FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5257, 208 aa 1>>>pF1KE5257 208 - 208 aa - 208 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0989+/-0.000296; mu= 14.8493+/- 0.018 mean_var=59.9626+/-12.090, 0's: 0 Z-trim(117.7): 81 B-trim: 1042 in 1/49 Lambda= 0.165628 statistics sampled from 29838 (29920) to 29838 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.351), width: 16 Scan time: 6.280 The best scores are: opt bits E(85289) NP_004456 (OMIM: 149730,180920,602115) fibroblast ( 208) 1434 350.3 1.3e-96 XP_005248321 (OMIM: 149730,180920,602115) PREDICTE ( 208) 1434 350.3 1.3e-96 NP_002000 (OMIM: 148180) fibroblast growth factor ( 194) 599 150.8 1.4e-36 NP_065688 (OMIM: 605831) fibroblast growth factor ( 170) 571 144.1 1.3e-34 NP_002001 (OMIM: 600921,612961) fibroblast growth ( 208) 422 108.5 7.9e-24 NP_003859 (OMIM: 300827,309630) fibroblast growth ( 207) 413 106.4 3.5e-23 NP_062825 (OMIM: 605558,615721) fibroblast growth ( 211) 401 103.5 2.6e-22 NP_004455 (OMIM: 165190,190330) fibroblast growth ( 268) 363 94.5 1.7e-19 NP_005238 (OMIM: 164950,610706) fibroblast growth ( 239) 338 88.5 9.8e-18 NP_004105 (OMIM: 300070) fibroblast growth factor ( 245) 330 86.6 3.7e-17 NP_378668 (OMIM: 300070) fibroblast growth factor ( 192) 328 86.1 4.2e-17 NP_001287741 (OMIM: 605831) fibroblast growth fact ( 165) 325 85.3 6.1e-17 XP_005247284 (OMIM: 601513,617166) PREDICTED: fibr ( 207) 324 85.1 8.8e-17 NP_001132970 (OMIM: 300070) fibroblast growth fact ( 199) 323 84.9 1e-16 NP_001132974 (OMIM: 300070) fibroblast growth fact ( 226) 323 84.9 1.1e-16 NP_001132973 (OMIM: 300070) fibroblast growth fact ( 226) 323 84.9 1.1e-16 NP_001132972 (OMIM: 300070) fibroblast growth fact ( 255) 323 84.9 1.2e-16 XP_005262456 (OMIM: 300070) PREDICTED: fibroblast ( 255) 323 84.9 1.2e-16 XP_011533298 (OMIM: 600921,612961) PREDICTED: fibr ( 158) 318 83.6 1.9e-16 NP_066360 (OMIM: 601513,617166) fibroblast growth ( 243) 320 84.2 2e-16 XP_006713601 (OMIM: 601513,617166) PREDICTED: fibr ( 178) 317 83.4 2.5e-16 NP_004104 (OMIM: 601513,617166) fibroblast growth ( 181) 317 83.4 2.5e-16 NP_066276 (OMIM: 134921) fibroblast growth factor ( 208) 310 81.8 9e-16 NP_004106 (OMIM: 601515,609307) fibroblast growth ( 247) 290 77.0 2.8e-14 NP_001308862 (OMIM: 601515,609307) fibroblast grow ( 187) 288 76.5 3.1e-14 NP_001308869 (OMIM: 601515,609307) fibroblast grow ( 187) 288 76.5 3.1e-14 NP_001308867 (OMIM: 601515,609307) fibroblast grow ( 187) 288 76.5 3.1e-14 NP_001308865 (OMIM: 601515,609307) fibroblast grow ( 184) 287 76.2 3.6e-14 NP_001308861 (OMIM: 601515,609307) fibroblast grow ( 184) 287 76.2 3.6e-14 NP_001308873 (OMIM: 601515,609307) fibroblast grow ( 184) 287 76.2 3.6e-14 NP_001308870 (OMIM: 601515,609307) fibroblast grow ( 185) 287 76.2 3.7e-14 NP_001308876 (OMIM: 601515,609307) fibroblast grow ( 200) 287 76.3 3.9e-14 NP_001308877 (OMIM: 601515,609307) fibroblast grow ( 213) 287 76.3 4.1e-14 NP_001308874 (OMIM: 601515,609307) fibroblast grow ( 213) 287 76.3 4.1e-14 NP_787125 (OMIM: 601515,609307) fibroblast growth ( 252) 287 76.3 4.8e-14 XP_016861368 (OMIM: 601513,617166) PREDICTED: fibr ( 157) 278 74.1 1.4e-13 NP_001138406 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001244136 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001244137 