FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5842, 1872 aa 1>>>pF1KE5842 1872 - 1872 aa - 1872 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9777+/-0.000358; mu= 13.5885+/- 0.023 mean_var=174.3545+/-35.579, 0's: 0 Z-trim(120.0): 267 B-trim: 703 in 1/56 Lambda= 0.097131 statistics sampled from 34291 (34622) to 34291 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.406), width: 16 Scan time: 19.520 The best scores are: opt bits E(85289) NP_620278 (OMIM: 300966,313650,314250) transcripti (1872) 12580 1776.4 0 XP_005262354 (OMIM: 300966,313650,314250) PREDICTE (1906) 11395 1610.3 0 NP_004597 (OMIM: 300966,313650,314250) transcripti (1893) 11376 1607.7 0 NP_001273003 (OMIM: 300966,313650,314250) transcri (1895) 11362 1605.7 0 XP_006724745 (OMIM: 300966,313650,314250) PREDICTE (1800) 10191 1441.6 0 XP_005262352 (OMIM: 300966,313650,314250) PREDICTE (1927) 10191 1441.6 0 XP_005262353 (OMIM: 300966,313650,314250) PREDICTE (1926) 10174 1439.2 0 NP_722516 (OMIM: 607798) transcription initiation (1826) 9783 1384.4 0 XP_005262357 (OMIM: 300966,313650,314250) PREDICTE ( 999) 5499 783.9 0 NP_001276975 (OMIM: 607576) cat eye syndrome criti (1300) 274 51.8 5.2e-05 XP_011544434 (OMIM: 607576) PREDICTED: cat eye syn (1409) 274 51.9 5.5e-05 XP_011544431 (OMIM: 607576) PREDICTED: cat eye syn (1436) 274 51.9 5.6e-05 XP_016884274 (OMIM: 607576) PREDICTED: cat eye syn (1463) 274 51.9 5.7e-05 NP_001276976 (OMIM: 607576) cat eye syndrome criti (1464) 274 51.9 5.7e-05 XP_011544430 (OMIM: 607576) PREDICTED: cat eye syn (1436) 258 49.6 0.00027 XP_016879937 (OMIM: 602301) PREDICTED: histone ace ( 476) 241 46.9 0.00059 XP_006721881 (OMIM: 602301) PREDICTED: histone ace ( 477) 241 46.9 0.00059 NP_066564 (OMIM: 602301) histone acetyltransferase ( 837) 241 47.1 0.00091 XP_006721880 (OMIM: 602301) PREDICTED: histone ace ( 838) 241 47.1 0.00091 NP_001278915 (OMIM: 601540) bromodomain-containing ( 681) 225 44.7 0.0037 NP_001186385 (OMIM: 601540) bromodomain-containing ( 754) 225 44.8 0.004 NP_005095 (OMIM: 601540) bromodomain-containing pr ( 801) 225 44.8 0.0042 NP_001106653 (OMIM: 601540) bromodomain-containing ( 801) 225 44.8 0.0042 NP_001186384 (OMIM: 601540) bromodomain-containing ( 836) 225 44.8 0.0043 XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 218 43.8 0.0076 XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 218 43.8 0.0076 XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 218 43.8 0.0076 NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 218 43.8 0.0076 XP_016883269 (OMIM: 615713) PREDICTED: protein kin ( 909) 219 44.0 0.0082 XP_016883268 (OMIM: 615713) PREDICTED: protein kin ( 917) 219 44.0 0.0083 XP_016883267 (OMIM: 615713) PREDICTED: protein kin ( 992) 219 44.0 0.0088 NP_001268700 (OMIM: 615713) protein kinase C-bindi (1054) 219 44.0 0.0092 XP_016862913 (OMIM: 602303) PREDICTED: histone ace ( 735) 216 43.5 0.0094 XP_016862912 (OMIM: 602303) PREDICTED: histone ace ( 735) 216 43.5 0.0094 NP_001268710 (OMIM: 615713) protein kinase C-bindi (1088) 219 44.1 0.0095 NP_001268705 (OMIM: 615713) protein kinase C-bindi (1107) 219 44.1 0.0096 XP_016883266 (OMIM: 615713) PREDICTED: protein kin (1118) 219 44.1 0.0097 XP_016883265 (OMIM: 615713) PREDICTED: protein kin (1126) 219 44.1 0.0097 NP_001268713 (OMIM: 615713) protein kinase C-bindi (1134) 219 44.1 0.0098 NP_898869 (OMIM: 615713) protein kinase C-binding (1135) 219 44.1 0.0098 NP_001268711 (OMIM: 615713) protein kinase C-bindi (1136) 219 44.1 0.0098 XP_016883264 (OMIM: 615713) PREDICTED: protein kin (1143) 219 44.1 0.0098 XP_016883263 (OMIM: 615713) PREDICTED: protein kin (1146) 219 44.1 0.0099 XP_016883262 (OMIM: 615713) PREDICTED: protein kin (1147) 219 44.1 0.0099 NP_036540 (OMIM: 615713) protein kinase C-binding (1160) 219 44.1 0.01 XP_016883261 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01 XP_016883259 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01 XP_016883260 (OMIM: 615713) PREDICTED: protein kin (1161) 219 44.1 0.01 NP_001268706 (OMIM: 615713) protein kinase C-bindi (1163) 219 44.1 0.01 >>NP_620278 (OMIM: 300966,313650,314250) transcription i (1872 aa) initn: 12580 init1: 12580 opt: 12580 Z-score: 9528.4 bits: 1776.4 E(85289): 0 Smith-Waterman score: 12580; 100.0% identity (100.0% similar) in 1872 aa overlap (1-1872:1-1872) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE5 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE5 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE5 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE5 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE5 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE5 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE5 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE5 