FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9552, 388 aa 1>>>pF1KE9552 388 - 388 aa - 388 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6990+/-0.000424; mu= 20.4014+/- 0.026 mean_var=112.5584+/-31.359, 0's: 0 Z-trim(111.8): 564 B-trim: 1085 in 1/50 Lambda= 0.120889 statistics sampled from 19780 (20538) to 19780 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.241), width: 16 Scan time: 7.890 The best scores are: opt bits E(85289) NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 2643 472.6 7e-133 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 2433 436.0 7.4e-122 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 2427 434.9 1.5e-121 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 2427 435.0 1.6e-121 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 2425 434.6 2e-121 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 2420 433.7 3.5e-121 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 705 134.6 4e-31 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 544 106.6 1.2e-22 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 544 106.6 1.2e-22 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 544 106.6 1.2e-22 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 544 106.6 1.2e-22 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 544 106.6 1.2e-22 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 544 106.6 1.2e-22 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 544 106.6 1.2e-22 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 544 106.6 1.2e-22 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 543 106.4 1.3e-22 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 520 102.3 1.9e-21 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 520 102.3 1.9e-21 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 520 102.3 2e-21 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 102.4 2.1e-21 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 102.4 2.1e-21 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 102.4 2.1e-21 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 102.4 2.1e-21 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 520 102.4 2.1e-21 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 520 102.4 2.2e-21 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 486 96.5 1.4e-19 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 469 93.5 1e-18 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 469 93.5 1e-18 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 469 93.6 1.1e-18 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 448 89.6 1.1e-17 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 448 89.7 1.1e-17 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 448 89.7 1.2e-17 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 447 89.5 1.2e-17 NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 446 89.4 1.5e-17 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 441 88.4 2.5e-17 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 441 88.5 2.8e-17 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 440 88.4 3.3e-17 NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 421 85.0 3e-16 XP_016856349 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 NP_722561 (OMIM: 612250) G-protein coupled recepto ( 529) 422 85.4 3.3e-16 XP_011507679 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_011507677 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_011507680 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_016856351 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_016856350 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_005245114 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 XP_011507678 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 NP_001254539 (OMIM: 612250) G-protein coupled rece ( 529) 422 85.4 3.3e-16 XP_005245113 (OMIM: 612250) PREDICTED: G-protein c ( 529) 422 85.4 3.3e-16 NP_001254540 (OMIM: 612250) G-protein coupled rece ( 546) 422 85.5 3.4e-16 >>NP_000861 (OMIM: 602164) 5-hydroxytryptamine receptor (388 aa) initn: 2643 init1: 2643 opt: 2643 Z-score: 2506.7 bits: 472.6 E(85289): 7e-133 Smith-Waterman score: 2643; 100.0% identity (100.0% similar) in 388 aa overlap (1-388:1-388) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD 310 320 330 340 350 360 370 380 pF1KE9 AVECGGQWESQCHPPATSPLVAAQPSDT :::::::::::::::::::::::::::: NP_000 AVECGGQWESQCHPPATSPLVAAQPSDT 370 380 >>NP_001035259 (OMIM: 602164) 5-hydroxytryptamine recept (387 aa) initn: 2451 init1: 2429 opt: 2433 Z-score: 2308.7 bits: 436.0 E(85289): 7.4e-122 Smith-Waterman score: 2433; 95.8% identity (97.4% similar) in 380 aa overlap (1-379:1-380) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRY 310 320 330 340 350 360 370 380 pF1KE9 AV-ECGGQWESQCHPPATSPLVAAQPSDT .: . : . : . : ..: NP_001 TVLHRGHHQELEKLPIHNDPESLESCF 370 380 >>NP_001035262 (OMIM: 602164) 5-hydroxytryptamine recept (360 aa) initn: 2427 init1: 2427 opt: 2427 Z-score: 2303.4 bits: 434.9 E(85289): 1.5e-121 Smith-Waterman score: 2427; 100.0% identity (100.0% similar) in 359 aa overlap (1-359:1-359) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRF 310 320 330 340 350 360 370 380 pF1KE9 AVECGGQWESQCHPPATSPLVAAQPSDT >>NP_001035263 (OMIM: 602164) 5-hydroxytryptamine recept (428 aa) initn: 2427 init1: 2427 opt: 2427 Z-score: 2302.6 bits: 435.0 E(85289): 1.6e-121 Smith-Waterman score: 2503; 90.5% identity (90.5% similar) in 420 aa overlap (1-380:1-420) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLR- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRT 310 320 330 340 350 360 360 370 380 pF1KE9 ---------------------------------------DAVECGGQWESQCHPPATSPL ::::::::::::::::::::: NP_001 DFLFDRDILARYWTKPARAGPFSGTLSIRCLTARKPVLGDAVECGGQWESQCHPPATSPL 370 380 390 400 410 420 pF1KE9 VAAQPSDT NP_001 VAAQPSDT >>NP_001273339 (OMIM: 602164) 5-hydroxytryptamine recept (411 aa) initn: 2447 init1: 2425 opt: 2425 Z-score: 2300.9 bits: 434.6 E(85289): 2e-121 Smith-Waterman score: 2425; 98.9% identity (99.7% similar) in 363 aa overlap (1-363:1-363) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: . NP_001 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSS 310 320 330 340 350 360 370 380 pF1KE9 AVECGGQWESQCHPPATSPLVAAQPSDT ..: NP_001 GTETDRKKLWNKEEKIDQTIQMPKRKRKKKASLSYEDLILLGRKSCFREGK 370 380 390 400 410 >>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa) initn: 2420 init1: 2420 opt: 2420 Z-score: 2296.6 bits: 433.7 E(85289): 3.5e-121 Smith-Waterman score: 