Result of FASTA (omim) for
pFN21AB4017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB4017, 464 aa
1>>>pF1KB4017 464 - 464 aa - 464 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8880+/-0.000375; mu= 14.9115+/- 0.023
mean_var=81.5269+/-15.722, 0's: 0 Z-trim(114.5): 40 B-trim: 0 in 0/54
Lambda= 0.142044
statistics sampled from 24385 (24423) to 24385 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.286), width: 16
Scan time: 9.450
The best scores are: opt bits E(85289)
XP_006716390 (OMIM: 601956) PREDICTED: GDNF family ( 464) 3198 665.2 1e-190
NP_001486 (OMIM: 601956) GDNF family receptor alph ( 464) 3198 665.2 1e-190
XP_011542786 (OMIM: 601956) PREDICTED: GDNF family ( 464) 3198 665.2 1e-190
NP_001158510 (OMIM: 601956) GDNF family receptor a ( 359) 2372 495.9 7.4e-140
NP_001158511 (OMIM: 601956) GDNF family receptor a ( 331) 2204 461.5 1.6e-129
NP_005255 (OMIM: 601496) GDNF family receptor alph ( 465) 1443 305.6 1.9e-82
XP_005269753 (OMIM: 601496) PREDICTED: GDNF family ( 465) 1443 305.6 1.9e-82
XP_011537936 (OMIM: 601496) PREDICTED: GDNF family ( 465) 1443 305.6 1.9e-82
NP_665736 (OMIM: 601496) GDNF family receptor alph ( 460) 1436 304.2 5e-82
NP_001138925 (OMIM: 601496) GDNF family receptor a ( 460) 1436 304.2 5e-82
NP_001487 (OMIM: 605710) GDNF family receptor alph ( 400) 574 127.5 6.7e-29
>>XP_006716390 (OMIM: 601956) PREDICTED: GDNF family rec (464 aa)
initn: 3198 init1: 3198 opt: 3198 Z-score: 3545.0 bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)
10 20 30 40 50 60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
370 380 390 400 410 420
430 440 450 460
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
::::::::::::::::::::::::::::::::::::::::::::
XP_006 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
430 440 450 460
>>NP_001486 (OMIM: 601956) GDNF family receptor alpha-2 (464 aa)
initn: 3198 init1: 3198 opt: 3198 Z-score: 3545.0 bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)
10 20 30 40 50 60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
370 380 390 400 410 420
430 440 450 460
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
::::::::::::::::::::::::::::::::::::::::::::
NP_001 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
430 440 450 460
>>XP_011542786 (OMIM: 601956) PREDICTED: GDNF family rec (464 aa)
initn: 3198 init1: 3198 opt: 3198 Z-score: 3545.0 bits: 665.2 E(85289): 1e-190
Smith-Waterman score: 3198; 100.0% identity (100.0% similar) in 464 aa overlap (1-464:1-464)
10 20 30 40 50 60
pF1KB4 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB4 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB4 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB4 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB4 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB4 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB4 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSM
370 380 390 400 410 420
430 440 450 460
pF1KB4 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
::::::::::::::::::::::::::::::::::::::::::::
XP_011 CFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
430 440 450 460
>>NP_001158510 (OMIM: 601956) GDNF family receptor alpha (359 aa)
initn: 2372 init1: 2372 opt: 2372 Z-score: 2631.9 bits: 495.9 E(85289): 7.4e-140
Smith-Waterman score: 2372; 100.0% identity (100.0% similar) in 346 aa overlap (119-464:14-359)
90 100 110 120 130 140
pF1KB4 PLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGT
::::::::::::::::::::::::::::::
NP_001 MILANVFCLFFFLGEEFYEASPYEPVTSRLSDIFRLASIFSGT
10 20 30 40
150 160 170 180 190 200
pF1KB4 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFF
50 60 70 80 90 100
210 220 230 240 250 260
pF1KB4 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRL
110 120 130 140 150 160
270 280 290 300 310 320
pF1KB4 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGS
170 180 190 200 210 220
330 340 350 360 370 380
pF1KB4 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDL
230 240 250 260 270 280
390 400 410 420 430 440
pF1KB4 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARP
290 300 310 320 330 340
450 460
pF1KB4 SAALTVLSVLMLKLAL
::::::::::::::::
NP_001 SAALTVLSVLMLKLAL
350
>>NP_001158511 (OMIM: 601956) GDNF family receptor alpha (331 aa)
initn: 2198 init1: 2198 opt: 2204 Z-score: 2446.4 bits: 461.5 E(85289): 1.6e-129
Smith-Waterman score: 2204; 97.6% identity (98.8% similar) in 330 aa overlap (135-464:3-331)
110 120 130 140 150 160
pF1KB4 CLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDA
:...: : .: ::::::::::::::::::
NP_001 MILANVFCLF-FFLGTGADPVVSAKSNHCLDA
10 20 30
170 180 190 200 210 220
pF1KB4 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSC
40 50 60 70 80 90
230 240 250 260 270 280
pF1KB4 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTS
100 110 120 130 140 150
290 300 310 320 330 340
pF1KB4 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTE
160 170 180 190 200 210
350 360 370 380 390 400
pF1KB4 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTS
220 230 240 250 260 270
410 420 430 440 450 460
pF1KB4 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
280 290 300 310 320 330
>>NP_005255 (OMIM: 601496) GDNF family receptor alpha-1 (465 aa)
initn: 1379 init1: 612 opt: 1443 Z-score: 1601.3 bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)
10 20 30 40 50 60
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
.:::.:.. : :..::..:::::::.::.