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE5 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE5 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE5 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE5 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE5 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE5 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE5 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE5 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE5 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT 1630 1640 1650 1660 1670 1680 1690 1700 1710 1720 1730 1740 pF1KE5 PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 PEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSA 1690 1700 1710 1720 1730 1740 1750 1760 1770 1780 1790 1800 pF1KE5 IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 IQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISY 1750 1760 1770 1780 1790 1800 1810 1820 1830 1840 1850 1860 pF1KE5 GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 GSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFH 1810 1820 1830 1840 1850 1860 1870 pF1KE5 SIAGDSDLDSDE :::::::::::: NP_620 SIAGDSDLDSDE 1870 >>XP_005262354 (OMIM: 300966,313650,314250) PREDICTED: t (1906 aa) initn: 12566 init1: 11359 opt: 11395 Z-score: 8630.8 bits: 1610.3 E(85289): 0 Smith-Waterman score: 12488; 98.2% identity (98.2% similar) in 1904 aa overlap (1-1870:1-1904) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGEKV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGED 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRW 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQ 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE5 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE5 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYG 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE5 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE5 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSES 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE5 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKD 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE5 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE5 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKL 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE5 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSST 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE5 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAA 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE5 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTT 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 1260 pF1KE5 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDL 1210 1220 1230 1240 1250 1260 1270 1280 1290 1300 1310 1320 pF1KE5 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEG 1270 1280 1290 1300 1310 1320 1330 1340 1350 1360 1370 1380 pF1KE5 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTD 1330 1340 1350 1360 1370 1380 1390 1400 1410 1420 1430 1440 pF1KE5 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYP 1390 1400 1410 1420 1430 1440 1450 1460 1470 1480 1490 1500 pF1KE5 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLD 1450 1460 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 pF1KE5 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKH 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 1610 1620 pF1KE5 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT 1570 1580 1590 1600 1610 1620 1630 1640 1650 1660 1670 1680 pF1KE5 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSAT 1630 1640 1650 1660 1670 1680 1690 1700 pF1KE5 PEKQVTQ----------------------------------EGEDGDGDLADEEEGTVQQ ::::::: ::::::::::::::::::: XP_005 PEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQ 1690 1700 1710 1720 1730 1740 1710 1720 1730 1740 1750 1760 pF1KE5 PQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQ 1750 1760 1770 1780 1790 1800 1770 1780 1790 1800 1810 1820 pF1KE5 ENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVS 1810 1820 1830 1840 1850 1860 1830 1840 1850 1860 1870 pF1KE5 EEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE :::::::::::::::::::::::::::::::::::::::::::: XP_005 EEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE 1870 1880 1890 1900 >>NP_004597 (OMIM: 300966,313650,314250) transcription i (1893 aa) initn: 11376 init1: 11376 opt: 11376 Z-score: 8616.5 bits: 1607.7 E(85289): 0 Smith-Waterman score: 12528; 98.9% identity (98.9% similar) in 1893 aa overlap (1-1872:1-1893) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA :::::::::::::::::::::::::::::::::::::::::: NP_004 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1600 1610 1620 1630 1640 1650 pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1630 