FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2022, 599 aa 1>>>pF1KE2022 599 - 599 aa - 599 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9280+/-0.000437; mu= 15.9284+/- 0.027 mean_var=89.3041+/-18.101, 0's: 0 Z-trim(111.0): 141 B-trim: 127 in 1/57 Lambda= 0.135718 statistics sampled from 19307 (19461) to 19307 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.228), width: 16 Scan time: 9.620 The best scores are: opt bits E(85289) NP_003844 (OMIM: 604509) interleukin-18 receptor a ( 599) 4040 801.9 0 XP_011510390 (OMIM: 604509) PREDICTED: interleukin ( 457) 3006 599.4 8.7e-171 XP_011510389 (OMIM: 604509) PREDICTED: interleukin ( 457) 3006 599.4 8.7e-171 XP_016860662 (OMIM: 604509) PREDICTED: interleukin ( 313) 1906 383.9 4.4e-106 NP_059112 (OMIM: 300277) X-linked interleukin-1 re ( 686) 749 157.6 1.3e-37 XP_016884892 (OMIM: 300277) PREDICTED: X-linked in ( 686) 749 157.6 1.3e-37 XP_011529207 (OMIM: 300277) PREDICTED: X-linked in ( 562) 712 150.3 1.7e-35 NP_055086 (OMIM: 300143,300206) interleukin-1 rece ( 696) 687 145.4 5.9e-34 XP_016884729 (OMIM: 300143,300206) PREDICTED: inte ( 696) 687 145.4 5.9e-34 XP_016884730 (OMIM: 300143,300206) PREDICTED: inte ( 570) 644 137.0 1.7e-31 XP_005264096 (OMIM: 604494) PREDICTED: interleukin ( 540) 563 121.1 9.8e-27 NP_003846 (OMIM: 604494) interleukin-18 receptor 1 ( 541) 561 120.7 1.3e-26 NP_002173 (OMIM: 602626) interleukin-1 receptor ac ( 570) 544 117.4 1.3e-25 NP_001161401 (OMIM: 602626) interleukin-1 receptor ( 570) 544 117.4 1.3e-25 NP_001161400 (OMIM: 602626) interleukin-1 receptor ( 570) 544 117.4 1.3e-25 NP_001269328 (OMIM: 604494) interleukin-18 recepto ( 385) 540 116.5 1.7e-25 XP_016860670 (OMIM: 604494) PREDICTED: interleukin ( 386) 538 116.1 2.2e-25 NP_001307907 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24 NP_001307911 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24 NP_001307910 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24 NP_000868 (OMIM: 147810) interleukin-1 receptor ty ( 569) 521 112.9 3.1e-24 XP_011509419 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 XP_005263991 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 XP_016859478 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 XP_005263987 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 XP_011509418 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 XP_011509420 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 NP_001307909 (OMIM: 147810) interleukin-1 receptor ( 569) 521 112.9 3.1e-24 XP_011509417 (OMIM: 147810) PREDICTED: interleukin ( 569) 521 112.9 3.1e-24 NP_001161403 (OMIM: 602626) interleukin-1 receptor ( 687) 512 111.2 1.2e-23 XP_016860663 (OMIM: 604512) PREDICTED: interleukin ( 606) 483 105.5 5.6e-22 NP_003845 (OMIM: 604512) interleukin-1 receptor-li ( 575) 480 104.8 8e-22 XP_005264093 (OMIM: 604512) PREDICTED: interleukin ( 575) 480 104.8 8e-22 XP_011510396 (OMIM: 604512) PREDICTED: interleukin ( 595) 480 104.9 8.3e-22 XP_005264092 (OMIM: 604512) PREDICTED: interleukin ( 603) 480 104.9 8.4e-22 XP_011510394 (OMIM: 604512) PREDICTED: interleukin ( 617) 480 104.9 8.5e-22 XP_011510393 (OMIM: 604512) PREDICTED: interleukin ( 622) 478 104.5 1.1e-21 XP_016860673 (OMIM: 604494) PREDICTED: interleukin ( 291) 468 102.3 2.4e-21 XP_016860672 (OMIM: 604494) PREDICTED: interleukin ( 291) 468 102.3 2.4e-21 XP_016860671 (OMIM: 604494) PREDICTED: interleukin ( 292) 466 101.9 3.1e-21 XP_016861837 (OMIM: 602626) PREDICTED: interleukin ( 376) 466 102.0 3.8e-21 NP_057316 (OMIM: 601203) interleukin-1 receptor-li ( 556) 460 100.9 1.2e-20 XP_006712902 (OMIM: 601203) PREDICTED: interleukin ( 556) 460 100.9 1.2e-20 NP_001307912 (OMIM: 147810) interleukin-1 receptor ( 425) 435 96.0 2.8e-19 NP_001307913 (OMIM: 147810) interleukin-1 