FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4002, 203 aa 1>>>pF1KE4002 203 - 203 aa - 203 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0378+/-0.000438; mu= 14.9310+/- 0.027 mean_var=82.9355+/-18.096, 0's: 0 Z-trim(112.6): 166 B-trim: 1321 in 2/47 Lambda= 0.140833 statistics sampled from 21326 (21577) to 21326 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.253), width: 16 Scan time: 4.690 The best scores are: opt bits E(85289) NP_201572 (OMIM: 612128) ras-like protein family m ( 203) 1392 292.5 3.1e-79 XP_016880790 (OMIM: 612128) PREDICTED: ras-like pr ( 203) 1392 292.5 3.1e-79 XP_016880789 (OMIM: 612128) PREDICTED: ras-like pr ( 211) 988 210.4 1.6e-54 NP_006468 (OMIM: 602220) ras-like protein family m ( 203) 680 147.8 1.1e-35 XP_011528125 (OMIM: 602220) PREDICTED: ras-like pr ( 155) 501 111.4 8.1e-25 XP_011528123 (OMIM: 602220) PREDICTED: ras-like pr ( 223) 501 111.5 1e-24 XP_011528124 (OMIM: 602220) PREDICTED: ras-like pr ( 223) 501 111.5 1e-24 NP_996563 (OMIM: 612403) ras-like protein family m ( 242) 227 55.9 6.4e-08 XP_016883322 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 212 52.9 6.2e-07 XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 212 52.9 6.2e-07 NP_076429 (OMIM: 612404) ras-like protein family m ( 248) 209 52.2 8.2e-07 XP_011527097 (OMIM: 610388) PREDICTED: GTP-binding ( 304) 203 51.1 2.2e-06 NP_001238847 (OMIM: 179530) ras-related protein Ra ( 142) 186 47.3 1.4e-05 NP_001238846 (OMIM: 179530) ras-related protein Ra ( 142) 186 47.3 1.4e-05 NP_001238850 (OMIM: 179530) ras-related protein Ra ( 165) 186 47.4 1.6e-05 XP_011514759 (OMIM: 601293) PREDICTED: GTP-binding ( 173) 186 47.4 1.6e-05 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 186 47.4 1.7e-05 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 186 47.4 1.7e-05 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 184 47.0 2.2e-05 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 184 47.0 2.2e-05 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 184 47.0 2.2e-05 XP_011528342 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05 XP_005261499 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05 XP_016884191 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05 NP_055125 (OMIM: 612842) GTP-binding protein Rhes ( 266) 183 47.0 3.3e-05 XP_016884190 (OMIM: 612842) PREDICTED: GTP-binding ( 278) 183 47.0 3.4e-05 NP_001318055 (OMIM: 612403) ras-like protein famil ( 200) 173 44.8 0.00011 NP_001122322 (OMIM: 179503) GTP-binding protein RA ( 308) 173 45.0 0.00015 NP_004156 (OMIM: 179503) GTP-binding protein RAD [ ( 308) 173 45.0 0.00015 NP_057168 (OMIM: 605550) dexamethasone-induced Ras ( 281) 172 44.8 0.00016 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 168 43.8 0.00022 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 168 43.8 0.00022 NP_001096139 (OMIM: 600098) ras-related protein R- ( 127) 164 42.8 0.00029 NP_001170786 (OMIM: 600098) ras-related protein R- ( 127) 164 42.8 0.00029 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 165 43.2 0.00032 XP_011509876 (OMIM: 179551) PREDICTED: ras-related ( 195) 165 43.2 0.00034 NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 164 42.9 0.00035 XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 164 42.9 0.00037 XP_016857447 (OMIM: 179510) PREDICTED: ras-related ( 219) 162 42.6 0.00056 NP_002858 (OMIM: 179510) ras-related protein Rab-3 ( 219) 162 42.6 0.00056 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 159 42.0 0.00085 NP_005252 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 158 41.9 0.0012 NP_859053 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 158 41.9 0.0012 NP_055814 (OMIM: 612398) ras-related protein Rab-2 ( 225) 156 41.4 0.0013 NP_112586 (OMIM: 605950,615222) ras-related protei ( 229) 155 41.2 0.0016 XP_011530601 (OMIM: 605950,615222) PREDICTED: ras- ( 277) 155 41.3 0.0018 NP_001138399 (OMIM: 604497) NF-kappa-B inhibitor-i ( 191) 150 40.1 0.0028 >>NP_201572 (OMIM: 612128) ras-like protein family membe (203 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1543.4 bits: 292.5 E(85289): 3.1e-79 Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_201 