FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5350, 306 aa 1>>>pF1KE5350 306 - 306 aa - 306 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6802+/-0.000345; mu= 13.6754+/- 0.021 mean_var=72.3665+/-14.691, 0's: 0 Z-trim(116.0): 16 B-trim: 740 in 1/55 Lambda= 0.150767 statistics sampled from 26894 (26900) to 26894 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.315), width: 16 Scan time: 6.880 The best scores are: opt bits E(85289) NP_001265352 (OMIM: 607894) polycystic kidney dise ( 306) 2007 445.5 6.2e-125 NP_001070248 (OMIM: 607894) polycystic kidney dise ( 991) 2007 445.8 1.7e-124 NP_001265354 (OMIM: 607894) polycystic kidney dise (1774) 1857 413.2 1.8e-114 NP_443124 (OMIM: 607894) polycystic kidney disease (2459) 1857 413.3 2.4e-114 >>NP_001265352 (OMIM: 607894) polycystic kidney disease (306 aa) initn: 2007 init1: 2007 opt: 2007 Z-score: 2364.0 bits: 445.5 E(85289): 6.2e-125 Smith-Waterman score: 2007; 99.7% identity (99.7% similar) in 306 aa overlap (1-306:1-306) 10 20 30 40 50 60 pF1KE5 MGEDSPVAMFSWYLDNTPTEQAEPLPDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRG ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 MGEDSPVAMFSWYLDNTPTEQAEPLLDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 FCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 DTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQGSCMGDSWEGAPPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQGSCMGDSWEGAPPAA 250 260 270 280 290 300 pF1KE5 HVSHAR :::::: NP_001 HVSHAR >>NP_001070248 (OMIM: 607894) polycystic kidney disease (991 aa) initn: 2007 init1: 2007 opt: 2007 Z-score: 2356.1 bits: 445.8 E(85289): 1.7e-124 Smith-Waterman score: 2007; 99.7% identity (99.7% similar) in 306 aa overlap (1-306:686-991) 10 20 30 pF1KE5 MGEDSPVAMFSWYLDNTPTEQAEPLPDACR ::::::::::::::::::::::::: :::: NP_001 SAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLLDACR 660 670 680 690 700 710 40 50 60 70 80 90 pF1KE5 LRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREV 720 730 740 750 760 770 100 110 120 130 140 150 pF1KE5 PACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEEN 780 790 800 810 820 830 160 170 180 190 200 210 pF1KE5 NDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQL 840 850 860 870 880 890 220 230 240 250 260 270 pF1KE5 LQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVL 900 910 920 930 940 950 280 290 300 pF1KE5 REVTCRSKELTPSAQGSCMGDSWEGAPPAAHVSHAR :::::::::::::::::::::::::::::::::::: NP_001 REVTCRSKELTPSAQGSCMGDSWEGAPPAAHVSHAR 960 970 980 990 >>NP_001265354 (OMIM: 607894) polycystic kidney disease (1774 aa) initn: 1847 init1: 1847 opt: 1857 Z-score: 2175.9 bits: 413.2 E(85289): 1.8e-114 Smith-Waterman score: 1857; 94.8% identity (96.1% similar) in 305 aa overlap (1-305:1-298) 10 20 30 40 50 60 pF1KE5 MGEDSPVAMFSWYLDNTPTEQAEPLPDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRG ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::::: NP_001 MGEDSPVAMFSWYLDNTPTEQAEPLLDACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVIRIRATALTRHAYGEDTYVISTVPPREVPACTIAPEEGTVLTSFAIFCNASTALGPLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 FCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLTVVISATNRAGDTQQTQAMAKVALG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 DTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSMLNQEHESQGSGQSLSIDVRQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQGSCMGDSWEGAPPAA ::::::::::::::::::::::::::::::::::::::::::::: ::.. NP_001 KVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQ-------WEASLALQ 250 260 270 280 290 pF1KE5 HVSHAR :.:.: NP_001 HASEALLTVSAKARPEDQRRQAATRDLFQAVGSVLEASLSNRPEEPAEASSSQIATVLRL 300 310 320 330 340 350 >>NP_443124 (OMIM: 607894) polycystic kidney disease pro (2459 aa) initn: 1847 init1: 1847 opt: 1857 Z-score: 2173.7 bits: 413.3 E(85289): 2.4e-114 Smith-Waterman score: 1857; 94.8% identity (96.1% similar) in 305 aa overlap (1-305:686-983) 10 20 30 pF1KE5 MGEDSPVAMFSWYLDNTPTEQAEPLPDACR ::::::::::::::::::::::::: :::: NP_443 SAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLLDACR 660 670 680 690 700 710 40 50 60 70 80 90 pF1KE5 LRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREV 720 730 740 750 760 770 100 110 120 130 140 150 pF1KE5 PACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 PACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEEN 780 790 800 810 820 830 160 170 180 190 200 210 pF1KE5 NDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 NDFVLTVVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQL 840 850 860 870 880 890 220 230 240 250 260 270 pF1KE5 LQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_443 LQLAKAVSSMLNQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVL 900 910 920 930 940 950 280 290 300 pF1KE5 REVTCRSKELTPSAQGSCMGDSWEGAPPAAHVSHAR ::::::::::::::: ::.. :.:.: NP_443 REVTCRSKELTPSAQ-------WEASLALQHASEALLTVSAKARPEDQRRQAATRDLFQA 960 970 980 990 1000 NP_443 VGSVLEASLSNRPEEPAEASSSQIATVLRLLRVMEHVQTTLLLGKLPGGLPAMLATPSIS 1010 1020 1030 1040 1050 1060 306 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:01:25 2016 done: Tue Nov 8 00:01:26 2016 Total Scan time: 6.880 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]