FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5789, 616 aa 1>>>pF1KE5789 616 - 616 aa - 616 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.6407+/-0.000516; mu= -11.4292+/- 0.032 mean_var=662.0919+/-140.236, 0's: 0 Z-trim(122.8): 72 B-trim: 1968 in 1/57 Lambda= 0.049844 statistics sampled from 41328 (41420) to 41328 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.77), E-opt: 0.2 (0.486), width: 16 Scan time: 8.750 The best scores are: opt bits E(85289) NP_056050 (OMIM: 611968) cleavage stimulation fact ( 616) 4237 320.1 1.4e-86 NP_001316 (OMIM: 300907) cleavage stimulation fact ( 577) 2535 197.6 9.6e-50 NP_001293135 (OMIM: 300907) cleavage stimulation f ( 597) 1888 151.1 1e-35 NP_001293138 (OMIM: 300907) cleavage stimulation f ( 560) 1675 135.8 3.9e-31 >>NP_056050 (OMIM: 611968) cleavage stimulation factor s (616 aa) initn: 4237 init1: 4237 opt: 4237 Z-score: 1675.2 bits: 320.1 E(85289): 1.4e-86 Smith-Waterman score: 4237; 100.0% identity (100.0% similar) in 616 aa overlap (1-616:1-616) 10 20 30 40 50 60 pF1KE5 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 ERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPHQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 GPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRDSRAMET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRDSRAMET 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 RAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RAMETEVLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 INIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 INIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 GGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQ 550 560 570 580 590 600 610 pF1KE5 SILILKEQIQKSTGAS :::::::::::::::: NP_056 SILILKEQIQKSTGAS 610 >>NP_001316 (OMIM: 300907) cleavage stimulation factor s (577 aa) initn: 1812 init1: 1221 opt: 2535 Z-score: 1014.0 bits: 197.6 E(85289): 9.6e-50 Smith-Waterman score: 2813; 69.7% identity (81.0% similar) in 631 aa overlap (1-615:1-576) 10 20 30 40 50 60 pF1KE5 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG :..:.:::::.::::::::::::::::::::::::::::: ::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID ::::::::::::::::::::::::::::::::::::::::::::: .::.:.::::. :. NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR ::::::::..:::::::::::::::::::::::: ::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ :.:::::::::::. .. :: :. : : : ::: : :: .::::: ::: : NP_001 IVDPEIALKILHRQTNIPTLIAGNPQ------PVHGAGPG--SGSNVSMNQQNPQAPQAQ 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL :. :. :::::. .:::.:::: .:::: : :::::.:::.:: :.:::: ::: . NP_001 SLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSM 240 250 260 270 280 290 310 320 330 340 350 pF1KE5 ERGQVQMSDPRAPIPRGPVTPGGLP-PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH ::::: :.:::: . :: . :...: :::::::::::::::::::::::::::::::::: NP_001 ERGQVPMQDPRAAMQRGSL-PANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 QGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRD----- :::::::. ::..::: ::.::::: .:: :..::::::.:::: :.::::::: NP_001 QGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGID 360 370 380 390 400 410 420 430 440 450 460 pF1KE5 SRAMETRAMETE----------VLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPV .:.::.::::.. ..:.:.:: :.::. :::.:.::.:::.:::.. :::: NP_001 ARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPV 420 430 440 450 460 470 470 480 490 500 510 520 pF1KE5 PSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQ :. :::. .:.:::.:::.:: ::: :::: . ::::::::.:: NP_001 PGPRGPIPSGMQGPSPINMGAV-VPQGSRQVPVM---------------QGTGMQGASIQ 480 490 500 510 530 540 550 560 570 580 pF1KE5 GGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVL :: :::..:::::.::::::.:::::::::: NP_001 GG------------------------------SQPGGFSPGQNQVTPQDHEKAALIMQVL 520 530 540 590 600 610 pF1KE5 QLTADQIAMLPPEQRQSILILKEQIQKSTGAS ::::::::::::::::::::::::::::::: NP_001 QLTADQIAMLPPEQRQSILILKEQIQKSTGAP 550 560 570 >>NP_001293135 (OMIM: 300907) cleavage stimulation facto (597 aa) initn: 2453 init1: 1221 opt: 1888 Z-score: 762.4 bits: 151.1 E(85289): 1e-35 Smith-Waterman score: 2763; 67.6% identity (78.5% similar) in 651 aa overlap (1-615:1-596) 10 20 30 40 50 60 pF1KE5 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG :..:.:::::.::::::::::::::::::::::::::::: ::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID ::::::::::::::::::::::::::::::::::::::::::::: .::.:.::::. :. NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR ::::::::..:::::::::::::::::::::::: ::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ :.:::::::::::. .. :: :. : : : ::: : :: .::::: ::: : NP_001 IVDPEIALKILHRQTNIPTLIAGNPQ------PVHGAGPG--SGSNVSMNQQNPQAPQAQ 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL :. :. :::::. .:::.:::: .:::: : :::::.:::.:: :.:::: ::: . NP_001 SLGGMHVNGAPPLMQASMQGGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSM 240 250 260 270 280 290 310 320 330 pF1KE5 ERGQ--------------------VQMSDPRAPIPRGPVTPGGLP-PRGLLGDAPNDPRG :::: : :.:::: . :: . :...: :::::::::::::: NP_001 ERGQGTLQHSPVGPAGPASIERVQVPMQDPRAAMQRGSL-PANVPTPRGLLGDAPNDPRG 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE5 GTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPM :::::::::::::::::::::::::::. ::..::: ::.::::: .:: :..:::::: NP_001 GTLLSVTGEVEPRGYLGPPHQGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPM 360 370 380 390 400 410 400 410 420 430 440 pF1KE5 IDQRGLPMDGRGGRD-----SRAMETRAMETE----------VLETRVMERRGMETCAME .:::: :.::::::: .:.::.::::.. ..:.:.:: :.::. ::: NP_001 LDQRGPPLDGRGGRDPRGIDARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAME 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE5 TRGMEARGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNP .:.::.:::.:::.. :::::. :::. .:.:::.:::.:: ::: :::: . NP_001 ARAMEVRGMEARGMDTRGPVPGPRGPIPSGMQGPSPINMGAV-VPQGSRQVPVM------ 480 490 500 510 520 510 520 530 540 550 560 pF1KE5 GAGMQGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSP ::::::::.:::: :::..::: NP_001 ---------QGTGMQGASIQGG------------------------------SQPGGFSP 530 540 570 580 590 600 610 pF1KE5 GQSQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS ::.::::::.::::::::::::::::::::::::::::::::::::::::: NP_001 GQNQVTPQDHEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAP 550 560 570 580 590 >>NP_001293138 (OMIM: 300907) cleavage stimulation facto (560 aa) initn: 1667 init1: 1256 opt: 1675 Z-score: 679.9 bits: 135.8 E(85289): 3.9e-31 Smith-Waterman score: 2726; 68.6% identity (79.2% similar) in 631 aa overlap (1-615:1-559) 10 20 30 40 50 60 pF1KE5 MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVSFRLVYDRETGKPKGYG :..:.:::::.::::::::::::::::::::::::::::: ::::::::::::::::::: NP_001 MAGLTVRDPAVDRSLRSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGPAAPIIDSPYGDPID ::::::::::::::::::::::::::::::::::::::::::::: .::.:.::::. :. NP_001 FCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELKSLGTGAPVIESPYGETIS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 PEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARNMLLQNPQLAYALLQAQVVMR ::::::::..:::::::::::::::::::::::: ::::::::::::::::::::::::: NP_001 PEDAPESISKAVASLPPEQMFELMKQMKLCVQNSPQEARNMLLQNPQLAYALLQAQVVMR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 IMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPGPGLCPGPNVLLNQQNPPAPQPQ :.:::::::::::. .. :: :. : : : ::: : :: .::::: ::: : NP_001 IVDPEIALKILHRQTNIPTLIAGNPQ------PVHGAGPG--SGSNVSMNQQNPQAPQAQ 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 HLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAGPGSLTPGGAMQPQLGMPGVGPVPL : ::.:::: .:::: : :::::.:::.:: :.:::: ::: . NP_001 SL-----------------GGVPAPGQMPAAVTGPGPGSLAPGGGMQAQVGMPGSGPVSM 240 250 260 270 310 320 330 340 350 pF1KE5 ERGQVQMSDPRAPIPRGPVTPGGLP-PRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH ::::: :.:::: . :: . :...: :::::::::::::::::::::::::::::::::: NP_001 ERGQVPMQDPRAAMQRGSL-PANVPTPRGLLGDAPNDPRGGTLLSVTGEVEPRGYLGPPH 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE5 QGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLIGEPRGPMIDQRGLPMDGRGGRD----- :::::::. ::..::: ::.::::: .:: :..::::::.:::: :.::::::: NP_001 QGPPMHHVPGHESRGPPPHELRGGPLPEPRPLMAEPRGPMLDQRGPPLDGRGGRDPRGID 340 350 360 370 380 390 420 430 440 450 460 pF1KE5 SRAMETRAMETE----------VLETRVMERRGMETCAMETRGMEARGMDARGLEMRGPV .:.::.::::.. ..:.:.:: :.::. :::.:.::.:::.:::.. :::: NP_001 ARGMEARAMEARGLDARGLEARAMEARAMEARAMEARAMEARAMEVRGMEARGMDTRGPV 400 410 420 430 440 450 470 480 490 500 510 520 pF1KE5 PSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGMQGTGIQGTGMQGAGIQ :. :::. .:.:::.:::.:: ::: :::: . ::::::::.:: NP_001 PGPRGPIPSGMQGPSPINMGAV-VPQGSRQVPVM---------------QGTGMQGASIQ 460 470 480 490 530 540 550 560 570 580 pF1KE5 GGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQSQVTPQDQEKAALIMQVL :: :::..:::::.::::::.:::::::::: NP_001 GG------------------------------SQPGGFSPGQNQVTPQDHEKAALIMQVL 500 510 520 590 600 610 pF1KE5 QLTADQIAMLPPEQRQSILILKEQIQKSTGAS ::::::::::::::::::::::::::::::: NP_001 QLTADQIAMLPPEQRQSILILKEQIQKSTGAP 530 540 550 560 616 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:40:17 2016 done: Tue Nov 8 06:40:18 2016 Total Scan time: 8.750 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]