Result of FASTA (omim) for
pFN21AE9442
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9442, 967 aa
1>>>pF1KE9442 967 - 967 aa - 967 aa
Library: /omim/omim.rfq.tfa
64369986 residues in 92320 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4105+/-0.000356; mu= 23.4674+/- 0.022
mean_var=136.6570+/-28.468, 0's: 0 Z-trim(117.9): 494 B-trim: 1605 in 1/54
Lambda= 0.109713
statistics sampled from 30977 (31549) to 30977 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.686), E-opt: 0.2 (0.342), width: 16
Scan time: 7.210
The best scores are: opt bits E(92320)
NP_001017403 (OMIM: 606653) leucine-rich repeat-co ( 967) 6538 1047.5 0
NP_067649 (OMIM: 606653) leucine-rich repeat-conta ( 915) 6010 963.9 0
XP_005245461 (OMIM: 606653) leucine-rich repeat-co ( 924) 6010 963.9 0
XP_016857486 (OMIM: 606653) leucine-rich repeat-co ( 833) 5536 888.8 0
XP_011508143 (OMIM: 606653) leucine-rich repeat-co ( 833) 5533 888.3 0
XP_011508148 (OMIM: 606653) leucine-rich repeat-co ( 777) 5232 840.6 0
XP_011508145 (OMIM: 606653) leucine-rich repeat-co ( 777) 5232 840.6 0
XP_011508144 (OMIM: 606653) leucine-rich repeat-co ( 777) 5232 840.6 0
XP_011508142 (OMIM: 606653) leucine-rich repeat-co ( 852) 5180 832.4 0
XP_011508140 (OMIM: 606653) leucine-rich repeat-co ( 900) 5154 828.4 0
NP_001017404 (OMIM: 606653) leucine-rich repeat-co ( 828) 5041 810.4 0
XP_011508146 (OMIM: 606653) leucine-rich repeat-co ( 708) 4765 766.6 0
XP_011508141 (OMIM: 606653) leucine-rich repeat-co ( 900) 4062 655.5 3.8e-187
XP_016857485 (OMIM: 606653) leucine-rich repeat-co ( 876) 4057 654.7 6.4e-187
XP_016857487 (OMIM: 606653) leucine-rich repeat-co ( 609) 3991 644.0 7.2e-184
NP_003658 (OMIM: 606667) leucine-rich repeat-conta ( 907) 3297 534.4 1.1e-150
NP_001264156 (OMIM: 606667) leucine-rich repeat-co ( 835) 2616 426.6 2.8e-118
NP_001264155 (OMIM: 606667) leucine-rich repeat-co ( 883) 2381 389.4 4.6e-107
NP_060960 (OMIM: 606666,615311) leucine-rich repea ( 951) 1676 277.9 1.9e-73
NP_001333361 (OMIM: 606666,615311) leucine-rich re ( 927) 1499 249.9 5.1e-65
NP_852111 (OMIM: 136435,233300,276400,608115) foll ( 669) 627 111.6 1.5e-23
XP_011531035 (OMIM: 136435,233300,276400,608115) f ( 729) 587 105.4 1.2e-21
NP_000224 (OMIM: 152790,176410,238320) lutropin-ch ( 699) 567 102.2 1.1e-20
NP_000136 (OMIM: 136435,233300,276400,608115) foll ( 695) 550 99.5 7e-20
XP_011531036 (OMIM: 136435,233300,276400,608115) f ( 618) 532 96.6 4.7e-19
NP_001186009 (OMIM: 608661) podocan precursor [Hom ( 613) 519 94.5 2e-18
NP_714914 (OMIM: 608661) podocan precursor [Homo s ( 613) 519 94.5 2e-18
XP_005270514 (OMIM: 608661) podocan isoform X2 [Ho ( 613) 519 94.5 2e-18
NP_001186010 (OMIM: 608661) podocan precursor [Hom ( 613) 519 94.5 2e-18
XP_016855783 (OMIM: 608661) podocan isoform X1 [Ho ( 652) 519 94.5 2e-18
XP_016859579 (OMIM: 152790,176410,238320) lutropin ( 487) 508 92.6 5.7e-18
XP_011531133 (OMIM: 152790,176410,238320) lutropin ( 487) 508 92.6 5.7e-18
XP_011531037 (OMIM: 136435,233300,276400,608115) f ( 431) 484 88.8 7.4e-17
XP_011531038 (OMIM: 136435,233300,276400,608115) f ( 431) 484 88.8 7.4e-17
NP_001094861 (OMIM: 609792) leucine-rich repeat an ( 592) 472 87.0 3.3e-16
NP_004479 (OMIM: 173511) platelet glycoprotein V p ( 560) 468 86.4 5e-16
XP_016859578 (OMIM: 152790,176410,238320) lutropin ( 614) 468 86.4 5.3e-16
XP_011535421 (OMIM: 275200,603372,603373,609152) t ( 671) 466 86.2 6.9e-16
NP_000360 (OMIM: 275200,603372,603373,609152) thyr ( 764) 466 86.2 7.5e-16
XP_005268094 (OMIM: 275200,603372,603373,609152) t ( 764) 466 86.2 7.5e-16
XP_005264366 (OMIM: 152790,176410,238320) lutropin ( 380) 445 82.5 4.9e-15
XP_011531136 (OMIM: 152790,176410,238320) lutropin ( 380) 445 82.5 4.9e-15
XP_006712078 (OMIM: 152790,176410,238320) lutropin ( 389) 445 82.5 5e-15
NP_056379 (OMIM: 610868) leucine-rich repeat trans ( 516) 441 82.0 9.2e-15
NP_001911 (OMIM: 125255,610048) decorin isoform a ( 359) 434 80.7 1.6e-14
NP_598010 (OMIM: 125255,610048) decorin isoform a ( 359) 434 80.7 1.6e-14
NP_001004432 (OMIM: 609794) leucine-rich repeat an ( 593) 427 79.9 4.6e-14
XP_016874279 (OMIM: 608870) leucine-rich repeats a ( 623) 414 77.9 2e-13
NP_001129523 (OMIM: 608870) leucine-rich repeats a (1059) 414 78.2 2.7e-13
NP_849161 (OMIM: 610867) leucine-rich repeat trans ( 522) 410 77.1 2.8e-13
>>NP_001017403 (OMIM: 606653) leucine-rich repeat-contai (967 aa)
initn: 6538 init1: 6538 opt: 6538 Z-score: 5599.3 bits: 1047.5 E(92320): 0
