Result of FASTA (omim) for
pFN21AE3046
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3046, 185 aa
1>>>pF1KE3046 185 - 185 aa - 185 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1256+/-0.000324; mu= 13.7937+/- 0.020
mean_var=61.5160+/-12.138, 0's: 0 Z-trim(115.5): 106 B-trim: 0 in 0/51
Lambda= 0.163523
statistics sampled from 25898 (26005) to 25898 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.305), width: 16
Scan time: 5.170
The best scores are: opt bits E(85289)
NP_003960 (OMIM: 603173) NEDD8-conjugating enzyme ( 183) 398 101.9 6e-22
NP_003333 (OMIM: 601569) ubiquitin-conjugating enz ( 170) 288 76.0 3.6e-14
NP_003329 (OMIM: 602961) ubiquitin-conjugating enz ( 147) 286 75.5 4.5e-14
NP_871622 (OMIM: 602963) ubiquitin-conjugating enz ( 149) 277 73.3 2e-13
NP_003330 (OMIM: 602962) ubiquitin-conjugating enz ( 147) 275 72.9 2.7e-13
NP_871621 (OMIM: 602963) ubiquitin-conjugating enz ( 148) 273 72.4 3.8e-13
NP_871619 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_871618 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_871616 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_003331 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_871617 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_871620 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_871615 (OMIM: 602963) ubiquitin-conjugating enz ( 147) 272 72.2 4.4e-13
NP_005330 (OMIM: 602846) ubiquitin-conjugating enz ( 200) 270 71.8 7.9e-13
XP_016865309 (OMIM: 602962) PREDICTED: ubiquitin-c ( 173) 268 71.3 9.7e-13
NP_689866 (OMIM: 602163) ubiquitin-conjugating enz ( 201) 261 69.6 3.5e-12
XP_005265489 (OMIM: 602163) PREDICTED: ubiquitin-c ( 201) 261 69.6 3.5e-12
NP_001191809 (OMIM: 602961) ubiquitin-conjugating ( 109) 253 67.6 7.7e-12
NP_001104582 (OMIM: 602846) ubiquitin-conjugating ( 157) 253 67.7 1e-11
XP_016872098 (OMIM: 602961) PREDICTED: ubiquitin-c ( 110) 251 67.1 1.1e-11
NP_006348 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 254 68.0 1.1e-11
NP_001265484 (OMIM: 604151) ubiquitin-conjugating ( 207) 254 68.0 1.1e-11
XP_005246301 (OMIM: 604151) PREDICTED: ubiquitin-c ( 207) 254 68.0 1.1e-11
NP_001265483 (OMIM: 604151) ubiquitin-conjugating ( 207) 254 68.0 1.1e-11
NP_872619 (OMIM: 604151) ubiquitin-conjugating enz ( 207) 254 68.0 1.1e-11
NP_862821 (OMIM: 602962) ubiquitin-conjugating enz ( 118) 249 66.7 1.6e-11
NP_003339 (OMIM: 603679) ubiquitin-conjugating enz ( 152) 249 66.7 1.9e-11
NP_003338 (OMIM: 603721) ubiquitin-conjugating enz ( 154) 247 66.3 2.7e-11
XP_016864073 (OMIM: 602963) PREDICTED: ubiquitin-c ( 118) 243 65.3 4.2e-11
NP_001287724 (OMIM: 602963) ubiquitin-conjugating ( 118) 243 65.3 4.2e-11
NP_001243284 (OMIM: 603721) ubiquitin-conjugating ( 212) 246 66.1 4.2e-11
NP_003332 (OMIM: 602916) ubiquitin-conjugating enz ( 193) 245 65.9 4.6e-11
XP_006723015 (OMIM: 116948) PREDICTED: ubiquitin-c ( 179) 240 64.7 9.7e-11
NP_004350 (OMIM: 116948) ubiquitin-conjugating enz ( 236) 240 64.7 1.2e-10
