FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE0765, 339 aa 1>>>pF1KE0765 339 - 339 aa - 339 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8583+/-0.000537; mu= 18.5150+/- 0.033 mean_var=101.8482+/-26.006, 0's: 0 Z-trim(107.7): 544 B-trim: 1789 in 2/47 Lambda= 0.127086 statistics sampled from 14963 (15736) to 14963 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.519), E-opt: 0.2 (0.185), width: 16 Scan time: 6.330 The best scores are: opt bits E(85289) NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 2315 435.9 5.7e-122 NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 983 191.7 1.9e-48 NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 941 184.0 4e-46 NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 920 180.2 5.7e-45 NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 755 149.9 7.4e-36 NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 712 142.0 1.6e-33 NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 561 114.4 3.7e-25 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 450 94.0 5.1e-19 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 450 94.0 5.1e-19 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 450 94.1 5.4e-19 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 450 94.1 5.7e-19 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 403 85.5 2.3e-16 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 392 83.5 8.9e-16 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 379 81.0 4.4e-15 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 379 81.2 5.1e-15 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 377 80.7 5.9e-15 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 372 79.9 1.2e-14 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 361 77.7 4.2e-14 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 357 77.1 8.1e-14 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 356 76.9 8.7e-14 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 356 76.9 8.7e-14 NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 356 77.0 9.9e-14 NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 355 76.7 1e-13 NP_000667 (OMIM: 600446) adenosine receptor A2b [H ( 332) 352 76.0 1.2e-13 NP_001265427 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13 NP_001265428 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13 NP_001265426 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13 NP_000666 (OMIM: 102776) adenosine receptor A2a [H ( 412) 353 76.3 1.3e-13 NP_001265429 (OMIM: 102776) adenosine receptor A2a ( 412) 353 76.3 1.3e-13 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 348 75.4 2.3e-13 NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 346 75.0 3e-13 NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 345 74.8 3.3e-13 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 344 74.6 3.6e-13 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 344 74.6 3.7e-13 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 344 74.6 3.7e-13 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 344 74.6 3.7e-13 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 344 74.6 3.8e-13 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 344 74.6 3.8e-13 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 344 74.7 3.9e-13 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 344 74.7 4e-13 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 330 72.1 2.3e-12 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 329 72.0 2.7e-12 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 328 71.8 3.2e-12 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 328 71.8 3.2e-12 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 327 71.6 3.5e-12 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 320 70.3 8.7e-12 >>NP_612200 (OMIM: 609333) trace amine-associated recept (339 aa) initn: 2315 init1: 2315 opt: 2315 Z-score: 2310.7 bits: 435.9 E(85289): 5.7e-122 Smith-Waterman score: 2315; 100.0% identity (100.0% similar) in 339 aa overlap (1-339:1-339) 10 20 30 40 50 60 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_612 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFN 250 260 270 280 290 300 310 320 330 pF1KE0 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ::::::::::::::::::::::::::::::::::::::: NP_612 PMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS 310 320 330 >>NP_778227 (OMIM: 608282) trace amine-associated recept (348 aa) initn: 981 init1: 512 opt: 983 Z-score: 990.7 bits: 191.7 E(85289): 1.9e-48 Smith-Waterman score: 983; 42.8% identity (73.1% similar) in 334 aa overlap (4-336:13-343) 10 20 30 40 50 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHF .:.. .: ::.:. .: :. ::... . . . :::.:...: :: NP_778 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAILHF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASI ::::::::.:: :.: .:::.: :::.: :::.: :::::. .::.:: : . ::. NP_778 KQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 FHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEI ::: ::.::: :: ::: : .:... : . : .:: ....:.... : .: ::. NP_778 FHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGIEEL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 YYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLI-SDANQK . : :::.. ... .: :. :.::. :. .: .:.:.::.::: : : :.: NP_778 VVA-LTCVGGCQAPLNQNWVLLCFLL-FFIPNVAMVFIYSKIFLVAKHQARKIESTASQA 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 LQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLI . . .:. ... .::::.:::::.:..::. : :... .:.: ....: :: . ..:. NP_778 QSSSESYKERVAK-RERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV 240 250 260 270 280 290 300 310 320 330 pF1KE0 WFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS : : ::..::..::::: :: ::.:... ::... ::: .:: : NP_778 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD 300 310 320 330 340 >>NP_778237 (OMIM: 608923) trace amine-associated recept (345 aa) initn: 932 init1: 506 opt: 941 Z-score: 949.1 bits: 184.0 E(85289): 4e-46 Smith-Waterman score: 941; 41.1% identity (71.2% similar) in 333 aa overlap (4-336:13-343) 10 20 30 40 50 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHF .:. .: :::: .: :. :: .. . . .. :::.:..:: :: NP_778 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISILHF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 KQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASI ::::.:::.:. :.: .:::.: :::.::::..: :::::. :: .:: :. . .:. NP_778 KQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCYSSL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 FHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEI ::: ::::::: :: ::: : .:... : . : .:: .: ... : .: . . : NP_778 FHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYS-GAVFYTGVYDDGLEE 130 140 150 160 170 180 190 200 210 220 230 pF1KE0 YYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKL ..: :::.. .. . ::: . ::.:: ::. .: :.:.:..::. : ....: NP_778 LSDALNCIGGCQTVVNQ-NWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSKT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 QIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIW . . : .. .::::.::::... .:.: : :. : ...: :. .: : . .. : NP_778 ESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICCW 240 250 260 270 280 290 300 310 320 330 pF1KE0 FGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS .: ::..::..::.::::::::.:... :......:. .:: : NP_778 CAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI 300 310 320 330 340 >>NP_444508 (OMIM: 606927) trace amine-associated recept (342 aa) initn: 887 init1: 481 opt: 920 Z-score: 928.4 bits: 180.2 E(85289): 5.7e-45 Smith-Waterman score: 920; 39.3% identity (71.4% similar) in 336 aa overlap (1-336:9-342) 10 20 30 40 50 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFK .. .:.. .: ::... .: :. ::. . . : .. :::.:..:. ::: NP_444 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE0 QLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIF :::.:::.:: :.: .:::.: :: .::::..: ::::: :: .:. :. . .:.. NP_444 QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE0 HLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIY :: :: :::: .: ::: : .:... : . : .:: .: ... .... .: : ::. NP_444 HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE0 YKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQ . ..: :::... :. .. :. :.:: .:. .: .:.::::.:: : ...:.. NP_444 -SALNCVGGCQIIVSQGWVLIDFLL-FFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVE 190 200 210 220 230 240 250 260 270 280 290 pF1KE0 IGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWF . : . ..::::.::::... .:.: : :. . ..: :. .. : . .. : NP_444 SSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWS 240 250 260 270 280 290 300 310 320 330 pF1KE0 GYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS .: ::..::..::.::::::::.:..: : ... .:: .:::: NP_444 AYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE 300 310 320 330 340 >>NP_001028252 (OMIM: 604849) trace amine-associated rec (351 aa) initn: 1065 init1: 610 opt: 755 Z-score: 764.7 bits: 149.9 E(85289): 7.4e-36 Smith-Waterman score: 1111; 50.6% identity (76.7% similar) in 322 aa overlap (5-324:25-335) 10 20 30 40 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVG : . : :: .:. : ::...::.:. :. :. : NP_001 MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE0 NLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHT :: .:.:::.:::::::::.:: ::: .::::: .:::::.::.:.::::: .::::. NP_001 NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE0 STDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIF : :.::: .::::: ..:::.::.: :: :..:..: :: .... ::::..::::..: NP_001 SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE0 LELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQ : : : : : : ..: :.:.:. :. ::..:. :::.:. .: .:. ..... NP_001 SEAYADGIEG-YDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKH 190 200 210 220 230 230 240 250 260 270 pF1KE0 ARLISD--ANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLH :. :.. ::. :. .:..::.::::::.::::.:: : :. ..::::. NP_001 AHAINNLRENQNNQV----------KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLN 240 250 260 270 280 280 290 300 310 320 330 pF1KE0 YIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELS . : .: :.: ::::.::: ::..:.:::::::.:::..:.:::: NP_001 FSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKE 290 300 310 320 330 340 pF1KE0 S NP_001 SE 350 >>NP_055441 (OMIM: 604849) trace amine-associated recept (306 aa) initn: 1029 init1: 574 opt: 712 Z-score: 722.8 bits: 142.0 E(85289): 1.6e-33 Smith-Waterman score: 1068; 51.5% identity (77.7% similar) in 301 aa overlap (26-324:1-290) 10 20 30 40 50 60 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW .::.:. :. :. ::: .:.:::.:::::::::. NP_055 MYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNF 10 20 30 70 80 90 100 110 120 pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID :: ::: .::::: .:::::.::.:.::::: .::::. : :.::: .::::: ..:: NP_055 LILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLCSVAID 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG :.::.: :: :..:..: :: .... ::::..::::..: : : : : : : . NP_055 RFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEG-YDILVACSS 100 110 120 130 140 150 190 200 210 220 230 pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISD--ANQKLQIGLEMK .: :.:.:. :. ::..:. :::.:. .: .:. .....:. :.. ::. :. NP_055 SCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQV----- 160 170 180 190 200 240 250 260 270 280 290 pF1KE0 NGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNST .:..::.::::::.::::.:: : :. ..::::.. : .: :.: ::::.::: NP_055 -----KKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNST 210 220 230 240 250 260 300 310 320 330 pF1KE0 FNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ::..:.:::::::.:::..:.:::: NP_055 CNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE 270 280 290 300 >>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa) initn: 762 init1: 440 opt: 561 Z-score: 572.7 bits: 114.4 E(85289): 3.7e-25 Smith-Waterman score: 893; 39.8% identity (71.0% similar) in 334 aa overlap (4-336:16-337) 10 20 30 40 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSI ::... : :: .. . .. .: . .: ..::..: .. NP_003 MRAVFIQGAEEHPAAFCYQV-NGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV 10 20 30 40 50 50 60 70 80 90 100 pF1KE0 SHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSS :.:: ::::::.:. :.: .:..:: ::.: : .::.: ::.::. .:..:: : .. NP_003 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE0 ASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGA .::::: ::::::. :.:::: : .:... : .:. .:.::: :. .:: . . NP_003 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPA--AYTSLFLYTDVVET 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE0 E-EIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDA . . ... : :.:.....:. : :.: :..: ::. .: .:...: .::. :. NP_003 RLSQWLEEMPCVGSCQLLLNKFWGWLNF-PLFFVPCLIMISLYVKIFVVATRQAQQITTL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE0 NQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLND ...: : .. .::::.:::::..:..:.:: :: : :..: .::.: :: . : NP_003 SKSLA-------GAAK-HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD 240 250 260 270 280 290 300 310 320 330 pF1KE0 VLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ..:::.:.::. ::..:.: : :::::::. : :.:. .. :. : NP_003 IFIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE 290 300 310 320 330 >>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa) initn: 570 init1: 345 opt: 450 Z-score: 462.4 bits: 94.0 E(85289): 5.1e-19 Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317) 10 20 30 40 50 60 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW :. . .. .....:: :..::..: .... ..:.. :: NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID .: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.: NP_071 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG :: :: ::::: . .. . . . . . : . ...: : : : .. : : . NP_071 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG :.: ... :.. ...::.: :: .::::. .:..::. :. .. . NP_071 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI----- 180 190 200 210 220 250 260 270 280 290 pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF .:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::.. NP_071 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 300 310 320 330 pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ::..:: . :: . .... .. ...: . .: NP_071 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 NP_071 VWSGTEVTAPQGATDR 350 >>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa) initn: 570 init1: 345 opt: 450 Z-score: 462.4 bits: 94.0 E(85289): 5.1e-19 Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317) 10 20 30 40 50 60 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW :. . .. .....:: :..::..: .... ..:.. :: XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID .: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.: XP_006 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG :: :: ::::: . .. . . . . . : . ...: : : : .. : : . XP_006 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG :.: ... :.. ...::.: :: .::::. .:..::. :. .. . XP_006 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI----- 180 190 200 210 220 250 260 270 280 290 pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF .:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::.. XP_006 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 300 310 320 330 pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ::..:: . :: . .... .. ...: . .: XP_006 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 XP_006 VWSGTEVTAPQGATDRNSS 350 360 >>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa) initn: 570 init1: 345 opt: 450 Z-score: 461.9 bits: 94.1 E(85289): 5.4e-19 Smith-Waterman score: 608; 32.3% identity (65.5% similar) in 316 aa overlap (19-333:14-317) 10 20 30 40 50 60 pF1KE0 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNW :. . .. .....:: :..::..: .... ..:.. :: NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNC 10 20 30 40 50 70 80 90 100 110 120 pF1KE0 LIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISID .: :.: .:.::: ::.:.: . . : ::.:::.:.:: :.:: .:::..: .::.: NP_001 FIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE0 RYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRG :: :: ::::: . .. . . . . . : . ...: : : : .. : : . NP_001 RYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS---KGNHTTS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE0 GCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNG :.: ... :.. ...::.: :: .::::. .:..::. :. .. . NP_001 KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATI----- 180 190 200 210 220 250 260 270 280 290 pF1KE0 ISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFL-HYIIPPTLNDVLIWFGYLNSTF .:.::. ::. :::.:.::: :.: :. . : .:. ...:.:: ::.. NP_001 ----REHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL 230 240 250 260 270 280 300 310 320 330 pF1KE0 NPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS ::..:: . :: . .... .. ...: . .: NP_001 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ 290 300 310 320 330 340 NP_001 VWSGTEVTAPQGATDRPWLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL 350 360 370 380 390 339 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 07:53:33 2016 done: Sun Nov 6 07:53:34 2016 Total Scan time: 6.330 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]