FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3763, 559 aa 1>>>pF1KE3763 559 - 559 aa - 559 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.3137+/-0.000585; mu= 10.5864+/- 0.035 mean_var=481.1548+/-114.562, 0's: 0 Z-trim(114.5): 2146 B-trim: 1588 in 2/56 Lambda= 0.058470 statistics sampled from 21645 (24463) to 21645 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.287), width: 16 Scan time: 10.590 The best scores are: opt bits E(85289) NP_006242 (OMIM: 602739) 5'-AMP-activated protein ( 559) 3762 333.4 1.1e-90 XP_016865114 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 533) 3481 309.7 1.5e-83 NP_996790 (OMIM: 602739) 5'-AMP-activated protein ( 574) 3002 269.3 2.3e-71 XP_016865113 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 548) 2980 267.5 8.1e-71 NP_006243 (OMIM: 600497) 5'-AMP-activated protein ( 552) 2829 254.7 5.5e-67 XP_016857182 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 2274 207.8 6.3e-53 XP_016857183 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 2274 207.8 6.3e-53 XP_016857181 (OMIM: 600497) PREDICTED: 5'-AMP-acti ( 462) 2274 207.8 6.3e-53 XP_006714545 (OMIM: 602739) PREDICTED: 5'-AMP-acti ( 301) 2022 186.1 1.3e-46 NP_056006 (OMIM: 608973) serine/threonine-protein ( 926) 976 98.8 7.8e-20 NP_775490 (OMIM: 605705,616341) serine/threonine-p ( 783) 956 97.0 2.3e-19 NP_003948 (OMIM: 609236) serine/threonine-protein ( 668) 933 94.9 8.4e-19 NP_001243558 (OMIM: 609236) serine/threonine-prote ( 674) 933 94.9 8.4e-19 XP_005253275 (OMIM: 609236) PREDICTED: serine/thre ( 720) 933 95.0 8.6e-19 NP_001243556 (OMIM: 609236) serine/threonine-prote ( 736) 933 95.0 8.7e-19 XP_006718437 (OMIM: 609236) PREDICTED: serine/thre ( 758) 933 95.0 8.8e-19 XP_016874025 (OMIM: 609236) PREDICTED: serine/thre ( 858) 933 95.1 9.3e-19 XP_016874022 (OMIM: 609236) PREDICTED: serine/thre ( 880) 933 95.2 9.4e-19 XP_011527776 (OMIM: 605705,616341) PREDICTED: seri ( 734) 930 94.8 1e-18 NP_001156769 (OMIM: 600526) serine/threonine-prote ( 709) 915 93.5 2.5e-18 NP_001156768 (OMIM: 600526) serine/threonine-prote ( 719) 915 93.5 2.5e-18 NP_004945 (OMIM: 600526) serine/threonine-protein ( 724) 915 93.5 2.5e-18 XP_011543100 (OMIM: 600526) PREDICTED: serine/thre ( 729) 915 93.5 2.5e-18 XP_016872800 (OMIM: 600526) PREDICTED: serine/thre ( 738) 915 93.5 2.5e-18 XP_011543099 (OMIM: 600526) PREDICTED: serine/thre ( 739) 915 93.5 2.5e-18 XP_011543098 (OMIM: 600526) PREDICTED: serine/thre ( 744) 915 93.5 2.5e-18 XP_011543097 (OMIM: 600526) PREDICTED: serine/thre ( 745) 915 93.5 2.5e-18 XP_011543096 (OMIM: 600526) PREDICTED: serine/thre ( 753) 915 93.5 2.5e-18 NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 915 93.5 2.6e-18 NP_059672 (OMIM: 600526) serine/threonine-protein ( 745) 911 93.2 3.2e-18 XP_016872799 (OMIM: 600526) PREDICTED: serine/thre ( 763) 911 93.2 3.2e-18 XP_011543093 (OMIM: 600526) PREDICTED: serine/thre ( 798) 911 93.2 3.3e-18 XP_011543095 (OMIM: 600526) PREDICTED: serine/thre ( 784) 901 92.4 5.8e-18 NP_001034558 (OMIM: 600526) serine/threonine-prote ( 788) 901 92.4 5.8e-18 XP_011543094 (OMIM: 600526) PREDICTED: serine/thre ( 793) 901 92.4 5.9e-18 XP_011543092 (OMIM: 600526) PREDICTED: serine/thre ( 799) 901 92.4 5.9e-18 XP_011543091 (OMIM: 600526) PREDICTED: serine/thre ( 808) 901 92.4 5.9e-18 XP_016872913 (OMIM: 614776) PREDICTED: serine/thre (1213) 902 92.8 6.6e-18 NP_001268678 (OMIM: 614776) serine/threonine-prote (1261) 902 92.9 6.7e-18 XP_005271539 (OMIM: 614776) PREDICTED: serine/thre (1321) 902 92.9 6.9e-18 NP_001243559 (OMIM: 609236) serine/threonine-prote ( 766) 898 92.1 6.9e-18 XP_005273191 (OMIM: 606511) PREDICTED: serine/thre ( 781) 895 91.9 8.3e-18 XP_011507863 (OMIM: 606511) PREDICTED: serine/thre ( 788) 895 91.9 8.3e-18 NP_001273053 (OMIM: 606511) serine/threonine-prote ( 796) 895 91.9 8.3e-18 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 893 91.5 8.5e-18 NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 893 91.6 9e-18 XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 893 91.6 9.1e-18 XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 893 91.7 9.1e-18 NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 893 91.7 9.1e-18 NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 893 91.7 9.1e-18 >>NP_006242 (OMIM: 602739) 5'-AMP-activated protein kina (559 aa) initn: 3762 init1: 3762 opt: 3762 Z-score: 1748.9 bits: 333.4 E(85289): 1.1e-90 Smith-Waterman score: 3762; 100.0% identity (100.0% similar) in 559 aa overlap (1-559:1-559) 10 20 30 40 50 60 pF1KE3 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE3 ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG 490 500 510 