FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9461, 481 aa 1>>>pF1KE9461 481 - 481 aa - 481 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4217+/-0.000359; mu= 19.4215+/- 0.023 mean_var=119.4877+/-25.141, 0's: 0 Z-trim(117.8): 321 B-trim: 2952 in 2/49 Lambda= 0.117331 statistics sampled from 29688 (30105) to 29688 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.353), width: 16 Scan time: 10.470 The best scores are: opt bits E(85289) NP_005293 (OMIM: 602583) prosaposin receptor GPR37 ( 613) 1420 251.7 4.3e-66 NP_001948 (OMIM: 131243,157300,616367) endothelin- ( 427) 465 89.8 1.6e-17 NP_000106 (OMIM: 131244,277580,600155,600501) endo ( 442) 459 88.9 3.2e-17 NP_001116131 (OMIM: 131244,277580,600155,600501) e ( 442) 459 88.9 3.2e-17 NP_001188326 (OMIM: 131244,277580,600155,600501) e ( 532) 459 88.9 3.7e-17 NP_003982 (OMIM: 131244,277580,600155,600501) endo ( 436) 417 81.7 4.4e-15 NP_005305 (OMIM: 305670) gastrin-releasing peptide ( 384) 345 69.5 1.9e-11 NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 333 67.5 8e-11 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 319 65.1 4e-10 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 319 65.1 4e-10 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 319 65.1 4e-10 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 307 63.1 1.7e-09 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 262 55.3 2.9e-07 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 262 55.4 3e-07 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 262 55.4 3.1e-07 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 262 55.4 3.3e-07 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 262 55.5 3.3e-07 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 262 55.6 3.9e-07 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 262 55.6 4.1e-07 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 259 55.0 5e-07 NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 252 53.8 1.2e-06 XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 252 53.8 1.2e-06 NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 244 52.4 2.7e-06 XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 242 52.1 3.4e-06 XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 242 52.1 3.6e-06 NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 242 52.1 3.6e-06 XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 242 52.1 3.6e-06 NP_009158 (OMIM: 604838) probable G-protein couple ( 372) 238 51.4 5.3e-06 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 238 51.4 5.5e-06 XP_016864182 (OMIM: 606925) PREDICTED: pyroglutamy ( 190) 233 50.2 6.2e-06 NP_004113 (OMIM: 601898) growth hormone secretagog ( 289) 235 50.7 6.4e-06 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 237 51.3 7e-06 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 237 51.4 7.5e-06 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 232 50.3 1.1e-05 NP_001243212 (OMIM: 131243,157300,616367) endothel ( 202) 226 49.0 1.5e-05 XP_011538239 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 228 49.7 1.7e-05 NP_005963 (OMIM: 601790) neuropeptide Y receptor t ( 375) 228 49.7 1.7e-05 NP_001265723 (OMIM: 601790) neuropeptide Y recepto ( 375) 228 49.7 1.7e-05 XP_016871875 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 228 49.7 1.7e-05 XP_011538238 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 228 49.7 1.7e-05 XP_016871876 (OMIM: 601790) PREDICTED: neuropeptid ( 375) 228 49.7 1.7e-05 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 226 49.4 2.3e-05 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 226 49.4 2.4e-05 NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 224 49.0 2.9e-05 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 224 49.1 3e-05 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 222 48.6 3.4e-05 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 222 48.6 3.4e-05 NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 220 48.3 4.5e-05 