FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6737, 866 aa 1>>>pF1KE6737 866 - 866 aa - 866 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0591+/-0.000424; mu= 22.6731+/- 0.026 mean_var=78.2703+/-16.049, 0's: 0 Z-trim(111.0): 37 B-trim: 473 in 1/53 Lambda= 0.144969 statistics sampled from 19491 (19523) to 19491 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.229), width: 16 Scan time: 8.900 The best scores are: opt bits E(85289) NP_037523 (OMIM: 605849,605850) dimethylglycine de ( 866) 5824 1228.6 0 XP_011541657 (OMIM: 605849,605850) PREDICTED: dime ( 750) 5077 1072.4 0 XP_011541656 (OMIM: 605849,605850) PREDICTED: dime ( 757) 5077 1072.4 0 XP_006714660 (OMIM: 605849,605850) PREDICTED: dime ( 774) 5077 1072.4 0 NP_001128179 (OMIM: 268900,604455) sarcosine dehyd ( 918) 572 130.2 4.2e-29 NP_009032 (OMIM: 268900,604455) sarcosine dehydrog ( 918) 572 130.2 4.2e-29 XP_016869856 (OMIM: 268900,604455) PREDICTED: sarc ( 878) 562 128.1 1.7e-28 XP_016869857 (OMIM: 268900,604455) PREDICTED: sarc ( 837) 461 107.0 3.9e-22 NP_000472 (OMIM: 238310,605899) aminomethyltransfe ( 403) 340 81.4 9.4e-15 NP_001158183 (OMIM: 238310,605899) aminomethyltran ( 347) 326 78.4 6.4e-14 NP_001158184 (OMIM: 238310,605899) aminomethyltran ( 386) 320 77.2 1.6e-13 NP_001158182 (OMIM: 238310,605899) aminomethyltran ( 359) 273 67.3 1.4e-10 NP_057602 (OMIM: 616713) peroxisomal sarcosine oxi ( 390) 202 52.5 4.5e-06 XP_016880211 (OMIM: 616713) PREDICTED: peroxisomal ( 294) 164 44.5 0.0009 XP_006718944 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018 XP_016873492 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018 XP_016873494 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018 XP_016873493 (OMIM: 252010,256000,613622) PREDICTE ( 275) 159 43.4 0.0018 XP_011541197 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002 XP_016873490 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002 XP_006718942 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002 XP_016873491 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002 XP_011541198 (OMIM: 252010,256000,613622) PREDICTE ( 316) 159 43.4 0.002 XP_016873495 (OMIM: 252010,256000,613622) PREDICTE ( 274) 153 42.1 0.0042 >>NP_037523 (OMIM: 605849,605850) dimethylglycine dehydr (866 aa) initn: 5824 init1: 5824 opt: 5824 Z-score: 6580.2 bits: 1228.6 E(85289): 0 Smith-Waterman score: 5824; 100.0% identity (100.0% similar) in 866 aa overlap (1-866:1-866) 10 20 30 40 50 60 pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE6 DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_037 DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPA 790 800 810 820 830 840 850 860 pF1KE6 VIIQEPLVLTEPTRNRLQKKGGKDKT :::::::::::::::::::::::::: NP_037 VIIQEPLVLTEPTRNRLQKKGGKDKT 850 860 >>XP_011541657 (OMIM: 605849,605850) PREDICTED: dimethyl (750 aa) initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.6 bits: 1072.4 E(85289): 0 Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750) 10 20 30 40 50 60 pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD :::::::::::::::::::::::::::::: XP_011 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNK 730 740 750 >>XP_011541656 (OMIM: 605849,605850) PREDICTED: dimethyl (757 aa) initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.6 bits: 1072.4 E(85289): 0 Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750) 10 20 30 40 50 60 pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD :::::::::::::::::::::::::::::: XP_011 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKGSMDLRN 730 740 750 >>XP_006714660 (OMIM: 605849,605850) PREDICTED: dimethyl (774 aa) initn: 5077 init1: 5077 opt: 5077 Z-score: 5736.5 bits: 1072.4 E(85289): 0 Smith-Waterman score: 5077; 100.0% identity (100.0% similar) in 750 aa overlap (1-750:1-750) 10 20 30 40 50 60 pF1KE6 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLRPGAQLLRGLLLRSCPLQGSPGRPRSVCGREGEEKPPLSAETQWKDRAETVIIGGGCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMNK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSLKARSDGTWDVETPQGSMR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIGFGYGIIHAGGVGKYLSDWILHGEP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PFDLIELDPNRYGKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLES 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KCSMGFHAGWEQPHWFYKPGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NIKGQDSIRLLDHLFANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSE 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE6 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTK 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE6 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRL 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE6 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD :::::::::::::::::::::::::::::: XP_006 EKAFRAWGLEMNCDTNPLEAGLEYFVKLNKDQNSCFAHFKEENGWVSRWAIRPY 730 740 750 760 770 >>NP_001128179 (OMIM: 268900,604455) sarcosine dehydroge (918 aa) initn: 1465 init1: 448 opt: 572 Z-score: 643.4 bits: 130.2 E(85289): 4.2e-29 Smith-Waterman score: 1514; 33.1% identity (61.9% similar) in 902 aa overlap (15-858:38-915) 10 20 30 40 pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA .: : : . :. :: . .: .: :. NP_001 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG :..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:. NP_001 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ .... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:. NP_001 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS ... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::. NP_001 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG 180 190 200 210 220 230 230 240 250 260 270 pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS ... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: :::: NP_001 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE : .. ..: .:: ..: ::: . :.: : ::.. . : . .:: NP_001 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG-- 300 310 320 330 340 340 350 360 370 380 390 pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG ::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... : NP_001 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN :. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. : NP_001 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY 410 420 430 440 450 460 460 470 480 490 500 pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------ : .:..: .::: .: . :...: .. : . . :::.: ::. : NP_001 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA 470 480 490 500 510 520 510 520 530 540 pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI .: :: . . : : : . :. . : .:: :.: :::: . : :. NP_001 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR 530 540 550 560 570 580 550 560 570 580 590 pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI . : :: :.: : : . ::. .: . ..:::: :: :: :. . : NP_001 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA 590 600 610 620 630 640 600 610 620 630 640 650 pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF :.. :. : . .. . ...::.... :: .: .::.. . :::...: NP_001 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF 650 660 670 680 690 700 660 670 680 690 700 710 pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA : : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : : NP_001 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA 710 720 730 740 750 760 720 730 740 750 760 770 pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC ...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.::::: NP_001 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC 770 780 790 800 810 820 780 790 800 810 820 pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYV------PVQLSEVGQ- .:. : : : :.:: ::.:::.. ......:.:..:..:. ::.:. : . NP_001 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSG 830 840 850 860 870 880 830 840 850 860 pF1KE6 QVEVELLGKNYPAVI-IQEPLVLTEPTRNRLQKKGGKDKT . .: .: .: : .. :. .:. .:.. NP_001 DYALERMGVTYGAQAHLKSPF---DPNNKRVKGIY 890 900 910 >>NP_009032 (OMIM: 268900,604455) sarcosine dehydrogenas (918 aa) initn: 1465 init1: 448 opt: 572 Z-score: 643.4 bits: 130.2 E(85289): 4.2e-29 Smith-Waterman score: 1514; 33.1% identity (61.9% similar) in 902 aa overlap (15-858:38-915) 10 20 30 40 pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA .: : : . :. :: . .: .: :. NP_009 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG :..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:. NP_009 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ .... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:. NP_009 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS ... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::. NP_009 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG 180 190 200 210 220 230 230 240 250 260 270 pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS ... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: :::: NP_009 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE : .. ..: .:: ..: ::: . :.: : ::.. . : . .:: NP_009 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG-- 300 310 320 330 340 340 350 360 370 380 390 pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG ::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... : NP_009 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN :. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. : NP_009 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY 410 420 430 440 450 460 460 470 480 490 500 pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------ : .:..: .::: .: . :...: .. : . . :::.: ::. : NP_009 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA 470 480 490 500 510 520 510 520 530 540 pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI .: :: . . : : : . :. . : .:: :.: :::: . : :. NP_009 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR 530 540 550 560 570 580 550 560 570 580 590 pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI . : :: :.: : : . ::. .: . ..:::: :: :: :. . : NP_009 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA 590 600 610 620 630 640 600 610 620 630 640 650 pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF :.. :. : . .. . ...::.... :: .: .::.. . :::...: NP_009 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF 650 660 670 680 690 700 660 670 680 690 700 710 pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA : : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : : NP_009 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA 710 720 730 740 750 760 720 730 740 750 760 770 pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC ...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.::::: NP_009 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC 770 780 790 800 810 820 780 790 800 810 820 pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYV------PVQLSEVGQ- .:. : : : :.:: ::.:::.. ......:.:..:..:. ::.:. : . NP_009 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVSLDFVKSG 830 840 850 860 870 880 830 840 850 860 pF1KE6 QVEVELLGKNYPAVI-IQEPLVLTEPTRNRLQKKGGKDKT . .: .: .: : .. :. .:. .:.. NP_009 DYALERMGVTYGAQAHLKSPF---DPNNKRVKGIY 890 900 910 >>XP_016869856 (OMIM: 268900,604455) PREDICTED: sarcosin (878 aa) initn: 1465 init1: 448 opt: 562 Z-score: 632.4 bits: 128.1 E(85289): 1.7e-28 Smith-Waterman score: 1504; 33.7% identity (62.3% similar) in 854 aa overlap (15-818:38-870) 10 20 30 40 pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA .: : : . :. :: . .: .: :. XP_016 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG :..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:. XP_016 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ .... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:. XP_016 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS ... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::. XP_016 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG 180 190 200 210 220 230 230 240 250 260 270 pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS ... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: :::: XP_016 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE : .. ..: .:: ..: ::: . :.: : ::.. . : . .:: XP_016 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG-- 300 310 320 330 340 340 350 360 370 380 390 pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG ::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... : XP_016 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN :. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. : XP_016 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY 410 420 430 440 450 460 460 470 480 490 500 pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------ : .:..: .::: .: . :...: .. : . . :::.: ::. : XP_016 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA 470 480 490 500 510 520 510 520 530 540 pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI .: :: . . : : : . :. . : .:: :.: :::: . : :. XP_016 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR 530 540 550 560 570 580 550 560 570 580 590 pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI . : :: :.: : : . ::. .: . ..:::: :: :: :. . : XP_016 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA 590 600 610 620 630 640 600 610 620 630 640 650 pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF :.. :. : . .. . ...::.... :: .: .::.. . :::...: XP_016 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF 650 660 670 680 690 700 660 670 680 690 700 710 pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA : : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : : XP_016 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA 710 720 730 740 750 760 720 730 740 750 760 770 pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC ...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.::::: XP_016 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC 770 780 790 800 810 820 780 790 800 810 820 830 pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELL .:. : : : :.:: ::.:::.. ......:.:..:..:. XP_016 FTME-DKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPA 830 840 850 860 870 840 850 860 pF1KE6 GKNYPAVIIQEPLVLTEPTRNRLQKKGGKDKT >>XP_016869857 (OMIM: 268900,604455) PREDICTED: sarcosin (837 aa) initn: 1361 init1: 448 opt: 461 Z-score: 518.5 bits: 107.0 E(85289): 3.9e-22 Smith-Waterman score: 1403; 33.6% identity (61.6% similar) in 813 aa overlap (15-777:38-830) 10 20 30 40 pF1KE6 MLRPGAQLLRGLLLRSCPLQGS--PGRPRSVCGREGEEKPPLSA .: : : . :. :: . .: .: :. XP_016 LRVAAAHPRQSPTRGMGPCNLSSAAGPTAEKSVPYQRTLKEGQGTSVVA-QGPSRPLPST 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 ETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPG :..:.:::: .: . ::::: ::. .::::. .::.:.:::.::: ..:. XP_016 -------ANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLTSGTTWHTAGLLWQLRPS 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 -INLKKIHYDSIKLYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQ .... . . . ..:::::: .:. : :.. .:.. :.::.: :. ...:. XP_016 DVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKRLMSLGKAYGVES 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 YLIEPEKIQEMFPLLNMNKVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTS ... : . . ..::.:.. . . :: : :: .:: . .:: .: :: . :::. XP_016 HVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVIENCPVTG 180 190 200 210 220 230 230 240 250 260 270 pF1KE6 LKARSDG-----TWDVETPQGSMRANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTS ... .: . ::: .::... .:: :: :: ::.: :.. ::. ..: :::: XP_016 IRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVVTE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE6 TISEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKVQDSWVTNGVPPGFGKE : .. ..: .:: ..: ::: . :.: : ::.. . : . .:: XP_016 RIEGIQ----NMPNVRDHDASVYLRLQGDALSVGGYEANPIF-----WEEVSDKFAFG-- 300 310 320 330 340 340 350 360 370 380 390 pF1KE6 LFESDLDRIMEHIKAAMEMVPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVAIG ::. : . . .::..:.. ::::.:. : ..: :: ...:: :..: .:..... : XP_016 LFDLDWEVFTQHIEGAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCG 350 360 370 380 390 400 400 410 420 430 440 450 pF1KE6 FGY-GIIHAGGVGKYLSDWILHGEPPFDLIELDPNRYGKWTTTQ--YTEAKARESYGFNN :. :.. .:: :. :. ::.::.: :. : :. . : . . . ...:::. : XP_016 FNSAGMMLGGGCGQELAHWIIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNY 410 420 430 440 450 460 460 470 480 490 500 pF1KE6 IVGYPKEERFAGRPTQRVSGLYQRLESK-CSMGFHAGWEQPHWFYKPG------------ : .:..: .::: .: . :...: .. : . . :::.: ::. : XP_016 SVVFPHDEPLAGRNMRR-DPLHEELLGQGCVFQERHGWERPGWFHPRGPAPVLEYDYYGA 470 480 490 500 510 520 510 520 530 540 pF1KE6 ------QDTQYRPSF--RRTNWFEPVGSEYKQ--VMQR--VAVTDLSPFGKFNIKGQDSI .: :: . . : : : . :. . : .:: :.: :::: . : :. XP_016 YGSRAHEDYAYRRLLADEYTFAFPPHHDTIKKECLACRGAAAVFDMSYFGKFYLVGLDAR 530 540 550 560 570 580 550 560 570 580 590 pF1KE6 RLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVS-----HQ-SP------GE-FLLI . : :: :.: : : . ::. .: . ..:::: :: :: :. . : XP_016 KAADWLFSADVSRPPGSTVYTCMLNHRGGTESDLTVSRLAPSHQASPLAPAFEGDGYYLA 590 600 610 620 630 640 600 610 620 630 640 650 pF1KE6 TGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVF :.. :. : . .. . ...::.... :: .: .::.. . :::...: XP_016 MGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMISIQGPASRAILQEVLDADLSNEAF 650 660 670 680 690 700 660 670 680 690 700 710 pF1KE6 KFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYA : : :.... : :.:.:..:::::::. . . : .: :.: :: ..:. : : : XP_016 PFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYRAVMAAGAKHGLINAGYRA 710 720 730 740 750 760 720 730 740 750 760 770 pF1KE6 MNALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVC ...: .::..: : .. : .:::::: . ::..:. :.:..::.: .: ::.::::: XP_016 IDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALEQQRAAGLRRRLVC 770 780 790 800 810 820 780 790 800 810 820 830 pF1KE6 LTLATDDVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELL .:. XP_016 FTMEDLPTAL 830 >>NP_000472 (OMIM: 238310,605899) aminomethyltransferase (403 aa) initn: 175 init1: 104 opt: 340 Z-score: 385.9 bits: 81.4 E(85289): 9.4e-15 Smith-Waterman score: 343; 26.6% identity (55.4% similar) in 395 aa overlap (470-850:34-397) 440 450 460 470 480 490 pF1KE6 YTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQ-RLESKCSMGFHAGWEQPHWFYK : . ::. .: .: ::: : NP_000 AVSVVARLGFRLQAFPPALCRPLSCAQEVLRRTPLYDFHLAHGGKMVAFAGWSLP----- 10 20 30 40 50 500 510 520 530 540 550 pF1KE6 PGQDTQYRPSFRRTNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIKGQDSIRLLDHL---- .::: : .. .. :. .. :.: . . .: :.: ..:.. : NP_000 ----VQYRDSHTDSHL---------HTRQHCSLFDVSHMLQTKILGSDRVKLMESLVVGD 60 70 80 90 100 560 570 580 590 600 610 pF1KE6 FANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEE---EA .:.. :. : ..: . . : . .: :.. : :.. .....: .:: ... : NP_000 IAELRPNQG--TLSLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVREL 110 120 130 140 150 160 620 630 640 650 660 670 pF1KE6 VKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTA . : :: .. . . : :.. :: : .::: ...:: . :. . ..: .. NP_000 QNQGRDVGLEVLDNAL--LALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCR 170 180 190 200 210 680 690 700 710 720 730 pF1KE6 I-RISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLE . : .:::: : :. .: : ::.. . . : : ..:::: .. .: . NP_000 VTRCGYTGEDGVEISVPVAGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGND 220 230 240 250 260 270 740 750 760 770 780 pF1KE6 MNCDTNPLEAGLEYFVKLNKPA--DFIGKQAL-KQIKAKGLKRR--LVCLTLATDDVDPE .. :.:.:..: . . . : :: : ... :.:.. .:: :.: .: NP_000 IDEHTTPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPI 280 290 300 310 320 330 790 800 810 820 830 840 pF1KE6 GNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPAVIIQE : ..: .:..::: : :..:..:..::: . :. : .. ::. :. ::. . NP_000 LN----MEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKM 340 350 360 370 380 390 850 860 pF1KE6 PLVLTEPTRNRLQKKGGKDKT :.: : NP_000 PFVPTNYYTLK 400 >>NP_001158183 (OMIM: 238310,605899) aminomethyltransfer (347 aa) initn: 173 init1: 104 opt: 326 Z-score: 370.9 bits: 78.4 E(85289): 6.4e-14 Smith-Waterman score: 326; 27.6% identity (58.1% similar) in 322 aa overlap (542-850:33-341) 520 530 540 550 560 pF1KE6 TNWFEPVGSEYKQVMQRVAVTDLSPFGKFNIKGQDSIRLLDHL----FANVIPKVGFTNI : :.: ..:.. : .:.. :. : .. NP_001 RAVSVVARLGFRLQAFPPALCRPLSCAQTKILGSDRVKLMESLVVGDIAELRPNQG--TL 10 20 30 40 50 60 570 580 590 600 610 620 pF1KE6 SHMLTPKGRVYAELTVSHQSPGEFLLITGSGSELHDLRWIEE---EAVKGGYDVEIKNIT : . . : . .: :.. : :.. .....: .:: ... : . : :: .. . NP_001 SLFTNEAGGILDDLIVTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLD 70 80 90 100 110 120 630 640 650 660 670 680 pF1KE6 DELGVLGVAGPQARKVLQKLTSEDLSDDVFKFLQTKSLKVSNIPVTAI-RISYTGELGWE . : :.. :: : .::: ...:: . :. . ..: .. . : .:::: : : NP_001 NAL--LALQGPTAAQVLQAGVADDLRK--LPFMTSAVMEVFGVSGCRVTRCGYTGEDGVE 130 140 150 160 170 690 700 710 720 730 740 pF1KE6 LYHRREDSVALYDAIMNAGQEEGIDNFGTYAMNALRLEKAFRAWGLEMNCDTNPLEAGLE . .: : ::.. . . : : ..:::: .. .: ... :.:.:..: NP_001 ISVPVAGAVHLATAILKNPE---VKLAGLAARDSLRLEAGLCLYGNDIDEHTTPVEGSLS 180 190 200 210 220 230 750 760 770 780 790 pF1KE6 YFVKLNKPA--DFIGKQAL-KQIKAKGLKRR--LVCLTLATDDVDPEGNESIWYNGKVVG . . . : :: : ... :.:.. .:: :.: .: : ..: .: NP_001 WTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMRAHSPILN----MEGTKIG 240 250 260 270 280 800 810 820 830 840 850 pF1KE6 NTTSGSYSYSIQKSLAFAYVPVQLSEVGQQVEVELLGKNYPAVIIQEPLVLTEPTRNRLQ ..::: : :..:..:..::: . :. : .. ::. :. ::. . :.: : NP_001 TVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVRRKQQMAVVSKMPFVPTNYYTLK 290 300 310 320 330 340 860 pF1KE6 KKGGKDKT 866 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:52:37 2016 done: Tue Nov 8 15:52:39 2016 Total Scan time: 8.900 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]