FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4212, 696 aa 1>>>pF1KE4212 696 - 696 aa - 696 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2621+/-0.000308; mu= 12.7841+/- 0.019 mean_var=157.8845+/-32.228, 0's: 0 Z-trim(121.7): 97 B-trim: 0 in 0/53 Lambda= 0.102071 statistics sampled from 38551 (38673) to 38551 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.453), width: 16 Scan time: 10.190 The best scores are: opt bits E(85289) NP_699172 (OMIM: 610872) E3 ubiquitin-protein liga ( 732) 4448 667.0 7.1e-191 XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 732) 4448 667.0 7.1e-191 NP_001287755 (OMIM: 610872) E3 ubiquitin-protein l ( 731) 4431 664.5 4e-190 XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 588) 3418 515.2 2.8e-145 NP_001120833 (OMIM: 610872) E3 ubiquitin-protein l ( 587) 3401 512.7 1.6e-144 XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 688) 3160 477.3 8.5e-134 XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96 XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96 NP_001267468 (OMIM: 607119) E3 ubiquitin-protein l ( 838) 2306 351.6 7e-96 NP_056250 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 2306 351.6 7e-96 XP_016868791 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96 NP_904355 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 2306 351.6 7e-96 XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 1907 292.8 3.3e-78 XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 1907 292.8 3.3e-78 XP_016868794 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 528) 1237 194.0 1.2e-48 XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 327 60.5 6.7e-08 XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 327 60.5 6.9e-08 XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 327 60.5 7.4e-08 NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens] (2517) 328 60.8 7.7e-08 XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 327 60.6 8e-08 XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 327 60.6 8.3e-08 XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 327 60.6 8.5e-08 XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08 XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08 XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08 NP_006453 (OMIM: 610924,615895) ranBP-type and C3H ( 468) 276 52.5 4.4e-06 NP_112506 (OMIM: 610924,615895) ranBP-type and C3H ( 510) 276 52.5 4.7e-06 XP_005260702 (OMIM: 610924,615895) PREDICTED: ranB ( 527) 276 52.5 4.9e-06 XP_011527440 (OMIM: 610924,615895) PREDICTED: ranB ( 551) 276 52.5 5e-06 XP_011527439 (OMIM: 610924,615895) PREDICTED: ranB ( 568) 276 52.5 5.1e-06 XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 465) 260 50.1 2.3e-05 XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 498) 260 50.1 2.4e-05 NP_005735 (OMIM: 605624) E3 ubiquitin-protein liga ( 557) 260 50.2 2.6e-05 XP_011531575 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 432) 247 48.2 8.1e-05 XP_016861024 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05 XP_011531572 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05 XP_011531573 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05 XP_016861023 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05 XP_016861022 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05 XP_011531570 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05 XP_011531567 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05 XP_011531569 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05 XP_011531568 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05 NP_001297261 (OMIM: 612487) E3 ubiquitin-protein l ( 921) 241 47.6 0.00026 NP_060469 (OMIM: 612487) E3 ubiquitin-protein liga (1072) 241 47.6 0.00029 NP_054643 (OMIM: 167000,211980,600116,602544,60757 ( 316) 221 44.2 0.00091 XP_016866398 (OMIM: 167000,211980,600116,602544,60 ( 385) 221 44.3 0.0011 NP_054642 (OMIM: 167000,211980,600116,602544,60757 ( 437) 221 44.3 0.0012 XP_011534165 (OMIM: 167000,211980,600116,602544,60 ( 464) 221 44.4 0.0012 NP_004553 (OMIM: 167000,211980,600116,602544,60757 ( 465) 221 44.4 0.0012 >>NP_699172 (OMIM: 610872) E3 ubiquitin-protein ligase R (732 aa) initn: 4448 init1: 4448 opt: 4448 Z-score: 3547.8 bits: 667.0 E(85289): 7.1e-191 Smith-Waterman score: 4730; 95.1% identity (95.1% similar) in 728 aa overlap (5-696:5-732) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: NP_699 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_699 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ 670 680 690 700 710 720 690 pF1KE4 TVLKPEGGEARV :::::::::::: NP_699 TVLKPEGGEARV 730 >>XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (732 aa) initn: 4448 init1: 4448 opt: 4448 Z-score: 3547.8 bits: 667.0 E(85289): 7.1e-191 Smith-Waterman score: 4730; 95.1% identity (95.1% similar) in 728 aa overlap (5-696:5-732) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY 550 560 570 580 590 600 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP 610 620 630 640 650 660 630 640 650 660 670 680 pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ 670 680 690 700 710 720 690 pF1KE4 TVLKPEGGEARV :::::::::::: XP_006 TVLKPEGGEARV 730 >>NP_001287755 (OMIM: 610872) E3 ubiquitin-protein ligas (731 aa) initn: 3505 init1: 3051 opt: 4431 Z-score: 3534.3 bits: 664.5 E(85289): 4e-190 Smith-Waterman score: 4719; 94.9% identity (94.9% similar) in 729 aa overlap (4-696:4-731) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: NP_001 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_001 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGP-DDIKPCPRCSAYIIKMNDG 250 260 270 280 290 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY 540 550 560 570 580 590 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP 600 610 620 630 640 650 630 640 650 660 670 680 pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ 660 670 680 690 700 710 690 pF1KE4 TVLKPEGGEARV :::::::::::: NP_001 TVLKPEGGEARV 720 730 >>XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (588 aa) initn: 3418 init1: 3418 opt: 3418 Z-score: 2729.3 bits: 515.2 E(85289): 2.8e-145 Smith-Waterman score: 3700; 93.8% identity (93.8% similar) in 578 aa overlap (5-546:5-582) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE 490 500 510 520 530 540 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::::::::::::::::::::::::::: XP_006 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRFSMIHA 550 560 570 580 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP >>NP_001120833 (OMIM: 610872) E3 ubiquitin-protein ligas (587 aa) initn: 2475 init1: 2021 opt: 3401 Z-score: 2715.8 bits: 512.7 E(85289): 1.6e-144 Smith-Waterman score: 3689; 93.6% identity (93.6% similar) in 579 aa overlap (4-546:4-581) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: NP_001 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_001 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGP-DDIKPCPRCSAYIIKMNDG 250 260 270 280 290 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 360 370 380 390 400 410 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 420 430 440 450 460 470 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE 480 490 500 510 520 530 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::::::::::::::::::::::::::: NP_001 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRFSMIHA 540 550 560 570 580 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP >>XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (688 aa) initn: 3144 init1: 3144 opt: 3160 Z-score: 2523.1 bits: 477.3 E(85289): 8.5e-134 Smith-Waterman score: 4358; 89.0% identity (89.0% similar) in 728 aa overlap (5-696:5-688) 10 20 30 40 50 60 pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA 10 20 30 40 50 60 70 80 pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP : ::::::::::::::::::::::: XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP 70 80 90 100 110 120 90 100 110 120 130 140 pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG 250 260 270 280 290 300 270 280 290 300 310 320 pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG 310 320 330 340 350 360 330 340 350 360 370 380 pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS 430 440 450 460 470 480 450 460 470 480 490 500 pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSR-- 490 500 510 520 530 510 520 530 540 550 560 pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY :::::::::::::::::: XP_006 ------------------------------------------ECNNMEIQVDIEAKPSHY 540 550 570 580 590 600 610 620 pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP 560 570 580 590 600 610 630 640 650 660 670 680 pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ 620 630 640 650 660 670 690 pF1KE4 TVLKPEGGEARV :::::::::::: XP_006 TVLKPEGGEARV 680 >>XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa) initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96 Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729) 10 20 pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR :::..: .: :. :: :. ... . XP_005 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK 10 20 30 40 50 60 30 40 50 60 70 pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG .::... :.: . ..: . .. :. . :. . ....: . XP_005 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE . .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.: XP_005 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC :.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.:::::::::: XP_005 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC :::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : :::::: XP_005 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT :::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.:::: XP_005 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT 370 380 390 400 410 420 380 390 400 410 420 pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD--- ::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::... XP_005 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN 430 440 450 460 470 480 430 440 450 460 470 480 pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL : :..:. .: .::::::.:. :::. ::.::: : ..... ::::: :: XP_005 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL 490 500 510 520 530 540 490 500 510 520 530 pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII .:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::. XP_005 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED .:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: : XP_005 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK 610 620 630 640 650 600 610 620 630 640 650 pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA . : : :: . .: :. ::: . . .:.: .: : . . XP_005 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS 660 670 680 690 700 710 660 670 680 690 pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV ::. : : :.:.. XP_005 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS 720 730 740 750 760 770 >>XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa) initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96 Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729) 10 20 pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR :::..: .: :. :: :. ... . XP_016 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK 10 20 30 40 50 60 30 40 50 60 70 pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG .::... :.: . ..: . .. :. . :. . ....: . XP_016 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE . .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.: XP_016 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC :.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.:::::::::: XP_016 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC :::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : :::::: XP_016 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT :::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.:::: XP_016 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT 370 380 390 400 410 420 380 390 400 410 420 pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD--- ::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::... XP_016 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN 430 440 450 460 470 480 430 440 450 460 470 480 pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL : :..:. .: .::::::.:. :::. ::.::: : ..... ::::: :: XP_016 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL 490 500 510 520 530 540 490 500 510 520 530 pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII .:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::. XP_016 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED .:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: : XP_016 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK 610 620 630 640 650 600 610 620 630 640 650 pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA . : : :: . .: :. ::: . . .:.: .: : . . XP_016 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS 660 670 680 690 700 710 660 670 680 690 pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV ::. : : :.:.. XP_016 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS 720 730 740 750 760 770 >>NP_001267468 (OMIM: 607119) E3 ubiquitin-protein ligas (838 aa) initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96 Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729) 10 20 pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR :::..: .: :. :: :. ... . NP_001 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK 10 20 30 40 50 60 30 40 50 60 70 pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG .::... :.: . ..: . .. :. . :. . ....: . NP_001 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE . .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.: NP_001 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC :.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.:::::::::: NP_001 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC :::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : :::::: NP_001 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT :::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.:::: NP_001 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT 370 380 390 400 410 420 380 390 400 410 420 pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD--- ::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::... NP_001 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN 430 440 450 460 470 480 430 440 450 460 470 480 pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL : :..:. .: .::::::.:. :::. ::.::: : ..... ::::: :: NP_001 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL 490 500 510 520 530 540 490 500 510 520 530 pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII .:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::. NP_001 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED .:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: : NP_001 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK 610 620 630 640 650 600 610 620 630 640 650 pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA . : : :: . .: :. ::: . . .:.: .: : . . NP_001 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS 660 670 680 690 700 710 660 670 680 690 pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV ::. : : :.:.. NP_001 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS 720 730 740 750 760 770 >>NP_056250 (OMIM: 607119) E3 ubiquitin-protein ligase R (838 aa) initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96 Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729) 10 20 pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR :::..: .: :. :: :. ... . NP_056 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK 10 20 30 40 50 60 30 40 50 60 70 pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG .::... :.: . ..: . .. :. . :. . ....: . NP_056 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE . .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.: NP_056 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC :.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.:::::::::: NP_056 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC :::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : :::::: NP_056 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT :::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.:::: NP_056 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT 370 380 390 400 410 420 380 390 400 410 420 pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD--- ::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::... NP_056 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN 430 440 450 460 470 480 430 440 450 460 470 480 pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL : :..:. .: .::::::.:. :::. ::.::: : ..... ::::: :: NP_056 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL 490 500 510 520 530 540 490 500 510 520 530 pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII .:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::. NP_056 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL 550 560 570 580 590 600 540 550 560 570 580 590 pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED .:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: : NP_056 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK 610 620 630 640 650 600 610 620 630 640 650 pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA . : : :: . .: :. ::: . . .:.: .: : . . NP_056 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS 660 670 680 690 700 710 660 670 680 690 pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV ::. : : :.:.. NP_056 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS 720 730 740 750 760 770 696 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:13:29 2016 done: Mon Nov 7 17:13:30 2016 Total Scan time: 10.190 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]