FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6641, 259 aa 1>>>pF1KE6641 259 - 259 aa - 259 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8749+/-0.000346; mu= 12.8348+/- 0.021 mean_var=100.5732+/-20.280, 0's: 0 Z-trim(116.8): 40 B-trim: 379 in 2/52 Lambda= 0.127889 statistics sampled from 28181 (28220) to 28181 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.708), E-opt: 0.2 (0.331), width: 16 Scan time: 5.210 The best scores are: opt bits E(85289) NP_055236 (OMIM: 605415) dickkopf-related protein ( 259) 1869 354.9 8.3e-98 NP_036374 (OMIM: 605189) dickkopf-related protein ( 266) 729 144.6 1.8e-34 NP_055235 (OMIM: 605417) dickkopf-related protein ( 224) 568 114.8 1.4e-25 XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-re ( 224) 568 114.8 1.4e-25 XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-re ( 224) 568 114.8 1.4e-25 >>NP_055236 (OMIM: 605415) dickkopf-related protein 2 pr (259 aa) initn: 1869 init1: 1869 opt: 1869 Z-score: 1876.9 bits: 354.9 E(85289): 8.3e-98 Smith-Waterman score: 1869; 99.6% identity (100.0% similar) in 259 aa overlap (1-259:1-259) 10 20 30 40 50 60 pF1KE6 MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 LAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPST 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RCNNGICIPVTESILTPHIPALDGTQHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEG :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: NP_055 RCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 DPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCK 190 200 210 220 230 240 250 pF1KE6 VWKDATYSSKARLHVCQKI ::::::::::::::::::: NP_055 VWKDATYSSKARLHVCQKI 250 >>NP_036374 (OMIM: 605189) dickkopf-related protein 1 pr (266 aa) initn: 595 init1: 436 opt: 729 Z-score: 740.0 bits: 144.6 E(85289): 1.8e-34 Smith-Waterman score: 729; 42.9% identity (68.1% similar) in 273 aa overlap (1-258:1-265) 10 20 30 40 50 pF1KE6 MAALMRSKDSSCCLLLLAAVL----MVESSQIGSSRAKLNSIKS---SLGGET--PGQAA : :: . . . ..::.: .. : .: . :.::. ::: . ::.:. NP_036 MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAV 10 20 30 40 50 60 60 70 80 90 100 pF1KE6 NRSAGMYQGLAFGGSK-KGKNLGQAYPCSSDKECEVGRYCHSPHQGSSA----CMVCRRK . . :. : ::.: . . : :::. :.:: . .:: :: .:..: :..::.. NP_036 SAAPGI---LYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKR 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 KKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTQHRDRNHGHYSNHDLGWQNLG .::: : .::::.. :.::::. .. . .: . : .. .. : :. : :.. NP_036 RKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEI---EETITESFGNDH-STLD-GYSRRT 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE6 RPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLE .:: : ::.::. ::::::: :.:::::::.:::::::..:.::::.:.::::::: NP_036 TLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLE 180 190 200 210 220 230 230 240 250 pF1KE6 IFQRCDCAKGLSCKVWKDATYSSKA-RLHVCQKI ::::: :..::::.. :: .:.. :::.::. NP_036 IFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH 240 250 260 >>NP_055235 (OMIM: 605417) dickkopf-related protein 4 pr (224 aa) initn: 429 init1: 242 opt: 568 Z-score: 580.5 bits: 114.8 E(85289): 1.4e-25 Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221) 40 50 60 70 80 90 pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH :..::.. : :: .:.. ..: .:. NP_055 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH . . : .:: ..::.::.::::.: : : .: . .. :: .. ::: : . . NP_055 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG :: ... : .: : :. ::.::. :::. :: :.::::::::::::::: .: NP_055 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG 120 130 140 150 160 170 220 230 240 250 pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI .::... .: . .. ::::::::. :: :. . .. ..:::.::::: NP_055 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL 180 190 200 210 220 >>XP_011542790 (OMIM: 605417) PREDICTED: dickkopf-relate (224 aa) initn: 429 init1: 242 opt: 568 Z-score: 580.5 bits: 114.8 E(85289): 1.4e-25 Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221) 40 50 60 70 80 90 pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH :..::.. : :: .:.. ..: .:. XP_011 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH . . : .:: ..::.::.::::.: : : .: . .. :: .. ::: : . . XP_011 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG :: ... : .: : :. ::.::. :::. :: :.::::::::::::::: .: XP_011 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG 120 130 140 150 160 170 220 230 240 250 pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI .::... .: . .. ::::::::. :: :. . .. ..:::.::::: XP_011 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL 180 190 200 210 220 >>XP_016868805 (OMIM: 605417) PREDICTED: dickkopf-relate (224 aa) initn: 429 init1: 242 opt: 568 Z-score: 580.5 bits: 114.8 E(85289): 1.4e-25 Smith-Waterman score: 568; 42.2% identity (68.8% similar) in 199 aa overlap (65-259:34-221) 40 50 60 70 80 90 pF1KE6 LNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPH :..::.. : :: .:.. ..: .:. XP_016 AVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQ------CLSDTDCNTRKFCLQPR 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 QGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTES--ILTPHIPALDGTQHRDRNH . . : .:: ..::.::.::::.: : : .: . .. :: .. ::: : . . XP_016 DEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGT-HAEGTT 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE6 GHYSNHDLGWQNLGRPHTKMSHI-KGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQG :: ... : .: : :. ::.::. :::. :: :.::::::::::::::: .: XP_016 GHPVQEN---QPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEG 120 130 140 150 160 170 220 230 240 250 pF1KE6 EVCTKQRKKGS-HGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI .::... .: . .. ::::::::. :: :. . .. ..:::.::::: XP_016 QVCSRRGHKDTAQAPEIFQRCDCGPGLLCRS-QLTSNRQHARLRVCQKIEKL 180 190 200 210 220 259 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:02:01 2016 done: Tue Nov 8 15:02:02 2016 Total Scan time: 5.210 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]