receptor ( 386) 398 88.7 4e-17 XP_006712883 (OMIM: 604512) PREDICTED: interleukin ( 529) 399 89.0 4.5e-17 XP_016860668 (OMIM: 604512) PREDICTED: interleukin ( 424) 380 85.2 4.9e-16 XP_016860667 (OMIM: 604512) PREDICTED: interleukin ( 424) 380 85.2 4.9e-16 XP_006712885 (OMIM: 604512) PREDICTED: interleukin ( 444) 380 85.2 5.1e-16 XP_016860664 (OMIM: 604512) PREDICTED: interleukin ( 508) 380 85.2 5.7e-16 >>NP_003844 (OMIM: 604509) interleukin-18 receptor acces (599 aa) initn: 4040 init1: 4040 opt: 4040 Z-score: 4279.6 bits: 801.9 E(85289): 0 Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 599 aa overlap (1-599:1-599) 10 20 30 40 50 60 pF1KE2 MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 RTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFI 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 LSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWR 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 GLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW 550 560 570 580 590 >>XP_011510390 (OMIM: 604509) PREDICTED: interleukin-18 (457 aa) initn: 3006 init1: 3006 opt: 3006 Z-score: 3187.2 bits: 599.4 E(85289): 8.7e-171 Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 457 aa overlap (143-599:1-457) 120 130 140 150 160 170 pF1KE2 FLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGS :::::::::::::::::::::::::::::: XP_011 MILEVKPQTNASCEYSASHKQDLLLGSTGS 10 20 30 180 190 200 210 220 230 pF1KE2 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE2 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE2 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE2 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE2 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE2 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE2 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR 400 410 420 430 440 450 pF1KE2 SSQPKEW ::::::: XP_011 SSQPKEW >>XP_011510389 (OMIM: 604509) PREDICTED: interleukin-18 (457 aa) initn: 3006 init1: 3006 opt: 3006 Z-score: 3187.2 bits: 599.4 E(85289): 8.7e-171 Smith-Waterman score: 3006; 100.0% identity (100.0% similar) in 457 aa overlap (143-599:1-457) 120 130 140 150 160 170 pF1KE2 FLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGS :::::::::::::::::::::::::::::: XP_011 MILEVKPQTNASCEYSASHKQDLLLGSTGS 10 20 30 180 190 200 210 220 230 pF1KE2 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSW 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE2 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIK 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE2 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQL 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE2 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE2 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIK 280 290 300 310 320 330 480 490 500 510 520 530 pF1KE2 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALR 340 350 360 370 380 390 540 550 560 570 580 590 pF1KE2 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGR 400 410 420 430 440 450 pF1KE2 SSQPKEW ::::::: XP_011 SSQPKEW >>XP_016860662 (OMIM: 604509) PREDICTED: interleukin-18 (313 aa) initn: 1906 init1: 1906 opt: 1906 Z-score: 2025.5 bits: 383.9 E(85289): 4.4e-106 Smith-Waterman score: 1906; 100.0% identity (100.0% similar) in 292 aa overlap (308-599:22-313) 280 290 300 310 320 330 pF1KE2 GFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVC :::::::::::::::::::::::::::::: XP_016 MSNQMCLQRMHSLIFRRCDPDIKSTLKDEIIERNIILEKVTQRDLRRKFVC 10 20 30 40 50 340 350 360 370 380 390 pF1KE2 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQS 60 70 80 90 100 110 400 410 420 430 440 450 pF1KE2 KDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDV 120 130 140 150 160 170 460 470 480 490 500 