1640 1650 1660 1670 1680 1660 1670 1680 1690 1700 1710 pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMS 1690 1700 1710 1720 1730 1740 1720 1730 1740 1750 1760 1770 pF1KE5 EGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESM 1750 1760 1770 1780 1790 1800 1780 1790 1800 1810 1820 1830 pF1KE5 MSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRS 1810 1820 1830 1840 1850 1860 1840 1850 1860 1870 pF1KE5 GPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE ::::::::::::::::::::::::::::::::: NP_004 GPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE 1870 1880 1890 >>NP_001273003 (OMIM: 300966,313650,314250) transcriptio (1895 aa) initn: 9889 init1: 9889 opt: 11362 Z-score: 8605.9 bits: 1605.7 E(85289): 0 Smith-Waterman score: 12514; 98.8% identity (98.8% similar) in 1895 aa overlap (1-1872:1-1895) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA :::::::::::::::::::::::::::::::::::::::::: NP_001 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1600 1610 1620 1630 1640 1650 pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQ--PPDLYDTNTSLS :::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: NP_001 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAKPPDLYDTNTSLS 1630 1640 1650 1660 1670 1680 1660 1670 1680 1690 1700 1710 pF1KE5 MSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSRDASVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLL 1690 1700 1710 1720 1730 1740 1720 1730 1740 1750 1760 1770 pF1KE5 MSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEE 1750 1760 1770 1780 1790 1800 1780 1790 1800 1810 1820 1830 pF1KE5 SMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMMSYEGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQ 1810 1820 1830 1840 1850 1860 1840 1850 1860 1870 pF1KE5 RSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE ::::::::::::::::::::::::::::::::::: NP_001 RSGPSVLSQVHLSEDEEDSEDFHSIAGDSDLDSDE 1870 1880 1890 >>XP_006724745 (OMIM: 300966,313650,314250) PREDICTED: t (1800 aa) initn: 11362 init1: 10155 opt: 10191 Z-score: 7719.4 bits: 1441.6 E(85289): 0 Smith-Waterman score: 11613; 96.9% identity (96.9% similar) in 1798 aa overlap (128-1870:1-1798) 100 110 120 130 140 150 pF1KE5 EGWVRSTEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMP :::::::::::::::::::::::::::::: XP_006 MGSLQPLCHSDYDEDDYDADCEDIDCKLMP 10 20 30 160 170 180 190 pF1KE5 PPPPPPGPMKKDKDQDSITG---------------------EKVDFSSSSDSESEMGPQE :::::::::::::::::::: ::::::::::::::::::: XP_006 PPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQE 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE5 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE5 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE5 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV 220 230 240 250 260 270 380 390 400 410 420 430 pF1KE5 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW 280 290 300 310 320 330 440 450 460 470 480 490 pF1KE5 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE 340 350 360 370 380 390 500 510 520 530 540 550 pF1KE5 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM 400 410 420 430 440 450 560 570 580 590 600 610 pF1KE5 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH 460 470 480 490 500 510 620 630 640 650 660 670 pF1KE5 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG 520 530 540 550 560 570 680 690 700 710 720 730 pF1KE5 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP 580 590 600 610 620 630 740 750 760 770 780 790 pF1KE5 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS 640 650 660 670 680 690 800 810 820 830 840 850 pF1KE5 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG 700 710 720 730 740 750 860 870 880 890 900 910 pF1KE5 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE 760 770 780 790 800 810 920 930 940 950 960 970 pF1KE5 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK 820 830 840 850 860 870 980 990 1000 1010 1020 1030 pF1KE5 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ 880 890 900 910 920 930 1040 1050 1060 1070 1080 1090 pF1KE5 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD 940 950 960 970 980 990 1100 1110 1120 1130 1140 1150 pF1KE5 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL 1000 1010 1020 1030 1040 1050 1160 1170 1180 1190 1200 1210 pF1KE5 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH 1060 1070 1080 1090 1100 1110 1220 1230 1240 1250 1260 1270 pF1KE5 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN 1120 1130 1140 1150 1160 1170 1280 1290 1300 1310 1320 1330 pF1KE5 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV 1180 1190 1200 1210 1220 1230 1340 1350 1360 1370 1380 1390 pF1KE5 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM 1240 1250 1260 1270 1280 1290 1400 1410 1420 