FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5805, 471 aa 1>>>pF1KB5805 471 - 471 aa - 471 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.1014+/-0.000404; mu= -4.4846+/- 0.026 mean_var=440.8448+/-88.926, 0's: 0 Z-trim(124.6): 24 B-trim: 38 in 1/56 Lambda= 0.061085 statistics sampled from 46597 (46630) to 46597 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.812), E-opt: 0.2 (0.547), width: 16 Scan time: 9.910 The best scores are: opt bits E(85289) XP_011512281 (OMIM: 606198) PREDICTED: iroquois-cl ( 471) 3219 297.5 5.2e-80 NP_001127694 (OMIM: 606198) iroquois-class homeodo ( 471) 3219 297.5 5.2e-80 NP_150366 (OMIM: 606198) iroquois-class homeodomai ( 471) 3219 297.5 5.2e-80 NP_001239126 (OMIM: 606195,611174) iroquois-class ( 482) 1138 114.1 8.5e-25 NP_005844 (OMIM: 606195,611174) iroquois-class hom ( 483) 1134 113.8 1.1e-24 XP_011521111 (OMIM: 606195,611174) PREDICTED: iroq ( 413) 784 82.9 1.9e-15 NP_077312 (OMIM: 612985) iroquois-class homeodomai ( 501) 729 78.1 6.2e-14 XP_005256196 (OMIM: 612985) PREDICTED: iroquois-cl ( 529) 729 78.1 6.4e-14 XP_016865334 (OMIM: 606197) PREDICTED: iroquois-cl ( 449) 607 67.3 9.9e-11 NP_077313 (OMIM: 606197) iroquois-class homeodomai ( 480) 607 67.3 1e-10 NP_001265561 (OMIM: 606199) iroquois-class homeodo ( 519) 568 63.9 1.2e-09 NP_001265563 (OMIM: 606199) iroquois-class homeodo ( 519) 568 63.9 1.2e-09 NP_057442 (OMIM: 606199) iroquois-class homeodomai ( 519) 568 63.9 1.2e-09 XP_005256194 (OMIM: 606196) PREDICTED: iroquois-cl ( 445) 552 62.5 2.8e-09 NP_077311 (OMIM: 606196) iroquois-class homeodomai ( 446) 552 62.5 2.8e-09 NP_001265564 (OMIM: 606199) iroquois-class homeodo ( 545) 486 56.7 1.8e-07 NP_001265562 (OMIM: 606199) iroquois-class homeodo ( 545) 486 56.7 1.8e-07 >>XP_011512281 (OMIM: 606198) PREDICTED: iroquois-class (471 aa) initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80 Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 430 440 450 460 470 >>NP_001127694 (OMIM: 606198) iroquois-class homeodomain (471 aa) initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80 Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 430 440 450 460 470 >>NP_150366 (OMIM: 606198) iroquois-class homeodomain pr (471 aa) initn: 3219 init1: 3219 opt: 3219 Z-score: 1557.4 bits: 297.5 E(85289): 5.2e-80 Smith-Waterman score: 3219; 100.0% identity (100.0% similar) in 471 aa overlap (1-471:1-471) 10 20 30 40 50 60 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 GFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRKN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 ATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 APRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 LPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGLAPPKPVTSSPLTGLEAPLLSPPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 EAAPRGGRKTPQGSRTSPGAPPPASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 ASTGAPPGGSPYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEA 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_150 LHTAPKAASDAGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL 430 440 450 460 470 >>NP_001239126 (OMIM: 606195,611174) iroquois-class home (482 aa) initn: 932 init1: 655 opt: 1138 Z-score: 566.2 bits: 114.1 E(85289): 8.5e-25 Smith-Waterman score: 1247; 51.8% identity (69.8% similar) in 440 aa overlap (1-405:1-423) 10 20 30 40 50 60 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT :::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: . NP_001 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP- 10 20 30 40 50 70 80 90 100 110 pF1KB5 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRK :..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. : .:::::: NP_001 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPYGDPAYRK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 WAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGE :.:::.::::.:.:. ...:: :. :. : ... :: ... . .: : NP_001 WTPRNRSEDEEEEENIDLEKNDE--DEPQK-PEDKGDPEGPEAGAEQKAASGC------E 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 KLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPLLSP .: : : .:.: . . .: . : .: .: .::. :: : : NP_001 RLQ---GPPT-PAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAED 230 240 250 260 270 280 300 310 320 330 340 pF1KB5 P----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SKPKLWSLAEIATSDLK : : .:: : ..: : .. : :::: .:::::::::::::. : NP_001 PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDK 290 300 310 320 330 340 350 360 370 380 pF1KB5 QPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPLYYT . : : : : :: : :. ::: . .: . :.:.. .:.:::::: NP_001 VKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYT 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 SPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRS .::: .:::::... :.:. NP_001 APFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS 410 420 430 440 450 460 >>NP_005844 (OMIM: 606195,611174) iroquois-class homeodo (483 aa) initn: 932 init1: 655 opt: 1134 Z-score: 564.3 bits: 113.8 E(85289): 1.1e-24 Smith-Waterman score: 1246; 51.8% identity (69.3% similar) in 440 aa overlap (1-405:1-424) 10 20 30 40 50 60 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPYPGSAAFTAQAAT :::::::::: .::::::::::..:....::..::.::.:::::::: ::.:::: . NP_005 MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSP- 10 20 30 40 50 70 80 90 100 110 pF1KB5 GFGSPLQYSAD-AAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYGSAAYPYQLNDPAYRK :..: :::.:: ::::::.: ::.:.::: :: ::.:...::::.. : .:::::: NP_005 GYNSHLQYGADPAAAAAAAFSSYVGSPYD-HTPGMAGSLGYHPYAAPLGSYPYGDPAYRK 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 WAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGE :.:::.::::.:.:. ...:: :. :. ::.: : .. .::. . NP_005 WTPRNRSEDEEEEENIDLEKNDE--DEPQK-----PEDKG-----DPEGPEAGGAEQKAA 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 KLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPVTSSPLTGLEAPLLSP . : : .:.: . . .: . : .: .: .::. :: : : NP_005 SGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTGGPSPAGPAAARLAED 230 240 250 260 270 280 300 310 320 330 340 pF1KB5 P----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SKPKLWSLAEIATSDLK : : .:: : ..: : .. : :::: .:::::::::::::. : NP_005 PAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKPKLWSLAEIATSSDK 290 300 310 320 330 340 350 360 370 380 pF1KB5 QPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGSPYPASPLLGRPLYYT . : : : : :: : :. ::: . .: . :.:.. .:.:::::: NP_005 VKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYT 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 SPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASDAGKAGAHPLESHYRS .::: .:::::... :.:. NP_005 APFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNRADALAKDPKMLRSQS 410 420 430 440 450 460 >>XP_011521111 (OMIM: 606195,611174) PREDICTED: iroquois (413 aa) initn: 916 init1: 601 opt: 784 Z-score: 398.4 bits: 82.9 E(85289): 1.9e-15 Smith-Waterman score: 896; 47.4% identity (64.7% similar) in 365 aa overlap (75-405:5-354) 50 60 70 80 90 100 pF1KB5 FSPYPGSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTTGMTGAISYHPYG ::.. .. :.::: :: ::.:...::::. XP_011 MEGRAAVARSAHGGSPYD-HTPGMAGSLGYHPYA 10 20 30 110 120 130 140 150 160 pF1KB5 SAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTW . : .::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTW 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 FANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHV ::::::::::::::::.:::.::::.:.:. ...:: :. :. ::.: XP_011 FANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDE--DEPQK-----PEDKG----- 100 110 120 130 140 230 240 250 260 270 280 pF1KB5 DSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL-APPKPV : .. .::. . . : : .:.: . . .: . : .: .: .::. XP_011 DPEGPEAGGAEQKAASGCERLQGPPTPAGKETEGSLSDSDFKEPPSEGRLDALQGPPRTG 150 160 170 180 190 200 290 300 310 320 pF1KB5 TSSPLTGLEAPLLSPP----PEAAPRGGR-----KTPQGS------RTSPGAPPPA--SK :: : : : : .:: : ..: : .. : :::: .: XP_011 GPSPAGPAAARLAEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAK 210 220 230 240 250 260 330 340 350 360 370 pF1KB5 PKLWSLAEIATSDLKQPSLGPG-----CGP-PGLP----------AAAAPASTGAPPGGS ::::::::::::. : . : : : : :: : :. ::: . .: . XP_011 PKLWSLAEIATSSDKVKDGGGGNEGSPCPPCPG-PIAGQALGGSRASPAPAPSRSPSAQC 270 280 290 300 310 320 380 390 400 410 420 430 pF1KB5 PYPASPLLGRPLYYTSPFYGNYTNYGNLNAALQGQGLLRYNSAAAAPGEALHTAPKAASD :.:.. .:.::::::.::: .:::::... :.:. XP_011 PFPGGTVLSRPLYYTAPFYPGYTNYGSFGH-LHGHPGPGPGPTTGPGSHFNGLNQTVLNR 