Result of FASTA (omim) for
pFN21AE2408
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2408, 2168 aa
1>>>pF1KE2408 2168 - 2168 aa - 2168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.7365+/-0.000569; mu= -19.8859+/- 0.036
mean_var=580.3311+/-118.454, 0's: 0 Z-trim(121.2): 118 B-trim: 0 in 0/52
Lambda= 0.053240
statistics sampled from 37229 (37357) to 37229 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.438), width: 16
Scan time: 24.630
The best scores are: opt bits E(85289)
NP_038478 (OMIM: 605683) bromodomain adjacent to z (2168) 14213 1108.7 0
XP_011509341 (OMIM: 605683) PREDICTED: bromodomain (2231) 12317 963.1 0
NP_001276904 (OMIM: 605683) bromodomain adjacent t (2132) 8992 707.7 3.7e-202
XP_011509344 (OMIM: 605683) PREDICTED: bromodomain (2207) 8229 649.1 1.6e-184
XP_011509353 (OMIM: 605683) PREDICTED: bromodomain (2141) 7994 631.0 4.4e-179
NP_001316787 (OMIM: 605683) bromodomain adjacent t (2143) 7986 630.4 6.7e-179
XP_011509345 (OMIM: 605683) PREDICTED: bromodomain (2197) 7096 562.1 2.6e-158
XP_016859412 (OMIM: 605683) PREDICTED: bromodomain (2212) 6655 528.2 4.1e-148
XP_011509340 (OMIM: 605683) PREDICTED: bromodomain (2240) 6655 528.2 4.1e-148
XP_011509356 (OMIM: 605683) PREDICTED: bromodomain (1976) 6629 526.2 1.5e-147
XP_011509355 (OMIM: 605683) PREDICTED: bromodomain (2036) 6629 526.2 1.5e-147
XP_005246546 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859407 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859409 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_016859408 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_006712524 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
XP_005246545 (OMIM: 605683) PREDICTED: bromodomain (2242) 6629 526.2 1.6e-147
NP_001316786 (OMIM: 605683) bromodomain adjacent t (2149) 6350 504.8 4.5e-141
XP_016859415 (OMIM: 605683) PREDICTED: bromodomain (2175) 6350 504.8 4.5e-141
XP_005246549 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_016859411 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_016859410 (OMIM: 605683) PREDICTED: bromodomain (2240) 6343 504.2 6.7e-141
XP_011509347 (OMIM: 605683) PREDICTED: bromodomain (2177) 6325 502.8 1.7e-140
XP_011509350 (OMIM: 605683) PREDICTED: bromodomain (2179) 6325 502.8 1.7e-140
XP_011509349 (OMIM: 605683) PREDICTED: bromodomain (2179) 6325 502.8 1.7e-140
XP_016859413 (OMIM: 605683) PREDICTED: bromodomain (2206) 6154 489.7 1.6e-136
XP_016859414 (OMIM: 605683) PREDICTED: bromodomain (2208) 6148 489.2 2.2e-136
XP_016859421 (OMIM: 605683) PREDICTED: bromodomain (2113) 6090 484.8 4.6e-135
XP_011509346 (OMIM: 605683) PREDICTED: bromodomain (2178) 6090 484.8 4.7e-135
XP_011509358 (OMIM: 605683) PREDICTED: bromodomain (1426) 5998 477.6 4.5e-133
XP_016859424 (OMIM: 605683) PREDICTED: bromodomain (2047) 5998 477.7 6e-133
XP_016859423 (OMIM: 605683) PREDICTED: bromodomain (2079) 5998 477.7 6e-133
XP_016859422 (OMIM: 605683) PREDICTED: bromodomain (2081) 5998 477.7 6e-133
XP_011509354 (OMIM: 605683) PREDICTED: bromodomain (2110) 5998 477.7 6.1e-133
XP_011509352 (OMIM: 605683) PREDICTED: bromodomain (2142) 5998 477.7 6.2e-133
XP_016859417 (OMIM: 605683) PREDICTED: bromodomain (2144) 5998 477.7 6.2e-133
XP_016859425 (OMIM: 605683) PREDICTED: bromodomain (2015) 5965 475.2 3.4e-132
XP_016859420 (OMIM: 605683) PREDICTED: bromodomain (2140) 5965 475.2 3.6e-132
XP_016859419 (OMIM: 605683) PREDICTED: bromodomain (2142) 5965 475.2 3.6e-132
XP_016859426 (OMIM: 605683) PREDICTED: bromodomain (1317) 5934 472.6 1.3e-131
XP_011536111 (OMIM: 605682) PREDICTED: bromodomain (1362) 904 86.3 2.6e-15
XP_016874231 (OMIM: 605682) PREDICTED: bromodomain (1873) 904 86.4 3.4e-15
XP_011536101 (OMIM: 605682) PREDICTED: bromodomain (1882) 904 86.4 3.4e-15
NP_001287834 (OMIM: 605682) bromodomain adjacent t (1903) 904 86.4 3.4e-15
XP_011536100 (OMIM: 605682) PREDICTED: bromodomain (1904) 904 86.4 3.4e-15
NP_038477 (OMIM: 605682) bromodomain adjacent to z (1905) 904 86.4 3.4e-15
XP_016874230 (OMIM: 605682) PREDICTED: bromodomain (1910) 904 86.4 3.4e-15
XP_011536108 (OMIM: 605682) PREDICTED: bromodomain (1910) 904 86.4 3.4e-15
XP_011536105 (OMIM: 605682) PREDICTED: bromodomain (1910) 904 86.4 3.4e-15