510 pF1KE2 APGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYF 180 190 200 210 220 230 520 530 540 550 560 570 pF1KE2 QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSR 240 250 260 270 280 290 580 590 pF1KE2 IFQWKGLSRTETTGRSSQPKEW :::::::::::::::::::::: XP_016 IFQWKGLSRTETTGRSSQPKEW 300 310 >>NP_059112 (OMIM: 300277) X-linked interleukin-1 recept (686 aa) initn: 469 init1: 205 opt: 749 Z-score: 796.3 bits: 157.6 E(85289): 1.3e-37 Smith-Waterman score: 749; 30.7% identity (62.4% similar) in 508 aa overlap (82-565:74-562) 60 70 80 90 100 110 pF1KE2 QKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTL ..::. ..:: : : : .. ... .. NP_059 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYK--NKGDLEEPIIFSEVRMSKEEDSI 50 60 70 80 90 100 120 130 140 150 160 pF1KE2 HFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYS-ASHKQDLLLG : . ...:: : : . .: : :.: : : : . .. : : . . . NP_059 WFHSAEAQDSGFYTCVLR--NSTY----CMKVSMSLTVAENESGLCYNSRIRYLEKSEVT 110 120 130 140 150 170 180 190 200 210 220 pF1KE2 STGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCD . ::::... ... : : :.:::. : . ....: ....:: . :.:.:. NP_059 KRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE 160 170 180 190 200 210 230 240 250 260 270 pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGF . :.. ..: ... : :: : :.:. ...:.:::::.: ::: ::: NP_059 LKYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGF 220 230 240 250 260 270 280 290 300 310 320 330 pF1KE2 ERVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFV .:.: :. .. .: .. : . .: : .. .: .:...:.. :: ... NP_059 SGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYT 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE2 CFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTY : :.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: . NP_059 CHVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH 340 350 360 370 380 400 410 420 430 440 450 pF1KE2 QSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLER . :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . :: NP_059 FGADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPER 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE2 DVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIK :. :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::. NP_059 DLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIE 450 460 470 480 490 500 520 530 540 550 560 pF1KE2 FCYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGF . :: ::: :.....: . :.: :: ::.:: .. :.::.:... NP_059 CTELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEML 510 520 530 540 550 560 570 580 590 pF1KE2 TWNQLRITSRIFQWKGLSRTETTGRSSQPKEW NP_059 PRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHE 570 580 590 600 610 620 >>XP_016884892 (OMIM: 300277) PREDICTED: X-linked interl (686 aa) initn: 469 init1: 205 opt: 749 Z-score: 796.3 bits: 157.6 E(85289): 1.3e-37 Smith-Waterman score: 749; 30.7% identity (62.4% similar) in 508 aa overlap (82-565:74-562) 60 70 80 90 100 110 pF1KE2 QKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTL ..::. ..:: : : : .. ... .. XP_016 LAGEPVRVKCALFYSYIRTNYSTAQSTGLRLMWYK--NKGDLEEPIIFSEVRMSKEEDSI 50 60 70 80 90 100 120 130 140 150 160 pF1KE2 HFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYS-ASHKQDLLLG : . ...:: : : . .: : :.: : : : . .. : : . . . XP_016 WFHSAEAQDSGFYTCVLR--NSTY----CMKVSMSLTVAENESGLCYNSRIRYLEKSEVT 110 120 130 140 150 170 180 190 200 210 220 pF1KE2 STGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCD . ::::... ... : : :.:::. : . ....: ....:: . :.:.:. XP_016 KRKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE 160 170 180 190 200 210 230 240 250 260 270 pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGF . :.. ..: ... : :: : :.:. ...:.:::::.: ::: ::: XP_016 LKYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGF 220 230 240 250 260 270 280 290 300 310 320 330 pF1KE2 ERVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFV .:.: :. .. .: .. : . .: : .. .: .:...:.. :: ... XP_016 SGESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYT 280 290 300 310 320 330 340 350 360 370 380 390 pF1KE2 CFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTY : :.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: . XP_016 CHVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQH 340 350 360 370 380 400 410 420 430 440 450 pF1KE2 QSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLER . :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . :: XP_016 FGADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPER 390 400 410 420 430 440 460 470 480 490 500 510 pF1KE2 DVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIK :. :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::. XP_016 DLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIE 450 460 470 480 490 500 520 530 540 550 560 pF1KE2 FCYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGF . :: ::: :.....: . :.: :: ::.:: .. :.::.:... XP_016 CTELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEML 510 520 530 540 550 560 570 580 590 pF1KE2 TWNQLRITSRIFQWKGLSRTETTGRSSQPKEW XP_016 PRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHE 570 580 590 600 610 620 >>XP_011529207 (OMIM: 300277) PREDICTED: X-linked interl (562 aa) initn: 469 init1: 205 opt: 712 Z-score: 758.4 bits: 150.3 E(85289): 1.7e-35 Smith-Waterman score: 712; 31.5% identity (63.5% similar) in 447 aa overlap (141-565:3-438) 120 130 140 150 160 pF1KE2 LHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYS-ASHKQDLLLGS :.: : : . .. : : . . . . XP_011 MKVSMSLTVAENESGLCYNSRIRYLEKSEVTK 10 20 30 170 180 190 200 210 220 pF1KE2 TGSISCPSLS-CQSDAQSPAVTWYKNGK-----LLSVERSNRIVVDEVYDYHQGTYVCDY ::::... ... : : :.:::. : . ....: ....:: . :.:.:. XP_011 RKEISCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCEL 40 50 60 70 80 90 230 240 250 260 270 280 pF1KE2 TQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVED---TLEVELGKPLTISCKARFGFE . :.. ..: ... : :: : :.:. ...:.:::::.: ::: ::: XP_011 KYEGKLVRRTTE--LKVTALLTDKPPKP--LFPMENQPSVIDVQLGKPLNIPCKAFFGFS 100 110 120 130 140 290 300 310 320 330 pF1KE2 RVFNPVIKWYIKDS---DLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVC .:.: :. .. .: .. : . .: : .. .: .:...:.. :: ...: XP_011 GESGPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADLA-NYTC 150 160 170 180 190 200 340 350 360 370 380 390 pF1KE2 FVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLLYRTYQ :.: : :: :. :. .. : : .:.. .:. ...:. . ::..:.:: . XP_011 HVENRNGRKHASVLLR-KKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLFYRQHF 210 220 230 240 250 260 400 410 420 430 440 450 pF1KE2 SKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERD . :.: :.:..::..::.: .. . .. ::..:: ..:::::..:::.: . ::: XP_011 GADETNDDNKEYDAYLSYTKVDQ-DTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERD 270 280 290 300 310 320 460 470 480 490 500 510 pF1KE2 VAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLKLILIKF . :.:.: ::.. ...::: :..:.:.:. : :::::.. .. : . .:.:::. XP_011 LIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIEC 330 340 350 360 370 380 520 530 540 550 560 pF1KE2 CYF------QEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFT . :: ::: :.....: . :.: :: ::.:: .. :.::.:... XP_011 TELKGKVNCQEVESL----KRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKKEMLP 390 400 410 420 430 440 570 580 590 pF1KE2 WNQLRITSRIFQWKGLSRTETTGRSSQPKEW XP_011 RCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKHEI 450 460 470 480 490 500 >>NP_055086 (OMIM: 300143,300206) interleukin-1 receptor (696 