FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6634, 216 aa 1>>>pF1KE6634 216 - 216 aa - 216 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0959+/-0.000347; mu= 15.1737+/- 0.022 mean_var=65.1467+/-12.971, 0's: 0 Z-trim(113.9): 51 B-trim: 24 in 1/51 Lambda= 0.158902 statistics sampled from 23364 (23416) to 23364 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.275), width: 16 Scan time: 5.000 The best scores are: opt bits E(85289) NP_665877 (OMIM: 603758) maleylacetoacetate isomer ( 216) 1428 335.8 3.2e-92 NP_001299589 (OMIM: 603758) maleylacetoacetate iso ( 161) 1056 250.5 1.2e-66 XP_016876732 (OMIM: 603758) PREDICTED: maleylaceto ( 177) 947 225.5 4.3e-59 XP_011534972 (OMIM: 603758) PREDICTED: maleylaceto ( 177) 947 225.5 4.3e-59 NP_665878 (OMIM: 603758) maleylacetoacetate isomer ( 174) 683 165.0 7e-41 XP_011534973 (OMIM: 603758) PREDICTED: maleylaceto ( 175) 683 165.0 7.1e-41 NP_004823 (OMIM: 605482) glutathione S-transferase ( 241) 216 58.0 1.5e-08 NP_001177932 (OMIM: 605482) glutathione S-transfer ( 213) 212 57.0 2.6e-08 NP_000838 (OMIM: 605449) glutathione S-transferase ( 222) 208 56.1 5.2e-08 NP_899062 (OMIM: 612314) glutathione S-transferase ( 243) 186 51.1 1.8e-06 XP_011537572 (OMIM: 612314) PREDICTED: glutathione ( 243) 186 51.1 1.8e-06 NP_665683 (OMIM: 138359) glutathione S-transferase ( 222) 184 50.6 2.3e-06 NP_001177943 (OMIM: 612314) glutathione S-transfer ( 215) 182 50.2 3.1e-06 NP_000837 (OMIM: 138360) glutathione S-transferase ( 222) 181 50.0 3.8e-06 XP_011512834 (OMIM: 138360) PREDICTED: glutathione ( 222) 181 50.0 3.8e-06 NP_714543 (OMIM: 607605) glutathione S-transferase ( 222) 179 49.5 5.2e-06 NP_001177931 (OMIM: 605482) glutathione S-transfer ( 208) 178 49.2 5.7e-06 XP_005249091 (OMIM: 138359) PREDICTED: glutathione ( 225) 168 47.0 3e-05 XP_006715135 (OMIM: 605449) PREDICTED: glutathione ( 172) 166 46.4 3.3e-05 XP_016866283 (OMIM: 605449) PREDICTED: glutathione ( 172) 166 46.4 3.3e-05 XP_006717687 (OMIM: 612314) PREDICTED: glutathione ( 183) 159 44.9 0.00011 XP_011537575 (OMIM: 612314) PREDICTED: glutathione ( 149) 153 43.4 0.00023 XP_005249092 (OMIM: 605450) PREDICTED: glutathione ( 222) 152 43.3 0.00038 NP_001503 (OMIM: 605450) glutathione S-transferase ( 222) 152 43.3 0.00038 XP_011537573 (OMIM: 612314) PREDICTED: glutathione ( 166) 150 42.8 0.00041 XP_011537574 (OMIM: 612314) PREDICTED: glutathione ( 166) 150 42.8 0.00041 XP_016871160 (OMIM: 612314) PREDICTED: glutathione ( 132) 148 42.2 0.00047 XP_016871159 (OMIM: 612314) PREDICTED: glutathione ( 132) 148 42.2 0.00047 NP_000844 (OMIM: 600436) glutathione S-transferase ( 240) 151 43.1 0.00047 NP_000845 (OMIM: 600437) glutathione S-transferase ( 244) 151 43.1 0.00048 NP_001177942 (OMIM: 612314) glutathione S-transfer ( 209) 149 42.6 0.00058 NP_001177944 (OMIM: 612314) glutathione S-transfer ( 181) 145 41.6 0.00097 XP_011512837 (OMIM: 605450) PREDICTED: glutathione ( 185) 144 41.4 0.0012 XP_011512836 (OMIM: 605450) PREDICTED: glutathione ( 185) 144 41.4 0.0012 NP_001289599 (OMIM: 600437) glutathione S-transfer ( 230) 141 40.8 0.0022 >>NP_665877 (OMIM: 603758) maleylacetoacetate isomerase (216 aa) initn: 1428 init1: 1428 opt: 1428 Z-score: 1776.6 bits: 335.8 E(85289): 3.2e-92 Smith-Waterman score: 1428; 100.0% identity (100.0% similar) in 216 aa overlap (1-216:1-216) 10 20 30 40 50 60 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL 130 140 150 160 170 180 190 200 210 pF1KE6 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA :::::::::::::::::::::::::::::::::::: NP_665 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA 190 200 210 >>NP_001299589 (OMIM: 603758) maleylacetoacetate isomera (161 aa) initn: 1056 init1: 1056 opt: 1056 Z-score: 1317.5 bits: 250.5 E(85289): 1.2e-66 Smith-Waterman score: 1056; 100.0% identity (100.0% similar) in 161 aa overlap (56-216:1-161) 30 40 50 60 