1430 1440 1450 pF1KE5 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS 1300 1310 1320 1330 1340 1350 1460 1470 1480 1490 1500 1510 pF1KE5 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT 1360 1370 1380 1390 1400 1410 1520 1530 1540 1550 1560 1570 pF1KE5 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL 1420 1430 1440 1450 1460 1470 1580 1590 1600 1610 1620 1630 pF1KE5 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP 1480 1490 1500 1510 1520 1530 1640 1650 1660 1670 1680 pF1KE5 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQ--------- ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLG 1540 1550 1560 1570 1580 1590 1690 1700 1710 1720 pF1KE5 -------------------------EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE ::::::::::::::::::::::::::::::::::: XP_006 EEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE 1600 1610 1620 1630 1640 1650 1730 1740 1750 1760 1770 1780 pF1KE5 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY 1660 1670 1680 1690 1700 1710 1790 1800 1810 1820 1830 1840 pF1KE5 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS 1720 1730 1740 1750 1760 1770 1850 1860 1870 pF1KE5 VLSQVHLSEDEEDSEDFHSIAGDSDLDSDE :::::::::::::::::::::::::::: XP_006 VLSQVHLSEDEEDSEDFHSIAGDSDLDSDE 1780 1790 1800 >>XP_005262352 (OMIM: 300966,313650,314250) PREDICTED: t (1927 aa) initn: 11362 init1: 10155 opt: 10191 Z-score: 7719.0 bits: 1441.6 E(85289): 0 Smith-Waterman score: 12436; 97.1% identity (97.1% similar) in 1925 aa overlap (1-1870:1-1925) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA :::::::::::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1210 1220 1230 1240 1250 1260 1240 1250 1260 1270 1280 1290 pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1270 1280 1290 1300 1310 1320 1300 1310 1320 1330 1340 1350 pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1330 1340 1350 1360 1370 1380 1360 1370 1380 1390 1400 1410 pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1390 1400 1410 1420 1430 1440 1420 1430 1440 1450 1460 1470 pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1450 1460 1470 1480 1490 1500 1480 1490 1500 1510 1520 1530 pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1510 1520 1530 1540 1550 1560 1540 1550 1560 1570 1580 1590 pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1570 1580 1590 1600 1610 1620 1600 1610 1620 1630 1640 1650 pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1630 1640 1650 1660 1670 1680 1660 1670 1680 pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ-------------------------------- :::::::::::::::::::::::::::: XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP 1690 1700 1710 1720 1730 1740 1690 1700 1710 1720 1730 1740 pF1KE5 --EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE 1750 1760 1770 1780 1790 1800 1750 1760 1770 1780 1790 1800 pF1KE5 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE 1810 1820 1830 1840 1850 1860 1810 1820 1830 1840 1850 1860 pF1KE5 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD 1870 1880 1890 1900 1910 1920 1870 pF1KE5 SDLDSDE ::::: XP_005 SDLDSDE >>XP_005262353 (OMIM: 300966,313650,314250) PREDICTED: t (1926 aa) initn: 8057 init1: 6536 opt: 10174 Z-score: 7706.1 bits: 1439.2 E(85289): 0 Smith-Waterman score: 12433; 97.1% identity (97.1% similar) in 1927 aa overlap (1-1872:1-1926) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA :::::::::::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_005 EREEQERKELQRMLLA-GSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE 1200 1210 1220 1230 1240 1250 1240 1250 1260 1270 1280 1290 pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ 1260 1270 1280 1290 1300 1310 1300 1310 1320 1330 1340 1350 pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG 1320 1330 1340 1350 1360 1370 1360 1370 1380 1390 1400 1410 pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK 1380 1390 1400 1410 1420 1430 1420 1430 1440 1450 1460 1470 pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1440 1450 1460 1470 1480 1490 1480 1490 1500 1510 1520 1530 pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1500 1510 1520 1530 1540 1550 1540 1550 1560 1570 1580 1590 pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV 1560 1570 1580 1590 1600 1610 1600 1610 1620 1630 1640 1650 pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS 1620 1630 1640 1650 1660 1670 1660 1670 1680 pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ-------------------------------- :::::::::::::::::::::::::::: XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP 1680 1690 1700 1710 1720 1730 1690 1700 1710 1720 1730 1740 pF1KE5 --EGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE 1740 1750 1760 1770 1780 1790 1750 1760 1770 1780 1790 1800 pF1KE5 