aa) initn: 497 init1: 194 opt: 687 Z-score: 730.6 bits: 145.4 E(85289): 5.9e-34 Smith-Waterman score: 691; 29.4% identity (60.0% similar) in 527 aa overlap (76-571:69-571) 50 60 70 80 90 100 pF1KE2 CDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHII : :: ..::.. . :: : : . .. NP_055 KKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLS-LMWYKSSGPGDFEEPIAFDGSRMS 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE2 QDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYSASHK- ... .. : ...:: : : . .: : :.: . : : . .. : :... : NP_055 KEEDSIWFRPTLLQDSGLYACVIR--NSTY----CMKVSISLTVGENDTGLC-YNSKMKY 100 110 120 130 140 150 170 180 190 200 210 pF1KE2 -QDLLLGSTGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYH . :... ::: .. . .. : . :::. . . : . . ... :: . NP_055 FEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDD 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE2 QGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTIS :.:.:. . : :: .... . . : : .: :.:. : :..:: ... NP_055 IGNYTCELKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLT 220 230 240 250 260 280 290 300 310 320 pF1KE2 CKARFGFERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEK :.: ::. .:.: : .:.: : . :: .. . .: : .. . ..:... NP_055 CRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDS 270 280 290 300 310 320 330 340 350 360 370 380 pF1KE2 VTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW : . :: .. :.:.:. : :: :. :: .. : : .:... .:. . .:. . NP_055 VEEGDLG-NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCY 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE2 -IEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLE :::.:.::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.:: NP_055 KIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLE 390 400 410 420 430 450 460 470 480 490 500 pF1KE2 NKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLA ..:::.: . .::. : :.: ::.. . .:.: :....:::: : :::::.. . NP_055 KHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNM 440 450 460 470 480 490 510 520 530 540 550 pF1KE2 LDDQTLKLILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAK : .:.:::. : .:: :.: : .: .: .. :.: : ::.:: . NP_055 LVTGEIKVILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKR 500 510 520 530 540 550 560 570 580 590 pF1KE2 MRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW ..:.:: : . .: .: NP_055 LQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNT 560 570 580 590 600 610 >>XP_016884729 (OMIM: 300143,300206) PREDICTED: interleu (696 aa) initn: 497 init1: 194 opt: 687 Z-score: 730.6 bits: 145.4 E(85289): 5.9e-34 Smith-Waterman score: 691; 29.4% identity (60.0% similar) in 527 aa overlap (76-571:69-571) 50 60 70 80 90 100 pF1KE2 CDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHII : :: ..::.. . :: : : . .. XP_016 KKYQVLVGEPVRIKCALFYGYIRTNYSLAQSAGLS-LMWYKSSGPGDFEEPIAFDGSRMS 40 50 60 70 80 90 110 120 130 140 150 160 pF1KE2 QDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVK--MILEVKPQTNASCEYSASHK- ... .. : ...:: : : . .: : :.: . : : . .. : :... : XP_016 KEEDSIWFRPTLLQDSGLYACVIR--NSTY----CMKVSISLTVGENDTGLC-YNSKMKY 100 110 120 130 140 150 170 180 190 200 210 pF1KE2 -QDLLLGSTGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYH . :... ::: .. . .. : . :::. . . : . . ... :: . XP_016 FEKAELSKSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDD 160 170 180 190 200 210 220 230 240 250 260 270 pF1KE2 QGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTIS :.:.:. . : :: .... . . : : .: :.:. : :..:: ... XP_016 IGNYTCELKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLT 220 230 240 250 260 280 290 300 310 320 pF1KE2 CKARFGFERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEK :.: ::. .:.: : .:.: : . :: .. . .: : .. . ..:... XP_016 CRAFFGYSGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDS 270 280 290 300 310 320 330 340 350 360 370 380 pF1KE2 VTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW : . :: .. :.:.:. : :: :. :: .. : : .:... .:. . .:. . XP_016 VEEGDLG-NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCY 330 340 350 360 370 380 390 400 410 420 430 440 pF1KE2 -IEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLE :::.:.::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.:: XP_016 KIEIMLFYRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLE 390 400 410 420 430 450 460 470 480 490 500 pF1KE2 NKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLA ..:::.: . .::. : :.: ::.. . .:.: :....:::: : :::::.. . XP_016 KHYGYKLFIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNM 440 450 460 470 480 490 510 520 530 540 550 pF1KE2 LDDQTLKLILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAK : .:.:::. : .:: :.: : .: .: .. :.: : ::.:: . XP_016 LVTGEIKVILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKR 500 510 520 530 540 550 560 570 580 590 pF1KE2 MRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW ..:.:: : . .: .: XP_016 LQYEMPFKRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNT 560 570 580 590 600 610 >>XP_016884730 (OMIM: 300143,300206) PREDICTED: interleu (570 aa) initn: 474 init1: 194 opt: 644 Z-score: 686.3 bits: 137.0 E(85289): 1.7e-31 Smith-Waterman score: 647; 30.0% identity (61.1% similar) in 460 aa overlap (141-571:3-445) 120 130 140 150 160 pF1KE2 LHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHK--QDLLLG :.. : : . .. : :... : . :. XP_016 MKVSISLTVGENDTGLC-YNSKMKYFEKAELS 10 20 30 170 180 190 200 210 220 pF1KE2 STGSISCPSL-SCQSDAQSPAVTWYKNGKLLS-----VERSNRIVVDEVYDYHQGTYVCD .. ::: .. . .. : . :::. . . : . . ... :: . :.:.:. XP_016 KSKEISCRDIEDFLLPTREPEILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCE 40 50 60 70 80 90 230 240 250 260 270 pF1KE2 YTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTL---EVELGKPLTISCKARFGF . : :: .... . . : : .: :.:. : :..:: ...:.: ::. XP_016 LKYGGFV----VRRTTELTVTAPLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGY 100 110 120 130 140 280 290 300 310 320 330 pF1KE2 ERVFNPVIKW-----YIKDSDLE--WEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLR .:.: : .:.: : . :: .. . .: : .. . ..:...: . :: XP_016 SGDVSPLIYWMKGEKFIEDLDENRVWESDI---RILKEHLGEQEVSISLIVDSVEEGDLG 150 160 170 180 190 200 340 350 360 370 380 390 pF1KE2 RKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHW-IEIVLL .. :.:.:. : :: :. :: .. : : .:... .:. . .:. . :::.:. XP_016 -NYSCYVENGNGRRHASVLLH-KRELMYTVELAGGLGAILLLLVCLVTIYKCYKIEIMLF 210 220 230 240 250 260 400 410 420 430 440 450 pF1KE2 YRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEH-LALSLFPDVLENKYGYSL ::.. . .. ::.::.::..::.: . :.. .. .::. .:: ..::.::..:::.: XP_016 YRNHFGAEELDGDNKDYDAYLSYTKVD--PDQWNQETGEEERFALEILPDMLEKHYGYKL 270 280 290 300 310 320 460 470 480 490 500 pF1KE2 CLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYV--NGPSIFELQAAVNLALDDQTLK . .::. : :.: ::.. . .:.: :....:::: : :::::.. . : .: XP_016 FIPDRDLIPTGTYIEDVARCVDQSKRLIIVMTPNYVVRRGWSIFELETRLRNMLVTGEIK 330 340 350 360 370 380 510 520 530 540 550 560 pF1KE2 LILIKFCY-------FQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPV .:::. : .:: :.: : .: .: .. :.: : ::.:: ...:.:: XP_016 VILIE-CSELRGIMNYQEVEALKHTIK----LLTVIKWHGPKCNKLNSKFWKRLQYEMPF 390 400 410 420 430 570 580 590 pF1KE2 KNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW : . .: .: XP_016 KRIEPITHEQALDVSEQGPFGELQTVSAISMAAATSTALATAHPDLRSTFHNTYHSQMRQ 440 450 460 470 480 490 599 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:22:02 2016 done: Sun Nov 6 18:22:03 2016 Total Scan time: 9.620 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]