330 340 350 360 370 440 450 460 470 pF1KB5 AGKAGAHPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL XP_011 ADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI 380 390 400 410 >>NP_077312 (OMIM: 612985) iroquois-class homeodomain pr (501 aa) initn: 650 init1: 513 opt: 729 Z-score: 371.2 bits: 78.1 E(85289): 6.2e-14 Smith-Waterman score: 780; 37.9% identity (59.5% similar) in 496 aa overlap (1-452:1-480) 10 20 30 40 pF1KB5 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P ::.:: :: : . ::. . . : . ..:.: :: : .. ....: : NP_077 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTT-GM---TGAISY-HPYG .:: .: :: :.:. : :.:. ::. .:: :. . . :. ..: .. ::. NP_077 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH- 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV : ::: :..::. :::::..:.:::::::::::::::::::::::::::::::::: NP_077 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS ::::::::::::::::::::::.....: . :. . .:: :. . : :.: .. NP_077 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG 180 190 200 210 220 230 230 240 250 260 270 pF1KB5 LHVDS-----LTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E . .. :.: . . : : :.: : .: : .:. .: . :....: : NP_077 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE 240 250 260 270 280 290 280 290 300 310 320 pF1KB5 EGERGLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----SK .. .:: .:. :. .: :: .::: :. . .: : .: :: :: .: NP_077 DSSEGLED-RPL---PVLSL-AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQK 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 PKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPLLGRPL-- ::.::::: ::: . :: : ::: ::.::.. :... : :.. :: NP_077 PKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLGK 350 360 370 380 390 400 390 400 410 420 430 pF1KB5 ---YYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAGA . . :: : . .: :.. :: .::. :. : : : ..: NP_077 FPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRC 410 420 430 440 450 460 440 450 460 470 pF1KB5 HPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL :: . . ...: NP_077 SALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS 470 480 490 500 >>XP_005256196 (OMIM: 612985) PREDICTED: iroquois-class (529 aa) initn: 650 init1: 513 opt: 729 Z-score: 370.9 bits: 78.1 E(85289): 6.4e-14 Smith-Waterman score: 780; 37.9% identity (59.5% similar) in 496 aa overlap (1-452:1-480) 10 20 30 40 pF1KB5 MSYPQ-GYLY-------QAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSPY---P ::.:: :: : . ::. . . : . ..:.: :: : .. ....: : XP_005 MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 GSAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYDAHTT-GM---TGAISY-HPYG .:: .: :: :.:. : :.:. ::. .:: :. . . :. ..: .. ::. XP_005 YAAAAAAAAAQGYGAFLPYAAELPI----FPQ-LGAQYELKDSPGVQHPAAAAAFPHPH- 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 SAAYPY---QLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV : ::: :..::. :::::..:.:::::::::::::::::::::::::::::::::: XP_005 PAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 STWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGIS ::::::::::::::::::::::.....: . :. . .:: :. . : :.: .. XP_005 STWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELG 180 190 200 210 220 230 230 240 250 260 270 pF1KB5 LHVDS-----LTDHSCSAESDGEKLPCRAGDP-LCESGSECKDK---YDDLEDDEDDD-E . .. :.: . . : : :.: : .: : .:. .: . :....: : XP_005 GEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSE 240 250 260 270 280 290 280 290 300 310 320 pF1KB5 EGERGLAPPKPVTSSPLTGLEAPLLSPPPEAAPRGGRKTPQGSRTSPGAPPPA-----SK .. .:: .:. :. .: :: .::: :. . .: : .: :: :: .: XP_005 DSSEGLED-RPL---PVLSL-AP--APPPVAVASPSLPSPPVS-LDPCAPAPAPASALQK 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 PKLWSLAEIATSDLKQPSLGPGCG--PPGLPAAAAPASTGAPPGGSPYPASPLLGRPL-- ::.::::: ::: . :: : ::: ::.::.. :... : :.. :: XP_005 PKIWSLAETATSPDNPRRSPPGAGGSPPG--AAVAPSALQLSPAAAAAAAHRLVSAPLGK 350 360 370 380 390 400 390 400 410 420 430 pF1KB5 ---YYTSPFYGNYTNYGNLNAALQGQG---LLRYNSAAAAPGEALHTAPKAASDAGKAGA . . :: : . .: :.. :: .::. :. : : : ..: XP_005 FPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRC 410 420 430 440 450 460 440 450 460 470 pF1KB5 HPLESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL :: . . ...: XP_005 