FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2623, 227 aa 1>>>pF1KE2623 227 - 227 aa - 227 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3349+/-0.000449; mu= -3.2648+/- 0.028 mean_var=242.2868+/-48.685, 0's: 0 Z-trim(117.2): 25 B-trim: 0 in 0/56 Lambda= 0.082397 statistics sampled from 28891 (28913) to 28891 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.339), width: 16 Scan time: 5.020 The best scores are: opt bits E(85289) NP_060282 (OMIM: 613748) MICOS complex subunit MIC ( 227) 1440 183.6 2.4e-46 NP_001304106 (OMIM: 613748) MICOS complex subunit ( 232) 1420 181.2 1.3e-45 NP_001304107 (OMIM: 613748) MICOS complex subunit ( 138) 757 102.2 4.5e-22 NP_115719 (OMIM: 615634) MICOS complex subunit MIC ( 235) 344 53.3 4.1e-07 XP_011511536 (OMIM: 615634) PREDICTED: MICOS compl ( 199) 342 53.0 4.2e-07 NP_001307539 (OMIM: 615634) MICOS complex subunit ( 236) 342 53.1 4.8e-07 >>NP_060282 (OMIM: 613748) MICOS complex subunit MIC19 i (227 aa) initn: 1440 init1: 1440 opt: 1440 Z-score: 953.1 bits: 183.6 E(85289): 2.4e-46 Smith-Waterman score: 1440; 100.0% identity (100.0% similar) in 227 aa overlap (1-227:1-227) 10 20 30 40 50 60 pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH 130 140 150 160 170 180 190 200 210 220 pF1KE2 PVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG ::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG 190 200 210 220 >>NP_001304106 (OMIM: 613748) MICOS complex subunit MIC1 (232 aa) initn: 1426 init1: 755 opt: 1420 Z-score: 940.1 bits: 181.2 E(85289): 1.3e-45 Smith-Waterman score: 1420; 97.8% identity (97.8% similar) in 232 aa overlap (1-227:1-232) 10 20 30 40 50 60 pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 KHL-----ARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK ::: :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHLDIEDKARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFK 130 140 150 160 170 180 180 190 200 210 220 pF1KE2 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG 190 200 210 220 230 >>NP_001304107 (OMIM: 613748) MICOS complex subunit MIC1 (138 aa) initn: 757 init1: 757 opt: 757 Z-score: 517.3 bits: 102.2 E(85289): 4.5e-22 Smith-Waterman score: 757; 98.4% identity (99.2% similar) in 125 aa overlap (1-125:1-125) 10 20 30 40 50 60 pF1KE2 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH ::: . NP_001 KHLIKVELLWVKPGVLTA 130 >>NP_115719 (OMIM: 615634) MICOS complex subunit MIC25 i (235 aa) initn: 503 init1: 337 opt: 344 Z-score: 248.8 bits: 53.3 E(85289): 4.1e-07 Smith-Waterman score: 468; 37.7% identity (69.9% similar) in 236 aa overlap (1-220:1-234) 10 20 30 40 50 pF1KE2 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESS-----PSGSKSQRYSGAY ::.: :. :::.: .::.: . :..:.::::::..:::: : :..: .: NP_115 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNL 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 GASVSDEELKRRVA----EELALEQAKKESEDQKRLKQAKELD---RERAAANEQLTRAI : .. : : . . ..... :. :... : : .. ::: ::... ..: NP_115 RAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKH-SKAS 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 LR--ERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQ : : :.::. :. .:::.:: .. :...:.:::::: :.:....:.:....::.. NP_115 LPTGEGSISHEEQ-KSVRLARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFH 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 KAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLE .:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :.. NP_115 EAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG 180 190 200 210 220 230 pF1KE2 KGG >>XP_011511536 (OMIM: 615634) PREDICTED: MICOS complex s (199 aa) initn: 400 init1: 327 opt: 342 Z-score: 248.5 bits: 53.0 E(85289): 4.2e-07 Smith-Waterman score: 347; 37.1% identity (67.2% similar) in 186 aa overlap (37-220:28-198) 10 20 30 40 50 60 pF1KE2 TRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRV :::. : : ::. : : .:: XP_011 MKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGS---SGGQQPSGMKEGVKRYE 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 AEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILR--ERICSEEERAKAKHLA :. :. : .: :. . ::: ::... ..: : : :.::. ... : XP_011 QEHAAI---------QDKLFQVAK--REREAATKH-SKASLPTGEGSISHEEQKSVRLQA 60 70 80 90 100 130 140 150 160 170 180 pF1KE2 RQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCA :.:: .. :...:.:::::: :.:....:.:....::...:: ..:. .: . .:::. XP_011 RELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFHEAASKMESTIKPRRVEPVCS 110 120 130 140 150 160 190 200 210 220 pF1KE2 DLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG :::.::.:::. :..: :: :. :..::. :.. XP_011 GLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG 170 180 190 >>NP_001307539 (OMIM: 615634) MICOS complex subunit MIC2 (236 aa) initn: 530 init1: 327 opt: 342 Z-score: 247.5 bits: 53.1 E(85289): 4.8e-07 Smith-Waterman score: 468; 36.9% identity (69.5% similar) in 236 aa overlap (1-220:1-235) 10 20 30 40 50 pF1KE2 MGGTTST--RRVTFEADENENITVVKGIRLSENVIDRMKESS-----PSGSKSQRYSGAY ::.: :. :::.: .::.: . :..:.::::::..:::: : :..: .: NP_001 MGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNL 10 20 30 40 50 60 60 70 80 90 100 pF1KE2 GASVSDEELKRRVA----EELALEQAKKESEDQKRLKQAKELD---RERAAANEQLTRAI : .. : : . . ..... :. :... : : .. ::: ::... ..: NP_001 RAPHKESTLPRSGSSGGQQPSGMKEGVKRYEQEHAAIQDKLFQVAKREREAATKH-SKAS 70 80 90 100 110 110 120 130 140 150 160 pF1KE2 LR--ERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQ : : :.::. ... ::.:: .. :...:.:::::: :.:....:.:....::.. NP_001 LPTGEGSISHEEQKSVRLQARELESREAELRRRDTFYKEQLERIERKNAEMYKLSSEQFH 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 KAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLE .:: ..:. .: . .:::. :::.::.:::. :..: :: :. :..::. :.. NP_001 EAASKMESTIKPRRVEPVCSGLQAQILHCYRDRPHEVLLCSDLVKAYQRCVSAAHKG 180 190 200 210 220 230 pF1KE2 KGG 227 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 17:16:11 2016 done: Tue Nov 8 17:16:11 2016 Total Scan time: 5.020 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]