Result of FASTA (omim) for
pFN21AB4086
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4086, 520 aa
1>>>pF1KB4086 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5039+/-0.00044; mu= 17.1634+/- 0.027
mean_var=65.6040+/-13.240, 0's: 0 Z-trim(109.8): 20 B-trim: 0 in 0/53
Lambda= 0.158347
statistics sampled from 18051 (18070) to 18051 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.212), width: 16
Scan time: 9.210
The best scores are: opt bits E(85289)
NP_001091742 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8 0
NP_002121 (OMIM: 142940) hydroxymethylglutaryl-CoA ( 520) 3456 798.8 0
NP_001311148 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8 0
NP_001311149 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8 0
NP_001317592 (OMIM: 142940) hydroxymethylglutaryl- ( 520) 3456 798.8 0
NP_005509 (OMIM: 600234,605911) hydroxymethylgluta ( 508) 2218 516.0 1e-145
NP_001311151 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
NP_001311153 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
NP_001311152 (OMIM: 142940) hydroxymethylglutaryl- ( 478) 2185 508.5 1.8e-143
XP_011512338 (OMIM: 142940) PREDICTED: hydroxymeth ( 323) 2142 498.6 1.2e-140
NP_001159579 (OMIM: 600234,605911) hydroxymethylgl ( 466) 1233 291.0 5.2e-78
XP_011539615 (OMIM: 600234,605911) PREDICTED: hydr ( 453) 985 234.3 5.8e-61
>>NP_001091742 (OMIM: 142940) hydroxymethylglutaryl-CoA (520 aa)
initn: 3456 init1: 3456 opt: 3456 Z-score: 4265.3 bits: 798.8 E(85289): 0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
430 440 450 460 470 480
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
490 500 510 520
>>NP_002121 (OMIM: 142940) hydroxymethylglutaryl-CoA syn (520 aa)
initn: 3456 init1: 3456 opt: 3456 Z-score: 4265.3 bits: 798.8 E(85289): 0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
430 440 450 460 470 480
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_002 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
490 500 510 520
>>NP_001311148 (OMIM: 142940) hydroxymethylglutaryl-CoA (520 aa)
initn: 3456 init1: 3456 opt: 3456 Z-score: 4265.3 bits: 798.8 E(85289): 0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
430 440 450 460 470 480
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
490 500 510 520
>>NP_001311149 (OMIM: 142940) hydroxymethylglutaryl-CoA (520 aa)
initn: 3456 init1: 3456 opt: 3456 Z-score: 4265.3 bits: 798.8 E(85289): 0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
430 440 450 460 470 480
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
490 500 510 520
>>NP_001317592 (OMIM: 142940) hydroxymethylglutaryl-CoA (520 aa)
initn: 3456 init1: 3456 opt: 3456 Z-score: 4265.3 bits: 798.8 E(85289): 0
Smith-Waterman score: 3456; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
430 440 450 460 470 480
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
490 500 510 520
>>NP_005509 (OMIM: 600234,605911) hydroxymethylglutaryl- (508 aa)
initn: 2218 init1: 2218 opt: 2218 Z-score: 2737.0 bits: 516.0 E(85289): 1e-145
Smith-Waterman score: 2218; 67.5% identity (89.7% similar) in 467 aa overlap (4-470:41-507)
10 20 30
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQ
..:: :::::::.:::.:::.:::::
NP_005 ILQLTRAVQETSLTPARLLPVAHQRFSTASAVPLAKTDTWPKDVGILALEVYFPAQYVDQ
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB4 AELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVG
..::::..:.:::::.::::..::::. .:::::::.:::: :::: .: .: .::::::
NP_005 TDLEKYNNVEAGKYTVGLGQTRMGFCSVQEDINSLCLTVVQRLMERIQLPWDSVGRLEVG
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB4 TETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYA
:::::::::.::: ::.::..::::::::::::::::::::..:::.::.::::::::::
NP_005 TETIIDKSKAVKTVLMELFQDSGNTDIEGIDTTNACYGGTASLFNAANWMESSSWDGRYA
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB4 LVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEY
.:: :::::: .::::::::.::::.::::.::: .:::::::::...::::::.. :::
NP_005 MVVCGDIAVYPSGNARPTGGAGAVAMLIGPKAPLALERGLRGTHMENVYDFYKPNLASEY
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB4 PIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQK
::::::::::::: ::::::. : :::. ::.. :.:. :::.:. .::::.:.::.:::
NP_005 PIVDGKLSIQCYLRALDRCYTSYRKKIQNQWKQAGSDRPFTLDDLQYMIFHTPFCKMVQK
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB4 SLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKA
::::...::::. .. ..:.:.:::::: .:::::: ..:..::..:::...:..::::
NP_005 SLARLMFNDFLSASSDTQTSLYKGLEAFGGLKLEDTYTNKDLDKALLKASQDMFDKKTKA
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB4 SLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDAT
:: .:..::::::::.:: :::.:...: :.:::.:::.:::::::::...:..:.:::.
