FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB4048, 596 aa 1>>>pF1KB4048 596 - 596 aa - 596 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 15.5674+/-0.000612; mu= -35.3323+/- 0.036 mean_var=712.3095+/-155.469, 0's: 0 Z-trim(115.4): 1576 B-trim: 0 in 0/57 Lambda= 0.048055 statistics sampled from 23877 (25886) to 23877 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.304), width: 16 Scan time: 6.490 The best scores are: opt bits E(85289) NP_002731 (OMIM: 600539) protein kinase C iota typ ( 596) 4128 302.7 2.2e-81 XP_016862349 (OMIM: 600539) PREDICTED: protein kin ( 464) 3064 228.9 3e-59 NP_002735 (OMIM: 176982) protein kinase C zeta typ ( 592) 2960 221.8 5.3e-57 XP_011540075 (OMIM: 176982) PREDICTED: protein kin ( 595) 2612 197.6 9.7e-50 NP_001229803 (OMIM: 176982) protein kinase C zeta ( 488) 2528 191.7 4.7e-48 XP_016857280 (OMIM: 176982) PREDICTED: protein kin ( 510) 2513 190.7 1e-47 XP_011540076 (OMIM: 176982) PREDICTED: protein kin ( 491) 2180 167.6 8.7e-41 XP_016857290 (OMIM: 176982) PREDICTED: protein kin ( 405) 2103 162.2 3.1e-39 NP_001028754 (OMIM: 176982) protein kinase C zeta ( 409) 2103 162.2 3.1e-39 XP_016857288 (OMIM: 176982) PREDICTED: protein kin ( 409) 2103 162.2 3.1e-39 NP_001028753 (OMIM: 176982) protein kinase C zeta ( 409) 2103 162.2 3.1e-39 XP_016857294 (OMIM: 176982) PREDICTED: protein kin ( 355) 2073 160.1 1.2e-38 XP_016857293 (OMIM: 176982) PREDICTED: protein kin ( 355) 2073 160.1 1.2e-38 XP_016857287 (OMIM: 176982) PREDICTED: protein kin ( 417) 2052 158.7 3.6e-38 XP_016857285 (OMIM: 176982) PREDICTED: protein kin ( 417) 2052 158.7 3.6e-38 XP_016857289 (OMIM: 176982) PREDICTED: protein kin ( 408) 1755 138.1 5.6e-32 XP_011540078 (OMIM: 176982) PREDICTED: protein kin ( 412) 1755 138.1 5.7e-32 XP_011540080 (OMIM: 176982) PREDICTED: protein kin ( 412) 1755 138.1 5.7e-32 XP_016857291 (OMIM: 176982) PREDICTED: protein kin ( 358) 1725 136.0 2.2e-31 XP_016857286 (OMIM: 176982) PREDICTED: protein kin ( 416) 1704 134.5 6.6e-31 XP_016857283 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31 XP_016857281 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31 XP_016857282 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31 XP_016857284 (OMIM: 176982) PREDICTED: protein kin ( 420) 1704 134.6 6.7e-31 XP_016857292 (OMIM: 176982) PREDICTED: protein kin ( 358) 1380 112.0 3.4e-24 XP_011540077 (OMIM: 176982) PREDICTED: protein kin ( 416) 1375 111.7 4.9e-24 XP_016857279 (OMIM: 176982) PREDICTED: protein kin ( 600) 1380 112.2 5e-24 XP_016857278 (OMIM: 176982) PREDICTED: protein kin ( 603) 1380 112.2 5.1e-24 XP_011531285 (OMIM: 176975) PREDICTED: protein kin ( 436) 1184 98.5 4.9e-20 XP_006712113 (OMIM: 176975) PREDICTED: protein kin ( 460) 1184 98.5 5.1e-20 XP_011531284 (OMIM: 176975) PREDICTED: protein kin ( 497) 1184 98.6 5.4e-20 XP_011531283 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20 XP_011531282 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20 XP_016859980 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20 XP_016859978 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20 XP_016859979 (OMIM: 176975) PREDICTED: protein kin ( 587) 1184 98.6 6.1e-20 XP_016859976 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20 XP_011531280 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20 XP_016859977 (OMIM: 176975) PREDICTED: protein kin ( 623) 1184 98.6 6.4e-20 XP_016859975 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20 XP_011531273 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20 XP_011531277 (OMIM: 176975) PREDICTED: protein kin ( 641) 1184 98.7 6.5e-20 XP_005264485 (OMIM: 176975) PREDICTED: protein kin ( 737) 1184 98.7 7.2e-20 NP_005391 (OMIM: 176975) protein kinase C epsilon ( 737) 1184 98.7 7.2e-20 XP_016876947 (OMIM: 601367,605437) PREDICTED: prot ( 522) 1027 87.7 1.1e-16 XP_011535257 (OMIM: 601367,605437) PREDICTED: prot ( 603) 1027 87.7 1.2e-16 XP_011535256 (OMIM: 601367,605437) PREDICTED: prot ( 604) 1027 87.7 1.2e-16 NP_006246 (OMIM: 601367,605437) protein kinase C e ( 683) 1027 87.8 1.3e-16 NP_872198 (OMIM: 603607) ribosomal protein S6 kina ( 549) 911 79.7 2.9e-14 NP_001309158 (OMIM: 603607) ribosomal protein S6 k ( 795) 911 79.8 3.8e-14 >>NP_002731 (OMIM: 600539) protein kinase C iota type [H (596 aa) initn: 4128 init1: 4128 opt: 4128 Z-score: 1582.0 bits: 302.7 E(85289): 2.2e-81 Smith-Waterman score: 4128; 100.0% identity (100.0% similar) in 596 aa overlap (1-596:1-596) 10 20 30 40 50 60 pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB4 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB4 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB4 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB4 