XP_016874229 (OMIM: 605682) PREDICTED: bromodomain (1910) 904 86.4 3.4e-15
>>NP_038478 (OMIM: 605683) bromodomain adjacent to zinc (2168 aa)
initn: 14213 init1: 14213 opt: 14213 Z-score: 5917.6 bits: 1108.7 E(85289): 0
Smith-Waterman score: 14213; 100.0% identity (100.0% similar) in 2168 aa overlap (1-2168:1-2168)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE2 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE2 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE2 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE2 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_038 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
2110 2120 2130 2140 2150 2160
pF1KE2 WTDTFKVS
::::::::
NP_038 WTDTFKVS
>>XP_011509341 (OMIM: 605683) PREDICTED: bromodomain adj (2231 aa)
initn: 14189 init1: 12317 opt: 12317 Z-score: 5130.4 bits: 963.1 E(85289): 0
Smith-Waterman score: 14117; 98.4% identity (98.4% similar) in 2200 aa overlap (1-2165:1-2200)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
1810 1820 1830 1840 1850 1860
1870 1880
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERR---------------------------------
:::::::::::::::::::::::::::
XP_011 ALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSVSGDG
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930 1940
pF1KE2 --IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
1930 1940 1950 1960 1970 1980
1950 1960 1970 1980 1990 2000
pF1KE2 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
1990 2000 2010 2020 2030 2040
2010 2020 2030 2040 2050 2060
pF1KE2 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
2050 2060 2070 2080 2090 2100
2070 2080 2090 2100 2110 2120
pF1KE2 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
2110 2120 2130 2140 2150 2160
2130 2140 2150 2160
pF1KE2 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
::::::::::::::::::::::::::::::::::::::::
XP_011 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSY
2170 2180 2190 2200 2210 2220
XP_011 HQLTSPVPEAS
2230
>>NP_001276904 (OMIM: 605683) bromodomain adjacent to zi (2132 aa)
initn: 9955 init1: 8903 opt: 8992 Z-score: 3750.5 bits: 707.7 E(85289): 3.7e-202
Smith-Waterman score: 13879; 98.3% identity (98.3% similar) in 2168 aa overlap (1-2168:1-2132)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_001 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFP--EWWRTTD
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
:::::::: ::::::::::::::::::
NP_001 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
780 790 800
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
1770 1780 1790 1800 1810 1820
1870 1880 1890 1900 1910 1920
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQ
1830 1840 1850 1860 1870 1880
1930 1940 1950 1960 1970 1980
pF1KE2 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIA
1890 1900 1910 1920 1930 1940
1990 2000 2010 2020 2030 2040
pF1KE2 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEE
1950 1960 1970 1980 1990 2000
2050 2060 2070 2080 2090 2100
pF1KE2 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKV
2010 2020 2030 2040 2050 2060
2110 2120 2130 2140 2150 2160
pF1KE2 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKK
2070 2080 2090 2100 2110 2120
pF1KE2 WTDTFKVS
::::::::
NP_001 WTDTFKVS
2130
>>XP_011509344 (OMIM: 605683) PREDICTED: bromodomain adj (2207 aa)
initn: 7776 init1: 7776 opt: 8229 Z-score: 3433.5 bits: 649.1 E(85289): 1.6e-184
Smith-Waterman score: 14171; 99.4% identity (99.4% similar) in 2177 aa overlap (1-2166:1-2177)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE-----------RERRR
:::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMVWERERRR
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE2 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE2 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE2 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE2 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KE2 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KE2 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KE2 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KE2 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KE2 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KE2 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KE2 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KE2 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KE2 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KE2 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KE2 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSA
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KE2 AQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIP
1930 1940 1950 1960 1970 1980
1970 1980 1990 2000 2010 2020
pF1KE2 DGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRG
1990 2000 2010 2020 2030 2040
2030 2040 2050 2060 2070 2080
pF1KE2 NKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPV
2050 2060 2070 2080 2090 2100
2090 2100 2110 2120 2130 2140
pF1KE2 NLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRA
2110 2120 2130 2140 2150 2160
2150 2160
pF1KE2 GHNMRKYFEKKWTDTFKVS
:::::::::::::::::
XP_011 GHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSYHQLTSPVPEAS
2170 2180 2190 2200
>>XP_011509353 (OMIM: 605683) PREDICTED: bromodomain adj (2141 aa)
initn: 12088 init1: 7747 opt: 7994 Z-score: 3336.2 bits: 631.0 E(85289): 4.4e-179
Smith-Waterman score: 13851; 97.9% identity (97.9% similar) in 2177 aa overlap (1-2168:1-2141)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFP--EWWRTTD
70 80 90 100 110
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
:::::::: ::::::::::::::::::
XP_011 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
780 790 800
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
870 880 890 900 910 920
970 980 990 1000 1010
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
:::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120 1130
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
1050 1060 1070 1080 1090 1100
1140 1150 1160 1170 1180 1190
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
1110 1120 1130 1140 1150 1160
1200 1210 1220 1230 1240 1250
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
1170 1180 1190 1200 1210 1220
1260 1270 1280 1290 1300 1310
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
1230 1240 1250 1260 1270 1280
1320 1330 1340 1350 1360 1370
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
1290 1300 1310 1320 1330 1340
1380 1390 1400 1410 1420 1430
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
1350 1360 1370 1380 1390 1400
1440 1450 1460 1470 1480 1490
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
1410 1420 1430 1440 1450 1460
1500 1510 1520 1530 1540 1550
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
1470 1480 1490 1500 1510 1520
1560 1570 1580 1590 1600 1610
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
1530 1540 1550 1560 1570 1580
1620 1630 1640 1650 1660 1670
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
1590 1600 1610 1620 1630 1640
1680 1690 1700 1710 1720 1730
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
1650 1660 1670 1680 1690 1700
1740 1750 1760 1770 1780 1790
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
1710 1720 1730 1740 1750 1760
1800 1810 1820 1830 1840 1850
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
1770 1780 1790 1800 1810 1820
1860 1870 1880 1890 1900 1910
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
1830 1840 1850 1860 1870 1880
1920 1930 1940 1950 1960 1970
pF1KE2 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
1890 1900 1910 1920 1930 1940
1980 1990 2000 2010 2020 2030
pF1KE2 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
1950 1960 1970 1980 1990 2000
2040 2050 2060 2070 2080 2090
pF1KE2 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
2010 2020 2030 2040 2050 2060
2100 2110 2120 2130 2140 2150
pF1KE2 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
2070 2080 2090 2100 2110 2120
2160
pF1KE2 NMRKYFEKKWTDTFKVS
:::::::::::::::::
XP_011 NMRKYFEKKWTDTFKVS
2130 2140
>>NP_001316787 (OMIM: 605683) bromodomain adjacent to zi (2143 aa)
initn: 12816 init1: 7747 opt: 7986 Z-score: 3332.8 bits: 630.4 E(85289): 6.7e-179
Smith-Waterman score: 13878; 98.0% identity (98.0% similar) in 2177 aa overlap (1-2168:1-2143)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
