.7e-90 Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 206 aa overlap (1-206:1-206) 10 20 30 40 50 60 pF1KE1 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLPPAIHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFE 130 140 150 160 170 180 190 200 pF1KE1 SMSPAKPVQHHRERKRASKSSKHSMS :::::::::::::::::::::::::: XP_016 SMSPAKPVQHHRERKRASKSSKHSMS 190 200 >>NP_079513 (OMIM: 122860,239100,269500,605740) sclerost (213 aa) initn: 469 init1: 227 opt: 462 Z-score: 565.3 bits: 111.6 E(85289): 9.5e-25 Smith-Waterman score: 464; 40.1% identity (63.8% similar) in 207 aa overlap (11-202:3-203) 10 20 30 40 pF1KE1 MLPPAIHFYLLPLA----CILMKSCL---------AFKNDATEILYSHVVKPVPAHP-SS :::: :.:... . :::::::::. : : . NP_079 MQLPLALCLVCLLVHTAFRVVEGQGWQAFKNDATEIIPELGEYPEPPPELEN 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 NSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLP :.:.:.:.:::: . .. . . .::::. :.:..:: : : .:. ::::.:.: : NP_079 NKTMNRAENGGRP-PHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 LPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDG-STRTYKITVVTACKC .::: :: : :.: : :. ..::. :. :.::.:: : : . :. :. .:..::: NP_079 ARLLPNAIGRG---KWW-RPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKC 120 130 140 150 160 170 180 190 200 pF1KE1 KRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS :: :: ::.: . . :.: . .. : :: .:.: NP_079 KRLTRFHNQSELKDFGTEAARPQKGRKPRPRA-RSAKANQAELENAY 170 180 190 200 210 206 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:26:25 2016 done: Sun Nov 6 16:26:25 2016 Total Scan time: 5.030 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]