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB4 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB4 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 490 500 510 520 530 540 550 560 570 580 590 pF1KB4 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 550 560 570 580 590 >>XP_016862349 (OMIM: 600539) PREDICTED: protein kinase (464 aa) initn: 3064 init1: 3064 opt: 3064 Z-score: 1184.8 bits: 228.9 E(85289): 3e-59 Smith-Waterman score: 3064; 100.0% identity (100.0% similar) in 446 aa overlap (151-596:19-464) 130 140 150 160 170 180 pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK :::::::::::::::::::::::::::::: XP_016 MCSLVYQNVLGCLVQEKIRAHCAICTDRIWGLGRQGYKCINCKLLVHK 10 20 30 40 190 200 210 220 230 240 pF1KB4 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KCHKLVTIECGRHSLPQEPVMPMDQSSMHSDHAQTVIPYNPSSHESLDQVGEEKEAMNTR 50 60 70 80 90 100 250 260 270 280 290 300 pF1KB4 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQ 110 120 130 140 150 160 310 320 330 340 350 360 pF1KB4 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 170 180 190 200 210 220 370 380 390 400 410 420 pF1KB4 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYI 230 240 250 260 270 280 430 440 450 460 470 480 pF1KB4 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIR 290 300 310 320 330 340 490 500 510 520 530 540 pF1KB4 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFK 350 360 370 380 390 400 550 560 570 580 590 pF1KB4 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 410 420 430 440 450 460 >>NP_002735 (OMIM: 176982) protein kinase C zeta type is (592 aa) initn: 2917 init1: 1317 opt: 2960 Z-score: 1144.4 bits: 221.8 E(85289): 5.3e-57 Smith-Waterman score: 2960; 72.8% identity (88.5% similar) in 589 aa overlap (18-596:11-592) 10 20 30 40 50 60 pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF ::: .::.::.: :::.:: . . .:: ::.:::::: . NP_002 MPSRTGPKMEGSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRL 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE ... .:.::.: ::::::::::.:::::::: . .: :.::::: .::.::.::::: NP_002 HQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK :::::::::::::::: :::: ::::::::::.:. :..:::::.::::.:::::::::: NP_002 DKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHK 120 130 140 150 160 170 190 200 210 220 230 pF1KB4 KCHKLVTIECGRHS---LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVG .:: :: . : .: .: ::: :.:... .: . : : :: :.:. . . NP_002 RCHGLVPLTCRKHMDSVMPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDS 180 190 200 210 220 240 250 260 270 280 290 pF1KB4 EE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELV :. : ... .. : :..::::::::.::::::::::::::::::.:.:::::::::::: NP_002 EDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELV 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB4 NDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKL .:::::::::::::::::::..:::::::::::: ::::.:::::::::::::::::::: NP_002 HDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB4 PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT ::::::::.::: .:::.:::::::::::::::::::..::::::::::::::: ::::: NP_002 PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB4 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL ::::::::::::::::::.::::::::::::::::::::::::::. .::::.:::::: NP_002 STFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB4 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM ::::::: ::::: :::::. :::.::::::::::::.:::::.::..: :::..:::.. NP_002 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLL 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB4 EQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM :.::..:::.:.:. ..::::::.:::.:::::::::.: ...::::::::::::::::. NP_002 EKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 530 540 550 560 570 580 pF1KB4 SAEECV :.:: : NP_002 STEESV 590 >>XP_011540075 (OMIM: 176982) PREDICTED: protein kinase (595 aa) initn: 2579 init1: 1327 opt: 2612 Z-score: 1013.9 bits: 197.6 E(85289): 9.7e-50 Smith-Waterman score: 2612; 72.8% identity (87.6% similar) in 526 aa overlap (18-533:11-529) 10 20 30 40 50 60 pF1KB4 MPTQRDSSTMSHTVAGGGSGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCNEVRDMCSF ::: .::.::.: :::.:: . . .:: ::.:::::: . XP_011 MPSRTGPKMEGSGG---RVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRL 10 20 30 40 50 70 80 90 100 110 120 pF1KB4 DNEQLFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGE ... .:.::.: ::::::::::.:::::::: . .: :.::::: .::.::.::::: XP_011 HQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB4 DKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHK :::::::::::::::: :::: ::::::::::.:. :..:::::.::::.:::::::::: XP_011 DKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHK 120 130 