Smith-Waterman score: 6538; 99.9% identity (100.0% similar) in 967 aa overlap (1-967:1-967)
10 20 30 40 50 60
pF1KE9 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFST
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE9 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPAPLPPVKFV
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_001 PSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE9 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE9 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE9 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIF
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE9 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE9 LRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE9 LISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSG
910 920 930 940 950 960
pF1KE9 LAFASHV
:::::::
NP_001 LAFASHV
>>NP_067649 (OMIM: 606653) leucine-rich repeat-containin (915 aa)
initn: 6010 init1: 6010 opt: 6010 Z-score: 5147.9 bits: 963.9 E(92320): 0
Smith-Waterman score: 6010; 99.9% identity (100.0% similar) in 896 aa overlap (72-967:20-915)
50 60 70 80 90 100
pF1KE9 QEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH
::::::::::::::::::::::::::::::
NP_067 MGRPRLTLVCQVSIIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNH
10 20 30 40
110 120 130 140 150 160
pF1KE9 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE9 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE9 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE9 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
230 240 250 260 270 280
350 360 370 380 390 400
pF1KE9 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
290 300 310 320 330 340
410 420 430 440 450 460
pF1KE9 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
350 360 370 380 390 400
470 480 490 500 510 520
pF1KE9 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
410 420 430 440 450 460
530 540 550 560 570 580
pF1KE9 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
470 480 490 500 510 520
590 600 610 620 630 640
pF1KE9 VLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
530 540 550 560 570 580
650 660 670 680 690 700
pF1KE9 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
590 600 610 620 630 640
710 720 730 740 750 760
pF1KE9 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
650 660 670 680 690 700
770 780 790 800 810 820
pF1KE9 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
710 720 730 740 750 760
830 840 850 860 870 880
pF1KE9 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
770 780 790 800 810 820
890 900 910 920 930 940
pF1KE9 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
830 840 850 860 870 880
950 960
pF1KE9 GSTPAGGGLSGGGGFQPSGLAFASHV
::::::::::::::::::::::::::
NP_067 GSTPAGGGLSGGGGFQPSGLAFASHV
890 900 910
>>XP_005245461 (OMIM: 606653) leucine-rich repeat-contai (924 aa)
initn: 6010 init1: 6010 opt: 6010 Z-score: 5147.8 bits: 963.9 E(92320): 0
Smith-Waterman score: 6010; 99.9% identity (100.0% similar) in 896 aa overlap (72-967:29-924)
50 60 70 80 90 100
pF1KE9 QEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH
::::::::::::::::::::::::::::::
XP_005 MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNH
10 20 30 40 50
110 120 130 140 150 160
pF1KE9 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE9 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE9 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
180 190 200 210 220 230
290 300 310 320 330 340
pF1KE9 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
240 250 260 270 280 290
350 360 370 380 390 400
pF1KE9 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
300 310 320 330 340 350
410 420 430 440 450 460
pF1KE9 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
360 370 380 390 400 410
470 480 490 500 510 520
pF1KE9 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
420 430 440 450 460 470
530 540 550 560 570 580
pF1KE9 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
480 490 500 510 520 530
590 600 610 620 630 640
pF1KE9 VLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
540 550 560 570 580 590
650 660 670 680 690 700
pF1KE9 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
600 610 620 630 640 650
710 720 730 740 750 760
pF1KE9 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
660 670 680 690 700 710
770 780 790 800 810 820
pF1KE9 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
720 730 740 750 760 770
830 840 850 860 870 880