SALEVEKKLLKTAFQPVPRRPRPRVLTPRAHPTVKPQHTHLQLDIILHCDTFLTIGPNPS 470 480 490 500 510 520 >>XP_016865334 (OMIM: 606197) PREDICTED: iroquois-class (449 aa) initn: 551 init1: 448 opt: 607 Z-score: 313.7 bits: 67.3 E(85289): 9.9e-11 Smith-Waterman score: 692; 37.6% identity (60.0% similar) in 447 aa overlap (4-422:17-402) 10 20 30 40 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP : .: . :: :: . : .::. . : . ::. .:...: . XP_016 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS 10 20 30 40 50 50 60 70 80 90 pF1KB5 YPG--SAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD------AH--TTGMTGA : .:: .: .... : :.:: . . : ::. :. .: : . : XP_016 VLGMYAAAGPYAGAPNYSAFLPYAADLS-----LFSQMGSQYELKDNPGVHPATFAAHTA 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT .:.:::. .: .::. :::::..:.:::::::::::::::::::::::::::::: XP_016 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED ::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . : XP_016 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE- 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL :. .:.. .: ::.. ..:::....: XP_016 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH 230 240 250 280 290 300 310 320 pF1KB5 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------ :: : . .:::.. : .:. :. .: : ....:. . : :::: XP_016 APAAPSALARDQGSPLAA--ADVLK--PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA 260 270 280 290 300 330 340 350 360 370 380 pF1KB5 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL : .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .: XP_016 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG 310 320 330 340 350 360 390 400 410 420 430 pF1KB5 YYTSPFYGNYTNYGNLNAALQGQG-LLRYNS--AAAAPGEALHTAPKAASDAGKAGAHPL :: . :...:. :.:. .:: :: . : ...:: : : XP_016 LYTCHI-GKFSNW--TNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIA 370 380 390 400 410 440 450 460 470 pF1KB5 ESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL XP_016 PGALNGDKASVRSSPTLPALWPRRRERRGS 420 430 440 >>NP_077313 (OMIM: 606197) iroquois-class homeodomain pr (480 aa) initn: 551 init1: 448 opt: 607 Z-score: 313.3 bits: 67.3 E(85289): 1e-10 Smith-Waterman score: 692; 37.6% identity (60.0% similar) in 447 aa overlap (4-422:17-402) 10 20 30 40 pF1KB5 MSYPQGYLYQAPGSLALYSCPAYGASALAAPRSEELARSASGSAFSP : .: . :: :: . : .::. . : . ::. .:...: . NP_077 MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASS-GRPGAAELGGGAGAAAVTS 10 20 30 40 50 50 60 70 80 90 pF1KB5 YPG--SAAFTAQAATGFGSPLQYSADAAAAAAGFPSYMGAPYD------AH--TTGMTGA : .:: .: .... : :.:: . . : ::. :. .: : . : NP_077 VLGMYAAAGPYAGAPNYSAFLPYAADLS-----LFSQMGSQYELKDNPGVHPATFAAHTA 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 ISYHPYGSAAYPYQLNDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT .:.:::. .: .::. :::::..:.:::::::::::::::::::::::::::::: NP_077 PAYYPYGQ----FQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAED ::::::::::::::::::::.::. :.:.... :. :.. .:.::.. : . : NP_077 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEG---DPEKAEDDEEIDLE- 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 EGISLHVDSLTDHSCSAESDGEKLPCRAGDPLCESGSECKDKYDDLEDDEDDDEEGERGL :. .:.. .: ::.. ..:::....: NP_077 ---SIDIDKIDEH------DGDQ------------------------SNEDDEDKAEAPH 230 240 250 280 290 300 310 320 pF1KB5 APPKPVT-----SSPLTGLEAPLLSPPPEAAPRG-GRKTPQGSRT---SPGAPP------ :: : . .:::.. : .:. :. .: : ....:. . : :::: NP_077 APAAPSALARDQGSPLAA--ADVLK--PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGA 260 270 280 290 300 330 340 350 360 370 380 pF1KB5 PASKPKLWSLAEIATSDLKQPSLGPGCGPPGLPAAAAPASTGAPPGGSPYPASPLLGRPL : .:::.::::: ::: :. .: .:: : :. :.. : : .:.: .: NP_077 PHGKPKIWSLAETATS----PDGAPKASPP--PPAGHPGAHG-PSAGAPLQHPAFLPSHG 310 320 330 340 350 360 390 400 410 420 430 pF1KB5 YYTSPFYGNYTNYGNLNAALQGQG-LLRYNS--AAAAPGEALHTAPKAASDAGKAGAHPL :: . :...:. :.:. .:: :: . : ...:: : : NP_077 LYTCHI-GKFSNW--TNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIA 370 380 390 400 410 440 450 460 470 pF1KB5 ESHYRSPGGGYEPKKDASEGCTVVGGGVQPYL NP_077 PGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPS 420 430 440 450 460 470 471 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 22:26:58 2016 done: Wed Nov 2 22:27:00 2016 Total Scan time: 9.910 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]