XP_005259747 (OMIM: 116948) PREDICTED: ubiquitin-c ( 269) 240 64.7 1.4e-10
NP_060281 (OMIM: 612506) ubiquitin-conjugating enz ( 238) 230 62.4 6.3e-10
NP_001189405 (OMIM: 602916) ubiquitin-conjugating ( 160) 226 61.3 8.7e-10
NP_004214 (OMIM: 603890) ubiquitin/ISG15-conjugati ( 153) 225 61.1 9.9e-10
XP_005265490 (OMIM: 602163) PREDICTED: ubiquitin-c ( 189) 226 61.4 1e-09
NP_001243285 (OMIM: 603721) ubiquitin-conjugating ( 122) 222 60.3 1.3e-09
NP_872607 (OMIM: 602916) ubiquitin-conjugating enz ( 176) 217 59.2 4.1e-09
NP_003335 (OMIM: 601082) ubiquitin-conjugating enz ( 183) 215 58.8 5.9e-09
NP_003327 (OMIM: 300860,312180) ubiquitin-conjugat ( 152) 212 58.0 8.3e-09
NP_003328 (OMIM: 179095) ubiquitin-conjugating enz ( 152) 210 57.5 1.1e-08
NP_055316 (OMIM: 610309) ubiquitin-conjugating enz ( 222) 209 57.4 1.9e-08
NP_919235 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 207 56.8 1.9e-08
NP_919236 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 207 56.8 1.9e-08
NP_003336 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 207 56.8 1.9e-08
XP_016879129 (OMIM: 601661) PREDICTED: SUMO-conjug ( 158) 207 56.8 1.9e-08
NP_919237 (OMIM: 601661) SUMO-conjugating enzyme U ( 158) 207 56.8 1.9e-08
>>NP_003960 (OMIM: 603173) NEDD8-conjugating enzyme Ubc1 (183 aa)
initn: 336 init1: 296 opt: 398 Z-score: 515.1 bits: 101.9 E(85289): 6e-22
Smith-Waterman score: 398; 38.3% identity (68.3% similar) in 167 aa overlap (15-181:12-169)
10 20 30 40 50 60
pF1KE3 MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPN
: ..:. .. :....:. . . :.. :: ::: :: . : ::.
NP_003 MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINEL--NLPKTCDISFSDPD
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLL
: :.:.. ::::.:..::: : .: ..: :::::: : ..:::: :..::..:
NP_003 DLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYI
:: : :. :......::. :: . : .:::: :::: ... :...:. .
NP_003 RE------DWKPVLTINSIIYGLQYLFLEP-NPEDPLNKEAAEVLQNNRRLFEQNVQRSM
120 130 140 150 160
pF1KE3 KRYAR
.
NP_003 RGGYIGSTYFERCLK
170 180
>>NP_003333 (OMIM: 601569) ubiquitin-conjugating enzyme (170 aa)
initn: 220 init1: 199 opt: 288 Z-score: 375.3 bits: 76.0 E(85289): 3.6e-14
Smith-Waterman score: 288; 31.4% identity (64.1% similar) in 156 aa overlap (36-182:9-163)
10 20 30 40 50 60
pF1KE3 SKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCF
:: ...:::. : .. . : : :. .
NP_003 MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRW
10 20 30
70 80 90 100 110 120
pF1KE3 Q-LTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHS
. : . : . :.:: :. . : : . :::.: .:.:::::. ..:..:.:.:.: .
NP_003 EVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPG
40 50 60 70 80 90
130 140 150 160 170
pF1KE3 IDGTG-------WAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKE-DFRNKV
: : : : .:.. .. .. :...: : :.: :..::.. .:.. .:. ::
NP_003 EDKYGYEKPEERWLPIHTVETIMISVISMLADP-NGDSPANVDAAKEWREDRNGEFKRKV
100 110 120 130 140 150
180
pF1KE3 DDYIKRYAR
...