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001138407 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001244139 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_000791 (OMIM: 131220) fibroblast growth factor ( 155) 270 72.1 5.3e-13 NP_001244134 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001138364 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001244138 (OMIM: 131220) fibroblast growth fact ( 155) 270 72.1 5.3e-13 NP_001290389 (OMIM: 601514) fibroblast growth fact ( 166) 270 72.2 5.6e-13 NP_001998 (OMIM: 164980) fibroblast growth factor ( 206) 270 72.2 6.7e-13 NP_004103 (OMIM: 601514) fibroblast growth factor ( 225) 270 72.2 7.2e-13 NP_001308872 (OMIM: 601515,609307) fibroblast grow ( 163) 261 70.0 2.4e-12 NP_001308860 (OMIM: 601515,609307) fibroblast grow ( 163) 261 70.0 2.4e-12 >>NP_004456 (OMIM: 149730,180920,602115) fibroblast grow (208 aa) initn: 1434 init1: 1434 opt: 1434 Z-score: 1855.7 bits: 350.3 E(85289): 1.3e-96 Smith-Waterman score: 1434; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE5 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVAL 130 140 150 160 170 180 190 200 pF1KE5 NGKGAPRRGQKTRRKNTSAHFLPMVVHS :::::::::::::::::::::::::::: NP_004 NGKGAPRRGQKTRRKNTSAHFLPMVVHS 190 200 >>XP_005248321 (OMIM: 149730,180920,602115) PREDICTED: f (208 aa) initn: 1434 init1: 1434 opt: 1434 Z-score: 1855.7 bits: 350.3 E(85289): 1.3e-96 Smith-Waterman score: 1434; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE5 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVAL 130 140 150 160 170 180 190 200 pF1KE5 NGKGAPRRGQKTRRKNTSAHFLPMVVHS :::::::::::::::::::::::::::: XP_005 NGKGAPRRGQKTRRKNTSAHFLPMVVHS 190 200 >>NP_002000 (OMIM: 148180) fibroblast growth factor 7 pr (194 aa) initn: 692 init1: 523 opt: 599 Z-score: 777.9 bits: 150.8 E(85289): 1.4e-36 Smith-Waterman score: 609; 47.3% identity (75.4% similar) in 207 aa overlap (1-206:1-193) 10 20 30 40 50 60 pF1KE5 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP : ::::: .: : :: .. ::... ..:. :: .:: ... . ::: NP_002 MHKWILTW---ILPTL--LYRSCFHIICLVGTISLACN----DM-TPEQM-ATNVNCSSP 10 20 30 40 70 80 90 100 110 pF1KE5 SSAGRHVRSYNHLQG-DVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIG ::.:::....: :.: :.:: :...:.:.: :::.::.. . :.:.:: .: .: NP_002 E---RHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 VVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVA .::.:...:..::::::.::::..:: :.::..:: : :: :::::: .: ::: .:.:: NP_002 IVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVA 110 120 130 140 150 160 180 190 200 pF1KE5 LNGKGAPRRGQKTRRKNTSAHFLPMVVHS :: :: : ::.::.... .::::::.. NP_002 LNQKGIPVRGKKTKKEQKTAHFLPMAIT 170 180 190 >>NP_065688 (OMIM: 605831) fibroblast growth factor 22 i (170 aa) initn: 635 init1: 571 opt: 571 Z-score: 742.6 bits: 144.1 E(85289): 1.3e-34 Smith-Waterman score: 571; 54.5% identity (85.5% similar) in 145 aa overlap (62-206:25-169) 40 50 60 70 80 90 pF1KE5 SVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLK ::.: ::: ::.::::::.::: :..::. NP_065 MRRRLWLGLAWLLLARAPDAAGTPSASRGPRSYPHLEGDVRWRRLFSSTHFFLR 10 20 30 40 50 100 110 120 130 140 150 pF1KE5 IEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCK .. .:.:.::. .. ::::: ::..:::..::..:..:.:::..:.::::. .. ::. NP_065 VDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSRLYTVDCR 60 70 80 90 100 110 160 170 180 190 200 pF1KE5 LKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS ..:::::::.::::: :.. :. :..::. .:.:: : .::: . ::::::..: NP_065 FRERIEENGHNTYASQRWRRRGQPMFLALDRRGGPRPGGRTRRYHLSAHFLPVLVS 120 130 140 150 160 170 >>NP_002001 (OMIM: 600921,612961) fibroblast growth fact (208 aa) initn: 419 init1: 311 opt: 422 Z-score: 548.8 bits: 108.5 E(85289): 7.9e-24 Smith-Waterman score: 422; 43.0% identity (79.6% similar) in 142 aa overlap (64-203:48-189) 40 50 60 70 80 90 pF1KE5 PVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIE : : . .::.: .: :.:. : . :.: NP_002 PFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIF 20 30 40 50 60 70 100 110 120 130 140 150 pF1KE5 KNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLK :: ..::.:.. ..:::. :. .:.:......:. ::.::.::.::::......: .. NP_002 PNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFR 80 90 100 110 120 130 160 170 180 190 200 pF1KE5 ERIEENGYNTYASFNWQH--NGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS :..::: ::::.: ..: .::..::::: :.::.: .:.:.. .:::: NP_002 EQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKV 140 150 160 170 180 190 NP_002 PELYKDILSQS 200 >>NP_003859 (OMIM: 300827,309630) fibroblast growth fact (207 aa) initn: 405 init1: 298 opt: 413 Z-score: 537.2 bits: 106.4 E(85289): 3.5e-23 Smith-Waterman score: 413; 43.4% identity (78.7% similar) in 136 aa overlap (70-203:53-188) 40 50 60 70 80 90 pF1KE5 LGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVS . ::.: .: :.:. : . :.: :: : NP_003 GNVPLADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVH 30 40 50 60 70 80 100 110 120 130 140 150 pF1KE5 GTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEEN ::.... ..:::. :. .:........:. ::.::..:.:::::... .: ..:..::: NP_003 GTRHDHSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEEN 90 100 110 120 130 140 160 170 180 190 200 pF1KE5 GYNTYASFNWQHNG--RQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS :::::: ..:. ::.::::: :.::.: .:.:.. .:::: NP_003 WYNTYASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRD 150 160 170 180 190 200 NP_003 LFHYR >>NP_062825 (OMIM: 605558,615721) fibroblast growth fact (211 aa) initn: 391 init1: 292 opt: 401 Z-score: 521.6 bits: 103.5 E(85289): 2.6e-22 Smith-Waterman score: 401; 37.4% identity (71.3% similar) in 174 aa overlap (38-203:19-192) 10 20 30 40 50 60 pF1KE5 HCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHV : .:. .. : : . :.: : . NP_062 MAPLAEVGGFLGGLEGLGQQVGSHFLLPPAGERPPLLGERRSAAERSA 10 20 30 40 70 80 90 100 110 120 pF1KE5 RS------YNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVV :. ::.: .: :.:. : . :.: .:.:.::.... ..:::. :: .:.: NP_062 RGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQDHSLFGILEFISVAVGLV 50 60 70 80 90 100 130 140 150 160 170 pF1KE5 AVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHN--GRQMYVA ......:. ::.:: ::.::::......: ..:..::: ::::.: ..:. ::...:: NP_062 SIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTYSSNIYKHGDTGRRYFVA 110 120 130 140 150 160 180 190 200 pF1KE5 LNGKGAPRRGQKTRRKNTSAHFLPMVVHS :: :.:: : ...:.. .:::: NP_062 LNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT 170 180 190 200 210 >>NP_004455 (OMIM: 