:::::::: ::::::::::::::::::
NP_001 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
790 800
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
870 880 890 900 910 920
970 980 990 1000 1010
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
:::::::::::::::::::::::::::::::::::::::::::: :::::::
NP_001 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
930 940 950 960 970 980
1020 1030 1040 1050 1060 1070
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
990 1000 1010 1020 1030 1040
1080 1090 1100 1110 1120 1130
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
1050 1060 1070 1080 1090 1100
1140 1150 1160 1170 1180 1190
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
1110 1120 1130 1140 1150 1160
1200 1210 1220 1230 1240 1250
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
1170 1180 1190 1200 1210 1220
1260 1270 1280 1290 1300 1310
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
1230 1240 1250 1260 1270 1280
1320 1330 1340 1350 1360 1370
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
1290 1300 1310 1320 1330 1340
1380 1390 1400 1410 1420 1430
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
1350 1360 1370 1380 1390 1400
1440 1450 1460 1470 1480 1490
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
1410 1420 1430 1440 1450 1460
1500 1510 1520 1530 1540 1550
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
1470 1480 1490 1500 1510 1520
1560 1570 1580 1590 1600 1610
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
1530 1540 1550 1560 1570 1580
1620 1630 1640 1650 1660 1670
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
1590 1600 1610 1620 1630 1640
1680 1690 1700 1710 1720 1730
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
1650 1660 1670 1680 1690 1700
1740 1750 1760 1770 1780 1790
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
1710 1720 1730 1740 1750 1760
1800 1810 1820 1830 1840 1850
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
1770 1780 1790 1800 1810 1820
1860 1870 1880 1890 1900 1910
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRIEEDIAPGLRVWRRALSEARSAAQ
1830 1840 1850 1860 1870 1880
1920 1930 1940 1950 1960 1970
pF1KE2 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALCIQQLQKSIAWEKSIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDG
1890 1900 1910 1920 1930 1940
1980 1990 2000 2010 2020 2030
pF1KE2 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNK
1950 1960 1970 1980 1990 2000
2040 2050 2060 2070 2080 2090
pF1KE2 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLKKRKMEENTSINLSKQESFTSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNL
2010 2020 2030 2040 2050 2060
2100 2110 2120 2130 2140 2150
pF1KE2 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGH
2070 2080 2090 2100 2110 2120
2160
pF1KE2 NMRKYFEKKWTDTFKVS
:::::::::::::::::
NP_001 NMRKYFEKKWTDTFKVS
2130 2140
>>XP_011509345 (OMIM: 605683) PREDICTED: bromodomain adj (2197 aa)
initn: 8879 init1: 7007 opt: 7096 Z-score: 2963.2 bits: 562.1 E(85289): 2.6e-158
Smith-Waterman score: 13810; 96.8% identity (96.8% similar) in 2200 aa overlap (1-2165:1-2166)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
:::::::: ::::::::::::::::::
XP_011 RQYPEVIK----------------------------------GMQWCLLKEEDVIPRIRA
790 800
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQERERRRQHMMLMKAMEA
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE2 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQKPLPELPRI
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE2 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDSMGEVQDLLV
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE2 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQTELTESLKTK
1110 1120 1130 1140 1150 1160
1210 1220 1230 1240 1250 1260
pF1KE2 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGKLRKLRIIHA
1170 1180 1190 1200 1210 1220
1270 1280 1290 1300 1310 1320
pF1KE2 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQGDEDDEDEED
1230 1240 1250 1260 1270 1280
1330 1340 1350 1360 1370 1380
pF1KE2 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHSLRSVMFGQD
1290 1300 1310 1320 1330 1340
