FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2239, 433 aa 1>>>pF1KE2239 433 - 433 aa - 433 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7624+/-0.000451; mu= 1.9912+/- 0.028 mean_var=210.3746+/-41.907, 0's: 0 Z-trim(117.0): 53 B-trim: 342 in 1/59 Lambda= 0.088426 statistics sampled from 28501 (28554) to 28501 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.335), width: 16 Scan time: 7.700 The best scores are: opt bits E(85289) NP_114172 (OMIM: 123836) G2/mitotic-specific cycli ( 433) 2834 374.4 3.1e-103 NP_004692 (OMIM: 602755) G2/mitotic-specific cycli ( 398) 1311 180.1 8.9e-45 NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] ( 432) 618 91.7 3.9e-18 NP_149020 (OMIM: 300456) G2/mitotic-specific cycli (1395) 603 90.2 3.6e-17 XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic- (1395) 603 90.2 3.6e-17 XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic- (1396) 597 89.4 6.2e-17 XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17 NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 584 87.4 7.7e-17 XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17 NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 584 87.4 7.7e-17 XP_011533598 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 584 87.4 7.7e-17 NP_001104515 (OMIM: 604036) cyclin-A1 isoform b [H ( 464) 584 87.4 8.3e-17 NP_003905 (OMIM: 604036) cyclin-A1 isoform a [Homo ( 465) 584 87.4 8.3e-17 XP_016885404 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16 XP_016885402 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16 XP_016885403 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 589 88.4 1.3e-16 XP_016885405 (OMIM: 300456) PREDICTED: G2/mitotic- (1403) 587 88.2 1.5e-16 NP_391990 (OMIM: 300456) G2/mitotic-specific cycli ( 291) 414 65.6 2e-10 NP_066970 (OMIM: 607752,615872) cyclin-O [Homo sap ( 350) 317 53.3 1.2e-06 XP_011515668 (OMIM: 603775) PREDICTED: G1/S-specif ( 288) 299 50.9 5.1e-06 NP_001309191 (OMIM: 123837) G1/S-specific cyclin-E ( 395) 300 51.1 5.9e-06 XP_011525742 (OMIM: 123837) PREDICTED: G1/S-specif ( 407) 300 51.1 6.1e-06 NP_001229 (OMIM: 123837) G1/S-specific cyclin-E1 i ( 410) 300 51.1 6.1e-06 XP_016869447 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06 XP_016869446 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06 NP_477097 (OMIM: 603775) G1/S-specific cyclin-E2 [ ( 404) 299 51.0 6.6e-06 XP_016869448 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 299 51.0 6.6e-06 NP_001309188 (OMIM: 123837) G1/S-specific cyclin-E ( 365) 289 49.7 1.5e-05 NP_001751 (OMIM: 123834) G1/S-specific cyclin-D3 i ( 292) 284 49.0 1.9e-05 NP_444284 (OMIM: 168461,193300,254500) G1/S-specif ( 295) 284 49.0 1.9e-05 NP_001752 (OMIM: 600227) cyclin-F isoform 1 [Homo ( 786) 286 49.6 3.5e-05 NP_001310467 (OMIM: 600227) cyclin-F isoform 2 [Ho ( 478) 281 48.8 3.7e-05 XP_016879311 (OMIM: 600227) PREDICTED: cyclin-F is ( 867) 286 49.6 3.8e-05 NP_001750 (OMIM: 123833,615938) G1/S-specific cycl ( 289) 244 43.9 0.00066 XP_011513273 (OMIM: 123834) PREDICTED: G1/S-specif ( 276) 232 42.3 0.0018 >>NP_114172 (OMIM: 123836) G2/mitotic-specific cyclin-B1 (433 aa) initn: 2834 init1: 2834 opt: 2834 Z-score: 1974.4 bits: 374.4 E(85289): 3.1e-103 Smith-Waterman score: 2834; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433) 10 20 30 40 50 60 pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 PMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 LPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_114 WTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS 370 380 390 400 410 420 430 pF1KE2 ALVQDLAKAVAKV ::::::::::::: NP_114 ALVQDLAKAVAKV 430 >>NP_004692 (OMIM: 602755) G2/mitotic-specific cyclin-B2 (398 aa) initn: 1228 init1: 1198 opt: 1311 Z-score: 924.9 bits: 180.1 E(85289): 8.9e-45 Smith-Waterman score: 1311; 52.7% identity (77.2% similar) in 395 aa overlap (40-427:6-391) 10 20 30 40 50 60 pF1KE2 KINAENKAKINMAGAKRVPTAPAATSKPGLRPRTA--LGDIGNKVSEQLQAKMPMKKEAK :: .. : .: . :. ...... ... . NP_004 MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVL 10 20 30 70 80 90 100 110 120 pF1KE2 PSATGKVIDK--KLPKPLE--KVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVD ..: . .. : . :::. :. ... . .: .::. :::.:. NP_004 EEIGNRVTTRAAQVAKKAQNTKVPVQ-PTKTTNVNKQLKPTASVKPVQMEKLAPK----- 40 50 60 70 80 130 140 150 160 170 180 pF1KE2 TASPSPMETSGCAPAEEDLCQAFSDVILA-VNDVDAEDGADPNLCSEYVKDIYAYLRQLE ::.: ..: ::.:::::::..: ..:.: :: .:.:::.:::::: :::::: NP_004 GPSPTPEDVS---MKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLE 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 EEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKK :.. :..: ::...: :::::.::::::. ::::::::.:: :.:.:::.: . : .: NP_004 VLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRK 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE2 MLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLP :::::.::...:::::::. :.: ::...:::.::. :::.:: ::. :.: :::::: NP_004 KLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLP 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE2 LHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWT ::::::::: ::::::::::::::::::..::::::. ::..::.: ::. :.: .:.:. NP_004 LHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWN 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE2 PTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSAL :.: .:::. .: ::::.::::: ::..::: ...:::::.:: ::: .::::: NP_004 LKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKA 330 340 350 360 370 380 430 pF1KE2 VQDLAKAVAKV :.::: NP_004 VKDLASPLIGRS 390 >>NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] (432 aa) initn: 538 init1: 380 opt: 618 Z-score: 446.6 bits: 91.7 E(85289): 3.9e-18 Smith-Waterman score: 618; 31.6% identity (62.4% similar) in 399 aa overlap (28-415:35-424) 10 20 30 40 50 pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQ : : ...: : :. :: . : NP_001 SAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSP . : ... : : :... : :. :. . : : : : . .:.. .:. NP_001 QR-PKTRRVAPLKDLPVNDEHVTVPPWKANSKQPA-FTIHVDEAEKEAQKKPAESQKIER 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 EPILV-DTASPSPMETSGCAPAEEDLCQAFS-----DVILAVNDVDAEDGADPNLCSEYV : :. ..: : . .: . . .: :. ....: : .. : .: NP_001 EDALAFNSAISLPGPRKPLVPLDYPMDGSFESPHTMDMSIVLED---EKPVSVNEVPDYH 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 KDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSII .::..:::..: . . :. . ..:..:::::.::::.: ...: .::....:. : NP_001 EDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 DRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKIL :::... : . :::::..::..:::.::.::::...:...::.::::.:. .:: .: NP_001 DRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVL 240 250 260 270 280 290 300 310 320 330 340 pF1KE2 RALNFGLGRPLPLHFLRRA---SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAA ..:.: :. : .:: . .. .. :: .:: .: ::...: : .... :: ::. NP_001 KVLTFDLAAPTVNQFLTQYFLHQQPANCKVE--SLAMFLGELSLIDADPYLKYLPSVIAG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE2 GAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYAT .:: ::: . . : .: . .:: ::: : .. : .. . . : ......:: . NP_001 AAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQH--AQQSIREKYKN 360 370 380 390 400 410 410 420 430 pF1KE2 SKHAKISTLPQLNSALVQDLAKAVAKV ::. .: : NP_001 SKYHGVSLLNPPETLNL 420 430 >>NP_149020 (OMIM: 300456) G2/mitotic-specific cyclin-B3 (1395 aa) initn: 580 init1: 542 opt: 603 Z-score: 429.2 bits: 90.2 E(85289): 3.6e-17 Smith-Waterman score: 640; 30.7% identity (62.4% similar) in 404 aa overlap (29-419:980-1376) 10 20 30 40 50 pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ ::: . ::: .. :..: :. ..: . NP_149 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL 950 960 970 980 990 1000 60 70 80 90 100 110 pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV . . . ::. ::: .. : : :.. : : .:. : :: . NP_149 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI 1010 1020 1030 1040 1050 1060 120 130 140 150 160 pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEED----LCQAFSDVILAVNDVDAEDGADPNL : : : . : . :.:.: : . .. : .:.: ::..::.. NP_149 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDID-EDSSDPSF 1070 1080 1090 1100 1110 1120 170 180 190 200 210 220 pF1KE2 CSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYM :.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.:. NP_149 NPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYL 1130 1140 1150 1160 1170 1180 230 240 250 260 270 280 pF1KE2 TVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQM .:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. .: NP_149 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSM 1190 1200 1210 1220 1230 1240 290 300 310 320 330 340 pF1KE2 EMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIA :..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :..: NP_149 EINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLA 1250 1260 1270 1280 1290 1300 350 360 370 380 390 400 pF1KE2 AGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYA :... ::: . : :.: :.:: .:. : :....: : ... . : .: ::. NP_149 AASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKYS 1310 1320 1330 1340 1350 1360 410 420 430 pF1KE2 TSKHAKISTLPQLNSALVQDLAKAVAKV ... .: :. NP_149 HPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL 1370 1380 1390 >>XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic-spec (1395 aa) initn: 580 init1: 542 opt: 603 Z-score: 429.2 bits: 90.2 E(85289): 3.6e-17 Smith-Waterman score: 640; 30.7% identity (62.4% similar) in 404 aa overlap (29-419:980-1376) 10 20 30 40 50 pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ ::: . ::: .. :..: :. ..: . XP_016 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL 950 960 970 980 990 1000 60 70 80 90 100 110 pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV . . . ::. ::: .. : : :.. : : .:. : :: . XP_016 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI 1010 1020 1030 1040 1050 1060 120 130 140 150 160 pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEED----LCQAFSDVILAVNDVDAEDGADPNL : : : . : . :.:.: : . .. : .:.: ::..::.. XP_016 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEITPREDID-EDSSDPSF 1070 1080 1090 1100 1110 1120 170 180 190 200 210 220 pF1KE2 CSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYM :.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.:. XP_016 NPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYL 1130 1140 1150 1160 1170 1180 230 240 250 260 270 280 pF1KE2 TVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQM .:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. .: XP_016 AVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSM 1190 1200 1210 1220 1230 1240 290 300 310 320 330 340 pF1KE2 EMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIA :..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :..: XP_016 EINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKLA 1250 1260 1270 1280 1290 1300 350 360 370 380 390 400 pF1KE2 AGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYA :... ::: . : :.: :.:: .:. : :....: : ... . : .: ::. XP_016 AASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKYS 1310 1320 1330 1340 1350 1360 410 420 430 pF1KE2 TSKHAKISTLPQLNSALVQDLAKAVAKV ... .: :. XP_016 HPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL 1370 1380 1390 >>XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic-spec (1396 aa) initn: 580 init1: 542 opt: 597 Z-score: 425.0 bits: 89.4 E(85289): 6.2e-17 Smith-Waterman score: 638; 31.1% identity (62.7% similar) in 405 aa overlap (29-419:980-1377) 10 20 30 40 50 pF1KE2 MALRVTRNSKINAENKAKINMAGAKRVPTAPAA-TSKPGLRPRTALGDIGNKVSEQLQ ::: . ::: .. :..: :. ..: . XP_016 ALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVGKSGT-INEAFL 950 960 970 980 990 1000 60 70 80 90 100 110 pF1KE2 AKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEP--VPEPEPEP-----EPEPV . . . ::. ::: .. : : :.. : : .:. : :: . XP_016 FEDMITLNEKPT-TGKELSFKEPLALQESPTCKEDTFLETFLIPQIGTSPYVFSTTPESI 1010 1020 1030 1040 1050 1060 120 130 140 150 160 pF1KE2 KEEKLSPEPILVDTASPSPMETSGCAPAEEDLC--QAFS---DVILAVNDVDAEDGADPN : : : . : . :.:.: : . :: . . : .:.: ::..::. XP_016 TE-KSSIATMTSVGKSRTTTESSACESASDKPVSPQAKGTPKEQITPREDID-EDSSDPS 1070 1080 1090 1100 1110 1120 170 180 190 200 210 220 pF1KE2 LCSEYVKDIYAYLRQLEEEQAVRPKYLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMY . :.:.:..:... .::: . :. . :.:..:::::.::::.::..:.. .::.: XP_016 FNPMYAKEIFSYMKE-REEQFILTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLY 1130 1140 1150 1160 1170 1180 230 240 250 260 270 280 pF1KE2 MTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQ ..:...: .... : :::.:.::..::.:.:: :.. ::... :..: . .. . XP_016 LAVKLVDLYLMKAVCKKDKLQLLGATAFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLS 1190 1200 1210 1220 1230 1240 290 300 310 320 330 340 pF1KE2 MEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQI ::..:: .:. .. :. ::::: .. ..... ::..:. :.:. .: .:. :.. XP_016 MEINILNVLKCDINIPIAYHFLRRYARCIHTNMKTLTLSRYICEMTLQEYHYVQEKASKL 1250 1260 1270 1280 1290 1300 350 360 370 380 390 400 pF1KE2 AAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKY ::... ::: . : :.: :.:: .:. : :....: : ... . : .: :: XP_016 AAASLLLALYMKKLGYWVPFLEHYSGYSISELHPLVRQLNKLLTFSSYDSLK--AVYYKY 1310 1320 1330 1340 1350 1360 410 420 430 pF1KE2 ATSKHAKISTLPQLNSALVQDLAKAVAKV . ... .: :. XP_016 SHPVFFEVAKIPALDMLKLEEILNCDCEAQGLVL 1370 1380 1390 >>XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa) initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17 Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421) 140 150 160 170 180 190 pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK :.: .::...:: :::. : .. . . XP_011 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH 130 140 150 160 170 180 200 210 220 230 240 pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV :. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::. XP_011 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA .::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: . XP_011 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY . : :. ..::::. ::..:. : .... :: :::.::::: ... : :: . XP_011 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK .:. ..: ...: : . . . ......:: .::. .: . :.: XP_011 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ 370 380 390 400 410 420 430 pF1KE2 AVAKV >>NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa) initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17 Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421) 140 150 160 170 180 190 pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK :.: .::...:: :::. : .. . . NP_001 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH 130 140 150 160 170 180 200 210 220 230 240 pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV :. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::. NP_001 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA .::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: . NP_001 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY . : :. ..::::. ::..:. : .... :: :::.::::: ... : :: . NP_001 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK .:. ..: ...: : . . . ......:: .::. .: . :.: NP_001 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ 370 380 390 400 410 420 430 pF1KE2 AVAKV >>XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 isofo (421 aa) initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17 Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421) 140 150 160 170 180 190 pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK :.: .::...:: :::. : .. . . XP_011 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH 130 140 150 160 170 180 200 210 220 230 240 pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV :. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::. XP_011 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA .::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: . XP_011 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY . : :. ..::::. ::..:. : .... :: :::.::::: ... : :: . XP_011 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK .:. ..: ...: : . . . ......:: .::. .: . :.: XP_011 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ 370 380 390 400 410 420 430 pF1KE2 AVAKV >>NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [Homo (421 aa) initn: 520 init1: 405 opt: 584 Z-score: 423.3 bits: 87.4 E(85289): 7.7e-17 Smith-Waterman score: 584; 36.8% identity (69.5% similar) in 266 aa overlap (161-424:158-421) 140 150 160 170 180 190 pF1KE2 ETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPK :.: .::...:: :::. : .. . . NP_001 DLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAH 130 140 150 160 170 180 200 210 220 230 240 pF1KE2 YLLGR-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGV :. . ..: .::.::.::::.: ...: ::.:..:...:::.. : . :::::. NP_001 YMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 TAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRA .::..::::::.::::. .:...::.::::.:. .:: .:..: : : : .:: . NP_001 AAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 SKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHY . : :. ..::::. ::..:. : .... :: :::.::::: ... : :: . NP_001 LRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAK .:. ..: ...: : . . . ......:: .::. .: . :.: NP_001 TGYSLSEIVPCLSELHKAYLDIPH--RPQQAIREKYKASKYLCVSLMEPPAVLLLQ 370 380 390 400 410 420 430 pF1KE2 AVAKV 433 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 20:12:52 2016 done: Sun Nov 6 20:12:53 2016 Total Scan time: 7.700 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]