pF1KE9 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
780 790 800 810 820 830
890 900 910 920 930 940
pF1KE9 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
840 850 860 870 880 890
950 960
pF1KE9 GSTPAGGGLSGGGGFQPSGLAFASHV
::::::::::::::::::::::::::
XP_005 GSTPAGGGLSGGGGFQPSGLAFASHV
900 910 920
>>XP_016857486 (OMIM: 606653) leucine-rich repeat-contai (833 aa)
initn: 5533 init1: 5533 opt: 5536 Z-score: 4742.8 bits: 888.8 E(92320): 0
Smith-Waterman score: 5536; 99.3% identity (99.5% similar) in 830 aa overlap (138-967:4-833)
110 120 130 140 150 160
pF1KE9 QAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHL
: . ::::::::::::::::::::::::
XP_016 MHSPRPGTQRLDANLISLVPERSFEGLSSLRHL
10 20 30
170 180 190 200 210 220
pF1KE9 WLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGT
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE9 HSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIH
100 110 120 130 140 150
290 300 310 320 330 340
pF1KE9 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGM
160 170 180 190 200 210
350 360 370 380 390 400
pF1KE9 CQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW
220 230 240 250 260 270
410 420 430 440 450 460
pF1KE9 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPK
280 290 300 310 320 330
470 480 490 500 510 520
pF1KE9 LRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDL
340 350 360 370 380 390
530 540 550 560 570 580
pF1KE9 DELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVF
400 410 420 430 440 450
590 600 610 620 630 640
pF1KE9 AGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGF
::::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGF
460 470 480 490 500 510
650 660 670 680 690 700
pF1KE9 LAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLAS
520 530 540 550 560 570
710 720 730 740 750 760
pF1KE9 VGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVW
580 590 600 610 620 630
770 780 790 800 810 820
pF1KE9 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLY
640 650 660 670 680 690
830 840 850 860 870 880
pF1KE9 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGR
700 710 720 730 740 750
890 900 910 920 930 940
pF1KE9 PPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAG
760 770 780 790 800 810
950 960
pF1KE9 GGLSGGGGFQPSGLAFASHV
::::::::::::::::::::
XP_016 GGLSGGGGFQPSGLAFASHV
820 830
>>XP_011508143 (OMIM: 606653) leucine-rich repeat-contai (833 aa)
initn: 5533 init1: 5533 opt: 5533 Z-score: 4740.3 bits: 888.3 E(92320): 0
Smith-Waterman score: 5533; 99.9% identity (100.0% similar) in 824 aa overlap (144-967:10-833)
120 130 140 150 160 170
pF1KE9 YSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNA
::::::::::::::::::::::::::::::
XP_011 MKERMNSTRRLDANLISLVPERSFEGLSSLRHLWLDDNA
10 20 30
180 190 200 210 220 230
pF1KE9 LTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGL
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE9 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPI
100 110 120 130 140 150
300 310 320 330 340 350
pF1KE9 QFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR
160 170 180 190 200 210
360 370 380 390 400 410
pF1KE9 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSI
220 230 240 250 260 270
420 430 440 450 460 470
pF1KE9 HPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEV
280 290 300 310 320 330
480 490 500 510 520 530
pF1KE9 PYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLE
340 350 360 370 380 390
540 550 560 570 580 590
pF1KE9 MEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.:
XP_011 MEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVP
400 410 420 430 440 450
600 610 620 630 640 650
pF1KE9 LPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGS
460 470 480 490 500 510
660 670 680 690 700 710
pF1KE9 EASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGA
520 530 540 550 560 570
720 730 740 750 760 770
pF1KE9 SPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVR
580 590 600 610 620 630
780 790 800 810 820 830
pF1KE9 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPH
640 650 660 670 680 690
840 850 860 870 880 890
pF1KE9 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLET
700 710 720 730 740 750
900 910 920 930 940 950
pF1KE9 YGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGG
760 770 780 790 800 810
960
pF1KE9 GGFQPSGLAFASHV
::::::::::::::
XP_011 GGFQPSGLAFASHV
820 830
>>XP_011508148 (OMIM: 606653) leucine-rich repeat-contai (777 aa)
initn: 5232 init1: 5232 opt: 5232 Z-score: 4483.1 bits: 840.6 E(92320): 0