2420; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_955 GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSG 310 320 330 340 350 360 370 380 pF1KE9 AVECGGQWESQCHPPATSPLVAAQPSDT NP_955 CSPVSSFLLLFCNRPVPV 370 >>NP_000015 (OMIM: 109690,600807,601665) beta-2 adrenerg (413 aa) initn: 589 init1: 254 opt: 705 Z-score: 679.7 bits: 134.6 E(85289): 4e-31 Smith-Waterman score: 705; 35.7% identity (63.7% similar) in 375 aa overlap (26-387:40-397) 10 20 30 40 50 pF1KE9 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKT .: ..: ..::.::..:. ..:. . : NP_000 FLLAPNRSHAPDHDVTQQRDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTV-T 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 NYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCIS ::::.::: :::.... :.:::: .... .: .:. .: ::.::: .:::: :: :. NP_000 NYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 LDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKF .:::.:: .:. :.. .: . ... :.. . :::::.. : ... . NP_000 VDRYFAIT-SPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA-----THQEAI 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE9 NQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQ-RAGA : .: : : :..:. :::. :.:.::.:...::..: :.. ::.. ..:. . : . NP_000 NCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHV 190 200 210 220 230 240 240 250 260 270 280 pF1KE9 SSESRPQSADQHSTHRMRT-------ETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDY .. :. .. : .. : .: : :: ::: :::: : ::: :::..::: . : NP_000 QNLSQVEQ-DGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 TVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCS . .:. . :.::.:::.::..: . .:: :: .:: :: :. . : NP_000 LIRKEVYILLNWIGYVNSGFNPLIYCR-SPDFRIAFQELLC-----LRRSSLKAYGNGYS 310 320 330 340 350 350 360 370 380 pF1KE9 TTTINGSTHVLRDA-VECGGQWESQCHP-PATSPLVAAQ---PSDT . ::.: :: . . :. :.: .:. : ::: NP_000 S---NGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSL 360 370 380 390 400 410 NP_000 L >>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa) initn: 541 init1: 212 opt: 544 Z-score: 527.8 bits: 106.6 E(85289): 1.2e-22 Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369) 10 20 30 40 50 pF1KE9 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI .. :..:: ..:. .::...:::.::...: :.:... XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC :.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. :: XP_006 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR ::.::: .. :: : . .: : . : :.. ::. :.. :: . . : XP_006 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED----- 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH--------- : : . . :.. .. .::.:. .... : :.::.::.... XP_006 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD 180 190 200 210 220 230 240 250 260 270 pF1KE9 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW :. . ..: .: . . ... . .:: .. : :::::: :..::: ::: XP_006 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW 230 240 250 260 270 280 280 290 300 310 320 pF1KE9 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC :::.. . :. :.. :. .::::.:: .::..: .. :..:: .: : XP_006 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 DDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT .. :: :. . ...: XP_006 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR 350 360 370 380 390 400 >>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa) initn: 541 init1: 212 opt: 544 Z-score: 527.8 bits: 106.6 E(85289): 1.2e-22 Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369) 10 20 30 40 50 pF1KE9 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI .. :..:: ..:. .::...:::.::...: :.:... NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC :.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. :: NP_150 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR ::.::: .. :: : . .: : . : :.. ::. :.. :: . . : NP_150 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED----- 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH--------- : : . . :.. .. .::.:. .... : :.::.::.... NP_150 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD 180 190 200 210 220 230 240 250 260 270 pF1KE9 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW :. . ..: .: . . ... . .:: .. : :::::: :..::: ::: NP_150 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW 230 240 250 260 270 280 280 290 300 310 320 pF1KE9 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC :::.. . :. :.. :. .::::.:: .::..: .. :..:: .: : NP_150 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 DDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT .. :: :. . ...: NP_150 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR 350 360 370 380 390 400 >>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa) initn: 541 init1: 212 opt: 544 Z-score: 527.5 bits: 106.6 E(85289): 1.2e-22 Smith-Waterman score: 598; 32.2% identity (61.2% similar) in 363 aa overlap (16-353:22-369) 10 20 30 40 50 pF1KE9 MDKLDANVSSEEGFGSVEKVVLL-TFLSTVILMAILGNLLVMVAVCWDRQLRKI .. :..:: ..:. .::...:::.::...: :.:... NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 KTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCC :.:.::.:: ::::.. :.::.:: : : .:.::: . ...::: ::::. :: NP_150 -THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCI 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKR ::.::: .. :: : . .: : . : :.. ::. :.. :: . . : NP_150 ISIDRYIGVS-YPLRYPTIVTQRRGLMALLCVWALSLVISIGPLF-GWRQPAPED----- 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 KFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAH--------- : : . . :.. .. .::.:. .... : :.::.::.... NP_150 -------ETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTD 180 190 200 210 220 230 240 250 260 270 pF1KE9 -----QIQM-LQRAGASSESRPQSADQHSTH------RMRTETKAAKTLCIIMGCFCLCW :. . ..: .: . . ... . .:: .. : :::::: :..::: ::: NP_150 KSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCW 230 240 250 260 270 280 280 290 300 310 320 pF1KE9 APFFVTNIVDPFIDYTVPGQ-VWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIIL--CC :::.. . :. :.. :. .::::.:: .::..: .. :..:: .: : NP_150 LPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQC 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE9 DDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT .. :: :. . ...: NP_150 LCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPR 350 360 370 380 390 400 388 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:06:39 2016 done: Sun Nov 6 17:06:40 2016 Total Scan time: 7.890 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]