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA 130 140 150 160 170 180 190 200 pF1KE4 RCKHVHAALRFQGALRRNRCAIM ::::::::::::::::::::::: NP_201 RCKHVHAALRFQGALRRNRCAIM 190 200 >>XP_016880790 (OMIM: 612128) PREDICTED: ras-like protei (203 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1543.4 bits: 292.5 E(85289): 3.1e-79 Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA 130 140 150 160 170 180 190 200 pF1KE4 RCKHVHAALRFQGALRRNRCAIM ::::::::::::::::::::::: XP_016 RCKHVHAALRFQGALRRNRCAIM 190 200 >>XP_016880789 (OMIM: 612128) PREDICTED: ras-like protei (211 aa) initn: 1007 init1: 988 opt: 988 Z-score: 1099.6 bits: 210.4 E(85289): 1.6e-54 Smith-Waterman score: 988; 99.3% identity (100.0% similar) in 147 aa overlap (1-147:60-206) 10 20 30 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFS :::::::::::::::::::::::::::::: XP_016 TVAEPPAPGICSPGEPQTAARTRWRSGAGGMVSTYRVAVLGARGVGKSAIVRQFLYNEFS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KE4 EVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYIL 90 100 110 120 130 140 100 110 120 130 140 150 pF1KE4 VYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 VYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLILAA 150 160 170 180 190 200 160 170 180 190 200 pF1KE4 WKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM XP_016 SL 210 >>NP_006468 (OMIM: 602220) ras-like protein family membe (203 aa) initn: 619 init1: 426 opt: 680 Z-score: 761.6 bits: 147.8 E(85289): 1.1e-35 Smith-Waterman score: 680; 52.9% identity (74.5% similar) in 208 aa overlap (1-203:1-203) 10 20 30 40 50 60 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF : .. ::::::: ::::.::.::::.... : :: . ::: :::...: :.::.: : NP_006 MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDGPRLYRPAVLLDGAVYDLSIRDG 10 20 30 40 50 60 70 80 90 100 110 pF1KE4 P---PISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIG : :. : . .:: :. .:... :..:::::: :::.:::..::.: ::: : NP_006 DVAGPGSS-PGGP-EEWPDAKDWSLQDTDAFVLVYDICSPDSFDYVKALRQRIAETRPAG 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 TSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSV . :.::..:::::: :: : :: .. :::. :.:::.:::::::::.: :: :::. NP_006 APEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAKYNWHVLRLFRELLR-- 120 130 140 150 160 170 180 190 200 pF1KE4 GCA--RCKHVHAALRFQGALRRNRCAIM :: : . .: :::.::::. ::..: NP_006 -CALVRARPAHPALRLQGALHPARCSLM 180 190 200 >>XP_011528125 (OMIM: 602220) PREDICTED: ras-like protei (155 aa) initn: 495 init1: 426 opt: 501 Z-score: 566.6 bits: 111.4 E(85289): 8.1e-25 Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:25-155) 50 60 70 80 90 100 pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE .:: :. .:... :..:::::: :::. XP_011 MRMSKDPLHPKHVSCGGSLHSWVQEEWPDAKDWSLQDTDAFVLVYDICSPDSFD 10 20 30 40 50 110 120 130 140 150 160 pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK :::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.::::: XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK 60 70 80 90 100 110 170 180 190 200 pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM ::::.: :: :::. :: : . .: :::.::::. ::..: XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM 120 130 140 150 >>XP_011528123 (OMIM: 602220) PREDICTED: ras-like protei (223 aa) initn: 496 init1: 426 opt: 501 Z-score: 564.5 bits: 111.5 E(85289): 1e-24 Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:93-223) 50 60 70 80 90 100 pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE .:: :. .:... :..:::::: :::. XP_011 GASSVWKSGRGSGWEGASILERVRGAGHAEEEWPDAKDWSLQDTDAFVLVYDICSPDSFD 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK :::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.::::: XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK 130 140 150 160 170 180 170 180 190 200 pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM ::::.: :: :::. :: : . .: :::.::::. ::..: XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM 190 200 210 220 >>XP_011528124 (OMIM: 602220) PREDICTED: ras-like protei (223 aa) initn: 496 init1: 426 opt: 501 Z-score: 564.5 bits: 111.5 E(85289): 1e-24 Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:93-223) 