Smith-Waterman score: 5232; 99.9% identity (100.0% similar) in 777 aa overlap (191-967:1-777)
170 180 190 200 210 220
pF1KE9 LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN
::::::::::::::::::::::::::::::
XP_011 MTLALNRISHIPDYAFQNLTSLVVLHLHNN
10 20 30
230 240 250 260 270 280
pF1KE9 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE9 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE9 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE9 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE9 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE9 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE9 LVLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE9 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE9 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE9 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE9 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
640 650 660 670 680 690
890 900 910 920 930 940
pF1KE9 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
700 710 720 730 740 750
950 960
pF1KE9 EGSTPAGGGLSGGGGFQPSGLAFASHV
:::::::::::::::::::::::::::
XP_011 EGSTPAGGGLSGGGGFQPSGLAFASHV
760 770
>>XP_011508145 (OMIM: 606653) leucine-rich repeat-contai (777 aa)
initn: 5232 init1: 5232 opt: 5232 Z-score: 4483.1 bits: 840.6 E(92320): 0
Smith-Waterman score: 5232; 99.9% identity (100.0% similar) in 777 aa overlap (191-967:1-777)
170 180 190 200 210 220
pF1KE9 LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN
::::::::::::::::::::::::::::::
XP_011 MTLALNRISHIPDYAFQNLTSLVVLHLHNN
10 20 30
230 240 250 260 270 280
pF1KE9 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE9 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE9 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE9 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE9 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE9 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE9 LVLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE9 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE9 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE9 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE9 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
640 650 660 670 680 690
890 900 910 920 930 940
pF1KE9 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
700 710 720 730 740 750
950 960
pF1KE9 EGSTPAGGGLSGGGGFQPSGLAFASHV
:::::::::::::::::::::::::::
XP_011 EGSTPAGGGLSGGGGFQPSGLAFASHV
760 770
>>XP_011508144 (OMIM: 606653) leucine-rich repeat-contai (777 aa)
initn: 5232 init1: 5232 opt: 5232 Z-score: 4483.1 bits: 840.6 E(92320): 0
Smith-Waterman score: 5232; 99.9% identity (100.0% similar) in 777 aa overlap (191-967:1-777)
170 180 190 200 210 220
pF1KE9 LSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNN
::::::::::::::::::::::::::::::
XP_011 MTLALNRISHIPDYAFQNLTSLVVLHLHNN
10 20 30
230 240 250 260 270 280
pF1KE9 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGN
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE9 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGI
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE9 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSL
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE9 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAF
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE9 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAE
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE9 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNG
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE9 LVLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGL
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE9 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLA
460 470 480 490 500 510
710 720 730 740 750 760
pF1KE9 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPR
520 530 540 550 560 570
770 780 790 800 810 820
pF1KE9 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPA
580 590 600 610 620 630
830 840 850 860 870 880
pF1KE9 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLIL
640 650 660 670 680 690
890 900 910 920 930 940
pF1KE9 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRA
700 710 720 730 740 750
950 960
pF1KE9 EGSTPAGGGLSGGGGFQPSGLAFASHV
:::::::::::::::::::::::::::
XP_011 EGSTPAGGGLSGGGGFQPSGLAFASHV
760 770
>>XP_011508142 (OMIM: 606653) leucine-rich repeat-contai (852 aa)
initn: 5176 init1: 5176 opt: 5180 Z-score: 4438.2 bits: 832.4 E(92320): 0
