FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6494, 617 aa 1>>>pF1KE6494 617 - 617 aa - 617 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8152+/-0.00042; mu= 22.3335+/- 0.026 mean_var=74.2980+/-16.812, 0's: 0 Z-trim(110.5): 197 B-trim: 929 in 1/52 Lambda= 0.148794 statistics sampled from 18612 (18840) to 18612 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.221), width: 16 Scan time: 7.550 The best scores are: opt bits E(85289) NP_660159 (OMIM: 610372) solute carrier family 2, ( 617) 3962 860.6 0 XP_016865800 (OMIM: 610372) PREDICTED: solute carr ( 502) 3061 667.1 4e-191 XP_006715412 (OMIM: 610372) PREDICTED: solute carr ( 538) 3052 665.2 1.6e-190 NP_443117 (OMIM: 611036) proton myo-inositol cotra ( 648) 834 189.2 3.9e-47 XP_011536152 (OMIM: 611036) PREDICTED: proton myo- ( 445) 619 142.9 2.3e-33 XP_011536151 (OMIM: 611036) PREDICTED: proton myo- ( 451) 619 142.9 2.3e-33 XP_011536149 (OMIM: 611036) PREDICTED: proton myo- ( 606) 619 143.0 2.9e-33 XP_016874254 (OMIM: 611036) PREDICTED: proton myo- ( 459) 568 131.9 4.7e-30 XP_016874253 (OMIM: 611036) PREDICTED: proton myo- ( 459) 568 131.9 4.7e-30 XP_011527363 (OMIM: 208050,606145) PREDICTED: solu ( 544) 539 125.8 4e-28 XP_016883576 (OMIM: 208050,606145) PREDICTED: solu ( 473) 536 125.1 5.6e-28 XP_011527367 (OMIM: 208050,606145) PREDICTED: solu ( 494) 536 125.1 5.8e-28 XP_011527366 (OMIM: 208050,606145) PREDICTED: solu ( 507) 536 125.1 5.9e-28 XP_011527365 (OMIM: 208050,606145) PREDICTED: solu ( 532) 536 125.1 6.1e-28 XP_011527364 (OMIM: 208050,606145) PREDICTED: solu ( 533) 536 125.1 6.1e-28 NP_110404 (OMIM: 208050,606145) solute carrier fam ( 541) 536 125.1 6.2e-28 XP_011527362 (OMIM: 208050,606145) PREDICTED: solu ( 562) 536 125.1 6.3e-28 XP_016874255 (OMIM: 611036) PREDICTED: proton myo- ( 408) 451 106.8 1.6e-22 NP_001033 (OMIM: 138190) solute carrier family 2, ( 509) 444 105.3 5.2e-22 XP_011539127 (OMIM: 610371) PREDICTED: solute carr ( 383) 424 100.9 8.3e-21 NP_997303 (OMIM: 610371) solute carrier family 2, ( 512) 424 101.1 1e-20 XP_011539126 (OMIM: 610371) PREDICTED: solute carr ( 517) 424 101.1 1e-20 NP_001315549 (OMIM: 138230) solute carrier family ( 457) 402 96.3 2.5e-19 XP_016857625 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857622 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857626 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 NP_003030 (OMIM: 138230) solute carrier family 2, ( 501) 402 96.3 2.7e-19 XP_016857623 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857624 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857630 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 NP_001315548 (OMIM: 138230) solute carrier family ( 501) 402 96.3 2.7e-19 XP_005263548 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857629 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857627 (OMIM: 138230) PREDICTED: solute carr ( 501) 402 96.3 2.7e-19 XP_016857631 (OMIM: 138230) PREDICTED: solute carr ( 442) 349 84.9 6.5e-16 XP_006714032 (OMIM: 606142,612076) PREDICTED: solu ( 423) 314 77.4 1.1e-13 XP_011512168 (OMIM: 606142,612076) PREDICTED: solu ( 445) 314 77.4 1.2e-13 XP_011512167 (OMIM: 606142,612076) PREDICTED: solu ( 452) 314 77.4 1.2e-13 XP_011512163 (OMIM: 606142,612076) PREDICTED: solu ( 486) 314 77.4 1.3e-13 XP_016863947 (OMIM: 606142,612076) PREDICTED: solu ( 487) 314 77.4 1.3e-13 NP_001001290 (OMIM: 606142,612076) solute carrier ( 511) 314 77.4 1.3e-13 XP_011512162 (OMIM: 606142,612076) PREDICTED: solu ( 537) 314 77.5 1.4e-13 XP_011512161 (OMIM: 606142,612076) PREDICTED: solu ( 538) 314 77.5 1.4e-13 NP_064425 (OMIM: 606142,612076) solute carrier fam ( 540) 314 77.5 1.4e-13 XP_006714031 (OMIM: 606142,612076) PREDICTED: solu ( 563) 314 77.5 1.4e-13 XP_011512160 (OMIM: 606142,612076) PREDICTED: solu ( 586) 314 77.5 1.4e-13 XP_011512159 (OMIM: 606142,612076) PREDICTED: solu ( 586) 314 77.5 1.4e-13 XP_016863946 (OMIM: 606142,612076) PREDICTED: solu ( 609) 314 77.5 1.5e-13 XP_011512158 (OMIM: 606142,612076) PREDICTED: solu ( 615) 314 77.5 1.5e-13 NP_001020109 (OMIM: 610367) solute carrier family ( 496) 307 75.9 3.6e-13 >>NP_660159 (OMIM: 610372) solute carrier family 2, faci (617 aa) initn: 3962 init1: 