50 60 70 80 90 100 pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE .:: :. .:... :..:::::: :::. XP_011 GASSVWKSGRGSGWEGASILERVRGAGHAEEEWPDAKDWSLQDTDAFVLVYDICSPDSFD 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK :::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.::::: XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK 130 140 150 160 170 180 170 180 190 200 pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM ::::.: :: :::. :: : . .: :::.::::. ::..: XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM 190 200 210 220 >>NP_996563 (OMIM: 612403) ras-like protein family membe (242 aa) initn: 201 init1: 74 opt: 227 Z-score: 263.2 bits: 55.9 E(85289): 6.4e-08 Smith-Waterman score: 227; 31.2% identity (63.6% similar) in 173 aa overlap (6-177:29-196) 10 20 30 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTT ..::::: :::::.. .:: ..: :.: NP_996 MRPLSMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGRVGKSAMIVRFLTKRFIGDYEPNT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE4 ARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCF .. :: : ..: .::: : : . ..: . .:. . .. .....:::.: . NP_996 GK-LYSRLVYVEGDQLSLQIQDTPGGVQIQ-DSLPQVVDSLSKCVQWAEGFLLVYSITDY 70 80 90 100 110 100 110 120 130 140 150 pF1KE4 DSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVE ::. .. . :.: .: :..:.:::::: :: ..: . . .:. . . ..: NP_996 DSYLSIRPLYQHI--RKVHPDSKAPVIIVGNKGDLLHARQVQTQDGIQLANELGSL-FLE 120 130 140 150 160 170 160 170 180 190 200 pF1KE4 CSAKYNWH-ILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM :.. :.. . .:..: : : NP_996 ISTSENYEDVCDVFQHLCKEVSKMHGLSGERRRASIIPRPRSPNMQDLKRRFKQALSPKV 180 190 200 210 220 230 >>XP_016883322 (OMIM: 610388) PREDICTED: GTP-binding pro (306 aa) initn: 169 init1: 70 opt: 212 Z-score: 245.5 bits: 52.9 E(85289): 6.2e-07 Smith-Waterman score: 212; 26.9% identity (60.7% similar) in 201 aa overlap (5-197:81-268) 10 20 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQF-------LYN :::..:: ::::.... : :.. XP_016 SLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHE 60 70 80 90 100 110 30 40 50 60 70 80 pF1KE4 EFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQE-WADTCCRGLRSVH .... .:..:. .: .....:. : ..: .. .. :.. :.. : :.. XP_016 QLGDPALPSVAEDVYERTLTVDGEDTTLVVVD-----TWEAEKLDKSWSQESC--LQGGS 120 130 140 150 160 90 100 110 120 130 140 pF1KE4 AYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHL ::..::.: ::: .. .: :. :. ....:::.:::: :: : : . . .. XP_016 AYVIVYSIADRGSFESASELRIQL--RRTHQADHVPIILVGNKADLARCREVSVEE-GRA 170 180 190 200 210 220 150 160 170 180 190 200 pF1KE4 VRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM .. : ..: :: . .. :: ..... : .. .: . : :: XP_016 CAVVFDCKFIETSATLQHNVAELFEGVVRQL---RLRRRDSAAKEPPAPRRPASLAQRAR 230 240 250 260 270 XP_016 RFLARLTARSARRRALKARSKSCHNLAVL 280 290 300 >>XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding pro (306 aa) initn: 169 init1: 70 opt: 212 Z-score: 245.5 bits: 52.9 E(85289): 6.2e-07 Smith-Waterman score: 212; 26.9% identity (60.7% similar) in 201 aa overlap (5-197:81-268) 10 20 pF1KE4 MVSTYRVAVLGARGVGKSAIVRQF-------LYN :::..:: ::::.... : :.. XP_005 SLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHE 60 70 80 90 100 110 30 40 50 60 70 80 pF1KE4 EFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQE-WADTCCRGLRSVH .... .:..:. .: .....:. : ..: .. .. :.. :.. : :.. XP_005 QLGDPALPSVAEDVYERTLTVDGEDTTLVVVD-----TWEAEKLDKSWSQESC--LQGGS 120 130 140 150 160 90 100 110 120 130 140 pF1KE4 AYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHL ::..::.: ::: .. .: :. :. ....:::.:::: :: : : . . .. XP_005 AYVIVYSIADRGSFESASELRIQL--RRTHQADHVPIILVGNKADLARCREVSVEE-GRA 170 180 190 200 210 220 150 160 170 180 190 200 pF1KE4 VRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM .. : ..: :: . .. :: ..... : .. .: . : :: XP_005 CAVVFDCKFIETSATLQHNVAELFEGVVRQL---RLRRRDSAAKEPPAPRRPASLAQRAR 230 240 250 260 270 XP_005 RFLARLTARSARRRALKARSKSCHNLAVL 280 290 300 203 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:39:41 2016 done: Mon Nov 7 16:39:41 2016 Total Scan time: 4.690 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]