FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1662, 180 aa 1>>>pF1KE1662 180 - 180 aa - 180 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7940+/-0.000235; mu= 12.6906+/- 0.015 mean_var=90.1615+/-17.927, 0's: 0 Z-trim(124.3): 15 B-trim: 0 in 0/61 Lambda= 0.135072 statistics sampled from 45818 (45833) to 45818 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.848), E-opt: 0.2 (0.537), width: 16 Scan time: 6.150 The best scores are: opt bits E(85289) NP_055258 (OMIM: 604627) interleukin-17B isoform 1 ( 180) 1283 258.4 4.6e-69 XP_016864835 (OMIM: 604627) PREDICTED: interleukin ( 245) 1221 246.4 2.5e-65 XP_011535924 (OMIM: 604627) PREDICTED: interleukin ( 128) 912 186.0 2e-47 XP_016864836 (OMIM: 604627) PREDICTED: interleukin ( 128) 912 186.0 2e-47 NP_001304916 (OMIM: 604627) interleukin-17B isofor ( 128) 912 186.0 2e-47 XP_016864837 (OMIM: 604627) PREDICTED: interleukin ( 128) 912 186.0 2e-47 XP_005266478 (OMIM: 607587) PREDICTED: interleukin ( 209) 256 58.3 9e-09 NP_612141 (OMIM: 607587) interleukin-17D precursor ( 202) 254 57.9 1.1e-08 NP_037410 (OMIM: 604628) interleukin-17C precursor ( 197) 201 47.6 1.4e-05 NP_443104 (OMIM: 606496,613956) interleukin-17F pr ( 163) 199 47.1 1.6e-05 XP_011512578 (OMIM: 606496,613956) PREDICTED: inte ( 163) 199 47.1 1.6e-05 NP_002181 (OMIM: 603149) interleukin-17A precursor ( 155) 198 46.9 1.8e-05 XP_005266479 (OMIM: 607587) PREDICTED: interleukin ( 114) 187 44.7 6.2e-05 NP_758525 (OMIM: 605658) interleukin-25 isoform 2 ( 161) 177 42.8 0.00032 NP_073626 (OMIM: 605658) interleukin-25 isoform 1 ( 177) 177 42.9 0.00034 >>NP_055258 (OMIM: 604627) interleukin-17B isoform 1 pre (180 aa) initn: 1283 init1: 1283 opt: 1283 Z-score: 1361.0 bits: 258.4 E(85289): 4.6e-69 Smith-Waterman score: 1283; 100.0% identity (100.0% similar) in 180 aa overlap (1-180:1-180) 10 20 30 40 50 60 pF1KE1 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARME 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 CLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 CLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 130 140 150 160 170 180 >>XP_016864835 (OMIM: 604627) PREDICTED: interleukin-17B (245 aa) initn: 1221 init1: 1221 opt: 1221 Z-score: 1293.8 bits: 246.4 E(85289): 2.5e-65 Smith-Waterman score: 1221; 100.0% identity (100.0% similar) in 173 aa overlap (8-180:73-245) 10 20 30 pF1KE1 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGP :::::::::::::::::::::::::::::: XP_016 VKLTCSHTVSESGDHPRRESAVSGRPGQSALFLLTISIFLGLGQPRSPKSKRKGQGRPGP 50 60 70 80 90 100 40 50 60 70 80 90 pF1KE1 LAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRS 110 120 130 140 150 160 100 110 120 130 140 150 pF1KE1 LSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPP 170 180 190 200 210 220 160 170 180 pF1KE1 PRTGPCRQRAVMETIAVGCTCIF ::::::::::::::::::::::: XP_016 PRTGPCRQRAVMETIAVGCTCIF 230 240 >>XP_011535924 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 912 init1: 912 opt: 912 Z-score: 972.3 bits: 186.0 E(85289): 2e-47 Smith-Waterman score: 912; 100.0% identity (100.0% similar) in 128 aa overlap (53-180:1-128) 30 40 50 60 70 80 pF1KE1 RSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQR :::::::::::::::::::::::::::::: XP_011 MKPYARMEEYERNIEEMVAQLRNSSELAQR 10 20 30 90 100 110 120 130 140 pF1KE1 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP 40 50 60 70 80 90 150 160 170 180 pF1KE1 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF :::::::::::::::::::::::::::::::::::::: XP_011 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 100 110 120 >>XP_016864836 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 912 init1: 912 opt: 912 Z-score: 972.3 bits: 186.0 E(85289): 2e-47 Smith-Waterman score: 912; 100.0% identity (100.0% similar) in 128 aa overlap (53-180:1-128) 30 40 50 60 70 80 pF1KE1 RSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQR :::::::::::::::::::::::::::::: XP_016 MKPYARMEEYERNIEEMVAQLRNSSELAQR 10 20 30 90 100 110 120 130 140 pF1KE1 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP 40 50 60 70 80 90 150 160 170 180 pF1KE1 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF :::::::::::::::::::::::::::::::::::::: XP_016 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 100 110 120 >>NP_001304916 (OMIM: 604627) interleukin-17B isoform 2 (128 aa) initn: 912 init1: 912 opt: 912 Z-score: 972.3 bits: 186.0 E(85289): 2e-47 Smith-Waterman score: 912; 100.0% identity (100.0% similar) in 128 aa overlap (53-180:1-128) 30 40 50 60 70 80 pF1KE1 RSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQR :::::::::::::::::::::::::::::: NP_001 MKPYARMEEYERNIEEMVAQLRNSSELAQR 10 20 30 90 100 110 120 130 140 pF1KE1 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP 40 50 60 70 80 90 150 160 170 180 pF1KE1 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF :::::::::::::::::::::::::::::::::::::: NP_001 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 100 110 120 >>XP_016864837 (OMIM: 604627) PREDICTED: interleukin-17B (128 aa) initn: 912 init1: 912 opt: 912 Z-score: 972.3 bits: 186.0 E(85289): 2e-47 Smith-Waterman score: 912; 100.0% identity (100.0% similar) in 128 aa overlap (53-180:1-128) 30 40 50 60 70 80 pF1KE1 RSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARMEEYERNIEEMVAQLRNSSELAQR :::::::::::::::::::::::::::::: XP_016 MKPYARMEEYERNIEEMVAQLRNSSELAQR 10 20 30 90 100 110 120 130 140 pF1KE1 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLGCVNPFTMQEDRSMVSVP 40 50 60 70 80 90 150 160 170 180 pF1KE1 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF :::::::::::::::::::::::::::::::::::::: XP_016 VFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTCIF 100 110 120 >>XP_005266478 (OMIM: 607587) PREDICTED: interleukin-17D (209 aa) initn: 275 init1: 205 opt: 256 Z-score: 278.5 bits: 58.3 E(85289): 9e-09 Smith-Waterman score: 256; 31.6% identity (58.2% similar) in 177 aa overlap (7-179:5-177) 10 20 30 40 50 pF1KE1 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQ--GRPGPLAPGPHQVPLDLVSRMKPYAR :...:. ...:.: . . : :. .:: : :... .: .:. . XP_005 MLGALVWMLVAGFLLALPPSWAAGAPRAGRRPARPRGCADRPEELLEQLYGRLAA-GV 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 MEEYERNIEEMV-AQLRNSSELAQ-RKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL . ...... : ::.: : : . .. .: ::.:::.: :..::.: : : XP_005 LSAFHHTLQLGPREQARNASCPAGGRPADRRFRP-PTNLRSVSPWAYRISYDPARYPRYL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 PEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGC ::: ::: ::.. . .:: . :.::. . : :: : : .. :: ::: XP_005 PEAYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRR--TPACAGGRSVYTEAYVTIPVGC 120 130 140 150 160 170 180 pF1KE1 TCIF ::. XP_005 TCVPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP 180 190 200 >>NP_612141 (OMIM: 607587) interleukin-17D precursor [Ho (202 aa) initn: 275 init1: 205 opt: 254 Z-score: 276.6 bits: 57.9 E(85289): 1.1e-08 Smith-Waterman score: 254; 32.9% identity (57.2% similar) in 173 aa overlap (9-179:6-170) 10 20 30 40 50 60 pF1KE1 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGPHQVPLDLVSRMKPYARME :::.. . : ::. ..: . :: : :... .: .:. . . NP_612 MLVAGFLLALPPSWAAGAPRA--GRRPA--RPRGCADRPEELLEQLYGRLAAGV-LS 10 20 30 40 50 70 80 90 100 110 pF1KE1 EYERNIEEMV-AQLRNSSELAQ-RKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPE ...... : ::.: : : . .. .: ::.:::.: :..::.: : ::: NP_612 AFHHTLQLGPREQARNASCPAGGRPADRRFRP-PTNLRSVSPWAYRISYDPARYPRYLPE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 ARCLCLGCVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETIAVGCTC : ::: ::.. . .:: . :.::. . : :: : : .. :: ::::: NP_612 AYCLCRGCLTGLFGEEDVRFRSAPVYMPTVVLRR--TPACAGGRSVYTEAYVTIPVGCTC 120 130 140 150 160 180 pF1KE1 IF . NP_612 VPEPEKDADSINSSIDKQGAKLLLGPNDAPAGP 170 180 190 200 >>NP_037410 (OMIM: 604628) interleukin-17C precursor [Ho (197 aa) initn: 197 init1: 162 opt: 201 Z-score: 220.9 bits: 47.6 E(85289): 1.4e-05 Smith-Waterman score: 205; 30.2% identity (54.1% similar) in 159 aa overlap (31-180:45-193) 10 20 30 40 50 pF1KE1 MDWPHNLLFLLTISIFLGLGQPRSPKSKRKGQGRPGPLAPGP---HQVPLDLVSRMKPYA ::. : :: : . .:. ::: .. . NP_037 TCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAAS 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE1 RMEEYER-NIEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDL . ..:: . . :: : :.. ...::.::: : .. : .: : : NP_037 HRGRHERPSATTQCPVLRPEEVL-----EAD-----THQRSISPWRYRVDTDEDRYPQKL 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 PEARCLCLGCVNPFTMQEDRSMVSVPVFSQVPV-RRRLCPPP----PRTGPCRQRAVMET :.::: ::.. : .: .. :: ..... : ::: : : : .. . NP_037 AFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIH 130 140 150 160 170 180 180 pF1KE1 IAVGCTCIF . :::::.. NP_037 VPVGCTCVLPRSV 190 >>NP_443104 (OMIM: 606496,613956) interleukin-17F precur (163 aa) initn: 213 init1: 138 opt: 199 Z-score: 220.0 bits: 47.1 E(85289): 1.6e-05 Smith-Waterman score: 199; 38.4% identity (61.6% similar) in 86 aa overlap (96-179:77-155) 70 80 90 100 110 120 pF1KE1 IEEMVAQLRNSSELAQRKCEVNLQLWMSNKRSLSPWGYSINHDPSRIPVDLPEARCLCLG :: :::.:... ::.: : .. .:.: :: NP_443 CPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLG 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 CVNPFTMQEDRSMVSVPVFSQVPVRRRLCPPPPRTGPCRQRAVMETI--AVGCTCIF :.: .:: :: :::. ... : :: . : .: . .:::::. NP_443 CINA-QGKEDISMNSVPIQQETLVVRR------KHQGCSVSFQLEKVLVTVGCTCVTPVI 110 120 130 140 150 NP_443 HHVQ 160 180 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:04:55 2016 done: Sun Nov 6 17:04:56 2016 Total Scan time: 6.150 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]