FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6536, 390 aa 1>>>pF1KB6536 390 - 390 aa - 390 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9662+/-0.000479; mu= 14.6125+/- 0.030 mean_var=140.1128+/-36.628, 0's: 0 Z-trim(111.3): 525 B-trim: 1110 in 1/49 Lambda= 0.108352 statistics sampled from 19166 (19827) to 19166 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.57), E-opt: 0.2 (0.232), width: 16 Scan time: 8.190 The best scores are: opt bits E(85289) NP_067637 (OMIM: 606792) histamine H4 receptor iso ( 390) 2584 416.2 6.5e-116 NP_001137300 (OMIM: 606792) histamine H4 receptor ( 302) 1612 264.2 3e-70 XP_011524435 (OMIM: 606792) PREDICTED: histamine H ( 127) 766 131.5 1.1e-30 NP_009163 (OMIM: 604525) histamine H3 receptor [Ho ( 445) 635 111.6 3.7e-24 XP_005260323 (OMIM: 604525) PREDICTED: histamine H ( 453) 635 111.6 3.7e-24 XP_016883112 (OMIM: 604525) PREDICTED: histamine H ( 399) 421 78.1 4e-14 NP_001153638 (OMIM: 606792) histamine H4 receptor ( 67) 407 75.0 5.8e-14 XP_016855649 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855645 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_005273089 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855648 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855643 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855647 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855651 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 NP_000731 (OMIM: 100100,118494) muscarinic acetylc ( 590) 417 77.7 8e-14 XP_016855644 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542343 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855641 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542345 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542347 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855652 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542346 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855642 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855650 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011542348 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_016855646 (OMIM: 100100,118494) PREDICTED: musc ( 590) 417 77.7 8e-14 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 416 77.5 8.6e-14 NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 379 71.7 4.6e-12 NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 379 71.7 4.6e-12 NP_001006632 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 NP_001006627 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 NP_001006633 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 NP_001006628 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 NP_001006631 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 NP_001006630 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 XP_011514071 (OMIM: 118493) PREDICTED: muscarinic ( 466) 369 70.1 1.2e-11 NP_000730 (OMIM: 118493) muscarinic acetylcholine ( 466) 369 70.1 1.2e-11 NP_001006629 (OMIM: 118493) muscarinic acetylcholi ( 466) 369 70.1 1.2e-11 XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 353 67.6 7e-11 NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 353 67.6 7e-11 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 331 64.0 6.1e-10 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 331 64.0 6.1e-10 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 331 64.0 6.5e-10 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 333 64.5 6.6e-10 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 331 64.0 6.8e-10 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 331 64.1 7e-10 NP_000732 (OMIM: 118495) muscarinic acetylcholine ( 479) 332 64.3 7e-10 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 324 63.0 1.6e-09 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 324 63.0 1.6e-09 >>NP_067637 (OMIM: 606792) histamine H4 receptor isoform (390 aa) initn: 2584 init1: 2584 opt: 2584 Z-score: 2202.0 bits: 416.2 E(85289): 6.5e-116 Smith-Waterman score: 2584; 100.0% identity (100.0% similar) in 390 aa overlap (1-390:1-390) 10 20 30 40 50 60 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 310 320 330 340 350 360 370 380 390 pF1KB6 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS :::::::::::::::::::::::::::::: NP_067 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 370 380 390 >>NP_001137300 (OMIM: 606792) histamine H4 receptor isof (302 aa) initn: 1612 init1: 1612 opt: 1612 Z-score: 1382.1 bits: 264.2 E(85289): 3e-70 Smith-Waterman score: 1816; 77.4% identity (77.4% similar) in 390 aa overlap (1-390:1-302) 10 20 30 40 50 60 