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE 1800 1810 1820 1830 1840 1850 1810 1820 1830 1840 1850 1860 pF1KE5 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGD 1860 1870 1880 1890 1900 1910 1870 pF1KE5 SDLDSDE ::::::: XP_005 SDLDSDE 1920 >>NP_722516 (OMIM: 607798) transcription initiation fact (1826 aa) initn: 11044 init1: 9207 opt: 9783 Z-score: 7410.3 bits: 1384.4 E(85289): 0 Smith-Waterman score: 11200; 92.2% identity (95.7% similar) in 1819 aa overlap (1-1769:1-1817) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD : ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.::::::::::::: NP_722 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::: :::::::::.::::::::::::::::::: NP_722 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE 60 70 80 90 100 110 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT---- :.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: NP_722 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE 120 130 140 150 160 170 180 190 200 210 pF1KE5 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA .::::::: :::::::::::::::::::::::::::::::::: NP_722 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::.::::::::::::::::::::: :::::::::::::: NP_722 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::.:::::::.::::::::::::.::::::::::: NP_722 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::: :::::::::::::::.:::::::::.::::::::.:::::::: NP_722 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD 360 370 380 390 400 410 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: ::: NP_722 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD 420 430 440 450 460 470 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::: NP_722 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::.::::::::::::::::::::::::.::::: NP_722 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL ::::::::::::::::.:: ::::::::::::.::::::::::::::::::::::::::: NP_722 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL 600 610 620 630 640 650 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK ::::::::::::::::::::::.::::::::::::::::::::::::::::::::::::: NP_722 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 660 670 680 690 700 710 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::.::::::::.::::::: NP_722 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE 720 730 740 750 760 770 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::.::: :::::::::::::::::: NP_722 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK 780 790 800 810 820 830 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK 840 850 860 870 880 890 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::.::::::::::::::::::::::::::::::::..:::::::::: NP_722 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI 900 910 920 930 940 950 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::::::::: :::::::::::::::: NP_722 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS 960 970 980 990 1000 1010 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ ::::::::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_722 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ 1020 1030 1040 1050 1060 1070 1060 1070 1080 1090 1100 1110 pF1KE5 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_722 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR 1080 1090 1100 1110 1120 1130 1120 1130 1140 1150 1160 1170 pF1KE5 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY : ::::::::.::::.::::::::::::: :::.:::.:::::.:::::::::::::::: NP_722 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY 1140 1150 1160 1170 1180 1190 1180 1190 1200 1210 1220 1230 pF1KE5 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE ::::::::::::::::::::::::.::.:::::::.:::::::::::::::::::::::: NP_722 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE 1200 1210 1220 1230 1240 1250 1240 1250 1260 1270 1280 1290 pF1KE5 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ :::::::::::::::::::::::::::::::::::::::::::::::.:::.:::::::: NP_722 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ 1260 1270 1280 1290 1300 1310 1300 1310 1320 1330 1340 1350 pF1KE5 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG :::::::::::::::::::::::::.::::::.. ::::::::::::::::::::::::: NP_722 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG 1320 1330 1340 1350 1360 1370 1360 1370 1380 1390 1400 1410 pF1KE5 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK ::::::::: :::::::::::::::::::::::::::::::::.:::::::::::::::: NP_722 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK 1380 1390 1400 1410 1420 1430 1420 1430 1440 1450 1460 1470 pF1KE5 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_722 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1440 1450 1460 1470 1480 1490 1480 1490 