XP_005263095 (OMIM: 602001) PREDICTED: neuropeptid ( 445) 220 48.4 4.9e-05 NP_001304020 (OMIM: 602001) neuropeptide Y recepto ( 445) 220 48.4 4.9e-05 >>NP_005293 (OMIM: 602583) prosaposin receptor GPR37 pre (613 aa) initn: 1557 init1: 686 opt: 1420 Z-score: 1307.6 bits: 251.7 E(85289): 4.3e-66 Smith-Waterman score: 1420; 51.1% identity (78.0% similar) in 405 aa overlap (81-481:215-613) 60 70 80 90 100 110 pF1KE9 EEAKGVQQYVPEEWAEYPRPIHPAGLQPTKPLVATSPNPDKDGGTPDSGQELRGNLTGAP : : . : . : . : ::: :. NP_005 RAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTN-- 190 200 210 220 230 240 120 130 140 150 160 170 pF1KE9 GQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILA .:....::.::.:. ::.:::.: :..:.:..::.:::.::::: :.::..: ::.:: NP_005 -RRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLA 250 260 270 280 290 300 180 190 200 210 220 230 pF1KE9 SLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFH .::.::::..:::::.:::.:.::. :: : ::. ::..::.:::::::.:::: ::::. NP_005 NLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFR 310 320 330 340 350 360 240 250 260 270 280 pF1KE9 VATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGTL--DSCIM .::.. . :: :.: :::::::::.. ::.::..: ::..: : . ::. NP_005 AATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCII 370 380 390 400 410 420 290 300 310 320 330 340 pF1KE9 KPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWR-VRGPPGRKSECRA : : .::...: :..::..::.::::::::::: :::.::.::: : .: ..:. :. NP_005 KISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIR--KAEKACTRG 430 440 450 460 470 350 360 370 380 390 400 pF1KE9 SKHE-QCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTLDLLGLINQFSTF .:.. : :::.: :::.::..:.:: .:::.::::.::..: ...::.:::..:.:: : NP_005 NKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLF 480 490 500 510 520 530 410 420 430 440 450 460 pF1KE9 FKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTEVSSSIYFH ::. .:::::.:.:.:...::..:::::: ::: : . ... .::. ::. : . NP_005 FKSCVTPVLLFCLCKPFSRAFMECCCCCC-EECIQKSSTVTSDDNDNEYTTELELSPFST 540 550 560 570 580 590 470 480 pF1KE9 KPRESPPLLPLGTPC :: . .:: : NP_005 IRREMSTFASVGTHC 600 610 >>NP_001948 (OMIM: 131243,157300,616367) endothelin-1 re (427 aa) initn: 465 init1: 115 opt: 465 Z-score: 435.7 bits: 89.8 E(85289): 1.6e-17 Smith-Waterman score: 465; 26.2% identity (61.3% similar) in 328 aa overlap (126-435:76-388) 100 110 120 130 140 150 pF1KE9 PDSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIV .: : ... ..: ::.::: ... :. NP_001 SFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRII 50 60 70 80 90 100 160 170 180 190 200 210 pF1KE9 WHSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEIT-----KQRLLGDVSCRAVPFME ... .... :...::::: :.. . . ::: .:. .. . .: :. ::.. NP_001 YQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQ 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE9 VSSLGVTTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLW ::.:.:...::::..::.. :... .:. : ... ::. :. ::.:: . . NP_001 KSSVGITVLNLCALSVDRYR-AVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGF 170 180 190 200 210 220 280 290 300 310 320 pF1KE9 QLAQEPAPTMGTLD-SCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFT---- .. : : .:... .... : ::... :: :: :::.:.. : NP_001 VMV--PFEYRGEQHKTCMLNATSKFME-------FYQDVKDWWLFGFYFCMPLVCTAIFY 230 240 250 260 270 330 340 350 360 370 380 pF1KE9 --VTCQLVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVA .::.... : : . . :.: . . .. .:: :.:..:.: .: .. :. NP_001 TLMTCEMLNRR-NG----SLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKK 280 290 300 310 320 330 390 400 410 420 430 pF1KE9 YLSTELTRQTLDLLG---LINQFS---TFFKGAITPVLLLCICRPLGQAFLDCCCCCCCE . .:. .. .::. :.. .. . ... :.:. : . . . . : .: :::: NP_001 TVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQ 340 350 360 370 380 390 440 450 460 470 480 pF1KE9 ECGGASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC NP_001 SKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN 400 410 