140 150 160 170 190 200 210 220 230 pF1KB4 KCHKLVTIECGRHS---LP-QEPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVG .:: :: . : .: .: ::: :.:... .: . : : :: :.:. . . XP_011 RCHGLVPLTCRKHMDSVMPSQEP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDS 180 190 200 210 220 240 250 260 270 280 290 pF1KB4 EE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELV :. : ... .. : :..::::::::.::::::::::::::::::.:.:::::::::::: XP_011 EDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELV 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB4 NDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKL .:::::::::::::::::::..:::::::::::: ::::.:::::::::::::::::::: XP_011 HDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKL 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB4 PEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT ::::::::.::: .:::.:::::::::::::::::::..::::::::::::::: ::::: XP_011 PEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB4 STFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYL ::::::::::::::::::.::::::::::::::::::::::::::. .::::.:::::: XP_011 STFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYL 410 420 430 440 450 460 480 490 500 510 520 530 pF1KB4 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMM ::::::: ::::: :::::. :::.::::::::::::.:::::.::..: :::..:::.: XP_011 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLM 470 480 490 500 510 520 540 550 560 570 580 590 pF1KB4 EQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM ... XP_011 HRQLRCTDARTTWTPRRCGRTDDMDAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDA 530 540 550 560 570 580 >>NP_001229803 (OMIM: 176982) protein kinase C zeta type (488 aa) initn: 2473 init1: 1317 opt: 2528 Z-score: 983.6 bits: 191.7 E(85289): 4.7e-48 Smith-Waterman score: 2528; 75.0% identity (89.4% similar) in 492 aa overlap (115-596:1-488) 90 100 110 120 130 140 pF1KB4 ELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQ : : :.:::::::::::::: :::: :: NP_001 MLTPRTDESIYRRGARRWRKLYRANGHLFQ 10 20 30 150 160 170 180 190 200 pF1KB4 AKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-QEPV ::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: ::: NP_001 AKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEP- 40 50 60 70 80 210 220 230 240 250 pF1KB4 MPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDF :.:... .: . : : :: :.:. . .:. : ... .. : :..:::::: NP_001 -PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDF 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB4 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF ::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::..:: NP_001 DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPF 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB4 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI :::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.:::::: NP_001 LVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGI 210 220 230 240 250 260 380 390 400 410 420 430 pF1KB4 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV :::::::::::::..::::::::::::::: :::::::::::::::::::::::.::::: NP_001 IYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 270 280 290 300 310 320 440 450 460 470 480 490 pF1KB4 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK :::::::::::::::::::::. .::::.::::::::::::: ::::: :::::. ::: NP_001 DWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 330 340 350 360 370 380 500 510 520 530 540 550 pF1KB4 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS .::::::::::::.:::::.::..: :::..:::..:.::..:::.:.:. ..::::::. NP_001 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDT 390 400 410 420 430 440 560 570 580 590 pF1KB4 QFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV :::.:::::::::.: ...::::::::::::::::.:.:: : NP_001 QFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 450 460 470 480 >>XP_016857280 (OMIM: 176982) PREDICTED: protein kinase (510 aa) initn: 2475 init1: 1317 opt: 2513 Z-score: 977.8 bits: 190.7 E(85289): 1e-47 Smith-Waterman score: 2513; 74.3% identity (88.9% similar) in 495 aa overlap (112-596:20-510) 90 100 110 120 130 140 pF1KB4 SQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGH :: . .:::::::::::::: :::: XP_016 MCTAHSIGVLGWWRGAGLRRPVFYSEMVGESIYRRGARRWRKLYRANGH 10 20 30 40 150 160 170 180 190 pF1KB4 TFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-Q ::::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: : XP_016 LFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQ 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB4 EPVMPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGL :: :.:... .: . : : :: :.:. . .:. : ... .. : :..::: XP_016 EP--PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGL 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB4 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN :::::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::. XP_016 QDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASS 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB4 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHE .:::::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.::: XP_016 NPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHE 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB4 RGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYG ::::::::::::::::..::::::::::::::: :::::::::::::::::::::::.:: XP_016 RGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYG 290 300 310 320 330 340 440 450 460 470 480 490 pF1KB4 FSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAAS ::::::::::::::::::::::::. .::::.::::::::::::: ::::: :::::. XP_016 FSVDWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASH 350 360 370 380 390 400 500 510 520 530 540 550 pF1KB4 VLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDN :::.::::::::::::.:::::.::..: :::..:::..:.::..:::.:.:. ..:::: XP_016 VLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDN 410 420 430 440 450 460 560 570 580 590 pF1KB4 FDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV ::.:::.:::::::::.: ...::::::::::::::::.:.:: : XP_016 FDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV 470 480 490 500 510 >>XP_011540076 (OMIM: 176982) PREDICTED: protein kinase (491 aa) initn: 2135 init1: 1327 opt: 2180 Z-score: 853.2 bits: 167.6 E(85289): 8.7e-41 Smith-Waterman score: 2180; 75.3% identity (88.6% similar) in 429 aa overlap (115-533:1-425) 90 100 110 120 130 140 pF1KB4 ELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQ : : :.:::::::::::::: :::: :: XP_011 MLTPRTDESIYRRGARRWRKLYRANGHLFQ 10 20 30 150 160 170 180 190 200 pF1KB4 AKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHS---LP-QEPV ::::::::.:. :..:::::.::::.::::::::::.:: :: . : .: .: ::: XP_011 AKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEP- 40 50 60 70 80 210 220 230 240 250 pF1KB4 MPMDQSSMHSD---HAQTVIPYNPSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDF :.:... .: . : : :: :.:. . .:. : ... .. : :..:::::: XP_011 -PVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDF 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB4 DLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPF ::.::::::::::::::::::.:.::::::::::::.:::::::::::::::::::..:: XP_011 DLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPF 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB4 LVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGI :::::::::: ::::.::::::::::::::::::::::::::::.::: .:::.:::::: XP_011 LVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGI 210 220 230 240 250 260 380 390 400 410 420 430 pF1KB4 IYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV :::::::::::::..::::::::::::::: :::::::::::::::::::::::.::::: XP_011 IYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 270 280 290 300 310 320 440 450 460 470 480 490 pF1KB4 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLK :::::::::::::::::::::. .::::.::::::::::::: ::::: :::::. ::: XP_011 DWWALGVLMFEMMAGRSPFDII--TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLK 330 340 350 360 370 380 500 510 520 530 540 550 pF1KB4 SFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDS .::::::::::::.:::::.::..: :::..:::.:... XP_011 GFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLMHRQLRCTDARTTWTPRRCGRTDDM 390 400 410 420 430 440 560 570 580 590 pF1KB4 QFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV XP_011 DAQTMWMHGRRRHTDDSSTDDSDARTPRRRGRTDDADAQMTWTHR 450 460 470 480 490 >>XP_016857290 (OMIM: 176982) PREDICTED: protein kinase (405 aa) initn: 2061 init1: 1317 opt: 2103 Z-score: 825.5 bits: 162.2 E(85289): 3.1e-39 Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:1-405) 170 180 190 200 210 220 pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN .: ::: :.:... .: . : : XP_016 MPSQEP--PVDDKNEDADLPSEETDGIAYI 10 20 230 240 250 260 270 pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD :: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.: XP_016 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND 30 40 50 60 70 80 280 290 300 310 320 330 pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG .::::::::::::.:::::::::::::::::::..:::::::::::: ::::.::::::: XP_016 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG 90 100 110 120 130 140 340 350 360 370 380 390 pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY :::::::::::::::::::::.::: .:::.:::::::::::::::::::..:::::::: XP_016 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY 150 160 170 180 190 200 400 410 420 430 440 450 pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG ::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::. XP_016 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII- 210 220 230 240 250 260 460 470 480 490 500 510 pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ .::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::. XP_016 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK 270 280 290 300 310 320 520 530 540 550 560 570 pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS .: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...:::: XP_016 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS 330 340 350 360 370 380 580 590 pF1KB4 EFEGFEYINPLLMSAEECV ::::::::::::.:.:: : XP_016 EFEGFEYINPLLLSTEESV 390 400 >>NP_001028754 (OMIM: 176982) protein kinase C zeta type (409 aa) initn: 2061 init1: 1317 opt: 2103 Z-score: 825.4 bits: 162.2 E(85289): 3.1e-39 Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:5-409) 170 180 190 200 210 220 pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN .: ::: :.:... .: . : : NP_001 MDSVMPSQEP--PVDDKNEDADLPSEETDGIAYI 10 20 30 230 240 250 260 270 pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD :: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.: NP_001 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND 40 50 60 70 80 90 280 290 300 310 320 330 pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG .::::::::::::.:::::::::::::::::::..:::::::::::: ::::.::::::: NP_001 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG 100 110 120 130 140 150 340 350 360 370 380 390 pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY :::::::::::::::::::::.::: .:::.:::::::::::::::::::..:::::::: NP_001 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY 160 170 180 190 200 210 400 410 420 430 440 450 pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG ::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::. NP_001 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII- 220 230 240 250 260 270 460 470 480 490 500 510 pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ .::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::. NP_001 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK 280 290 300 310 320 330 520 530 540 550 560 570 pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS .: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...:::: NP_001 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS 340 350 360 370 380 390 580 590 pF1KB4 EFEGFEYINPLLMSAEECV ::::::::::::.:.:: : NP_001 EFEGFEYINPLLLSTEESV 400 >>XP_016857288 (OMIM: 176982) PREDICTED: protein kinase (409 aa) initn: 2061 init1: 1317 opt: 2103 Z-score: 825.4 bits: 162.2 E(85289): 3.1e-39 Smith-Waterman score: 2103; 76.0% identity (91.0% similar) in 409 aa overlap (195-596:5-409) 170 180 190 200 210 220 pF1KB4 GRQGYKCINCKLLVHKKCHKLVTIECGRHSLP-QEPVMPMDQSSMHSD---HAQTVIPYN .: ::: :.:... .: . : : XP_016 MDSVMPSQEP--PVDDKNEDADLPSEETDGIAYI 10 20 30 230 240 250 260 270 pF1KB4 PSS--HESLDQVGEE-KEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTD :: :.:. . .:. : ... .. : :..::::::::.::::::::::::::::::.: XP_016 SSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKND 40 50 60 70 80 90 280 290 300 310 320 330 pF1KB4 RIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNG .::::::::::::.:::::::::::::::::::..:::::::::::: ::::.::::::: XP_016 QIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNG 100 110 120 130 140 150 340 350 360 370 380 390 pF1KB4 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDY :::::::::::::::::::::.::: .:::.:::::::::::::::::::..:::::::: XP_016 GDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDY 160 170 180 190 200 210 400 410 420 430 440 450 pF1KB4 GMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVG ::::::: :::::::::::::::::::::::.::::::::::::::::::::::::::. XP_016 GMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDII- 220 230 240 250 260 270 460 470 480 490 500 510 pF1KB4 SSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQ .::::.::::::::::::: ::::: :::::. :::.::::::::::::.:::::.::. XP_016 -TDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIK 280 290 300 310 320 330 520 530 540 550 560 570 pF1KB4 GHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQS .: :::..:::..:.::..:::.:.:. ..::::::.:::.:::::::::.: ...:::: XP_016 SHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQS 340 350 360 370 380 390 580 590 pF1KB4 EFEGFEYINPLLMSAEECV ::::::::::::.:.:: : XP_016 EFEGFEYINPLLLSTEESV 400 596 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:39:22 2016 done: Sun Nov 6 17:39:23 2016 Total Scan time: 6.490 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]