FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3963, 468 aa 1>>>pF1KE3963 468 - 468 aa - 468 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2726+/-0.000353; mu= 11.1013+/- 0.022 mean_var=200.6023+/-42.339, 0's: 0 Z-trim(121.2): 269 B-trim: 1607 in 1/55 Lambda= 0.090554 statistics sampled from 37225 (37538) to 37225 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.44), width: 16 Scan time: 8.390 The best scores are: opt bits E(85289) NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 3249 436.9 5.6e-122 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 3231 434.6 2.8e-121 XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 1554 215.4 2.3e-55 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 1315 184.3 6.4e-46 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1315 184.3 6.4e-46 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 1315 184.3 6.4e-46 NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 1231 173.3 1.3e-42 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 1177 166.2 1.7e-40 NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 1156 163.5 1.2e-39 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 899 129.8 1.2e-29 NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 844 122.7 2.2e-27 NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 805 117.6 7.1e-26 NP_001291425 (OMIM: 613184) E3 ubiquitin-protein l ( 262) 786 114.9 2.8e-25 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 782 114.3 4e-25 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 782 114.3 4e-25 NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 761 111.9 4.2e-24 NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 754 111.0 7.6e-24 NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 754 111.0 7.8e-24 NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 735 108.5 4.4e-23 NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 715 105.9 2.6e-22 NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 715 105.9 2.6e-22 NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 675 100.7 9.8e-21 NP_001723 (OMIM: 601610) butyrophilin subfamily 1 ( 526) 673 100.4 1.2e-20 XP_005249397 (OMIM: 601610) PREDICTED: butyrophili ( 626) 673 100.5 1.4e-20 XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 664 99.2 2.6e-20 NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 664 99.2 2.6e-20 XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 652 97.4 5.6e-20 NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 652 97.5 5.9e-20 XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 652 97.5 5.9e-20 NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 652 97.5 6.2e-20 NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 652 97.7 7.8e-20 NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 642 96.4 1.9e-19 XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313) 622 93.5 8.8e-19 NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313) 622 93.5 8.8e-19 XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407) 622 93.7 1e-18 NP_853509 (OMIM: 613591) butyrophilin subfamily 2 ( 407) 622 93.7 1e-18 XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407) 622 93.7 1e-18 XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461) 622 93.7 1.1e-18 XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461) 622 93.7 1.1e-18 NP_008926 (OMIM: 613591) butyrophilin subfamily 2 ( 523) 622 93.8 1.2e-18 XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18 NP_001184166 (OMIM: 613591) butyrophilin subfamily ( 523) 622 93.8 1.2e-18 XP_006715016 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18 XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 622 93.8 1.2e-18 NP_001229732 (OMIM: 613595) butyrophilin subfamily ( 374) 614 92.6 2e-18 NP_932078 (OMIM: 613595) butyrophilin subfamily 3 ( 535) 614 92.7 2.6e-18 NP_008925 (OMIM: 613595) butyrophilin subfamily 3 ( 584) 614 92.8 2.7e-18 XP_006715046 (OMIM: 613593) PREDICTED: butyrophili ( 419) 594 90.0 1.3e-17 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 3249 init1: 3249 opt: 3249 Z-score: 2310.9 bits: 436.9 E(85289): 5.6e-122 Smith-Waterman score: 3249; 100.0% identity (100.0% similar) in 468 aa overlap (1-468:1-468) 10 20 30 40 50 60 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_660 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA 370 380 390 400 410 420 430 440 450 460 pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ :::::::::::::::::::::::::::::::::::::::::::::::: NP_660 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 430 440 450 460 >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 2015 init1: 2015 opt: 3231 Z-score: 2298.2 bits: 434.6 E(85289): 2.8e-121 Smith-Waterman score: 3231; 99.8% identity (99.8% similar) in 468 aa overlap (1-468:1-467) 10 20 30 40 50 60 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG :::::::::::::::::::::::::::::::::::::::::::::::: ::::::::::: XP_016 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ-MVESQRQNVLG 130 140 150 160 170 190 200 210 220 230 240 pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA 360 370 380 390 400 410 430 440 450 460 pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 420 430 440 450 460 >>XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (391 aa) initn: 1544 init1: 1544 opt: 1554 Z-score: 1115.1 bits: 215.4 E(85289): 2.3e-55 Smith-Waterman score: 2600; 83.5% identity (83.5% similar) in 468 aa overlap (1-468:1-391) 10 20 30 40 50 60 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ------------ 130 140 150 160 190 200 210 220 230 240 pF1KE3 EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA XP_011 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KE3 LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 -----DIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE3 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE3 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA 290 300 310 320 330 340 430 440 450 460 pF1KE3 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ 350 360 370 380 390 >>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa) initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46 Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY : : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: . NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : NP_057 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . NP_057 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. NP_057 