420 >>NP_000106 (OMIM: 131244,277580,600155,600501) endothel (442 aa) initn: 459 init1: 236 opt: 459 Z-score: 430.0 bits: 88.9 E(85289): 3.2e-17 Smith-Waterman score: 463; 25.6% identity (56.9% similar) in 445 aa overlap (11-435:13-405) 10 20 30 40 50 pF1KE9 MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQ .:..:: ::::. : .:: ..: . : NP_000 MQPPPSLCGRALVALVLACGLSRIWG-------------------EERGFPPDRATPLLQ 10 20 30 40 60 70 80 90 100 110 pF1KE9 ----YVPEEWAEYPRPIHPAGLQPTKPLVATSPNPDKDGGTPDSGQELRGNLTGAPGQRL ..: . .:. . . . : : :. :. .:.: ... : NP_000 TAEIMTPPTKTLWPKGSNASLARSLAP--AEVPKGDRTAGSPPR------TISPPP---- 50 60 70 80 120 130 140 150 160 170 pF1KE9 QIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLAL :.:. . :. : ... .::..::.:: ... :.... .... : ..::::: NP_000 -CQGPI-EIKETF--KYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLAL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE9 WDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATS :.: . . .:: ... .... .: :. :::.. .:.:.:..:::::.:::.. :.. NP_000 GDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYR-AVA 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE9 TLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGT-LDSCIMKPSAS . ... : . .....::: :..::::: . ... :. : :...: . NP_000 SWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDII--TMDYKGSYLRICLLHPVQK 210 220 230 240 250 260 300 310 320 330 340 pF1KE9 LPESLYSLVMTYQNARMWWYFGCYFCLPILFT------VTCQLVTWRVRGPPGRKSECRA .... :..:. :: :. :::::. .: .::.. .: : . NP_000 T-----AFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM----LRKKSGMQIAL-- 270 280 290 300 310 350 360 370 380 390 pF1KE9 SKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIV--VAYLSTELTR-------QTLDLLG . : . . .. .:: :..:.:.: :: .. :. . : ... .: .:: .: NP_000 NDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIG 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE9 LINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTE ::. : ... :.:. : . . . . : .: :: : NP_000 -INMAS--LNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDH 380 390 400 410 420 460 470 480 pF1KE9 VSSSIYFHKPRESPPLLPLGTPC NP_000 GYDNFRSSNKYSSS 430 440 >>NP_001116131 (OMIM: 131244,277580,600155,600501) endot (442 aa) initn: 459 init1: 236 opt: 459 Z-score: 430.0 bits: 88.9 E(85289): 3.2e-17 Smith-Waterman score: 463; 25.6% identity (56.9% similar) in 445 aa overlap (11-435:13-405) 10 20 30 40 50 pF1KE9 MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQ .:..:: ::::. : .:: ..: . : NP_001 MQPPPSLCGRALVALVLACGLSRIWG-------------------EERGFPPDRATPLLQ 10 20 30 40 60 70 80 90 100 110 pF1KE9 ----YVPEEWAEYPRPIHPAGLQPTKPLVATSPNPDKDGGTPDSGQELRGNLTGAPGQRL ..: . .:. . . . : : :. :. .:.: ... : NP_001 TAEIMTPPTKTLWPKGSNASLARSLAP--AEVPKGDRTAGSPPR------TISPPP---- 50 60 70 80 120 130 140 150 160 170 pF1KE9 QIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLAL :.:. . :. : ... .::..::.:: ... :.... .... : ..::::: NP_001 -CQGPI-EIKETF--KYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLAL 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE9 WDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATS :.: . . .:: ... .... .: :. :::.. .:.:.:..:::::.:::.. :.. NP_001 GDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYR-AVA 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE9 TLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGT-LDSCIMKPSAS . ... : . .....::: :..::::: . ... :. : :...: . NP_001 SWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDII--TMDYKGSYLRICLLHPVQK 210 220 230 240 250 260 300 310 320 330 340 pF1KE9 LPESLYSLVMTYQNARMWWYFGCYFCLPILFT------VTCQLVTWRVRGPPGRKSECRA .... :..:. :: :. :::::. .: .::.. .: : . NP_001 T-----AFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEM----LRKKSGMQIAL-- 270 280 290 300 310 350 360 370 380 390 pF1KE9 SKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIV--VAYLSTELTR-------QTLDLLG . : . . .. .:: :..:.:.: :: .. :. . : ... .: .:: .: NP_001 NDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIG 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE9 LINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTE ::. : ... :.:. : . . . . : .: :: : NP_001 -INMAS--LNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDH 380 390 400 410 420 460 470 480 pF1KE9 VSSSIYFHKPRESPPLLPLGTPC NP_001 GYDNFRSSNKYSSS 430 440 >>NP_001188326 (OMIM: 131244,277580,600155,600501) endot (532 aa) initn: 459 init1: 236 opt: 459 Z-score: 429.1 bits: 88.9 E(85289): 3.7e-17 Smith-Waterman score: 463; 25.6% identity (56.9% similar) in 445 aa overlap (11-435:103-495) 10 20 30 40 pF1KE9 MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQ .:..:: ::::. : NP_001 EALKLRSGHRTPSGAGSSMQPPPSLCGRALVALVLACGLSRIWG---------------- 80 90 100 110 50 60 70 80 90 pF1KE9 QSRSKRGTEDEEAKGVQQ----YVPEEWAEYPRPIHPAGLQPTKPLVATSPNPDKDGGTP .:: ..: . : ..: . .:. . . . : : :. :. .:.: NP_001 ---EERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAP--AEVPKGDRTAGSP 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE9 DSGQELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVW ... : :.:. . :. : ... .::..::.:: ... :.. NP_001 PR------TISPPP-----CQGPI-EIKETF--KYINTVVSCLVFVLGIIGNSTLLRIIY 180 190 200 210 160 170 180 190 200 210 pF1KE9 HSYYLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGV .. .... : ..::::: :.: . . .:: ... .... .: :. :::.. .:.:. NP_001 KNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGI 220 230 240 250 260 270 220 230 240 250 260 270 pF1KE9 TTFSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEP :..:::::.:::.. :... ... : . .....::: :..::::: . ... NP_001 TVLSLCALSIDRYR-AVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDII--T 280 290 300 310 320 330 280 290 300 310 320 pF1KE9 APTMGT-LDSCIMKPSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFT------VTCQ :. : :...: . .... :..:. :: :. :::::. .: .::. NP_001 MDYKGSYLRICLLHPVQKT-----AFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE 340 350 360 370 380 330 340 350 360 370 380 pF1KE9 LVTWRVRGPPGRKSECRASKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIV--VAYLST . .: : . . : . . .. .:: :..:.:.: :: .. :. . : .. NP_001 M----LRKKSGMQIAL--NDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQN 390 400 410 420 430 440 390 400 410 420 430 440 pF1KE9 ELTR-------QTLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECG . .: .:: .: ::. : ... :.:. : . . . . : .: :: : NP_001 DPNRCELLSFLLVLDYIG-INMAS--LNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEE 450 460 470 480 490 500 450 460 470 480 pF1KE9 GASEASAANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC NP_001 KQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS 510 520 530 >>NP_003982 (OMIM: 131244,277580,600155,600501) endothel (436 aa) initn: 433 init1: 236 opt: 417 Z-score: 391.7 bits: 81.7 E(85289): 4.4e-15 Smith-Waterman score: 421; 24.9% identity (56.1% similar) in 437 aa overlap (11-427:13-397) 10 20 30 40 50 pF1KE9 MRWLWPLAVSLAVILAVGLSRVSGGAPLHLGRHRAETQEQQSRSKRGTEDEEAKGVQQ .:..:: ::::. : .:: ..: . : NP_003 MQPPPSLCGRALVALVLACGLSRIWG-------------------EERGFPPDRATPLLQ 10 20 30 40 60 70 80 90 100 110 pF1KE9 ----YVPEEWAEYPRPIHPAGLQPTKPLVATSPNPDKDGGTPDSGQELRGNLTGAPGQRL ..: . .:. . . . : : :. :. .:.: ... : : NP_003 TAEIMTPPTKTLWPKGSNASLARSLAP--AEVPKGDRTAGSPPR------TISPPPCQG- 50 60 70 80 90 120 130 140 150 160 170 pF1KE9 QIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLAL :. . : ... .::..::.:: ... :.... .... : ..::::: NP_003 -------PIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLAL 100 110 120 130 140 180 190 200 210 220 230 pF1KE9 WDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSLCALGIDRFHVATS :.: . . .:: ... .... .: :. :::.. .:.:.:..:::::.:::.. :.. NP_003 GDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYR-AVA 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE9 TLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAPTMGT-LDSCIMKPSAS . ... : . .....::: :..::::: . ... :. : :...: . NP_003 SWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIIT--MDYKGSYLRICLLHPVQK 210 220 230 240 250 260 300 310 320 330 340 pF1KE9 LPESLYSLVMTYQNARMWWYFGCYFCLPILFT------VTCQLVTWRVRGPPGRKSECRA .... :..:. :: :. :::::. .: .::... : : . NP_003 T-----AFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEML----RKKSGMQIA--L 270 280 290 300 310 350 360 370 380 390 pF1KE9 SKHEQCESQLNSTVVGLTVVYAFCTLPENVCNIV--VAYLSTELTR-------QTLDLLG . : . . .. .:: :..:.:.: :: .. :. . : ... .: .:: .: NP_003 NDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIG 320 330 340 350 360 370 400 410 420 430 440 450 pF1KE9 LINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDNKLKTE ::. : ... :.:. : . . . . : NP_003 -INMAS--LNSCINPIALYLVSKRFKNCFKAGPHVGNKLVMLFSVNIECDGTVNQNPTMW 380 390 400 410 420 >>NP_005305 (OMIM: 305670) gastrin-releasing peptide rec (384 aa) initn: 321 init1: 215 opt: 345 Z-score: 326.5 bits: 69.5 E(85289): 1.9e-11 Smith-Waterman score: 348; 24.8% identity (58.2% similar) in 311 aa overlap (131-434:41-340) 110 120 130 140 150 160 pF1KE9 ELRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYY :.: . :.. .:..::.... : NP_005 LEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKS 20 30 40 50 60 70 170 180 190 200 210 220 pF1KE9 LKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFS .... : ...:::: :.:.:. : :. .. . :.: ..:. .::....:.::..:. NP_005 MRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFT 80 90 100 110 120 130 230 240 250 260 270 pF1KE9 LCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQ-EPAPT : ::. ::... . . .. . ..: : : ::. :: ::.:: .. .: . : NP_005 LTALSADRYKAIVRPMD-IQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEEST 140 150 160 170 180 280 290 300 310 320 330 pF1KE9 MGTLDSCIMKP-SASLPESLYSLVMTYQNARMWWYFGCYFCLPI-LFTVTCQLVTWR-VR :. :: : : : ...:.. : .. .:. ...: ... .. NP_005 NQTFISCAPYPHSNELHPKIHSMAS----------FLVFYVIPLSIISVYYYFIAKNLIQ 190 200 210 220 230 340 350 360 370 380 390 pF1KE9 GPPGRKSECRASKHEQCESQ--LNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQTL . . : ..: ::. : .::. .. ..::: ::..: . .: .:. . : NP_005 SAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSML 240 250 260 270 280 290 400 410 420 430 440 450 pF1KE9 DLLGLI-NQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSDN .. : .. .: .. ..: : . . . . : :: NP_005 HFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMT 300 310 320 330 340 350 460 470 480 pF1KE9 KLKTEVSSSIYFHKPRESPPLLPLGTPC NP_005 SLKSTNPSVATFSLINGNICHERYV 360 370 380 >>NP_001718 (OMIM: 300107) bombesin receptor subtype-3 [ (399 aa) initn: 215 init1: 215 opt: 333 Z-score: 315.3 bits: 67.5 E(85289): 8e-11 Smith-Waterman score: 336; 23.2% identity (62.5% similar) in 315 aa overlap (132-437:49-351) 110 120 130 140 150 160 pF1KE9 LRGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAVGIVGNLSVMCIVWHSYYL ::.. :...:::.:: .. . ... . NP_001 DTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSM 20 30 40 50 60 70 170 180 190 200 210 220 pF1KE9 KSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTFSL ... : ...:::. :.:.:. :.:. . ... :.: ..:... :....:.::..:.: NP_001 QTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGCKVLSFIRLTSVGVSVFTL 80 90 100 110 120 130 230 240 250 260 270 pF1KE9 CALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLA--QEPAPT :. ::...... : . .: . . .: . .:. :: .:.:: .. .. ..: . NP_001 TILSADRYKAVVKPLER-QPSNAILKTCVKAGCVWIVSMIFALPEAIFSNVYTFRDPNKN 140 150 160 170 180 190 280 290 300 310 320 330 pF1KE9 MGTLDSCIMKP-SASLPESLYSLVMTYQNARMWWYFGCYFCLPI-LFTVTCQLVTWRV-R : :..:: : : .: . ..::. : .. .:. ...: .:.. . . NP_001 M-TFESCTSYPVSKKLLQEIHSLLC----------FLVFYIIPLSIISVYYSLIARTLYK 200 210 220 230 240 340 350 360 370 380 390 pF1KE9 GPPGRKSECRASKHEQCESQ--LNSTVVGLTVVYAFCTLPENVCNIVVAYLS-TELTRQT . . .: .. ..: ::. . ::. :....:.: ::... . .. : : . .. NP_001 STLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQTYVDPSA 250 260 270 280 290 300 400 410 420 430 440 450 pF1KE9 LDLLGLI-NQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASEASAANGSD . .. : .. .: .. ..: : . . . . : :: : NP_001 MHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADTSLTTLA 310 320 330 340 350 360 460 470 480 pF1KE9 NKLKTEVSSSIYFHKPRESPPLLPLGTPC NP_001 VMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF 370 380 390 >>NP_000900 (OMIM: 162641) neuropeptide Y receptor type (384 aa) initn: 231 init1: 161 opt: 319 Z-score: 302.7 bits: 65.1 E(85289): 4e-10 Smith-Waterman score: 319; 24.4% identity (59.7% similar) in 315 aa overlap (133-431:40-338) 110 120 130 140 150 pF1KE9 RGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAV---GIVGNLSVMCIVWHSY :. :::. :: :. :::... :. .. NP_000 ENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQK 10 20 30 40 50 60 160 170 180 190 200 210 pF1KE9 YLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTF .... : ....:.. :.:: ..:::... . . ..:.. :. ::.. :. :. : NP_000 EMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIF 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE9 SLCALGIDRFHVATSTLPK-VRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAP :: ....: .. . :. :: .: . .::::: ... ..: :. ...:: NP_000 SLVLIAVERHQLIIN--PRGWRPNNRHAYV--GIAVIWVLAVASSLPFLIYQVMTDEPFQ 130 140 150 160 170 180 280 290 300 310 320 330 pF1KE9 TMGTLDS------CIMK-PSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQL- .. :::. :. . :: : : .:... : ::: :. : : . NP_000 NV-TLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ------YFG-----PLCFIFICYFK 190 200 210 220 230 340 350 360 370 380 pF1KE9 VTWRVRGPPGRKSECRASKHEQCESQ-LNSTVVGLTVVYAFCTLPENVCNIVVAYLSTEL . :.. . .. : .:... :.. .: .....:..: : :: .. : : . . NP_000 IYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQII 240 250 260 270 280 290 390 400 410 420 430 440 pF1KE9 TRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLG---QAFLDCCCCCCCEECGGASEAS . . .:: :. ....... ..:.. . . . : :.. : NP_000 ATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMS 300 310 320 330 340 350 450 460 470 480 pF1KE9 AANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC NP_000 TMHTDVSKTSLKQASPVAFKKINNNDDNEKI 360 370 380 >>XP_005263088 (OMIM: 162641) PREDICTED: neuropeptide Y (384 aa) initn: 231 init1: 161 opt: 319 Z-score: 302.7 bits: 65.1 E(85289): 4e-10 Smith-Waterman score: 319; 24.4% identity (59.7% similar) in 315 aa overlap (133-431:40-338) 110 120 130 140 150 pF1KE9 RGNLTGAPGQRLQIQNPLYPVTESSYSAYAIMLLALVVFAV---GIVGNLSVMCIVWHSY :. :::. :: :. :::... :. .. XP_005 ENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQK 10 20 30 40 50 60 160 170 180 190 200 210 pF1KE9 YLKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTTF .... : ....:.. :.:: ..:::... . . ..:.. :. ::.. :. :. : XP_005 EMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIF 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE9 SLCALGIDRFHVATSTLPK-VRPIERCQSILAKLAVIWVGSMTLAVPELLLWQLAQEPAP :: ....: .. . :. :: .: . .::::: ... ..: :. ...:: XP_005 SLVLIAVERHQLIIN--PRGWRPNNRHAYV--GIAVIWVLAVASSLPFLIYQVMTDEPFQ 130 140 150 160 170 180 280 290 300 310 320 330 pF1KE9 TMGTLDS------CIMK-PSASLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQL- .. :::. :. . :: : : .:... : ::: :. : : . XP_005 NV-TLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQ------YFG-----PLCFIFICYFK 190 200 210 220 230 340 350 360 370 380 pF1KE9 VTWRVRGPPGRKSECRASKHEQCESQ-LNSTVVGLTVVYAFCTLPENVCNIVVAYLSTEL . :.. . .. : .:... :.. .: .....:..: : :: .. : : . . XP_005 IYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQII 240 250 260 270 280 290 390 400 410 420 430 440 pF1KE9 TRQTLDLLGLINQFSTFFKGAITPVLLLCICRPLG---QAFLDCCCCCCCEECGGASEAS . . .:: :. ....... ..:.. . . . : :.. : XP_005 ATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMS 300 310 320 330 340 350 450 460 470 480 pF1KE9 AANGSDNKLKTEVSSSIYFHKPRESPPLLPLGTPC XP_005 TMHTDVSKTSLKQASPVAFKKINNNDDNEKI 360 370 380 481 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:43:35 2016 done: Sun Nov 6 18:43:37 2016 Total Scan time: 10.470 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]