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV :::: NP_001 DFFV-------------------------------------------------------- 130 140 150 160 170 180 pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF :::::::::::::::::::::::::::: NP_001 --------------------------------VSESWKDEGSECEPGFFSEWYILAITSF 70 80 90 190 200 210 220 230 240 pF1KB6 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB6 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB6 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL 220 230 240 250 260 270 370 380 390 pF1KB6 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS :::::::::::::::::::::::::::::: NP_001 CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS 280 290 300 >>XP_011524435 (OMIM: 606792) PREDICTED: histamine H4 re (127 aa) initn: 766 init1: 766 opt: 766 Z-score: 671.7 bits: 131.5 E(85289): 1.1e-30 Smith-Waterman score: 766; 100.0% identity (100.0% similar) in 119 aa overlap (1-119:1-119) 10 20 30 40 50 60 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF XP_011 HMDDLKF >>NP_009163 (OMIM: 604525) histamine H3 receptor [Homo s (445 aa) initn: 961 init1: 312 opt: 635 Z-score: 554.8 bits: 111.6 E(85289): 3.7e-24 Smith-Waterman score: 896; 39.5% identity (63.6% similar) in 423 aa overlap (10-382:29-439) 10 20 30 40 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFV .: . ..:: .:.:. : .::::::.:::: NP_009 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 VDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTA .:..:: ....:.::::::::.::.. ::::.:..: .: ::. .: .::..::::::. NP_009 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS 70 80 90 100 110 120 110 120 130 140 150 pF1KB6 SVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK-- :..:::::::::.:::. :::::.:. . . : :. :::::::. :: :: ::. NP_009 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYL 130 140 150 160 170 160 170 180 190 pF1KB6 DEGS-----ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIY--------------- . :: .: :: .::.: .: ::: : . :..::..:: NP_009 SGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAR 180 190 200 210 220 230 200 210 220 230 pF1KB6 ---------------------WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSS :. :.. : : : .::... :.. : .. NP_009 EAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGG 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE :... : .: :. .: :: .:. . .: .. ..: ::: . :: . NP_009 GGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FR 300 310 320 330 340 300 310 320 330 340 350 pF1KB6 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN : : :..:::::.....:..:::::.:. :. . . : . ::. .::: : :: :: NP_009 LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVN 350 360 370 380 390 400 360 370 380 390 pF1KB6 PLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRSVSS :.::::::. :..:: :..: .: :: : NP_009 PVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK 410 420 430 440 >>XP_005260323 (OMIM: 604525) PREDICTED: histamine H3 re (453 aa) initn: 961 init1: 312 opt: 635 Z-score: 554.7 bits: 111.6 E(85289): 3.7e-24 Smith-Waterman score: 896; 39.5% identity (63.6% similar) in 423 aa overlap (10-382:29-439) 10 20 30 40 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFV .: . ..:: .:.:. : .::::::.:::: XP_005 MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 VDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLF-EWDFGKEICVFWLTTDYLLCTA .:..:: ....:.::::::::.::.. ::::.:..: .: ::. .: .::..::::::. XP_005 ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS 70 80 90 100 110 120 110 120 130 140 150 pF1KB6 SVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK-- :..:::::::::.:::. :::::.:. . . : :. :::::::. :: :: ::. XP_005 SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYL 130 140 150 160 170 160 170 180 190 pF1KB6 DEGS-----ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIY--------------- . :: .: :: .::.: .: ::: : . :..::..:: XP_005 SGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAR 180 190 200 210 220 230 200 210 220 230 pF1KB6 ---------------------WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSS :. :.. : : : .::... :.. : .. XP_005 EAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGG 240 250 260 270 280 290 240 250 260 270 280 290 pF1KB6 RRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVE :... : .: :. .: :: .:. . .: .. ..: ::: . :: . XP_005 GGSVASPTSSSGS-SSRGTERPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FR 300 310 320 330 340 300 310 320 330 340 350 pF1KB6 LLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVN : : :..:::::.....:..:::::.:. :. . . : . ::. .::: : :: :: XP_005 LSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVN 350 360 370 380 390 400 360 370 380 390 pF1KB6 PLLYPLCHKRFQKAFLKIFCIKK---QPLPSQHSRSVSS :.::::::. :..:: :..: .: :: : XP_005 PVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWKKMKKKTCL 410 420 430 440 450 >>XP_016883112 (OMIM: 604525) PREDICTED: histamine H3 re (399 aa) initn: 905 init1: 312 opt: 421 Z-score: 374.5 bits: 78.1 E(85289): 4e-14 Smith-Waterman score: 817; 38.5% identity (61.0% similar) in 410 aa overlap (22-382:1-385) 10 20 30 40 50 60 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS :.:. : .::::::.::::.:..:: ....:.:::::: XP_016 MALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAIS 10 20 30 70 80 90 100 110 120 pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV ::.:: .: ::. .: .::..::::::.:..:::::::::.:::. :: XP_016 DFLVG-------------RWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAV 40 50 60 70 80 130 140 150 160 170 pF1KB6 SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWK--DEGS-----ECEPGFFSEWY :::.:. . . : :. :::::::. :: :: ::. . :: .: :: .:: XP_016 SYRAQQGDTRRAVRKMLLVWVLAFLLYGPAIL---SWEYLSGGSSIPEGHCYAEFFYNWY 90 100 110 120 130 140 180 190 pF1KB6 ILAITSFLEFVIPVILVAYFNMNIY----------------------------------- .: .: ::: : . :..::..:: XP_016 FLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPG 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB6 -WSLWKRDHLSRCQSHP---GLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQR :. :.. : : : .::... :.. : .. :... : .: :. . XP_016 CWGCWQKGHGEAMPLHRYGVGEAAVGAEA-GEATLGGGGGGGSVASPTSSSGS-SSRGTE 210 220 230 240 250 260 260 270 280 290 300 310 pF1KB6 RKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAV : :: .:. . .: .. ..: ::: . :: .: : :..:::::.....:.. XP_016 RPRSLKRGSKPSASSASLEKRMKMVSQS----FTQR--FRLSRDRKVAKSLAVIVSIFGL 270 280 290 300 310 320 330 340 350 360 370 pF1KB6 CWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFC :::::.:. :. . . : . ::. .::: : :: :::.::::::. :..:: :..: XP_016 CWAPYTLLMIIRAACHGHCVP-DYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLC 320 330 340 350 360 370 380 390 pF1KB6 IKK---QPLPSQHSRSVSS .: :: : XP_016 PQKLKIQPHSSLEHCWKKMKKKTCL 380 390 >>NP_001153638 (OMIM: 606792) histamine H4 receptor isof (67 aa) initn: 407 init1: 407 opt: 407 Z-score: 371.7 bits: 75.0 E(85289): 5.8e-14 Smith-Waterman score: 407; 98.5% identity (100.0% similar) in 67 aa overlap (1-67:1-67) 10 20 30 40 50 60 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV ::::::. NP_001 DFFVGVL >>XP_016855649 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa) initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14 Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336) 10 20 30 40 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN : .::. ...:.. ..:: :::..: :.:. XP_016 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN :. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.: XP_016 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS- ...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . . XP_016 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV 160 170 180 190 200 210 170 180 190 200 210 pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV :: :.:: : :.. : .:: ... .:: ..:. . .: . :: : XP_016 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM ... ..: .: :: : : :. . .. .::: . . :.... :. .. XP_016 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ- 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK . :.::: XP_016 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN 330 340 350 360 370 380 >-- initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05 Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578) 210 220 230 240 250 260 pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM .:....:.. . : :: . . .:.. XP_016 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD 380 390 400 410 420 430 270 280 290 300 pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL .. . .::. . :. ::... ::. .:... :.. .. :..:. . XP_016 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI 440 450 460 470 480 490 310 320 330 340 350 360 pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA : .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. . XP_016 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT 500 510 520 530 540 550 370 380 390 pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS : .. : ::. .:... : XP_016 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 560 570 580 590 >>XP_016855645 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa) initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14 Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336) 10 20 30 40 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN : .::. ...:.. ..:: :::..: :.:. XP_016 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN :. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.: XP_016 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS- ...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . . XP_016 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV 160 170 180 190 200 210 170 180 190 200 210 pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV :: :.:: : :.. : .:: ... .:: ..:. . .: . :: : XP_016 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM ... ..: .: :: : : :. . .. .::: . . :.... :. .. XP_016 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ- 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK . :.::: XP_016 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN 330 340 350 360 370 380 >-- initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05 Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578) 210 220 230 240 250 260 pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM .:....:.. . : :: . . .:.. XP_016 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD 380 390 400 410 420 430 270 280 290 300 pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL .. . .::. . :. ::... ::. .:... :.. .. :..:. . XP_016 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI 440 450 460 470 480 490 310 320 330 340 350 360 pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA : .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. . XP_016 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT 500 510 520 530 540 550 370 380 390 pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS : .. : ::. .:... : XP_016 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 560 570 580 590 >>XP_005273089 (OMIM: 100100,118494) PREDICTED: muscarin (590 aa) initn: 449 init1: 162 opt: 417 Z-score: 369.2 bits: 77.7 E(85289): 8e-14 Smith-Waterman score: 417; 30.6% identity (65.5% similar) in 278 aa overlap (16-284:69-336) 10 20 30 40 pF1KB6 MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKN : .::. ...:.. ..:: :::..: :.:. XP_005 SYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQ 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB6 LRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFE-WDFGKEICVFWLTTDYLLCTASVYN :. ..::.:.:: .:...::::. :. . ... : .:. : .::. ::. .:::.: XP_005 LKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMN 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB6 IVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAV-WVLAFLVNGPMILVSESWKDEGS- ...::.:::.:.. ..::...: : . .:... ::..:.. .: :: . . . . XP_005 LLVISFDRYFSITRPLTYRAKRT--TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV 160 170 180 190 200 210 170 180 190 200 210 pF1KB6 ---ECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAV :: :.:: : :.. : .:: ... .:: ..:. . .: . :: : XP_005 PPGECFIQFLSEPTITFGTAIAAFYMPVTIMTI----LYWRIYKETE-KRTKELAGLQAS 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 SSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSS---LMFSSRTKMNSNTIASKM ... ..: .: :: : : :. . .. .::: . . :.... :. .. XP_005 GTEAETENFVHPTGSSRSCS-SYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQ- 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 GSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPK . :.::: XP_005 -DHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDN 330 340 350 360 370 380 >-- initn: 153 init1: 105 opt: 224 Z-score: 206.1 bits: 47.5 E(85289): 9.7e-05 Smith-Waterman score: 224; 26.4% identity (62.6% similar) in 174 aa overlap (231-389:407-578) 210 220 230 240 250 260 pF1KB6 LWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLM .:....:.. . : :: . . .:.. XP_005 ILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVD 380 390 400 410 420 430 270 280 290 300 pF1KB6 FSSRTKMNSN---TIASKMGSFSQSD---SVALH------QREHVELLRARRLAKSLAIL .. . .::. . :. ::... ::. .:... :.. .. :..:. . XP_005 TAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAI 440 450 460 470 480 490 310 320 330 340 350 360 pF1KB6 LGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKA : .: . :.::.....: .: .: ::. : ...:: ..:: :::. : ::.: :. . XP_005 LLAFIITWTPYNIMVLVNTFCDSCI-PKTFW-NLGYWLCYINSTVNPVCYALCNKTFRTT 500 510 520 530 540 550 370 380 390 pF1KB6 FLKIF---CIKKQPLPSQHSRSVSS : .. : ::. .:... : XP_005 FKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 560 570 580 590 390 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:00:57 2016 done: Mon Nov 7 16:00:58 2016 Total Scan time: 8.190 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]