70 80 pF1KE6 LKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPT :::::::::::::::::::::::::::::: NP_001 MKQVPTLKIDGITIHQSLAIIEYLEEMRPT 10 20 30 90 100 110 120 130 140 pF1KE6 PRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 LQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPC 100 110 120 130 140 150 210 pF1KE6 RQPDTPTELRA ::::::::::: NP_001 RQPDTPTELRA 160 >>XP_016876732 (OMIM: 603758) PREDICTED: maleylacetoacet (177 aa) initn: 947 init1: 947 opt: 947 Z-score: 1181.9 bits: 225.5 E(85289): 4.3e-59 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 144 aa overlap (73-216:34-177) 50 60 70 80 90 100 pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMI :::::::::::::::::::::::::::::: XP_016 EEEKEEFAGPVPSGPGVLGPLPASLLPSGQLAIIEYLEEMRPTPRLLPQDPKKRASVRMI 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE6 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA 70 80 90 100 110 120 170 180 190 200 210 pF1KE6 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA 130 140 150 160 170 >>XP_011534972 (OMIM: 603758) PREDICTED: maleylacetoacet (177 aa) initn: 947 init1: 947 opt: 947 Z-score: 1181.9 bits: 225.5 E(85289): 4.3e-59 Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 144 aa overlap (73-216:34-177) 50 60 70 80 90 100 pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMI :::::::::::::::::::::::::::::: XP_011 EEEKEEFAGPVPSGPGVLGPLPASLLPSGQLAIIEYLEEMRPTPRLLPQDPKKRASVRMI 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE6 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA 70 80 90 100 110 120 170 180 190 200 210 pF1KE6 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA 130 140 150 160 170 >>NP_665878 (OMIM: 603758) maleylacetoacetate isomerase (174 aa) initn: 1141 init1: 674 opt: 683 Z-score: 854.9 bits: 165.0 E(85289): 7e-41 Smith-Waterman score: 1061; 80.6% identity (80.6% similar) in 216 aa overlap (1-216:1-174) 10 20 30 40 50 60 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK :::::::::::: :::::: NP_665 TLKIDGITIHQS------------------------------------------NLSVLK 70 130 140 150 160 170 180 pF1KE6 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL 80 90 100 110 120 130 190 200 210 pF1KE6 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA :::::::::::::::::::::::::::::::::::: NP_665 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA 140 150 160 170 >>XP_011534973 (OMIM: 603758) PREDICTED: maleylacetoacet (175 aa) initn: 1125 init1: 674 opt: 683 Z-score: 854.9 bits: 165.0 E(85289): 7.1e-41 Smith-Waterman score: 1045; 79.5% identity (80.5% similar) in 215 aa overlap (2-216:3-175) 10 20 30 40 50 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV ..:::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTESGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 PTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL ::::::::::::: ::::: XP_011 PTLKIDGITIHQS------------------------------------------NLSVL 70 120 130 140 150 160 170 pF1KE6 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVD 80 90 100 110 120 130 180 190 200 210 pF1KE6 LTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA ::::::::::::::::::::::::::::::::::::: XP_011 LTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA 140 150 160 170 >>NP_004823 (OMIM: 605482) glutathione S-transferase ome (241 aa) initn: 167 init1: 96 opt: 216 Z-score: 274.3 bits: 58.0 E(85289): 1.5e-08 Smith-Waterman score: 216; 29.9% identity (55.4% similar) in 184 aa overlap (4-182:22-197) 10 20 30 40 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDG :. .::. . :.:..: ::: .:.. ::: :. NP_004 MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININL-KNK 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 GQQFSKDFQALNPMKQVPTLKID-GITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRM . : : ::. ::.:. . : :..: :::.: : .:::.:: ..: .: NP_004 PEWFFKK----NPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKM 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 ISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTM : .:.. . : . . .: :.. . .. . :. ::..: . . :. ..: NP_004 ILELFSK-VPSLVGSFIRSQNKEDY--AGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISM 120 130 140 150 160 170 170 180 190 200 210 pF1KE6 ADLCLVPQVANAERFK----VDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA : . : : .: :: :: NP_004 IDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQN 180 190 200 210 220 230 >>NP_001177932 (OMIM: 605482) glutathione S-transferase (213 aa) initn: 164 init1: 96 opt: 212 Z-score: 270.1 bits: 57.0 E(85289): 2.6e-08 Smith-Waterman score: 212; 30.8% identity (56.2% similar) in 169 aa overlap (19-182:9-169) 10 20 30 40 50 60 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP :.:..: ::: .:.. ::: :. . : : ::. :: NP_001 MRFCPFAERTRLVLKAKGIRHEVININL-KNKPEWFFKK----NPFGLVP 10 20 30 40 70 80 90 100 110 pF1KE6 TLKID-GITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL .:. . : :..: :::.: : .:::.:: ..: .:: .:.. . : . . NP_001 VLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSK-VPSLVGSFIR 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFK-- .: :.. . .. . :. ::..: . . :. ..: : . : : .: NP_001 SQNKEDY--AGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLN 110 120 130 140 150 160 180 190 200 210 pF1KE6 --VDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA :: :: NP_001 ECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL 170 180 190 200 210 >>NP_000838 (OMIM: 605449) glutathione S-transferase A3 (222 aa) initn: 158 init1: 80 opt: 208 Z-score: 264.9 bits: 56.1 E(85289): 5.2e-08 Smith-Waterman score: 208; 26.2% identity (57.9% similar) in 221 aa overlap (3-216:2-212) 10 20 30 40 50 pF1KE6 MQAGKPILYSYFRSSCSWR-VRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV :::: :. :: . . .: :: :...: :. .: :. . .: . . ..:: NP_000 MAGKPKLH-YFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGK-LRNDGSLM--FQQV 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 PTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL : ..:::. . :. ::..:. : .: :.:: . : .. .: . . : . NP_000 PMVEIDGMKLVQTRAILNYIASKY---NLYGKDIKERALIDMYTEGMADLNEMILLLPLC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 KQVGEEMQLTWAQNAITCG-FNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKV . .. ... .. : :.:..::: . : ::.... ::. :: . .:.. NP_000 RPEEKDAKIALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDS 120 130 140 150 160 170 180 190 200 210 pF1KE6 DL-TPYPTISSINKRL----LVLEAFQVSHPCRQPDTPTELRA .: . .: ..... :. : . .: . : :.: :.. .: NP_000 SLISNFPLLKALKTRISNLPTVKKFLQPGSP-RKP--PADAKALEEARKIFRF 180 190 200 210 220 >>NP_899062 (OMIM: 612314) glutathione S-transferase ome (243 aa) initn: 85 init1: 85 opt: 186 Z-score: 237.0 bits: 51.1 E(85289): 1.8e-06 Smith-Waterman score: 186; 28.4% identity (54.3% similar) in 162 aa overlap (8-168:26-180) 10 20 30 40 pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDG .::. : :.:..: : : .:.: ::: . NP_899 MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGIT-IHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRM ..: .:. ..:.:. . :..:. :::.. : .:.: :: .:: .: NP_899 EWYYTK-----HPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKM 70 80 90 100 110 110 120 130 140 150 160 pF1KE6 ISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTM . .:. . .. : . :.: : . :. :. ::.::. . : ..: NP_899 LLELFCKVPHLTKECLVALRCGRE--CTNLKAALRQEFSNLEEILEYQNTTFFGGTCISM 120 130 140 150 160 170 170 180 190 200 210 pF1KE6 ADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA : : : NP_899 IDYLLWPWFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQN 180 190 200 210 220 230 216 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:58:13 2016 done: Tue Nov 8 14:58:14 2016 Total Scan time: 5.000 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]