FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1640, 155 aa 1>>>pF1KE1640 155 - 155 aa - 155 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2270+/-0.000292; mu= 12.3312+/- 0.018 mean_var=65.0759+/-13.075, 0's: 0 Z-trim(118.5): 15 B-trim: 0 in 0/54 Lambda= 0.158988 statistics sampled from 31499 (31514) to 31499 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.369), width: 16 Scan time: 4.750 The best scores are: opt bits E(85289) NP_002181 (OMIM: 603149) interleukin-17A precursor ( 155) 1077 255.0 3.6e-68 NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 431 106.8 1.5e-23 XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 431 106.8 1.5e-23 XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07 NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 198 53.3 1.5e-07 XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07 XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 198 53.3 1.5e-07 NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 198 53.4 2e-07 XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 198 53.5 2.6e-07 NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 189 51.4 9.2e-07 XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 189 51.4 9.5e-07 NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 167 46.3 3e-05 XP_005266479 (OMIM: 607587) PREDICTED: interleukin ( 114) 154 43.2 0.00015 NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 134 38.7 0.0048 NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 134 38.7 0.0052 >>NP_002181 (OMIM: 603149) interleukin-17A precursor [Ho (155 aa) initn: 1077 init1: 1077 opt: 1077 Z-score: 1344.9 bits: 255.0 E(85289): 3.6e-68 Smith-Waterman score: 1077; 100.0% identity (100.0% similar) in 155 aa overlap (1-155:1-155) 10 20 30 40 50 60 pF1KE1 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 KRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEIL 70 80 90 100 110 120 130 140 150 pF1KE1 VLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA ::::::::::::::::::::::::::::::::::: NP_002 VLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA 130 140 150 >>NP_443104 (OMIM: 606496,613956) interleukin-17F precur (163 aa) initn: 411 init1: 411 opt: 431 Z-score: 543.7 bits: 106.8 E(85289): 1.5e-23 Smith-Waterman score: 431; 49.0% identity (68.2% similar) in 151 aa overlap (7-154:18-162) 10 20 30 40 pF1KE1 MTPGKTSLVSLLLLLSLEA--IVKAGITIPRNP-GCPNSEDKNFPRTVM :...: .: : : :.: :. ..: .:: : : NP_443 MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPP-----VPGGSM 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 VNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNV .:.: : : . : . .::::::: . ::.:::: . .:.::.::::::.:. NP_443 -KLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKE 60 70 80 90 100 110 110 120 130 140 150 pF1KE1 DYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA : ::::::::: ::.::. : ::.:::.::.::::::::..::: NP_443 DISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ 120 130 140 150 160 >>XP_011512578 (OMIM: 606496,613956) PREDICTED: interleu (163 aa) initn: 411 init1: 411 opt: 431 Z-score: 543.7 bits: 106.8 E(85289): 1.5e-23 Smith-Waterman score: 431; 49.0% identity (68.2% similar) in 151 aa overlap (7-154:18-162) 10 20 30 40 pF1KE1 MTPGKTSLVSLLLLLSLEA--IVKAGITIPRNP-GCPNSEDKNFPRTVM :...: .: : : :.: :. ..: .:: : : XP_011 MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPP-----VPGGSM 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 VNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNV .:.: : : . : . .::::::: . ::.:::: . .:.::.::::::.:. XP_011 -KLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKE 60 70 80 90 100 110 110 120 130 140 150 pF1KE1 DYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA : ::::::::: ::.::. : ::.:::.::.::::::::..::: XP_011 DISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ 120 130 140 150 160 >>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 80 90 100 110 120 pF1KE1 VA >>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa) initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: NP_001 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. NP_001 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 80 90 100 110 120 pF1KE1 VA >>XP_011535924 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: XP_011 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. XP_011 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 80 90 100 110 120 pF1KE1 VA >>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 193 init1: 125 opt: 198 Z-score: 256.5 bits: 53.3 E(85289): 1.5e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:44-127) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 80 90 100 110 120 pF1KE1 VA >>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa) initn: 193 init1: 125 opt: 198 Z-score: 254.3 bits: 53.4 E(85289): 2e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:96-179) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: NP_055 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. NP_055 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 130 140 150 160 170 180 pF1KE1 VA >>XP_016864835 (OMIM: 604627) PREDICTED: interleukin-17B (245 aa) initn: 193 init1: 125 opt: 198 Z-score: 252.3 bits: 53.5 E(85289): 2.6e-07 Smith-Waterman score: 198; 39.3% identity (59.5% similar) in 84 aa overlap (69-147:161-244) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG :: :::. :.:: : : . ::.: :: XP_016 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG 140 150 160 170 180 190 100 110 120 130 140 150 pF1KE1 CINA-DGNVDYHMNSVPIQQEILVLRR--EPPHCPNSFRLEKIL--VSVGCTCVTPIVHH :.: . : : :::. ... : :: :: . : . .. ..:::::. XP_016 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 200 210 220 230 240 pF1KE1 VA >>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa) initn: 191 init1: 109 opt: 189 Z-score: 242.4 bits: 51.4 E(85289): 9.2e-07 Smith-Waterman score: 189; 39.8% identity (60.2% similar) in 83 aa overlap (69-147:89-170) 40 50 60 70 80 90 pF1KE1 KNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLG ::.::: . . :: ::: . :: : : NP_612 QLGPREQARNASCPAGGRPADRRFRPPTNLRSVSPWAYRISYDPARYPRYLPEAYCLCRG 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 CINAD-GNVDYHMNSVPIQQEILVLRREPPHCPN--SFRLEK-ILVSVGCTCVTPIVHHV :... :. : .. :.:. . .:::: : : . : : . . :::::: NP_612 CLTGLFGEEDVRFRSAPVYMPTVVLRRTPA-CAGGRSVYTEAYVTIPVGCTCVPEPEKDA 120 130 140 150 160 170 pF1KE1 A NP_612 DSINSSIDKQGAKLLLGPNDAPAGP 180 190 200 155 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:48:26 2016 done: Sun Nov 6 16:48:27 2016 Total Scan time: 4.750 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]