NP_005 SLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSQDAA
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB4 PGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTW
::: :::...: :: .:: :: :.:. :.: :. ::. .: ::. : :. .::: :::
NP_005 PGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMNQREQFYHKVNFSPPGDTNSLFPGTW
440 450 460 470 480 490
460 470 480 490 500 510
pF1KB4 YLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAA
:: ::::.::: :::::
NP_005 YLERVDEQHRRKYARRPV
500
>>NP_001311151 (OMIM: 142940) hydroxymethylglutaryl-CoA (478 aa)
initn: 2185 init1: 2185 opt: 2185 Z-score: 2696.6 bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
130 140 150
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
160 170 180 190
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
380 390 400 410 420 430
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
440 450 460 470
>>NP_001311153 (OMIM: 142940) hydroxymethylglutaryl-CoA (478 aa)
initn: 2185 init1: 2185 opt: 2185 Z-score: 2696.6 bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
130 140 150
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
160 170 180 190
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
380 390 400 410 420 430
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
440 450 460 470
>>NP_001311152 (OMIM: 142940) hydroxymethylglutaryl-CoA (478 aa)
initn: 2185 init1: 2185 opt: 2185 Z-score: 2696.6 bits: 508.5 E(85289): 1.8e-143
Smith-Waterman score: 3093; 91.9% identity (91.9% similar) in 520 aa overlap (1-520:1-478)
10 20 30 40 50 60
pF1KB4 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALL
::::::::::::::::::::::::::::::
NP_001 EGIDTTNACYGGTAAVFNAVNWIESSSWDG------------------------------
130 140 150
190 200 210 220 230 240
pF1KB4 IGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ------------LRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKI
160 170 180 190
250 260 270 280 290 300
pF1KB4 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEA
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB4 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQY
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB4 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAP
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB4 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEG
380 390 400 410 420 430
490 500 510 520
pF1KB4 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
::::::::::::::::::::::::::::::::::::::::
NP_001 VGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
440 450 460 470
>>XP_011512338 (OMIM: 142940) PREDICTED: hydroxymethylgl (323 aa)
initn: 2142 init1: 2142 opt: 2142 Z-score: 2646.2 bits: 498.6 E(85289): 1.2e-140
Smith-Waterman score: 2142; 100.0% identity (100.0% similar) in 323 aa overlap (198-520:1-323)
170 180 190 200 210 220
pF1KB4 ARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLS
::::::::::::::::::::::::::::::
XP_011 MQHAYDFYKPDMLSEYPIVDGKLSIQCYLS
10 20 30
230 240 250 260 270 280
pF1KB4 ALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQ
40 50 60 70 80 90
290 300 310 320 330 340
pF1KB4 NRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTS
100 110 120 130 140 150
350 360 370 380 390 400
pF1KB4 SVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCD
160 170 180 190 200 210
410 420 430 440 450 460
pF1KB4 LKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYA
220 230 240 250 260 270
470 480 490 500 510 520
pF1KB4 RRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
280 290 300 310 320
520 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:36:13 2016 done: Sat Nov 5 05:36:14 2016
Total Scan time: 9.210 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]