1500 1510 1520 1530 pF1KE5 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_722 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD 1500 1510 1520 1530 1540 1550 1540 1550 1560 1570 1580 1590 pF1KE5 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV :::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::. NP_722 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI 1560 1570 1580 1590 1600 1610 1600 1610 1620 1630 1640 1650 pF1KE5 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS ::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: : NP_722 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS 1620 1630 1640 1650 1660 1670 1660 1670 1680 1690 pF1KE5 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED-------------- :::::::::::.::::: .::::::. : :: : NP_722 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE 1680 1690 1700 1710 1720 1730 1700 1710 1720 1730 1740 1750 pF1KE5 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::::::: NP_722 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS 1740 1750 1760 1770 1780 1790 1760 1770 1780 1790 1800 1810 pF1KE5 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS ::: :::::::: :::. . NP_722 DVGYGGIRPKQPFMLQHASGEHKDGHGK 1800 1810 1820 >>XP_005262357 (OMIM: 300966,313650,314250) PREDICTED: t (999 aa) initn: 5499 init1: 5499 opt: 5499 Z-score: 4169.6 bits: 783.9 E(85289): 0 Smith-Waterman score: 6651; 97.9% identity (97.9% similar) in 997 aa overlap (1-976:1-997) 10 20 30 40 50 60 pF1KE5 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITG--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE 130 140 150 160 170 180 180 190 200 210 pF1KE5 ------------------EKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA :::::::::::::::::::::::::::::::::::::::::: XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE5 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE5 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE5 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE5 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE5 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE5 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE5 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE5 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE5 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE5 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE5 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS ::::::::::::::::::::::::::::::::::::: XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKVG 970 980 990 1000 1010 1020 1030 1040 1050 pF1KE5 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ >>NP_001276975 (OMIM: 607576) cat eye syndrome critical (1300 aa) initn: 225 init1: 225 opt: 274 Z-score: 210.9 bits: 51.8 E(85289): 5.2e-05 Smith-Waterman score: 278; 24.1% identity (54.8% similar) in 345 aa overlap (1354-1677:104-435) 1330 1340 1350 1360 1370 1380 pF1KE5 VLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMV ..:.. . :.: . . : .. :. NP_001 GPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQR 80 90 100 110 120 130 1390 1400 1410 1420 1430 1440 pF1KE5 TLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIIT--RPMDLQTLRENVRKRLYPS : . . ..: .. . .::: ... :. : : . : . ... .. : NP_001 TKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQKKEQEQML--- 140 150 160 170 180 190 1450 1460 1470 1480 1490 pF1KE5 REEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKL-----ARLEKAIN .:: ...:: :: :. . :. . .. : ..: . ..: : :: . NP_001 KEERKRELEEKVK--AVEDRAKRRKLREERAWLLAQGKELPPELSHLDPNSPMREEKKTK 200 210 220 230 240 1500 1510 1520 1530 1540 1550 pF1KE5 PLLD-DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRK :.. ::: .:. .:: . ..: ::::: .::.....:.::..: :::. ...: NP_001 DLFELDDDFTAMYKVLDVVKAHK-----DSWPFLEPVDESYAPNYYQIIKAPMDISSMEK 250 260 270 280 290 300 1560 1570 1580 1590 1600 pF1KE5 NISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEY-------- ... : ..: :..:.. .. : :::: :.::: .... .... .. NP_001 KLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGEDGDT 310 320 330 340 350 360 1610 1620 1630 1640 1650 1660 pF1KE5 DEHL-----TQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMSRDA ::.. . :: : ... .. .: :: : : : . . . :: .: : NP_001 DEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDP--EGSSRKQQP-MENGGKSLPPTRRA 370 380 390 400 410 420 1670 1680 1690 1700 1710 1720 pF1KE5 SVFQDESNMSVLDIPSATPEKQVTQEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE :... : . : NP_001 PSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTFGPLRGSD 430 440 450 460 470 480 1872 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 03:58:17 2016 done: Tue Nov 8 03:58:20 2016 Total Scan time: 19.520 Total Display time: 1.210 Function used was FASTA [36.3.4 Apr, 2011]