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . NP_057 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . NP_057 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: NP_057 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 420 430 440 450 460 470 pF1KE3 TLAPQ >>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46 Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY : : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: . XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 420 430 440 450 460 470 pF1KE3 TLAPQ >>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46 Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY : : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: . XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : XP_006 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . XP_006 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. XP_006 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . XP_006 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . XP_006 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: XP_006 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 420 430 440 450 460 470 pF1KE3 TLAPQ >>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46 Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY : : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: . XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 420 430 440 450 460 470 pF1KE3 TLAPQ >>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa) initn: 1068 init1: 453 opt: 1315 Z-score: 945.3 bits: 184.3 E(85289): 6.4e-46 Smith-Waterman score: 1315; 46.8% identity (68.8% similar) in 459 aa overlap (1-442:1-456) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY : : .:. .:::::::.:::::::::::: ::::::: ::. : :. .: . NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : NP_001 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . NP_001 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. NP_001 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 240 250 260 270 280 290 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . NP_001 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . NP_001 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: NP_001 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 420 430 440 450 460 470 pF1KE3 TLAPQ >>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa) initn: 1158 init1: 894 opt: 1231 Z-score: 886.1 bits: 173.3 E(85289): 1.3e-42 Smith-Waterman score: 1232; 43.8% identity (68.6% similar) in 475 aa overlap (1-464:1-473) 10 20 30 40 50 60 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS ::. : . ::.:: :::: :..:: .:::.::.::: . :. : .:: ::. NP_003 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-GKGGGS-VCPVCRQRF 10 20 30 40 50 70 80 90 100 110 pF1KE3 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGV-CPAHREPLAAFCGDELRLLCAACERSG .:::::: ::.:.. ... . :: : .: : : :: . . :: .: .: NP_003 LLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSR 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNV .: : . ::..::.. . ::. .: .::.... : .... . :.: ::.:.. . NP_003 KHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRI 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE3 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL .:: . . .:.::::. ::.::..: : : : : :.:.::: : :::.::. ::. NP_003 HAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHS 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE3 PALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANP :: :::.. .:.: .. .:. ... :::.::.:::: . :: .::::::::: NP_003 SALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE3 ELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGV ::::::::.:. :: .:..: . :::: : ::: ..: ::.:::::.: . .: ::: NP_003 WLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 CRENVNRKEKGELSAGNGFW-ILVFLGSYYNSSERALAPL--RDPPRRVGIFLDYEAGHL ::..: :: . ::. .::: : .. . :... .:: . :: .:::::::::: . NP_003 CRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMV 360 370 380 390 400 410 420 430 440 450 460 pF1KE3 SFYSATD-GSLLFIFPEIPFSGTLRPLFSPL----SSSPTPMTICRPKGGS-GDTLAPQ :::. :: :::.. : : :.: :::.::: ... .:.:.: . :: :.: NP_003 SFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 420 430 440 450 460 470 >>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa) initn: 982 init1: 453 opt: 1177 Z-score: 848.2 bits: 166.2 E(85289): 1.7e-40 Smith-Waterman score: 1177; 45.1% identity (67.6% similar) in 432 aa overlap (28-442:1-429) 10 20 30 40 50 pF1KE3 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCW----GQP-----EGPY :: ::::::: ::. : :. .: . XP_011 MTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF 10 20 30 60 70 80 90 100 110 pF1KE3 ACPECRELSPQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLC ::::::.:::::: ::: :.:.::::.. :: : .: :.::: :: . .: XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HPGLQ-KQDLCQEHHEPLKLFCQKDQSPIC 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE3 AACERSGEHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMV ..:..: :: ::: : ..:.. : :::...:.::.:. . .::. ... . :: : XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE3 ESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAE . .:. .. :::.. :.::::.::: :: :: :. ::::..: : .:. : :. . XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE3 LEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVP-MELRTVCRVPGLVETLRRFRGDVT :: : : .:::.:. : : ..:..: :::.: . :::::::: .:.:: : ::. XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVV 220 230 240 250 260 270 300 310 320 330 340 pF1KE3 LDPDTANPELILSEDRRSVQRGDLRQALP-DSPERFDPGPCVLGQERFTSGRHYWEVEV- : .: : :.: :.:. :. .. : .:: ::..:: :.:::::::: . XP_011 PDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMN 280 290 300 310 320 330 350 360 370 380 390 400 pF1KE3 --GDRTSWALGVCRENVNRKEKGELSAGNGFWILVFL-GSYYNSSERALAP--LRDPPRR :: . :::::::.::.::.. ::::.. . :. : :. ::.: : .:: . XP_011 ITGD-ALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSH 340 350 360 370 380 390 410 420 430 440 450 460 pF1KE3 VGIFLDYEAGHLSFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGD .:::::.:::..::::..::: : . . : : :.:.: XP_011 MGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG 400 410 420 430 440 450 pF1KE3 TLAPQ 468 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:31:21 2016 done: Sun Nov 6 08:31:22 2016 Total Scan time: 8.390 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]