520 530 540 550 pF1KE3 SHTIEFFEMCANLIKILAQ ::::::::::::::::::: NP_006 SHTIEFFEMCANLIKILAQ 550 >>XP_016865114 (OMIM: 602739) PREDICTED: 5'-AMP-activate (533 aa) initn: 3481 init1: 3481 opt: 3481 Z-score: 1620.9 bits: 309.7 E(85289): 1.5e-83 Smith-Waterman score: 3481; 100.0% identity (100.0% similar) in 517 aa overlap (43-559:17-533) 20 30 40 50 60 70 pF1KE3 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI :::::::::::::::::::::::::::::: XP_016 MQVKNIRKLPCQIIQSVGKHELTGHKVAVKILNRQKIRSLDVVGKI 10 20 30 40 80 90 100 110 120 130 pF1KE3 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQ 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE3 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAA 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE3 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSV 170 180 190 200 210 220 260 270 280 290 300 310 pF1KE3 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFE 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE3 CSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHP 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE3 ERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLD 350 360 370 380 390 400 440 450 460 470 480 490 pF1KE3 YEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQ 410 420 430 440 450 460 500 510 520 530 540 550 pF1KE3 RSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCAN 470 480 490 500 510 520 pF1KE3 LIKILAQ ::::::: XP_016 LIKILAQ 530 >>NP_996790 (OMIM: 602739) 5'-AMP-activated protein kina (574 aa) initn: 3748 init1: 2963 opt: 3002 Z-score: 1402.3 bits: 269.3 E(85289): 2.3e-71 Smith-Waterman score: 3722; 97.4% identity (97.4% similar) in 574 aa overlap (1-559:1-574) 10 20 30 40 50 60 pF1KE3 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG 70 80 90 100 110 120 130 140 150 160 pF1KE3 R---------------LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK : :::::::::::::::::::::::::::::::::::::::::::: NP_996 RKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE3 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE3 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE3 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 NEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE3 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV 430 440 450 460 470 480 470 480 490 500 510 520 pF1KE3 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_996 DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSV 490 500 510 520 530 540 530 540 550 pF1KE3 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ :::::::::::::::::::::::::::::::::: NP_996 TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 550 560 570 >>XP_016865113 (OMIM: 602739) PREDICTED: 5'-AMP-activate (548 aa) initn: 3467 init1: 2963 opt: 2980 Z-score: 1392.4 bits: 267.5 E(85289): 8.1e-71 Smith-Waterman score: 3441; 97.2% identity (97.2% similar) in 532 aa overlap (43-559:17-548) 20 30 40 50 60 70 pF1KE3 AEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKI :::::::::::::::::::::::::::::: XP_016 MQVKNIRKLPCQIIQSVGKHELTGHKVAVKILNRQKIRSLDVVGKI 10 20 30 40 80 90 100 110 120 pF1KE3 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGR----------- ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTG 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 ----LDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 STKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSD 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKI 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSST 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE3 MIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSP 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE3 PDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRP 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE3 NDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSI 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE3 DDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTP 470 480 490 500 510 520 540 550 pF1KE3 RPGSHTIEFFEMCANLIKILAQ :::::::::::::::::::::: XP_016 RPGSHTIEFFEMCANLIKILAQ 530 540 >>NP_006243 (OMIM: 600497) 5'-AMP-activated protein kina (552 aa) initn: 2851 init1: 2081 opt: 2829 Z-score: 1323.6 bits: 254.7 E(85289): 5.5e-67 Smith-Waterman score: 2829; 76.1% identity (90.4% similar) in 553 aa overlap (13-559:2-552) 10 20 30 40 50 60 pF1KE3 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR :::::::::::::::.::::::::::::::.:.:.::::::::::::: NP_006 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNR 10 20 30 40 70 80 90 100 110 120 pF1KE3 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG ::::::::::::.::::::::::::::::::::::::.:.::::::::::::::::::.: NP_006 QKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHG 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF :..: :.:::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_006 RVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG :::::::::::::::::::::::::::::: ::::::::::::::::.::::::::: : NP_006 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGG 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID .:: :.::: :: .:: :::::::.:::::::::::::::::::.:::::::::....:: NP_006 VFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVID 230 240 250 260 270 280 310 320 330 340 350 pF1KE3 DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD- :::.:::::::::.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. NP_006 DEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSG 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE3 SFLDDH--HLT---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQ ::.:: :. .:::::.: :.:..:.:: :: :: : : .:.::::::::::: NP_006 SFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQ 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE3 SRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDF :.: :::::: ::.::::.:::::: :.::::::::::..: ::::::: ::.:.::::: NP_006 SKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDF 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE3 RSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVD .:::::..: .::..::::: :... . . : ... :...: :::.:.:. :. . NP_006 KSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSS 470 480 490 500 510 520 540 550 pF1KE3 LTPRPGSHTIEFFEMCANLIKILAQ ..:: ::::..::::::.:: ::. NP_006 VSPRLGSHTMDFFEMCASLITTLAR 530 540 550 >>XP_016857182 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 2296 init1: 1526 opt: 2274 Z-score: 1071.1 bits: 207.8 E(85289): 6.3e-53 Smith-Waterman score: 2274; 73.1% identity (88.6% similar) in 464 aa overlap (102-559:1-462) 80 90 100 110 120 130 pF1KE3 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF :::::::::::::::::.::..: :.:::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 140 150 160 170 180 190 pF1KE3 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS ::::::::::::::::::: ::::::::::::::::.::::::::: :.:: :.::: : XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKF : .:: :::::::.:::::::::::::::::::.:::::::::....:::::.::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 320 330 340 350 360 pF1KE3 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDH--HLT ::.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. ::.:: :. XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 ---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVC .:::::.: :.:..:.:: :: :: : : .:.::::::::::::.: :::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAK ::.::::.:::::: :.::::::::::..: ::::::: ::.:.:::::.:::::..: . XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIE ::..::::: :... . . : ... :...: :::.:.:. :. ...:: ::::.. XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSSVSPRLGSHTMD 400 410 420 430 440 550 pF1KE3 FFEMCANLIKILAQ ::::::.:: ::. XP_016 FFEMCASLITTLAR 450 460 >>XP_016857183 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 2296 init1: 1526 opt: 2274 Z-score: 1071.1 bits: 207.8 E(85289): 6.3e-53 Smith-Waterman score: 2274; 73.1% identity (88.6% similar) in 464 aa overlap (102-559:1-462) 80 90 100 110 120 130 pF1KE3 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF :::::::::::::::::.::..: :.:::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 140 150 160 170 180 190 pF1KE3 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS ::::::::::::::::::: ::::::::::::::::.::::::::: :.:: :.::: : XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKF : .:: :::::::.:::::::::::::::::::.:::::::::....:::::.::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 320 330 340 350 360 pF1KE3 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDH--HLT ::.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. ::.:: :. XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 ---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVC .:::::.: :.:..:.:: :: :: : : .:.::::::::::::.: :::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAK ::.::::.:::::: :.::::::::::..: ::::::: ::.:.:::::.:::::..: . XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIE ::..::::: :... . . : ... :...: :::.:.:. :. ...:: ::::.. XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSSVSPRLGSHTMD 400 410 420 430 440 550 pF1KE3 FFEMCANLIKILAQ ::::::.:: ::. XP_016 FFEMCASLITTLAR 450 460 >>XP_016857181 (OMIM: 600497) PREDICTED: 5'-AMP-activate (462 aa) initn: 2296 init1: 1526 opt: 2274 