3962 opt: 3962 Z-score: 4596.5 bits: 860.6 E(85289): 0 Smith-Waterman score: 3962; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617) 10 20 30 40 50 60 pF1KE6 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 SLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 SLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLE 550 560 570 580 590 600 610 pF1KE6 CNKLCGRGQSRQLSPET ::::::::::::::::: NP_660 CNKLCGRGQSRQLSPET 610 >>XP_016865800 (OMIM: 610372) PREDICTED: solute carrier (502 aa) initn: 3043 init1: 3043 opt: 3061 Z-score: 3552.3 bits: 667.1 E(85289): 4e-191 Smith-Waterman score: 3061; 96.8% identity (98.0% similar) in 504 aa overlap (1-503:1-500) 10 20 30 40 50 60 pF1KE6 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 PMPWLVLSEIFPGGIR-GRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSL : . ::: .:. :. .::. XP_016 PS----IESIFPENIKIGEILALSCF 490 500 >>XP_006715412 (OMIM: 610372) PREDICTED: solute carrier (538 aa) initn: 3043 init1: 3043 opt: 3052 Z-score: 3541.5 bits: 665.2 E(85289): 1.6e-190 Smith-Waterman score: 3052; 95.3% identity (98.0% similar) in 508 aa overlap (1-506:1-508) 10 20 30 40 50 60 pF1KE6 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLG 430 440 450 460 470 480 490 500 510 520 530 pF1KE6 PMPWLVL--SEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMS : . . : .:.. .: ........ XP_006 PRDVIFIGQSTNLPSAPEGDTISISKTIYYAAYNKAIIQTALERQPRAKTVSAFSHKT 490 500 510 520 530 >>NP_443117 (OMIM: 611036) proton myo-inositol cotranspo (648 aa) initn: 743 init1: 369 opt: 834 Z-score: 967.3 bits: 189.2 E(85289): 3.9e-47 Smith-Waterman score: 837; 31.2% identity (65.5% similar) in 536 aa overlap (39-560:80-605) 10 20 30 40 50 60 pF1KE6 GPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQI :... .: .:..:.: ::. :..:::.: . NP_443 SLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLL 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE6 KTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL : :.:. ::..::: : .: ...:.::.: .:::.::.:.: :. :: :: . NP_443 KRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAAN 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE6 SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYA . .:..::...:..:...:... :::::..: . :: ::..: :.:. : . : . . : NP_443 NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE6 FANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTT :. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...:. . NP_443 FSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTID 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE6 EELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPNILFYAS :: ::.....: . : .. : : : ...: : .: :..: .:..:.. NP_443 EEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSA 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE6 TVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSK--TFLCIGSSVMAASLVT :.:. : .... : .. .. .. : :. .. ::..:: . :: ......: ... NP_443 TILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILA 350 360 370 380 390 400 370 380 390 400 410 pF1KE6 MGIV---NLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRS .:.: ... ...: : : .. . . : :. . : :. . . NP_443 LGFVLSAQVSPRITFKPIAPSGQNATCT----------RYSYCNECMLDPDCGFCYKMNK 410 420 430 440 450 420 430 440 450 460 470 pF1KE6 SLMPLRNDVDKRGETTSASLLNAGLSHTEYQ---IVTDPGDVPAFLKWLSLASLLVYVAA : . . : .:. . . ..:... : . :. .: .: .:..:.. NP_443 STVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGLILYLVF 460 470 480 490 500 510 480 490 500 510 520 530 pF1KE6 FSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIY :. :.::::: : :::.: :. . : .:..:: .:.:.::::: ... . . :.: NP_443 FAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLY 520 530 540 550 560 570 540 550 560 570 580 590 pF1KE6 TIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKP . .. ..:::. .::::: .::.: NP_443 AGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHL 580 590 600 610 620 630 >>XP_011536152 (OMIM: 611036) PREDICTED: proton myo-inos (445 aa) initn: 500 init1: 334 opt: 619 Z-score: 719.9 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 619; 33.8% identity (70.7% similar) in 334 aa overlap (39-364:80-413) 10 20 30 40 50 60 pF1KE6 GPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQI :... .: .:..:.: ::. :..:::.: . XP_011 SLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLL 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE6 KTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL : :.:. ::..::: : .: ...:.::.: .:::.::.:.: :. :: :: . XP_011 KRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAAN 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE6 SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYA . .:..::...:..:...:... :::::..: . :: ::..: :.:. : . : . . : XP_011 NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE6 FANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTT :. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...:. . XP_011 FSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTID 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE6 EELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPNILFYAS :: ::.....: . : .. : : : ...: : .: :..: .:..:.. XP_011 EEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSA 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE6 TVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSK--TFLCIGSSVMAASLVT :.:. : .... : .. .. .. : :. .. ::..:: . :: ......: ... XP_011 TILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILA 350 360 370 380 390 400 370 380 390 400 410 420 pF1KE6 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM .:.: XP_011 LGFVLSAQVSPRITFKPIAPSGQNATCTRYSLQAPY 410 420 430 440 >>XP_011536151 (OMIM: 611036) PREDICTED: proton myo-inos (451 aa) initn: 500 init1: 334 opt: 619 Z-score: 719.9 bits: 142.9 E(85289): 2.3e-33 Smith-Waterman score: 619; 33.8% identity (70.7% similar) in 334 aa overlap (39-364:80-413) 10 20 30 40 50 60 pF1KE6 GPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQI :... .: .:..:.: ::. :..:::.: . XP_011 SLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLL 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE6 KTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL : :.:. ::..::: : .: ...:.::.: .:::.::.:.: :. :: :: . XP_011 KRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAAN 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE6 SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYA . .:..::...:..:...:... :::::..: . :: ::..: :.:. : . : . . : XP_011 NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE6 FANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTT :. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...:. . XP_011 FSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTID 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE6 EELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPNILFYAS :: ::.....: . : .. : : : ...: : .: :..: .:..:.. XP_011 EEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSA 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE6 TVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSK--TFLCIGSSVMAASLVT :.:. : .... : .. .. .. : :. .. ::..:: . :: ......: ... XP_011 TILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTVALIILA 350 360 370 380 390 400 370 380 390 400 410 420 pF1KE6 MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLM .:.: XP_011 LGFVLSAQVSPRITFKPIAPSGQNATCTRYSGQPHQDSGMLF 410 420 430 440 450 >>XP_011536149 (OMIM: 611036) PREDICTED: proton myo-inos (606 aa) initn: 708 init1: 334 opt: 619 Z-score: 718.2 bits: 143.0 E(85289): 2.9e-33 Smith-Waterman score: 798; 31.1% identity (63.6% similar) in 528 aa overlap (39-560:80-563) 10 20 30 40 50 60 pF1KE6 GPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQI :... .: .:..:.: ::. :..:::.: . XP_011 SLQSAGAGGGGVGDLERAARRQFQQDETPAFVYVVAVFSALGGFLFGYDTGVVSGAMLLL 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE6 KTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSL : :.:. ::..::: : .: ...:.::.: .:::.::.:.: :. :: :: . XP_011 KRQLSLDALWQELLVSSTVGAAAVSALAGGALNGVFGRRAAILLASALFTAGSAVLAAAN 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE6 SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYA . .:..::...:..:...:... :::::..: . :: ::..: :.:. : . : . . : XP_011 NKETLLAGRLVVGLGIGIASMTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFASVVDGA 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE6 FANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTT :. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...:. . XP_011 FSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMRGNQTID 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE6 EELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPNILFYAS :: ::.....: . : .. : : : ...: : .: :..: .:..:.. XP_011 EEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINTIMYYSA 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE6 TVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMG :.:. : .... : .. .. .. : :. .. ::..:: . : .:: .:.. :.. XP_011 TILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRK-LTFGS--LAGTTVALI 350 360 370 380 390 400 370 380 390 400 410 420 pF1KE6 IVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPL :. :.. .. ... . . : : .: : XP_011 ILALGF------------VLSAQVSPRITFKPIAPSGQNATCT----------------- 410 420 430 430 440 450 460 470 480 pF1KE6 RNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPM : ... . . ... : :.. : .: .: .:..:.. :. :.::: XP_011 RYRCENETKFKTEDIFWA------YNFCPTP------YSWTALLGLILYLVFFAPGMGPM 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 PWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASL :: : :::.: :. . : .:..:: .:.:.::::: ... . . :.:. .. ..: XP_011 PWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYYGAFFLYAGFAAVGL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 LFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECN ::. .::::: .::.: XP_011 LFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVKGSNYHLSDNDASDV 550 560 570 580 590 600 >>XP_016874254 (OMIM: 611036) PREDICTED: proton myo-inos (459 aa) initn: 474 init1: 222 opt: 568 Z-score: 660.6 bits: 131.9 E(85289): 4.7e-30 Smith-Waterman score: 568; 29.1% identity (62.3% similar) in 422 aa overlap (153-560:5-416) 130 140 150 160 170 180 pF1KE6 VLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSA :::::..: . :: ::..: :.:. : . : XP_016 MTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFA 10 20 30 190 200 210 220 230 240 pF1KE6 YISNYAFANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLR . . ::. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...: XP_016 SVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMR 40 50 60 70 80 90 250 260 270 280 290 pF1KE6 ALSDTTEELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPN . . :: ::.....: . : .. : : : ...: : .: :..: . XP_016 GNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINT 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE6 ILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSK--TFLCIGSSVM :..:..:.:. : .... : .. .. .. : :. .. ::..:: . :: ...... XP_016 IMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE6 AASLVTMGIV---NLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGI : ....:.: ... ...: : : .. . . : :. . : :. XP_016 ALIILALGFVLSAQVSPRITFKPIAPSGQNATCT----------RYSYCNECMLDPDCGF 220 230 240 250 260 420 430 440 450 460 pF1KE6 SSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQ---IVTDPGDVPAFLKWLSLASL . .: . . : .:. . . ..:... : . :. .: .: .: XP_016 CYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGL 270 280 290 300 310 320 470 480 490 500 510 520 pF1KE6 LVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLP ..:.. :. :.::::: : :::.: :. . : .:..:: .:.:.::::: ... . XP_016 ILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYY 330 340 350 360 370 380 530 540 550 560 570 580 pF1KE6 WVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQ . :.:. .. ..:::. .::::: .::.: XP_016 GAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVK 390 400 410 420 430 440 590 600 610 pF1KE6 PQKRKPQEQLLECNKLCGRGQSRQLSPET XP_016 GSNYHLSDNDASDVE 450 >>XP_016874253 (OMIM: 611036) PREDICTED: proton myo-inos (459 aa) initn: 474 init1: 222 opt: 568 Z-score: 660.6 bits: 131.9 E(85289): 4.7e-30 Smith-Waterman score: 568; 29.1% identity (62.3% similar) in 422 aa overlap (153-560:5-416) 130 140 150 160 170 180 pF1KE6 VLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSA :::::..: . :: ::..: :.:. : . : XP_016 MTVPVYIAEVSPPNLRGRLVTINTLFITGGQFFA 10 20 30 190 200 210 220 230 240 pF1KE6 YISNYAFANVFH-GWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLR . . ::. . . ::.::.::. .:.: ... ::: :::.:..::: : ..:...: XP_016 SVVDGAFSYLQKDGWRYMLGLAAVPAVIQFFGFLFLPESPRWLIQKGQTQKARRILSQMR 40 50 60 70 80 90 250 260 270 280 290 pF1KE6 ALSDTTEELTVIKSSLKDEYQY--SFWDLF-R--SKDNMRTRIMIGLTLVFFVQITGQPN . . :: ::.....: . : .. : : : ...: : .: :..: . XP_016 GNQTIDEEYDSIKNNIEEEEKEVGSAGPVICRMLSYPPTRRALIVGCGLQMFQQLSGINT 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE6 ILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSK--TFLCIGSSVM :..:..:.:. : .... : .. .. .. : :. .. ::..:: . :: ...... XP_016 IMYYSATILQMSGVEDDRLAIWLASVTAFTNFIFTLVGVWLVEKVGRRKLTFGSLAGTTV 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE6 AASLVTMGIV---NLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGI : ....:.: ... ...: : : .. . . : :. . : :. XP_016 ALIILALGFVLSAQVSPRITFKPIAPSGQNATCT----------RYSYCNECMLDPDCGF 220 230 240 250 260 420 430 440 450 460 pF1KE6 SSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQ---IVTDPGDVPAFLKWLSLASL . .: . . : .:. . . ..:... : . :. .: .: .: XP_016 CYKMNKSTVIDSSCVPVNKASTNEAAWGRCENETKFKTEDIFWAYNFCPTPYSWTALLGL 270 280 290 300 310 320 470 480 490 500 510 520 pF1KE6 LVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLP ..:.. :. :.::::: : :::.: :. . : .:..:: .:.:.::::: ... . XP_016 ILYLVFFAPGMGPMPWTVNSEIYPLWARSTGNACSSGINWIFNVLVSLTFLHTAEYLTYY 330 340 350 360 370 380 530 540 550 560 570 580 pF1KE6 WVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQ . :.:. .. ..:::. .::::: .::.: XP_016 GAFFLYAGFAAVGLLFIYGCLPETKGKKLEEIESLFDNRLCTCGTSDSDEGRYIEYIRVK 390 400 410 420 430 440 590 600 610 pF1KE6 PQKRKPQEQLLECNKLCGRGQSRQLSPET XP_016 GSNYHLSDNDASDVE 450 >>XP_011527363 (OMIM: 208050,606145) PREDICTED: solute c (544 aa) initn: 1197 init1: 536 opt: 539 Z-score: 626.0 bits: 125.8 E(85289): 4e-28 Smith-Waterman score: 1191; 40.7% identity (67.8% similar) in 543 aa overlap (27-566:5-517) 10 20 30 40 50 60 pF1KE6 MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGI :. :: :. ..:. :: ::::.. XP_011 MKAYSHSPPVLPLCASVSLLG-------GLTFGYELAV 10 20 30 70 80 90 100 110 120 pF1KE6 ISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLG :::::: .. ..::: :::..:.::..:::::::.:: ::: :::. ::. :. .: : XP_011 ISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE6 SLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL ::.: :. : . :..:: ..: .:::::.: :.:..:.. ..::.:::: : :..::: XP_011 SLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGIL 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE6 SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRL .: :::.:.. ::..::: . .:::.... ::: . .: :. : : : XP_011 LSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGT-------DETATHKDLIPL 160 170 180 190 200 250 260 270 280 290 300 pF1KE6 RALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFY .. . .: . .::: ::::..:::: : .:: ::.: :.:::::.: : XP_011 QG--GEAPKLGPGRP------RYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCY 210 220 230 240 250 310 320 330 340 350 360 pF1KE6 ASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT :::...::::... .: :::.:.:.::: .:. : :::..: ...: : ..:: :. XP_011 ASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSG 260 270 280 290 300 310 370 380 390 400 410 pF1KE6 MGIVNLNIHMNFTHICRS-HNSINQSL--DESVIYGPGNLSTNNNTLRDHFKGISSHSRS .:.:.. . :. : . :. .:. .: . ..: : .:. . : : ... XP_011 IGLVSFAVPMDSGPSCLAVPNATGQTGLPGDSGLLQDSSLPPIPRTNEDQREPILSTAKK 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE6 SLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSI . : . : . : :...: :. :.:.: .: :.:.:.:::. XP_011 T-KPHPRSGDPSAPPRLA--LSSALPGPPL-----PARGHALLRWTALLCLMVFVSAFSF 380 390 400 410 420 480 490 500 510 520 530 pF1KE6 GLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIM :.::. :::::::.: :::::.:. .:.::. ::.:::.:: . ::: :. ..: . XP_011 GFGPVTWLVLSEIYPVEIRGRAFAFCNSFNWAANLFISLSFLDLIGTIGLSWTFLLYGLT 430 440 450 460 470 480 540 550 560 570 580 590 pF1KE6 SLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQ .. .: :. .:.::::: :: .:.... : XP_011 AVLGLGFIYLFVPETKGQSLAEIDQQFQKRRFTLSFGHRQNSTGIPYSRIEISAAS 490 500 510 520 530 540 617 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:51:35 2016 done: Tue Nov 8 13:51:36 2016 Total Scan time: 7.550 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]