NP_003 ARCVRKSQETAFE
160 170
>>NP_003329 (OMIM: 602961) ubiquitin-conjugating enzyme (147 aa)
initn: 225 init1: 169 opt: 286 Z-score: 373.7 bits: 75.5 E(85289): 4.5e-14
Smith-Waterman score: 286; 34.4% identity (62.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...:. . : :.. : . :
NP_003 MALKRIQKELSDLQRDPPAHCSAG-PVGDDLFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. : .. :::: : . .. : : . :::. :::.::::. .: :::..::
NP_003 WQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: . :. . ::: . .. .. ..:
NP_003 ----SQWSPALTVSKVLLSICSLLCDP-NPDDPLVPDIAQIYKSDKEKYNRHAREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_003 AM
>>NP_871622 (OMIM: 602963) ubiquitin-conjugating enzyme (149 aa)
initn: 214 init1: 168 opt: 277 Z-score: 362.1 bits: 73.3 E(85289): 2e-13
Smith-Waterman score: 277; 33.8% identity (60.3% similar) in 151 aa overlap (35-184:6-148)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: : ::...: . : :.. : . .
NP_871 MLSNRKCLSKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_871 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . .. ..:
NP_871 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRISREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_871 AM
>>NP_003330 (OMIM: 602962) ubiquitin-conjugating enzyme (147 aa)
initn: 220 init1: 168 opt: 275 Z-score: 359.7 bits: 72.9 E(85289): 2.7e-13
Smith-Waterman score: 275; 33.8% identity (60.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::. .: . : :.. : . .
NP_003 MALKRIHKELNDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_003 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.: . . .. ..:
NP_003 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDREKYNRIAREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_003 AM
>>NP_871621 (OMIM: 602963) ubiquitin-conjugating enzyme (148 aa)
initn: 215 init1: 168 opt: 273 Z-score: 357.1 bits: 72.4 E(85289): 3.8e-13
Smith-Waterman score: 273; 33.1% identity (60.9% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...: . : :.. : . .
NP_871 MALKRINKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_871 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . . .. ..:
NP_871 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRLAREWTEKY
100 110 120 130 140
pF1KE3 AR
:
NP_871 AML
>>NP_871619 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa)
initn: 214 init1: 168 opt: 272 Z-score: 355.9 bits: 72.2 E(85289): 4.4e-13
Smith-Waterman score: 272; 33.1% identity (60.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...: . : :.. : . .
NP_871 MALKRINKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_871 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . .. ..:
NP_871 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRISREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_871 AM
>>NP_871618 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa)
initn: 214 init1: 168 opt: 272 Z-score: 355.9 bits: 72.2 E(85289): 4.4e-13
Smith-Waterman score: 272; 33.1% identity (60.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...: . : :.. : . .
NP_871 MALKRINKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_871 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . .. ..:
NP_871 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRISREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_871 AM
>>NP_871616 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa)
initn: 214 init1: 168 opt: 272 Z-score: 355.9 bits: 72.2 E(85289): 4.4e-13
Smith-Waterman score: 272; 33.1% identity (60.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...: . : :.. : . .
NP_871 MALKRINKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_871 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . .. ..:
NP_871 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRISREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_871 AM
>>NP_003331 (OMIM: 602963) ubiquitin-conjugating enzyme (147 aa)
initn: 214 init1: 168 opt: 272 Z-score: 355.9 bits: 72.2 E(85289): 4.4e-13
Smith-Waterman score: 272; 33.1% identity (60.3% similar) in 151 aa overlap (35-184:4-146)
10 20 30 40 50 60
pF1KE3 ASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHC
: . ::...: . : :.. : . .
NP_003 MALKRINKELSDLARDPPAQCSAG-PVGDDMFH
10 20 30
70 80 90 100 110 120
pF1KE3 FQLTVT-PDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREH
.: :. :... :::: : . . : : . :::: :.:.::::. .: :::..::
NP_003 WQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILR--
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 SIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRY
. :.:. :.. :. .. ::. : : :::: : :. . :.. . .. ..:
NP_003 ----SQWSPALTISKVLLSICSLLCDP-NPDDPLVPEIARIYKTDRDKYNRISREWTQKY
100 110 120 130 140
pF1KE3 AR
:
NP_003 AM
185 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:57:31 2016 done: Sun Nov 6 17:57:32 2016
Total Scan time: 5.170 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]