Smith-Waterman score: 5401; 91.9% identity (92.0% similar) in 896 aa overlap (72-967:29-852)
50 60 70 80 90 100
pF1KE9 QEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH
::::::::::::::::::::::::::::::
XP_011 MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNH
10 20 30 40 50
110 120 130 140 150 160
pF1KE9 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSL------------------
60 70 80 90 100
170 180 190 200 210 220
pF1KE9 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
::::::
XP_011 ------------------------------------------------------HLHNNR
230 240 250 260 270 280
pF1KE9 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
110 120 130 140 150 160
290 300 310 320 330 340
pF1KE9 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
170 180 190 200 210 220
350 360 370 380 390 400
pF1KE9 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
230 240 250 260 270 280
410 420 430 440 450 460
pF1KE9 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
290 300 310 320 330 340
470 480 490 500 510 520
pF1KE9 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
350 360 370 380 390 400
530 540 550 560 570 580
pF1KE9 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
410 420 430 440 450 460
590 600 610 620 630 640
pF1KE9 VLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
470 480 490 500 510 520
650 660 670 680 690 700
pF1KE9 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
530 540 550 560 570 580
710 720 730 740 750 760
pF1KE9 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
590 600 610 620 630 640
770 780 790 800 810 820
pF1KE9 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
650 660 670 680 690 700
830 840 850 860 870 880
pF1KE9 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
710 720 730 740 750 760
890 900 910 920 930 940
pF1KE9 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
770 780 790 800 810 820
950 960
pF1KE9 GSTPAGGGLSGGGGFQPSGLAFASHV
::::::::::::::::::::::::::
XP_011 GSTPAGGGLSGGGGFQPSGLAFASHV
830 840 850
>>XP_011508140 (OMIM: 606653) leucine-rich repeat-contai (900 aa)
initn: 5137 init1: 5137 opt: 5154 Z-score: 4415.7 bits: 828.4 E(92320): 0
Smith-Waterman score: 5786; 97.2% identity (97.3% similar) in 896 aa overlap (72-967:29-900)
50 60 70 80 90 100
pF1KE9 QEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNH
::::::::::::::::::::::::::::::
XP_011 MRLEGEGRSARAGQNLSRAGSARRGAPRDLSMNNLTELQPGLFHHLRFLEELRLSGNH
10 20 30 40 50
110 120 130 140 150 160
pF1KE9 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGL
60 70 80 90 100 110
170 180 190 200 210 220
pF1KE9 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVL------
120 130 140 150 160 170
230 240 250 260 270 280
pF1KE9 IQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
::::::::::::::::::::::::::::::::::::::::::
XP_011 ------------------DLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNP
180 190 200 210
290 300 310 320 330 340
pF1KE9 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIR
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE9 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE9 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFS
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE9 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAEN
400 410 420 430 440 450
530 540 550 560 570 580
pF1KE9 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGL
460 470 480 490 500 510
590 600 610 620 630 640
pF1KE9 VLLTVFAGGPAPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLG
520 530 540 550 560 570
650 660 670 680 690 700
pF1KE9 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAA
580 590 600 610 620 630
710 720 730 740 750 760
pF1KE9 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRG
640 650 660 670 680 690
770 780 790 800 810 820
pF1KE9 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC
700 710 720 730 740 750
830 840 850 860 870 880
pF1KE9 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILE
760 770 780 790 800 810
890 900 910 920 930 940
pF1KE9 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAE
820 830 840 850 860 870
950 960
pF1KE9 GSTPAGGGLSGGGGFQPSGLAFASHV
::::::::::::::::::::::::::
XP_011 GSTPAGGGLSGGGGFQPSGLAFASHV
880 890 900
967 residues in 1 query sequences
64369986 residues in 92320 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Oct 24 21:36:45 2019 done: Thu Oct 24 21:36:46 2019
Total Scan time: 7.210 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]