FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB8949, 324 aa 1>>>pF1KB8949 324 - 324 aa - 324 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4500+/-0.000322; mu= 6.2097+/- 0.020 mean_var=269.9676+/-54.642, 0's: 0 Z-trim(124.8): 7 B-trim: 0 in 0/60 Lambda= 0.078058 statistics sampled from 47066 (47076) to 47066 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.552), width: 16 Scan time: 8.970 The best scores are: opt bits E(85289) NP_005058 (OMIM: 602213) E3 ubiquitin-protein liga ( 324) 2288 269.8 5.3e-72 XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1552 186.9 4.3e-47 NP_003022 (OMIM: 602212) E3 ubiquitin-protein liga ( 282) 1552 186.9 4.3e-47 XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquiti ( 282) 1552 186.9 4.3e-47 NP_001006611 (OMIM: 602212) E3 ubiquitin-protein l ( 313) 1552 186.9 4.6e-47 NP_942146 (OMIM: 615609) seven in absentia homolog ( 269) 660 86.4 7.3e-17 >>NP_005058 (OMIM: 602213) E3 ubiquitin-protein ligase S (324 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 1413.6 bits: 269.8 E(85289): 5.3e-72 Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 324 aa overlap (1-324:1-324) 10 20 30 40 50 60 pF1KB8 MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB8 GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB8 SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB8 LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB8 GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFD 250 260 270 280 290 300 310 320 pF1KB8 TAIAHLFADNGNLGINVTISTCCP :::::::::::::::::::::::: NP_005 TAIAHLFADNGNLGINVTISTCCP 310 320 >>XP_011521581 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa) initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47 Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282) 10 20 30 40 50 60 pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP : .: :.: : . : :. : XP_011 MSRQTATALPTGTSKCPPSQRV---PALTG---- 10 20 70 80 90 100 110 120 pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA .. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : :::::: XP_011 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS :::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.::: XP_011 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF :::: ::::::::::::::::::::::::::::::::::: ::::::::::::.:::::: XP_011 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL ::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.: XP_011 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL 210 220 230 240 250 260 310 320 pF1KB8 FADNGNLGINVTISTCCP ::.::::::::::: : XP_011 FAENGNLGINVTISMC 270 280 >>NP_003022 (OMIM: 602212) E3 ubiquitin-protein ligase S (282 aa) initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47 Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282) 10 20 30 40 50 60 pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP : .: :.: : . : :. : NP_003 MSRQTATALPTGTSKCPPSQRV---PALTG---- 10 20 70 80 90 100 110 120 pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA .. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : :::::: NP_003 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS :::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.::: NP_003 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF :::: ::::::::::::::::::::::::::::::::::: ::::::::::::.:::::: NP_003 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL ::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.: NP_003 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL 210 220 230 240 250 260 310 320 pF1KB8 FADNGNLGINVTISTCCP ::.::::::::::: : NP_003 FAENGNLGINVTISMC 270 280 >>XP_006721309 (OMIM: 602212) PREDICTED: E3 ubiquitin-pr (282 aa) initn: 1563 init1: 1243 opt: 1552 Z-score: 966.4 bits: 186.9 E(85289): 4.3e-47 Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:5-282) 10 20 30 40 50 60 pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP : .: :.: : . : :. : XP_006 MSRQTATALPTGTSKCPPSQRV---PALTG---- 10 20 70 80 90 100 110 120 pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA .. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : :::::: XP_006 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS :::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.::: XP_006 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF :::: ::::::::::::::::::::::::::::::::::: ::::::::::::.:::::: XP_006 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL ::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.: XP_006 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL 210 220 230 240 250 260 310 320 pF1KB8 FADNGNLGINVTISTCCP ::.::::::::::: : XP_006 FAENGNLGINVTISMC 270 280 >>NP_001006611 (OMIM: 602212) E3 ubiquitin-protein ligas (313 aa) initn: 1563 init1: 1243 opt: 1552 Z-score: 965.9 bits: 186.9 E(85289): 4.6e-47 Smith-Waterman score: 1552; 77.6% identity (89.2% similar) in 286 aa overlap (37-322:36-313) 10 20 30 40 50 60 pF1KB8 TGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGGGGGAGP : .: :.: : . : :. : NP_001 TPPSLYSWRGVLFTCLPAARTRKRKEMSRQTATALPTGTSKCPPSQRV---PALTG---- 10 20 30 40 50 70 80 90 100 110 120 pF1KB8 VSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLA .. ....:.::::::::::::::::::::.:::::..:: ::.::::::: : :::::: NP_001 TTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLG-SIRNLA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB8 MEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMS :::::..::::::::..:: .:: :::: .::..::.::::::::::::::::::.::: NP_001 MEKVANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMP 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB8 HLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFF :::: ::::::::::::::::::::::::::::::::::: ::::::::::::.:::::: NP_001 HLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFF 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB8 AIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHL ::: :::::::::::::::::::.::::::::::::::.:.:.::::::::::::.::.: NP_001 AIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQL 240 250 260 270 280 290 310 320 pF1KB8 FADNGNLGINVTISTCCP ::.::::::::::: : NP_001 FAENGNLGINVTISMC 300 310 >>NP_942146 (OMIM: 615609) seven in absentia homolog 3 [ (269 aa) initn: 657 init1: 536 opt: 660 Z-score: 423.8 bits: 86.4 E(85289): 7.3e-17 Smith-Waterman score: 660; 54.1% identity (79.7% similar) in 172 aa overlap (149-320:90-258) 120 130 140 150 160 170 pF1KB8 TPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQ ::: : : . : : :: ::.:. NP_942 QGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHAN--PVTPCLCMCPLFSCQWE 60 70 80 90 100 110 180 190 200 210 220 230 pF1KB8 GSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEK : ::.:. :: . :. . ::: .:::::::..::. .::..:.::.::::.:::.:::. NP_942 GRLEVVVPHLRQIHR-VDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQER 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB8 YEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLV .::: :::: ..:::: ::. :.:::::: :.::: :::::::. . : ..: ..:::: NP_942 HEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLV 180 190 200 210 220 230 300 310 320 pF1KB8 FDTAIAHLFADNGNLGINVTISTCCP ..:..:.::.:::.:.:...:. NP_942 LNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM 240 250 260 324 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:40:39 2016 done: Sun Nov 6 17:40:40 2016 Total Scan time: 8.970 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]