1390 1400 1410 1420 1430 1440
pF1KE2 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFETSGDSLNCSN
1350 1360 1370 1380 1390 1400
1450 1460 1470 1480 1490 1500
pF1KE2 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNAGANGCTLSY
1410 1420 1430 1440 1450 1460
1510 1520 1530 1540 1550 1560
pF1KE2 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKTLTEKNRQWF
1470 1480 1490 1500 1510 1520
1570 1580 1590 1600 1610 1620
pF1KE2 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVGLNPFALSPL
1530 1540 1550 1560 1570 1580
1630 1640 1650 1660 1670 1680
pF1KE2 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTSNVASSKSES
1590 1600 1610 1620 1630 1640
1690 1700 1710 1720 1730 1740
pF1KE2 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALLKVLHLRGIR
1650 1660 1670 1680 1690 1700
1750 1760 1770 1780 1790 1800
pF1KE2 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQAMEMDLSVL
1710 1720 1730 1740 1750 1760
1810 1820 1830 1840 1850 1860
pF1KE2 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEFTGEDESSAH
1770 1780 1790 1800 1810 1820
1870 1880
pF1KE2 ALERKSDNPLDIAVTRLADLERNIERR---------------------------------
:::::::::::::::::::::::::::
XP_011 ALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPAPAPSVSGDG
1830 1840 1850 1860 1870 1880
1890 1900 1910 1920 1930 1940
pF1KE2 --IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQICRKGDNEEL
1890 1900 1910 1920 1930 1940
1950 1960 1970 1980 1990 2000
pF1KE2 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKG
1950 1960 1970 1980 1990 2000
2010 2020 2030 2040 2050 2060
pF1KE2 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVKKPKRDDSKD
2010 2020 2030 2040 2050 2060
2070 2080 2090 2100 2110 2120
pF1KE2 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETF
2070 2080 2090 2100 2110 2120
2130 2140 2150 2160
pF1KE2 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
::::::::::::::::::::::::::::::::::::::::
XP_011 ALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAAQPYGAANSY
2130 2140 2150 2160 2170 2180
XP_011 HQLTSPVPEAS
2190
>>XP_016859412 (OMIM: 605683) PREDICTED: bromodomain adj (2212 aa)
initn: 8598 init1: 6495 opt: 6655 Z-score: 2780.1 bits: 528.2 E(85289): 4.1e-148
Smith-Waterman score: 14022; 98.0% identity (98.0% similar) in 2200 aa overlap (1-2156:1-2200)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000 1010
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
:::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_016 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
1810 1820 1830 1840 1850 1860
1860 1870 1880
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERR------------------------
::::::::::::::::::::::::::::::::::::
XP_016 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPA
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930
pF1KE2 -----------IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPSVSGDGDGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE2 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE2 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE2 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160
pF1KE2 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
::::::::::::::::::::::::::::::::::::::::
XP_016 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
2170 2180 2190 2200 2210
>>XP_011509340 (OMIM: 605683) PREDICTED: bromodomain adj (2240 aa)
initn: 8588 init1: 6495 opt: 6655 Z-score: 2780.1 bits: 528.2 E(85289): 4.1e-148
Smith-Waterman score: 14022; 98.0% identity (98.0% similar) in 2200 aa overlap (1-2156:1-2200)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000 1010
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE---------RERRRQH
:::::::::::::::::::::::::::::::::::::::::::: :::::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMERERRRQH
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE2 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLADQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE2 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIGDS
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE2 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCGQT
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE2 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVEGK
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE2 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDDQG
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE2 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDASHS
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE2 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMFET
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE2 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKPNA
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE2 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLLKT
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE2 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNPVG
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE2 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFLTS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE2 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKALL
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE2 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVEEQ
1750 1760 1770 1780 1790 1800
1800 1810 1820 1830 1840 1850
pF1KE2 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDGEF
1810 1820 1830 1840 1850 1860
1860 1870 1880
pF1KE2 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERR------------------------
::::::::::::::::::::::::::::::::::::
XP_011 TGEDESSAHALERKSDNPLDIAVTRLADLERNIERRYLKSPLSTTIQIKLDNVGTVTVPA
1870 1880 1890 1900 1910 1920
1890 1900 1910 1920 1930
pF1KE2 -----------IEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PAPSVSGDGDGIEEDIAPGLRVWRRALSEARSAAQVALCIQQLQKSIAWEKSIMKVYCQI
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE2 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CRKGDNEELLLLCDGCDKGCHTYCHRPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKG
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE2 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKTNESKKGKKVTLTGDTEDEDSASTSSSLKRGNKDLKKRKMEENTSINLSKQESFTSVK
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE2 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160
pF1KE2 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKVS
::::::::::::::::::::::::::::::::::::::::
XP_011 GQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFKPLCYEDALAA
2170 2180 2190 2200 2210 2220
XP_011 QPYGAANSYHQLTSPVPEAS
2230 2240
>>XP_011509356 (OMIM: 605683) PREDICTED: bromodomain adj (1976 aa)
initn: 12632 init1: 6541 opt: 6629 Z-score: 2770.0 bits: 526.2 E(85289): 1.5e-147
Smith-Waterman score: 12295; 96.8% identity (97.7% similar) in 1960 aa overlap (1-1941:1-1960)
10 20 30 40 50 60
pF1KE2 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MESGERLPSSAASSTTPTSSSTPSVASVVSKGGLSTGVASLSSTINPCGHLFRTAGDQPF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLSTVSSAFPMVSHPVFGLHSASSGHSEFGGLGTLGTPTALAAHPQLASFPGAEWWRTTD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AHTRTGATFFPPLLGIPPLFAPPAQNHDSSSFHSRTSGKSNRNGPEKGVNGSINGSNTSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIGINTSVLSTTASSSMGQTKSTSSGGGNRKCNQEQSKNQPLDARVDKIKDKKPRKKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSNSDSDSGTSSDTSSEGISSSDSDDLEEDEEEEDQSIEESEDDDSDSESEAQHKSNNQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLHGISDPKADGQKATEKAQEKRIHQPLPLASESQTHSFQSQQKQPQVLSQQLPFIFQS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQAKEESVNKHTSVIQSTGLVSNVKPLSLVNQAKKETYMKLIVPSPDVLKAGNKNTSEES
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 SSLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLLTSELRSKREQYKQAFPSQLKKQESSKSLKKVIAALSNPKATSSSPAHPKQTLENNHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPFLTNALLGNHQPNGVIQSVIQEAPLALTTKTKMQSKINENIAAASSTPFSSPVNLSTS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GRRTPGNQTPVMPSASPILHSQGKEKAVSNNVNPVKTQHHSHPAKSLVEQFRGTDSDIPS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE2 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSESDSNSESDTEGSEEEDDDDKDQDESD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE2 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDTEGEKTSMKLNKTTSSVKSPSMSLTGHSTPRNLHIAKAPGSAPAALCSESQSPAFLGT