165190,190330) fibroblast growth fact (268 aa) initn: 356 init1: 226 opt: 363 Z-score: 471.0 bits: 94.5 E(85289): 1.7e-19 Smith-Waterman score: 363; 39.5% identity (70.3% similar) in 172 aa overlap (38-203:48-217) 10 20 30 40 50 60 pF1KE5 HCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHV :. .. : : :..: ..:..: .: : . NP_004 AWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGS-GLEQ 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE5 RSYNHLQGDVRWRKLFSFTK--YFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKA :.. . : .:. . . :.: .:::.:... : :.::: .: :.:.... NP_004 SSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANM-LSVLEIFAVSQGIVGIRG 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE5 INSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYAS--FNWQHNGRQMYVALNGK . :: .:::.:::::..: .:..:::..::..::.:::::: ...::. ::::: . NP_004 VFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKR 140 150 160 170 180 190 190 200 pF1KE5 GAPRRGQKTRRK--NTSAHFLPMVVHS : .:: . : : . :.:::: NP_004 GKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKN 200 210 220 230 240 250 >>NP_005238 (OMIM: 164950,610706) fibroblast growth fact (239 aa) initn: 448 init1: 252 opt: 338 Z-score: 439.4 bits: 88.5 E(85289): 9.8e-18 Smith-Waterman score: 422; 47.4% identity (71.2% similar) in 156 aa overlap (63-206:29-183) 40 50 60 70 80 90 pF1KE5 VPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKI :: . :.:: : : :::. ::: :.. NP_005 MGLIWLLLLSLLEPGWPAAGPGARLRRDAGGRGGVYEHLGGAPRRRKLYCATKYHLQL 10 20 30 40 50 100 110 120 130 140 150 pF1KE5 EKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKL . .:.:.:. :: :::::::.::.:.::.... :. ::::::.:.::.:.... .:.. NP_005 HPSGRVNGSL-ENSAYSILEITAVEVGIVAIRGLFSGRYLAMNKRGRLYASEHYSAECEF 60 70 80 90 100 110 160 170 180 190 200 pF1KE5 KERIEENGYNTYASFNWQHNG------------RQMYVALNGKGAPRRGQKTRRKNTSAH :::.: ::::::: .. . : ::..:::: :::: :::: . :. NP_005 VERIHELGYNTYASRLYRTVSSTPGARRQPSAERLWYVSVNGKGRPRRGFKTRRTQKSSL 120 130 140 150 160 170 pF1KE5 FLPMVVHS ::: :. NP_005 FLPRVLDHRDHEMVRQLQSGLPRPPGKGVQPRRRRQKQSPDNLEPSHVQASRLGSQLEAS 180 190 200 210 220 230 >>NP_004105 (OMIM: 300070) fibroblast growth factor 13 i (245 aa) initn: 257 init1: 236 opt: 330 Z-score: 428.9 bits: 86.6 E(85289): 3.7e-17 Smith-Waterman score: 330; 37.2% identity (70.3% similar) in 145 aa overlap (61-203:54-196) 40 50 60 70 80 90 pF1KE5 SSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFL :. :. : .:.: : ::.: : : NP_004 ACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIV--TKLYSRQGYHL 30 40 50 60 70 80 100 110 120 130 140 150 pF1KE5 KIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDC ... .: ..::: :. :..... : . :::....... :::::..: :: :. :. .: NP_004 QLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPEC 90 100 110 120 130 140 160 170 180 190 200 pF1KE5 KLKERIEENGYNTYAS--FNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS :.:: . :: : ::.: . :..:: :..:: .: .:....... .::::: NP_004 KFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKV 150 160 170 180 190 200 NP_004 AMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 210 220 230 240 208 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:56:48 2016 done: Mon Nov 7 22:56:49 2016 Total Scan time: 6.280 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]