Z-score: 1071.1 bits: 207.8 E(85289): 6.3e-53 Smith-Waterman score: 2274; 73.1% identity (88.6% similar) in 464 aa overlap (102-559:1-462) 80 90 100 110 120 130 pF1KE3 IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLF :::::::::::::::::.::..: :.:::: XP_016 MVMEYVSGGELFDYICKHGRVEEMEARRLF 10 20 30 140 150 160 170 180 190 pF1KE3 QQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA :::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE3 APEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPS ::::::::::::::::::: ::::::::::::::::.::::::::: :.:: :.::: : XP_016 APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE3 VISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKF : .:: :::::::.:::::::::::::::::::.:::::::::....:::::.::::::: XP_016 VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF 160 170 180 190 200 210 320 330 340 350 360 pF1KE3 ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPD-SFLDDH--HLT ::.: ::.. ::. . :: ::::::::::::::::.:..::::.:::. ::.:: :. XP_016 ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 ---RPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVC .:::::.: :.:..:.:: :: :: : : .:.::::::::::::.: :::::: XP_016 PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 RAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAK ::.::::.:::::: :.::::::::::..: ::::::: ::.:.:::::.:::::..: . XP_016 RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR 340 350 360 370 380 390 490 500 510 520 530 540 pF1KE3 SGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIE ::..::::: :... . . : ... :...: :::.:.:. :. ...:: ::::.. XP_016 SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTG--STLSSVSPRLGSHTMD 400 410 420 430 440 550 pF1KE3 FFEMCANLIKILAQ ::::::.:: ::. XP_016 FFEMCASLITTLAR 450 460 >>XP_006714545 (OMIM: 602739) PREDICTED: 5'-AMP-activate (301 aa) initn: 2022 init1: 2022 opt: 2022 Z-score: 957.7 bits: 186.1 E(85289): 1.3e-46 Smith-Waterman score: 2022; 100.0% identity (100.0% similar) in 301 aa overlap (259-559:1-301) 230 240 250 260 270 280 pF1KE3 HVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLF :::::::::::::::::::::::::::::: XP_006 MLQVDPMKRATIKDIREHEWFKQDLPKYLF 10 20 30 290 300 310 320 330 340 pF1KE3 PEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEA 40 50 60 70 80 90 350 360 370 380 390 400 pF1KE3 KDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWH 100 110 120 130 140 150 410 420 430 440 450 460 pF1KE3 LGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSR 160 170 180 190 200 210 470 480 490 500 510 520 pF1KE3 TYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSL 220 230 240 250 260 270 530 540 550 pF1KE3 DSSPVDLTPRPGSHTIEFFEMCANLIKILAQ ::::::::::::::::::::::::::::::: XP_006 DSSPVDLTPRPGSHTIEFFEMCANLIKILAQ 280 290 300 >>NP_056006 (OMIM: 608973) serine/threonine-protein kina (926 aa) initn: 978 init1: 824 opt: 976 Z-score: 477.1 bits: 98.8 E(85289): 7.8e-20 Smith-Waterman score: 977; 40.2% identity (71.9% similar) in 381 aa overlap (10-386:3-367) 10 20 30 40 50 60 pF1KE3 MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR :: . .. . : :..: : . ::: :.:. ::.:.:..: .::.::... NP_056 MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDK 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG ... .... :: ::.: .:.. ::::::::::. : : ...: ::...::.:::. ..: NP_056 SQLDAVNLE-KIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE3 RLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF ::.:.:.:: : ::::.::::: . .:::::: ::.::: .:: ::::::..:....::. NP_056 RLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGEL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDG : : :::: ::::::. :. : ::..:::: ::.::.:.::.:::: .: : ... .: NP_056 LATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEG 180 190 200 210 220 230 250 260 270 280 290 pF1KE3 IFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP---KYLFPEDPSYSST : : ... . :...:: .:: :: :: .:.::.:. ..: :.:.. . NP_056 RFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVPVQRPVLYPQEQENEPS 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 MID-DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATS . . .: . .. ... ...... : :... . .:. : :... :. .. ..: NP_056 IGEFNEQVLRLMHSLGIDQQKTIESLQNKSY-NHFAAIYFLLVE--RLKSHRSSF----- 300 310 320 330 340 360 370 380 390 400 410 pF1KE3 PPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSR : .. :: . .: : .:: :. NP_056 PVEQRLDGR-------QRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVE 350 360 370 380 390 559 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 07:03:58 2016 done: Sun Nov 6 07:03:59 2016 Total Scan time: 10.590 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]