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE2 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSTLTSSPHSGTSKRRRVTDERELRIPLEYGWQRETRIRNFGGRLQGEVAYYAPCGKKL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE2 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYPEVIKYLSRNGIMDISRDNFSFSAKIRVGDFYEARDGPQGMQWCLLKEEDVIPRIRA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE2 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEGRRGRPPNPDRQRAREESRMRRRKGRPPNVGNAEFLDNADAKLLRKLQAQEIARQAAQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE2 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKLLRKLQKQEQARVAKEAKKQQAIMAAEEKRKQKEQIKIMKQQEKIKRIQQIRMEKELR
910 920 930 940 950 960
970 980 990 1000
pF1KE2 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQE-----------RERRR
:::::::::::::::::::::::::::::::::::::::::::: :::::
XP_011 AQQILEAKKKKKEEAANAKLLEAEKRIKEKEMRRQQAVLLKHQELERHRLDMVWERERRR
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE2 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QHMMLMKAMEARKKAEEKERLKQEKRDEKRLNKERKLEQRRLELEMAKELKKPNEDMCLA
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE2 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQKPLPELPRIPGLVLSGSTFSDCLMVVQFLRNFGKVLGFDVNIDVPNLSVLQEGLLNIG
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE2 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSMGEVQDLLVRLLSAAVCDPGLITGYKAKTALGEHLLNVGVNRDNVSEILQIFMEAHCG
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE2 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTELTESLKTKAFQAHTPAQKASVLAFLINELACSKSVVSEIDKNIDYMSNLRRDKWVVE
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KE2 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKLRKLRIIHAKKTGKRDTSGGIDLGEEQHPLGTPTPGRKRRRKGGDSDYDDDDDDDSDD
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340 1350 1360
pF1KE2 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGDEDDEDEEDKEDKKGKKTDICEDEDEGDQAASVEELEKQIEKLSKQQSQYRRKLFDAS
1330 1340 1350 1360 1370 1380
1370 1380 1390 1400 1410 1420
pF1KE2 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HSLRSVMFGQDRYRRRYWILPQCGGIFVEGMESGEGLEEIAKEREKLKKAESVQIKEEMF
1390 1400 1410 1420 1430 1440
1430 1440 1450 1460 1470 1480
pF1KE2 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETSGDSLNCSNTDHCEQKEDLKEKDNTNLFLQKPGSFSKLSKLLEVAKMPPESEVMTPKP
1450 1460 1470 1480 1490 1500
1490 1500 1510 1520 1530 1540
pF1KE2 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAGANGCTLSYQNSGKHSLGSVQSTATQSNVEKADSNNLFNTGSSGPGKFYSPLPNDQLL
1510 1520 1530 1540 1550 1560
1550 1560 1570 1580 1590 1600
pF1KE2 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTLTEKNRQWFSLLPRTPCDDTSLTHADMSTASLVTPQSQPPSKSPSPTPAPLGSSAQNP
1570 1580 1590 1600 1610 1620
1610 1620 1630 1640 1650 1660
pF1KE2 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGLNPFALSPLQVKGGVSMMGLQFCGWPTGVVTSNIPFTSSVPSLGSGLGLSEGNGNSFL
1630 1640 1650 1660 1670 1680
1670 1680 1690 1700 1710 1720
pF1KE2 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSNVASSKSESPVPQNEKATSAQPAAVEVAKPVDFPSPKPIPEEMQFGWWRIIDPEDLKA
1690 1700 1710 1720 1730 1740
1730 1740 1750 1760 1770 1780
pF1KE2 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLKVLHLRGIREKALQKQIQKHLDYITQACLKNKDVAIIELNENEENQVTRDIVENWSVE
1750 1760 1770 1780 1790 1800
1790 1800 1810 1820 1830 1840
pF1KE2 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQAMEMDLSVLQQVEDLERRVASASLQVKGWMCPEPASEREDLVYFEHKSFTKLCKEHDG
1810 1820 1830 1840 1850 1860
1850 1860 1870 1880 1890 1900
pF1KE2 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERR----IEEDIAPGLRVWRRALSE
::::::::::::::::::::::::::::::::::::: .:..: . . :...
XP_011 EFTGEDESSAHALERKSDNPLDIAVTRLADLERNIERSTAKSVEREIMKNCFFFVMAVTK
1870 1880 1890 1900 1910 1920
1910 1920 1930 1940 1950 1960
pF1KE2 ARSAAQVALCIQQLQKSIAWEK----SIMKVYCQICRKGDNEELLLLCDGCDKGCHTYCH
: . . .:: : .. . ::. .: . . ::
XP_011 AVIPTAIDPRLQQSQMETGFVQLALLSILAIYHSSSKLGDIRSVISFKPFYVSTAF
1930 1940 1950 1960 1970
1970 1980 1990 2000 2010 2020
pF1KE2 RPKITTIPDGDWFCPACIAKASGQTLKIKKLHVKGKKTNESKKGKKVTLTGDTEDEDSAS
2168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 19:04:01 2016 done: Sat Nov 5 19:04:05 2016
Total Scan time: 24.630 Total Display time: 1.700
Function used was FASTA [36.3.4 Apr, 2011]