FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5860, 490 aa 1>>>pF1KB5860 490 - 490 aa - 490 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0754+/-0.000372; mu= 15.0182+/- 0.023 mean_var=92.0901+/-18.878, 0's: 0 Z-trim(115.4): 70 B-trim: 873 in 1/49 Lambda= 0.133650 statistics sampled from 25844 (25915) to 25844 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.674), E-opt: 0.2 (0.304), width: 16 Scan time: 7.280 The best scores are: opt bits E(85289) NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [H ( 490) 3293 645.2 1.2e-184 XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm ( 508) 3293 645.2 1.2e-184 XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm ( 503) 3243 635.6 9.9e-182 NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 ( 392) 2498 491.9 1.4e-138 NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 ( 267) 1502 299.7 6.7e-81 NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 ( 440) 1497 298.9 2e-80 XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm ( 458) 1497 298.9 2e-80 NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 ( 164) 950 193.2 4.9e-49 XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 u ( 491) 886 181.1 6.2e-45 NP_002383 (OMIM: 164785,614401) E3 ubiquitin-prote ( 497) 886 181.1 6.3e-45 NP_001265447 (OMIM: 602704) protein Mdm4 isoform 6 ( 116) 751 154.7 1.3e-37 NP_001265445 (OMIM: 602704) protein Mdm4 isoform 4 ( 140) 751 154.7 1.5e-37 XP_006719462 (OMIM: 164785,614401) PREDICTED: E3 u ( 430) 752 155.2 3.3e-37 XP_006719463 (OMIM: 164785,614401) PREDICTED: E3 u ( 390) 592 124.4 6e-28 NP_001265391 (OMIM: 164785,614401) E3 ubiquitin-pr ( 321) 558 117.7 4.8e-26 NP_001138812 (OMIM: 164785,614401) E3 ubiquitin-pr ( 295) 501 106.7 9.1e-23 NP_001138809 (OMIM: 164785,614401) E3 ubiquitin-pr ( 444) 352 78.1 5.7e-14 NP_001138811 (OMIM: 164785,614401) E3 ubiquitin-pr ( 442) 325 72.9 2.1e-12 >>NP_002384 (OMIM: 602704) protein Mdm4 isoform 1 [Homo (490 aa) initn: 3293 init1: 3293 opt: 3293 Z-score: 3435.9 bits: 645.2 E(85289): 1.2e-184 Smith-Waterman score: 3293; 100.0% identity (100.0% similar) in 490 aa overlap (1-490:1-490) 10 20 30 40 50 60 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE 430 440 450 460 470 480 490 pF1KB5 IQLVIKVFIA :::::::::: NP_002 IQLVIKVFIA 490 >>XP_016856800 (OMIM: 602704) PREDICTED: protein Mdm4 is (508 aa) initn: 3293 init1: 3293 opt: 3293 Z-score: 3435.7 bits: 645.2 E(85289): 1.2e-184 Smith-Waterman score: 3293; 100.0% identity (100.0% similar) in 490 aa overlap (1-490:19-508) 10 20 30 40 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA :::::::::::::::::::::::::::::::::::::::::: XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH 430 440 450 460 470 480 470 480 490 pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA :::::::::::::::::::::::::::: XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA 490 500 >>XP_016856801 (OMIM: 602704) PREDICTED: protein Mdm4 is (503 aa) initn: 1773 init1: 1773 opt: 3243 Z-score: 3383.7 bits: 635.6 E(85289): 9.9e-182 Smith-Waterman score: 3243; 99.0% identity (99.0% similar) in 490 aa overlap (1-490:19-503) 10 20 30 40 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA :::::::::::::::::::::::::::::::::::::::::: XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND :::::::::::::::::::::::::::::::::::::::::::::::: ::::::: XP_016 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKV-----IEVGKND 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE 360 370 380 390 400 410 410 420 430 440 450 460 pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH 420 430 440 450 460 470 470 480 490 pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA :::::::::::::::::::::::::::: XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA 480 490 500 >>NP_001265446 (OMIM: 602704) protein Mdm4 isoform 5 [Ho (392 aa) initn: 2493 init1: 2493 opt: 2498 Z-score: 2608.9 bits: 491.9 E(85289): 1.4e-138 Smith-Waterman score: 2498; 96.9% identity (98.4% similar) in 382 aa overlap (112-490:11-392) 90 100 110 120 130 pF1KB5 GELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLA---LAQDHSMDIPSQDQLKQ .:.:.: .. . ::::::::::::::: NP_001 MTSFSTSAQCSTSDSACRISPGQINQDHSMDIPSQDQLKQ 10 20 30 40 140 150 160 170 180 190 pF1KB5 SAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGL 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB5 PWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAA 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB5 DTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKR 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB5 YCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYI 230 240 250 260 270 280 380 390 400 410 420 430 pF1KB5 KKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCS 290 300 310 320 330 340 440 450 460 470 480 490 pF1KB5 LCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA 350 360 370 380 390 >>NP_001265448 (OMIM: 602704) protein Mdm4 isoform 7 [Ho (267 aa) initn: 1502 init1: 1502 opt: 1502 Z-score: 1573.4 bits: 299.7 E(85289): 6.7e-81 Smith-Waterman score: 1502; 99.5% identity (100.0% similar) in 218 aa overlap (273-490:50-267) 250 260 270 280 290 300 pF1KB5 ESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSED :.:::::::::::::::::::::::::::: NP_001 SPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVIEVGKNDDLEDSKSLSDDTDVEVTSED 20 30 40 50 60 70 310 320 330 340 350 360 pF1KB5 EWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDC 80 90 100 110 120 130 370 380 390 400 410 420 pF1KB5 RRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRT 140 150 160 170 180 190 430 440 450 460 470 480 pF1KB5 DTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQ 200 210 220 230 240 250 490 pF1KB5 LVIKVFIA :::::::: NP_001 LVIKVFIA 260 >-- initn: 320 init1: 320 opt: 320 Z-score: 341.7 bits: 71.8 E(85289): 2.7e-12 Smith-Waterman score: 320; 100.0% identity (100.0% similar) in 49 aa overlap (1-49:1-49) 10 20 30 40 50 60 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVIEVGKNDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL NP_001 LEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLST 70 80 90 100 110 120 >>NP_001191100 (OMIM: 602704) protein Mdm4 isoform 2 [Ho (440 aa) initn: 1497 init1: 1497 opt: 1497 Z-score: 1565.1 bits: 298.9 E(85289): 2e-80 Smith-Waterman score: 2874; 89.8% identity (89.8% similar) in 490 aa overlap (1-490:1-440) 10 20 30 40 50 60 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF :::::::::::::::::::::::::::::::::::::::::::: NP_001 DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQ---------------- 190 200 210 220 250 260 270 280 290 300 pF1KB5 LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS :::::::::::::::::::::::::: NP_001 ----------------------------------VIEVGKNDDLEDSKSLSDDTDVEVTS 230 240 250 310 320 330 340 350 360 pF1KB5 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE 380 390 400 410 420 430 490 pF1KB5 IQLVIKVFIA :::::::::: NP_001 IQLVIKVFIA 440 >>XP_016856802 (OMIM: 602704) PREDICTED: protein Mdm4 is (458 aa) initn: 1497 init1: 1497 opt: 1497 Z-score: 1564.8 bits: 298.9 E(85289): 2e-80 Smith-Waterman score: 2874; 89.8% identity (89.8% similar) in 490 aa overlap (1-490:19-458) 10 20 30 40 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA :::::::::::::::::::::::::::::::::::::::::: XP_016 MQNLSKVLPTDCSFFTTKMTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSE 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQT 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 NQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKND :: :::::::: XP_016 NQ--------------------------------------------------VIEVGKND 250 290 300 310 320 330 340 pF1KB5 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLS 260 270 280 290 300 310 350 360 370 380 390 400 pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE 320 330 340 350 360 370 410 420 430 440 450 460 pF1KB5 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFH 380 390 400 410 420 430 470 480 490 pF1KB5 CARRLKKAGASCPICKKEIQLVIKVFIA :::::::::::::::::::::::::::: XP_016 CARRLKKAGASCPICKKEIQLVIKVFIA 440 450 >>NP_001191101 (OMIM: 602704) protein Mdm4 isoform 3 [Ho (164 aa) initn: 950 init1: 950 opt: 950 Z-score: 1001.3 bits: 193.2 E(85289): 4.9e-49 Smith-Waterman score: 950; 99.3% identity (100.0% similar) in 139 aa overlap (352-490:26-164) 330 340 350 360 370 380 pF1KB5 RCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKE .::::::::::::::::::::::::::::: NP_001 MTSFSTSAQCSTSDSACRISPGQINQENEGNDVPDCRRTISAPVVRPKDAYIKKE 10 20 30 40 50 390 400 410 420 430 440 pF1KB5 NSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCE 60 70 80 90 100 110 450 460 470 480 490 pF1KB5 KRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA 120 130 140 150 160 >>XP_005268929 (OMIM: 164785,614401) PREDICTED: E3 ubiqu (491 aa) initn: 512 init1: 346 opt: 886 Z-score: 927.7 bits: 181.1 E(85289): 6.2e-45 Smith-Waterman score: 886; 33.9% identity (64.2% similar) in 481 aa overlap (23-488:24-489) 10 20 30 40 50 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQY : . :::: :::.:...::: . .:.:::. ::::: XP_005 MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 IMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA-TTDAAQ ::.:.:::...::.:::..::::.:.: :::::. .: :. .:::.. ..:.. XP_005 IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENL ... . : .: .: : .: . : .. . :. . .. ...:. : . . XP_005 SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENSDELSGE 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 AQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNGS--TDLQTNQDVGTAIVSD : . . : :.:.: ..: : .: ::..: : .: :. : ::. XP_005 RQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD-AGVSE 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 TTDDLWFLNESVSEQLGVGIKVEAADTEQ--TSEEVGKVSDKKVIEVGKNDDLEDSKSLS . : :. ..:::.:..: ..::. :.:. ::: ..::. :: . . ..: . XP_005 HSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDD-EVYQVTVYQAGESDT 240 250 260 270 280 300 310 320 330 340 pF1KB5 D--DTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSLSTSDITA : . : :.. : :.:: :...: : .: ::::::..: : .: .: . XP_005 DSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLE 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 IPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETIS . .:: :::::..:: : ... ......:. . .: : : .. : :. : XP_005 NSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIY 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 SMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCA : :.. .. ...:. :..:. : ..:: .:. ::..: :.::.::::..:: :: XP_005 SSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCA 410 420 430 440 450 460 470 480 490 pF1KB5 RRLKKAGASCPICKKEIQLVIKVFIA ..::: . ::.:.. ::... .. XP_005 KKLKKRNKPCPVCRQPIQMIVLTYFP 470 480 490 >>NP_002383 (OMIM: 164785,614401) E3 ubiquitin-protein l (497 aa) initn: 512 init1: 346 opt: 886 Z-score: 927.6 bits: 181.1 E(85289): 6.3e-45 Smith-Waterman score: 886; 33.9% identity (64.2% similar) in 481 aa overlap (23-488:30-495) 10 20 30 40 50 pF1KB5 MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVM : . :::: :::.:...::: . .:.:::. NP_002 MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 HYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATA- :::::::.:.:::...::.:::..::::.:.: :::::. .: :. .:::.. NP_002 FYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQE 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDE ..:.. ... . : .: .: : .: . : .. . :. . .. ...:. NP_002 SSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSR--PSTSSRRRAISETEENS 130 140 150 160 170 180 190 200 210 220 pF1KB5 DLIENLAQDETSRLD---LGFEEWDVAGLPWWFLGNLRSNYTPRSNGS--TDLQTNQDVG : . . : . . : :.:.: ..: : .: ::..: : .: :. NP_002 DELSGERQRKRHKSDSISLSFDE-SLA------LCVIREICCERSSSSESTGTPSNPDLD 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 TAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQ--TSEEVGKVSDKKVIEVGKNDDLE : ::. . : :. ..:::.:..: ..::. :.:. ::: ..::. :: . . NP_002 -AGVSEHSGD-WLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDD-EVYQVTVYQ 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 DSKSLSD--DTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYS-DCSKLTHSLS ..: .: . : :.. : :.:: :...: : .: ::::::..: : .: .: NP_002 AGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEIS 290 300 310 320 330 340 350 360 370 380 390 400 pF1KB5 TSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSE . . .:: :::::..:: : ... ......:. . .: : : .. : NP_002 EKAKLENSTQAEEGFDVPDCKKTI---VNDSRESCVEENDDKITQASQSQESEDYSQPST 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 SQETISSMGEQLDNLSEQRTDT--ENMEDCQ--NLLKPCSLCEKRPRDGNIIHGRTGHLV :. : : :.. .. ...:. :..:. : ..:: .:. ::..: :.::.::::. NP_002 SSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLM 410 420 430 440 450 460 460 470 480 490 pF1KB5 TCFHCARRLKKAGASCPICKKEIQLVIKVFIA .:: ::..::: . ::.:.. ::... .. NP_002 ACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP 470 480 490 490 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 18:52:30 2016 done: Mon Nov 7 18:52:31 2016 Total Scan time: 7.280 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]