FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5449, 335 aa 1>>>pF1KE5449 335 - 335 aa - 335 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5941+/-0.00037; mu= 1.6952+/- 0.023 mean_var=205.3053+/-41.308, 0's: 0 Z-trim(119.9): 8 B-trim: 53 in 1/57 Lambda= 0.089511 statistics sampled from 34360 (34368) to 34360 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.403), width: 16 Scan time: 8.170 The best scores are: opt bits E(85289) NP_001257906 (OMIM: 616434) IST1 homolog isoform d ( 335) 2197 296.0 7.7e-80 NP_001257904 (OMIM: 616434) IST1 homolog isoform a ( 366) 1685 229.9 6.6e-60 NP_001257905 (OMIM: 616434) IST1 homolog isoform c ( 379) 1685 229.9 6.8e-60 NP_055576 (OMIM: 616434) IST1 homolog isoform b [H ( 360) 1673 228.3 1.9e-59 NP_001257907 (OMIM: 616434) IST1 homolog isoform e ( 218) 760 110.2 4e-24 NP_001257908 (OMIM: 616434) IST1 homolog isoform e ( 218) 760 110.2 4e-24 >>NP_001257906 (OMIM: 616434) IST1 homolog isoform d [Ho (335 aa) initn: 2197 init1: 2197 opt: 2197 Z-score: 1554.3 bits: 296.0 E(85289): 7.7e-80 Smith-Waterman score: 2197; 100.0% identity (100.0% similar) in 335 aa overlap (1-335:1-335) 10 20 30 40 50 60 pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV 250 260 270 280 290 300 310 320 330 pF1KE5 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT ::::::::::::::::::::::::::::::::::: NP_001 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT 310 320 330 >>NP_001257904 (OMIM: 616434) IST1 homolog isoform a [Ho (366 aa) initn: 1762 init1: 1670 opt: 1685 Z-score: 1196.5 bits: 229.9 E(85289): 6.6e-60 Smith-Waterman score: 2125; 91.5% identity (91.5% similar) in 366 aa overlap (1-335:1-366) 10 20 30 40 50 60 pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS 190 200 210 220 230 240 250 260 pF1KE5 ANTPFSYPLPKGP-------------------------------VDDINADKNISSAQIV ::::::::::::: :::::::::::::::: NP_001 ANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE5 GPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFE 310 320 330 340 350 360 330 pF1KE5 ELKKKT :::::: NP_001 ELKKKT >>NP_001257905 (OMIM: 616434) IST1 homolog isoform c [Ho (379 aa) initn: 1762 init1: 1670 opt: 1685 Z-score: 1196.3 bits: 229.9 E(85289): 6.8e-60 Smith-Waterman score: 2125; 91.5% identity (91.5% similar) in 366 aa overlap (1-335:14-379) 10 20 30 40 pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAG ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVFKLKTKEEQHSMLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE5 KDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDERARIRVEHIIREDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE5 PRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRLQSEVAELKIVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLI 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE5 EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIAKNYNVPYEPDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGT 190 200 210 220 230 240 230 240 250 pF1KE5 VPMPMPMPMPMPSANTPFSYPLPKGP-------------------------------VDD :::::::::::::::::::::::::: ::: NP_001 VPMPMPMPMPMPSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDD 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE5 INADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 INADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSAS 310 320 330 340 350 360 320 330 pF1KE5 EDIDFDDLSRRFEELKKKT ::::::::::::::::::: NP_001 EDIDFDDLSRRFEELKKKT 370 >>NP_055576 (OMIM: 616434) IST1 homolog isoform b [Homo (360 aa) initn: 1762 init1: 1670 opt: 1673 Z-score: 1188.2 bits: 228.3 E(85289): 1.9e-59 Smith-Waterman score: 1673; 89.1% identity (94.6% similar) in 294 aa overlap (1-294:1-287) 10 20 30 40 50 60 pF1KE5 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPMPS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 ANTPFSYPLPKGPVDDINADKNISSAQIVGPGPKPEASAKLPSRPADNYDNFVLPELPSV ::::::::::::: .:.:. ... : :. .: ..:. : .:....: NP_055 ANTPFSYPLPKGP-SDFNGLP-MGTYQAF-PNIHPP---QIPATPP-SYESMTLMLIRIS 250 260 270 280 290 310 320 330 pF1KE5 PDTLPTASAGASTSASEDIDFDDLSRRFEELKKKT NP_055 LLHRLLVLDPSQKPLQSFLPDLQITMTTLSYQSCHLCQTHYQLHLLVPAPQHLKTLTLMI 300 310 320 330 340 350 >>NP_001257907 (OMIM: 616434) IST1 homolog isoform e [Ho (218 aa) initn: 837 init1: 745 opt: 760 Z-score: 554.0 bits: 110.2 E(85289): 4e-24 Smith-Waterman score: 1200; 85.8% identity (85.8% similar) in 218 aa overlap (149-335:1-218) 120 130 140 150 160 170 pF1KE5 IVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYE :::::::::::::::::::::::::::::: NP_001 MHKLSVEAPPKILVERYLIEIAKNYNVPYE 10 20 30 180 190 200 210 220 230 pF1KE5 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM 40 50 60 70 80 90 240 250 260 pF1KE5 PSANTPFSYPLPKGP-------------------------------VDDINADKNISSAQ ::::::::::::::: :::::::::::::: NP_001 PSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQ 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE5 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR 160 170 180 190 200 210 330 pF1KE5 FEELKKKT :::::::: NP_001 FEELKKKT >>NP_001257908 (OMIM: 616434) IST1 homolog isoform e [Ho (218 aa) initn: 837 init1: 745 opt: 760 Z-score: 554.0 bits: 110.2 E(85289): 4e-24 Smith-Waterman score: 1200; 85.8% identity (85.8% similar) in 218 aa overlap (149-335:1-218) 120 130 140 150 160 170 pF1KE5 IVADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYE :::::::::::::::::::::::::::::: NP_001 MHKLSVEAPPKILVERYLIEIAKNYNVPYE 10 20 30 180 190 200 210 220 230 pF1KE5 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDSVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPM 40 50 60 70 80 90 240 250 260 pF1KE5 PSANTPFSYPLPKGP-------------------------------VDDINADKNISSAQ ::::::::::::::: :::::::::::::: NP_001 PSANTPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQ 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE5 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVGPGPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRR 160 170 180 190 200 210 330 pF1KE5 FEELKKKT :::::::: NP_001 FEELKKKT 335 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:52:41 2016 done: Tue Nov 8 00:52:42 2016 Total Scan time: 8.170 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]