FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2180, 417 aa 1>>>pF1KE2180 417 - 417 aa - 417 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5824+/-0.000286; mu= 13.7021+/- 0.018 mean_var=130.9026+/-26.680, 0's: 0 Z-trim(122.0): 79 B-trim: 1971 in 1/53 Lambda= 0.112099 statistics sampled from 39278 (39373) to 39278 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.784), E-opt: 0.2 (0.462), width: 16 Scan time: 8.830 The best scores are: opt bits E(85289) NP_079492 (OMIM: 150400,224750,257980,606268) prot ( 417) 3013 498.0 1.8e-140 XP_011510231 (OMIM: 150400,224750,257980,606268) P ( 385) 2743 454.3 2.4e-127 NP_003385 (OMIM: 225300,601906,617073) protein Wnt ( 389) 1282 218.0 3.2e-56 XP_011510232 (OMIM: 150400,224750,257980,606268) P ( 299) 890 154.5 3.2e-37 XP_011537024 (OMIM: 225300,601906,617073) PREDICTE ( 267) 791 138.5 2e-32 XP_016875408 (OMIM: 225300,601906,617073) PREDICTE ( 267) 791 138.5 2e-32 NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 741 130.5 6.8e-30 NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 726 128.1 3.5e-29 NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 710 125.5 2.1e-28 XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 710 125.6 2.5e-28 XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 693 122.6 1.2e-27 NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 693 122.7 1.4e-27 NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 683 121.1 4.3e-27 XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 683 121.1 4.4e-27 XP_011537026 (OMIM: 225300,601906,617073) PREDICTE ( 164) 579 104.0 2.9e-22 XP_016865315 (OMIM: 606360) PREDICTED: protein Wnt ( 255) 568 102.4 1.4e-21 NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 570 102.8 1.4e-21 NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 568 102.5 1.7e-21 NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 568 102.5 1.8e-21 NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 568 102.5 1.9e-21 XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt ( 391) 568 102.6 1.9e-21 XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt ( 408) 568 102.6 1.9e-21 XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 564 101.8 2.4e-21 NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 564 101.9 2.8e-21 XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 471 86.8 9.4e-17 XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 471 86.8 9.4e-17 NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 471 86.9 9.7e-17 XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 471 86.9 9.9e-17 XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt ( 337) 468 86.3 1.2e-16 NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 461 85.2 2.8e-16 NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 461 85.2 2.8e-16 NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 427 79.7 1.3e-14 XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 427 79.7 1.3e-14 XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 410 76.9 7.5e-14 NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 410 77.0 8.5e-14 XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 410 77.0 8.9e-14 XP_011543543 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 393 74.1 4.5e-13 XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 393 74.1 4.5e-13 NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 393 74.2 5.8e-13 XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 393 74.2 5.8e-13 XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13 XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13 XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 393 74.2 5.9e-13 NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 391 73.8 6.4e-13 >>NP_079492 (OMIM: 150400,224750,257980,606268) protein (417 aa) initn: 3013 init1: 3013 opt: 3013 Z-score: 2642.8 bits: 498.0 E(85289): 1.8e-140 Smith-Waterman score: 3013; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK 370 380 390 400 410 >>XP_011510231 (OMIM: 150400,224750,257980,606268) PREDI (385 aa) initn: 2743 init1: 2743 opt: 2743 Z-score: 2407.3 bits: 454.3 E(85289): 2.4e-127 Smith-Waterman score: 2743; 100.0% identity (100.0% similar) in 380 aa overlap (38-417:6-385) 10 20 30 40 50 60 pF1KE2 PWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGL :::::::::::::::::::::::::::::: XP_011 MTPPSRSAPNDILDLRLPPEPVLNANTVCLTLPGL 10 20 30 70 80 90 100 110 120 pF1KE2 SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 RESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKG 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 LSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNN 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 RVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 GQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSA 280 290 300 310 320 330 370 380 390 400 410 pF1KE2 GSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK 340 350 360 370 380 >>NP_003385 (OMIM: 225300,601906,617073) protein Wnt-10b (389 aa) initn: 1791 init1: 664 opt: 1282 Z-score: 1130.2 bits: 218.0 E(85289): 3.2e-56 Smith-Waterman score: 1776; 60.4% identity (80.9% similar) in 404 aa overlap (14-417:5-389) 10 20 30 40 50 60 pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV :.:.: :. . :.:: : . :. :.:: :.:: :: :.:::: NP_003 MLEEPRPRPPPSGLAGLLFLALCS----RALSNEILGLKLPGEPPLTANTV 10 20 30 40 70 80 90 100 110 120 pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES :::: :::.::. .:.:.:::.:::.::..::.::::::.::::::::.:: ...:..: NP_003 CLTLSGLSKRQLGLCLRNPDVTASALQGLHIAVHECQHQLRDQRWNCSALEGGGRLPHHS 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD :..::::::::.... ::::.:::..::.:::: .::: . :... .: :: :::. NP_003 AILKRGFRESAFSFSMLAAGVMHAVATACSLGKLVSCGCGWKGSGEQDRLRAKL--LQLQ 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA ::.:::.. :..: . ::: ::.::::::. :: :::.::.::::::: :::.: NP_003 ALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRDFLDSREAPRDIQA 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI :::.::::::::.: ::..:::::::::::::.::::...::::.::: :: :. :: .: NP_003 RMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVGAALRERLGRAIFI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR ::::.: ..: ::: .. .:::::::::::::.: . : :: :: NP_003 DTHNRNSGAFQPRLR-----------PRRLSG--ELVYFEKSPDFCERDPTMGSPGTRGR 290 300 310 320 330 370 380 390 400 410 pF1KE2 LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK :::.: :::::.:::::::.::::: :::::::::::.:.:.::..::::.::: NP_003 ACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDECKVTEWVNVCK 340 350 360 370 380 >>XP_011510232 (OMIM: 150400,224750,257980,606268) PREDI (299 aa) initn: 923 init1: 890 opt: 890 Z-score: 789.1 bits: 154.5 E(85289): 3.2e-37 Smith-Waterman score: 890; 100.0% identity (100.0% similar) in 126 aa overlap (1-126:1-126) 10 20 30 40 50 60 pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD :::::: XP_011 PIFSRGSDGEHAAEVQVPRHVRQLPAQDVLAGDARVPHRGGAAAQPLPPRHAHPAAQPQR 130 140 150 160 170 180 >>XP_011537024 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa) initn: 1321 init1: 664 opt: 791 Z-score: 703.3 bits: 138.5 E(85289): 2e-32 Smith-Waterman score: 1285; 62.1% identity (80.0% similar) in 280 aa overlap (138-417:3-267) 110 120 130 140 150 160 pF1KE2 SSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDE ::::.:::..::.:::: .::: . :.. XP_011 MLAAGVMHAVATACSLGKLVSCGCGWKGSGEQ 10 20 30 170 180 190 200 210 220 pF1KE2 EAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKD . .: :: :::.::.:::.. :..: . ::: ::.::::::. :: :::.::.: XP_011 DRLRAKL--LQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE2 FLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVG :::::: :::.::::.::::::::.: ::..:::::::::::::.::::...::::.:: XP_011 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE2 ALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCE : :: :. :: .: ::::.: ..: ::: . ..:::::::::::: XP_011 AALRERLGRAIFIDTHNRNSGAFQPRLR-----------PRRLS--GELVYFEKSPDFCE 160 170 180 190 350 360 370 380 390 400 pF1KE2 REPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEEC :.: . : :: :: :::.: :::::.:::::::.::::: :::::::::::.:.:.:: XP_011 RDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDEC 200 210 220 230 240 250 410 pF1KE2 RITEWVSVCK ..::::.::: XP_011 KVTEWVNVCK 260 >>XP_016875408 (OMIM: 225300,601906,617073) PREDICTED: p (267 aa) initn: 1321 init1: 664 opt: 791 Z-score: 703.3 bits: 138.5 E(85289): 2e-32 Smith-Waterman score: 1285; 62.1% identity (80.0% similar) in 280 aa overlap (138-417:3-267) 110 120 130 140 150 160 pF1KE2 SSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDE ::::.:::..::.:::: .::: . :.. XP_016 MLAAGVMHAVATACSLGKLVSCGCGWKGSGEQ 10 20 30 170 180 190 200 210 220 pF1KE2 EAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKD . .: :: :::.::.:::.. :..: . ::: ::.::::::. :: :::.::.: XP_016 DRLRAKL--LQLQALSRGKSFPHSLPSPGPGSSPSPGPQDTWEWGGCNHDMDFGEKFSRD 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE2 FLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVG :::::: :::.::::.::::::::.: ::..:::::::::::::.::::...::::.:: XP_016 FLDSREAPRDIQARMRIHNNRVGRQVVTENLKRKCKCHGTSGSCQFKTCWRAAPEFRAVG 100 110 120 130 140 150 290 300 310 320 330 340 pF1KE2 ALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCE : :: :. :: .: ::::.: ..: ::: . ..:::::::::::: XP_016 AALRERLGRAIFIDTHNRNSGAFQPRLR-----------PRRLS--GELVYFEKSPDFCE 160 170 180 190 350 360 370 380 390 400 pF1KE2 REPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEEC :.: . : :: :: :::.: :::::.:::::::.::::: :::::::::::.:.:.:: XP_016 RDPTMGSPGTRGRACNKTSRLLDGCGSLCCGRGHNVLRQTRVERCHCRFHWCCYVLCDEC 200 210 220 230 240 250 410 pF1KE2 RITEWVSVCK ..::::.::: XP_016 KVTEWVNVCK 260 >>NP_005421 (OMIM: 164820,615220,615221) proto-oncogene (370 aa) initn: 1036 init1: 373 opt: 741 Z-score: 657.7 bits: 130.5 E(85289): 6.8e-30 Smith-Waterman score: 948; 38.4% identity (60.1% similar) in 404 aa overlap (23-416:10-369) 10 20 30 40 50 pF1KE2 MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPND------ILDLRLPPEPV :: .:: ::: : :. :... . . NP_005 MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLL 10 20 30 40 60 70 80 90 100 110 pF1KE2 LNANTVCLTL-PGL---SRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSL ..... :.: :.: ::.: .. ..: . :. :.: :..::. :::..:::: . NP_005 TDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE2 ETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAF . . . : .:: ::.:: .::..:::.:.:. .:. :....: :: ::: NP_005 PGPHLF---GKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRG----- 110 120 130 140 150 180 190 200 210 220 230 pF1KE2 RRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLD :: : :.::::: .. ::. :...:.: NP_005 --------------------------------PGGPD-WHWGGCSDNIDFGRLFGREFVD 160 170 180 240 250 260 270 280 290 pF1KE2 SREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALL : : ::.. : ::::..:: .:. .::..::::: :::: ..:::. : .:.:: .: NP_005 SGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVL 190 200 210 220 230 240 300 310 320 330 340 350 pF1KE2 RSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREP :.:: :. . ::.... . : : : :: :::::::::.:: NP_005 RDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKP---PSPHDLVYFEKSPNFCTYSG 250 260 270 280 290 300 360 370 380 390 400 410 pF1KE2 RLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRIT :: .:::.:: ::.:: . ::: .:::::: : .:::.: ::::: : :..: : NP_005 RLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHT 310 320 330 340 350 360 pF1KE2 EWVSVCK . . : NP_005 RVLHECL 370 >>NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt-3 p (355 aa) initn: 1037 init1: 374 opt: 726 Z-score: 644.8 bits: 128.1 E(85289): 3.5e-29 Smith-Waterman score: 985; 39.3% identity (64.0% similar) in 361 aa overlap (60-417:44-355) 30 40 50 60 70 80 pF1KE2 LLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGI .: ..::: .:.. : . .. :. .:. NP_110 LGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGV 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE2 QIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNAC ...:.::::::: .::::.... ... .:..... :::::..:::.:::. ::. .: NP_110 KLGIQECQHQFRGRRWNCTTID--DSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSC 80 90 100 110 120 130 150 160 170 180 190 200 pF1KE2 ALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSW : : ::::. ..: : :: ..: NP_110 AEGTSTICGCDSHHKG---------------------------P---------PG--EGW 140 150 210 220 230 240 250 260 pF1KE2 EWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSG .::::: : :: :..: :.:: . : .. : :::..:: .....:. :::::: :: NP_110 KWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSG 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE2 SCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEPGPAGAPSPAPGAPGP ::..:::: . :.::..: .:.... :. ... : .. : .: : : : NP_110 SCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKP----P 220 230 240 250 260 330 340 350 360 370 380 pF1KE2 RRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQT .: ::::.:.::.::: .:. : :: : :: .: : ::: .::::::: . NP_110 TER----DLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEK 270 280 290 300 310 320 390 400 410 pF1KE2 RSERCHCRFHWCCFVVCEEC-RITEWVSVCK :.:.::: :::::.: :.:: :: . : .:: NP_110 RKEKCHCIFHWCCYVSCQECIRIYD-VHTCK 330 340 350 >>NP_149122 (OMIM: 606359) protein Wnt-3a precursor [Hom (352 aa) initn: 1014 init1: 369 opt: 710 Z-score: 630.9 bits: 125.5 E(85289): 2.1e-28 Smith-Waterman score: 969; 38.7% identity (61.6% similar) in 372 aa overlap (49-417:35-352) 20 30 40 50 60 70 pF1KE2 RPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRH : .:.: : ..::: .:.. : . NP_149 GYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPIL-----CASIPGLVPKQLRFCRNY 10 20 30 40 50 80 90 100 110 120 130 pF1KE2 PDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAA .. :. .::.:.:.::::::: .::::.... ... .:..... :::::..:::. NP_149 VEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVH--DSLAIFGPVLDKATRESAFVHAIAS 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE2 AGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAL :::. ::. .:: : :::.. ..: NP_149 AGVAFAVTRSCAEGTAAICGCSSRHQG--------------------------------- 120 130 140 200 210 220 230 240 250 pF1KE2 PTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENM ::: .:.::::: :. :: :..: :.:: . : .. : :::..::::. .: NP_149 ---SPG--KGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHM 150 160 170 180 190 260 270 280 290 300 310 pF1KE2 RRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEP-GPA . :::::: ::::..:::: :.::..: .:.... :. ... : .. : .: : NP_149 HLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPR 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE2 GAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSM . .: . ::::.: ::.::: .:. : :: : :: :: : ::: . NP_149 YTYFKVP---------TERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLL 260 270 280 290 300 310 380 390 400 410 pF1KE2 CCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK ::::::: . : :.:.: :::::.: :.:: . : .:: NP_149 CCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK 320 330 340 350 >>XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt-3a (446 aa) initn: 992 init1: 369 opt: 710 Z-score: 629.5 bits: 125.6 E(85289): 2.5e-28 Smith-Waterman score: 969; 38.7% identity (61.6% similar) in 372 aa overlap (49-417:35-352) 20 30 40 50 60 70 pF1KE2 RPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRH : .:.: : ..::: .:.. : . XP_011 GYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPIL-----CASIPGLVPKQLRFCRNY 10 20 30 40 50 80 90 100 110 120 130 pF1KE2 PDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAA .. :. .::.:.:.::::::: .::::.... ... .:..... :::::..:::. XP_011 VEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVH--DSLAIFGPVLDKATRESAFVHAIAS 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE2 AGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAL :::. ::. .:: : :::.. ..: XP_011 AGVAFAVTRSCAEGTAAICGCSSRHQG--------------------------------- 120 130 140 200 210 220 230 240 250 pF1KE2 PTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENM ::: .:.::::: :. :: :..: :.:: . : .. : :::..::::. .: XP_011 ---SPG--KGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHM 150 160 170 180 190 260 270 280 290 300 310 pF1KE2 RRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRAT--LIRPHNRNGGQLEP-GPA . :::::: ::::..:::: :.::..: .:.... :. ... : .. : .: : XP_011 HLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPR 200 210 220 230 240 250 320 330 340 350 360 370 pF1KE2 GAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSM . .: . ::::.: ::.::: .:. : :: : :: :: : ::: . XP_011 YTYFKVP---------TERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLL 260 270 280 290 300 310 380 390 400 410 pF1KE2 CCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK ::::::: . : :.:.: :::::.: :.:: . : .:: XP_011 CCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCKPCHSWATGREGRRRWSTL 320 330 340 350 360 370 XP_011 GCGPRDGCLRTGHSGPCRSLAWIWSPGSQGHDLLEQLPRSGGLGQCSSLQNWTAVSGCLR 380 390 400 410 420 430 417 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:12:41 2016 done: Sun Nov 6 03:12:42 2016 Total Scan time: 8.830 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]