FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1887, 413 aa 1>>>pF1KE1887 413 - 413 aa - 413 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1135+/-0.000478; mu= 18.2558+/- 0.030 mean_var=113.1270+/-28.673, 0's: 0 Z-trim(109.2): 660 B-trim: 1038 in 1/48 Lambda= 0.120584 statistics sampled from 16534 (17320) to 16534 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.203), width: 16 Scan time: 5.870 The best scores are: opt bits E(85289) NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 2774 494.6 1.9e-139 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 978 182.2 2.4e-45 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 733 139.5 1.5e-32 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 706 134.7 3.6e-31 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 706 134.8 3.9e-31 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 706 134.8 3.9e-31 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 706 134.9 4.1e-31 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 706 134.9 4.1e-31 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 705 134.6 4.2e-31 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 706 134.9 4.2e-31 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 706 134.9 4.2e-31 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 703 134.2 5.1e-31 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 703 134.2 5.3e-31 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 703 134.3 5.5e-31 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 703 134.3 5.6e-31 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 605 117.1 6.2e-26 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 605 117.1 6.3e-26 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 605 117.1 6.4e-26 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 605 117.1 6.7e-26 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 605 117.2 7e-26 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 605 117.2 7e-26 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 586 114.0 7.7e-25 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 581 113.1 1.4e-24 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 524 103.3 1.6e-21 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 503 99.4 1.4e-20 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 503 99.4 1.4e-20 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 503 99.4 1.5e-20 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 503 99.5 1.6e-20 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 503 99.5 1.6e-20 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 503 99.6 1.9e-20 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 503 99.6 2e-20 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 494 97.8 4.5e-20 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 494 97.8 4.5e-20 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 494 97.9 4.7e-20 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 494 97.9 4.9e-20 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 467 93.2 1.3e-18 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 467 93.3 1.3e-18 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 467 93.3 1.4e-18 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 462 92.4 2.5e-18 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 461 92.1 2.5e-18 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 460 92.0 2.8e-18 NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 451 90.6 1e-17 NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 451 90.6 1e-17 XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 450 90.5 1.2e-17 >>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa) initn: 2774 init1: 2774 opt: 2774 Z-score: 2624.4 bits: 494.6 E(85289): 1.9e-139 Smith-Waterman score: 2774; 99.8% identity (99.8% similar) in 413 aa overlap (1-413:1-413) 10 20 30 40 50 60 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: NP_000 MGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL 370 380 390 400 410 >>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa) initn: 1324 init1: 957 opt: 978 Z-score: 935.1 bits: 182.2 E(85289): 2.4e-45 Smith-Waterman score: 1311; 54.4% identity (74.9% similar) in 390 aa overlap (4-365:35-413) 10 20 30 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV :.. : :: : .:..:. ..:: :. NP_000 VLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPP-ASESPE-PLSQQ----WT 10 20 30 40 50 40 50 60 70 80 90 pF1KE1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAH .:::..:.:::: :: ::::::.:::: ::::.:: :: ::: ::::::: ::::::. NP_000 AGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE1 ILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVI .. : .:.:.::.:::.::::::::::::::::.:::.::::::.::::::. .:: . NP_000 VVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE1 ILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLV . :: .:.:.::::: :::.:: .:: :: . :::: ::.:::::::.::::::: NP_000 VCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLC 180 190 200 210 220 230 220 230 240 250 pF1KE1 IMVFVYSRVFQEAKRQLQKIDKSEGRF-------HVQNLSQVEQ---------------- ::.::: :::.::..:..:::. : :: . : : NP_000 IMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAAT 240 250 260 270 280 290 260 270 280 290 300 pF1KE1 ----DGRTGHGLRRSSKFC-LKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK .::.:. :: :.. :.:.:::::::::::.:::::::::..:.:.... .:. NP_000 APLANGRAGK--RRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPD 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE1 EVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSG ......::.::.::.:::.::::::::: ::: ::: : .: ....:. . :: NP_000 RLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCAR---RAARRRHATHGDRPRASG 360 370 380 390 400 410 370 380 390 400 410 pF1KE1 YHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL NP_000 CLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFAS 420 430 440 450 460 470 >>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa) initn: 1068 init1: 533 opt: 733 Z-score: 705.5 bits: 139.5 E(85289): 1.5e-32 Smith-Waterman score: 1049; 47.9% identity (71.7% similar) in 357 aa overlap (4-341:5-361) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPN-GSHAPDHDVTQQRDEV-WVVGM-GIVMSLIVLAIVFGNVLVIT : ..:.. :. . ::. :. : : ... : ...: ::: : ::.:::. NP_000 MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLC ::: ::::.:: :.:::: ::::::: ::: .:. : : .: ::.:::.:::: NP_000 AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE1 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA :::::::::..:::::.:.:.:..: .:.:: ::. ...::.::. .:: ::. .:.:. NP_000 VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE1 -THQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDK . :: :..: :: : .:. :.. :: ::::.::..:.:::.::: : :::. . NP_000 GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG 190 200 210 220 230 240 240 250 260 270 280 pF1KE1 SEGRFHVQNLSQVEQ--------------DGRTGHGLRRSSKFCLKEHKALKTLGIIMGT ::: .. . . .: . : : . . :.::.:: :::.:::: NP_000 ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 FTLCWLPFFIVNIVHVIQD-NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELL :::::::::..:..... .:. ... :::.::.::.::::::::::::: ::..:: NP_000 FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE1 CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNID : NP_000 CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS 370 380 390 400 >>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa) initn: 589 init1: 254 opt: 706 Z-score: 680.5 bits: 134.7 E(85289): 3.6e-31 Smith-Waterman score: 706; 36.7% identity (65.6% similar) in 343 aa overlap (40-365:26-360) 10 20 30 40 50 60 pF1KE1 FLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T .: ..: ..::.::..:. ..:. . : NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA ::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :. NP_955 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI .:::.:: .:. :.. .: . ... :.. . :::::.. : ... . NP_955 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV : .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : . NP_955 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN .. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . : NP_955 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY 240 250 260 270 280 310 320 330 340 350 pF1KE1 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS . .:. . :.::.:::.::..: . .:: :: .:: :: :. . : NP_955 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 S---NGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSL . ::.: :: NP_955 TTTINGSTHVLSGCSPVSSFLLLFCNRPVPV 350 360 370 >>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa) initn: 659 init1: 372 opt: 706 Z-score: 679.9 bits: 134.8 E(85289): 3.9e-31 Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA .:. . . . :: : . . .:.... ..: :.::.::: . XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV .: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...:::: XP_006 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT :::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . . XP_006 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------ .. : :: . .:.. :.. :::.::.:.. .: ::. :::. . XP_006 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF : :::.. :.: .: : . . : : :: .:.:: :::::..: : XP_006 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL .:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..: XP_006 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD :: :.. . .. ::. . . : : XP_006 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS 350 360 370 380 390 400 >>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa) initn: 659 init1: 372 opt: 706 Z-score: 679.9 bits: 134.8 E(85289): 3.9e-31 Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA .:. . . . :: : . . .:.... ..: :.::.::: . NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV .: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...:::: NP_150 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT :::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . . NP_150 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------ .. : :: . .:.. :.. :::.::.:.. .: ::. :::. . NP_150 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF : :::.. :.: .: : . . : : :: .:.:: :::::..: : NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL .:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..: NP_150 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD :: :.. . .. ::. . . : : NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS 350 360 370 380 390 400 >>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa) initn: 659 init1: 372 opt: 706 Z-score: 679.6 bits: 134.9 E(85289): 4.1e-31 Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA .:. . . . :: : . . .:.... ..: :.::.::: . NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV .: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...:::: NP_150 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT :::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . . NP_150 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------ .. : :: . .:.. :.. :::.::.:.. .: ::. :::. . NP_150 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF : :::.. :.: .: : . . : : :: .:.:: :::::..: : NP_150 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL .:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..: NP_150 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD :: :.. . .. ::. . . : : NP_150 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS 350 360 370 380 390 400 >>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa) initn: 659 init1: 372 opt: 706 Z-score: 679.5 bits: 134.9 E(85289): 4.1e-31 Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA .:. . . . :: : . . .:.... ..: :.::.::: . NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV .: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...:::: NP_000 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT :::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . . NP_000 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------ .. : :: . .:.. :.. :::.::.:.. .: ::. :::. . NP_000 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF : :::.. :.: .: : . . : : :: .:.:: :::::..: : NP_000 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL .:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..: NP_000 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD :: :.. . .. ::. . . : : NP_000 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS 350 360 370 380 390 400 >>NP_000861 (OMIM: 602164) 5-hydroxytryptamine receptor (388 aa) initn: 589 init1: 254 opt: 705 Z-score: 679.4 bits: 134.6 E(85289): 4.2e-31 Smith-Waterman score: 705; 35.7% identity (63.7% similar) in 375 aa overlap (40-397:26-387) 10 20 30 40 50 60 pF1KE1 FLLAPNGSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T .: ..: ..::.::..:. ..:. . : NP_000 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA ::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :. NP_000 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI .:::.:: .:. :.. .: . ... :.. . :::::.. : ... . NP_000 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV : .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : . NP_000 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN .. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . : NP_000 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY 240 250 260 270 280 310 320 330 340 350 pF1KE1 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS . .:. . :.::.:::.::..: . .:: :: .:: :: :. . : NP_000 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE1 S---NGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSL . ::.: :: . . :. :.: .:. : ::: NP_000 TTTINGSTHVLRDA-VECGGQWESQCHP-PATSPLVAAQ---PSDT 350 360 370 380 pF1KE1 L >>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa) initn: 659 init1: 372 opt: 706 Z-score: 679.4 bits: 134.9 E(85289): 4.2e-31 Smith-Waterman score: 729; 34.0% identity (65.2% similar) in 376 aa overlap (15-367:5-371) 10 20 30 40 50 pF1KE1 MGQPGNGSAFLLAPNGSHAPDHDVTQQRDEVWV---VGMGIVMSLIVLAIVFGNVLVITA .:. . . . :: : . . .:.... ..: :.::.::: . XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCV .: ..:..::.:.:..:: :::.. .:.::.: .. .:.:: .:..:...:::: XP_016 VACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 TASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT :::: ::.:..:::.... :..: ...:. .. . .: :: .: . :. :. . : . . XP_016 TASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPL-FGWRQPA 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 HQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQ------ .. : :: . .:.. :.. :::.::.:.. .: ::. :::. . XP_016 PEDETICQINE-------EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGL 170 180 190 200 210 220 240 250 260 270 280 pF1KE1 KIDKSEG-----RFHVQNL----SQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTF : :::.. :.: .: : . . : : :: .:.:: :::::..: : XP_016 KTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFS-REKKAAKTLGIVVGCF 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 TLCWLPFFIVNIVHVIQDNLIRKE-VYILLNWIGYVNSGFNPLIY-CRSPDFRIAFQELL .:::::::.: . . .. .: :. .. :.::.:: .::.:: : : .:. :::..: XP_016 VLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 290 300 310 320 330 340 350 360 370 380 390 pF1KE1 ---CLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSD :: :.. . .. ::. . . : : XP_016 RIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFS 350 360 370 380 390 400 413 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:05:27 2016 done: Sun Nov 6 17:05:28 2016 Total Scan time: 5.870 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]