NP_005 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_005 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
: ::::::.::::::::.. ..: . . :.:.::::::::::.: ::: ::.::
NP_005 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_005 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
NP_005 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
NP_005 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
300 310 320 330 340 350
370 380 390 400 410
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
NP_005 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
360 370 380 390 400 410
420 430 440 450 460
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
.:... . .. .:. . : ..: :: .:. : ::..
NP_005 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
420 430 440 450 460
>>XP_005269753 (OMIM: 601496) PREDICTED: GDNF family rec (465 aa)
initn: 1379 init1: 612 opt: 1443 Z-score: 1601.3 bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)
10 20 30 40 50 60
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
.:::.:.. : :..::..:::::::.::.
XP_005 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_005 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
: ::::::.::::::::.. ..: . . :.:.::::::::::.: ::: ::.::
XP_005 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_005 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
XP_005 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
XP_005 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
300 310 320 330 340 350
370 380 390 400 410
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
XP_005 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
360 370 380 390 400 410
420 430 440 450 460
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
.:... . .. .:. . : ..: :: .:. : ::..
XP_005 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
420 430 440 450 460
>>XP_011537936 (OMIM: 601496) PREDICTED: GDNF family rec (465 aa)
initn: 1379 init1: 612 opt: 1443 Z-score: 1601.3 bits: 305.6 E(85289): 1.9e-82
Smith-Waterman score: 1443; 49.8% identity (75.2% similar) in 436 aa overlap (38-460:27-452)
10 20 30 40 50 60
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
.:::.:.. : :..::..:::::::.::.
XP_011 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
XP_011 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
: ::::::.::::::::.. ..: . . :.:.::::::::::.: ::: ::.::
XP_011 LEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
XP_011 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
XP_011 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
XP_011 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
300 310 320 330 340 350
370 380 390 400 410
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
XP_011 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
360 370 380 390 400 410
420 430 440 450 460
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
.:... . .. .:. . : ..: :: .:. : ::..
XP_011 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
420 430 440 450 460
>>NP_665736 (OMIM: 601496) GDNF family receptor alpha-1 (460 aa)
initn: 1385 init1: 612 opt: 1436 Z-score: 1593.6 bits: 304.2 E(85289): 5e-82
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (38-460:27-447)
10 20 30 40 50 60
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
.:::.:.. : :..::..:::::::.::.
NP_665 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_665 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
: ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.::
NP_665 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_665 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
180 190 200 210 220
250 260 270 280 290 300
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
NP_665 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
NP_665 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
290 300 310 320 330 340
370 380 390 400 410
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
NP_665 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
350 360 370 380 390 400
420 430 440 450 460
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
.:... . .. .:. . : ..: :: .:. : ::..
NP_665 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
410 420 430 440 450 460
>>NP_001138925 (OMIM: 601496) GDNF family receptor alpha (460 aa)
initn: 1385 init1: 612 opt: 1436 Z-score: 1593.6 bits: 304.2 E(85289): 5e-82
Smith-Waterman score: 1436; 49.8% identity (75.5% similar) in 436 aa overlap (38-460:27-447)
10 20 30 40 50 60
pF1KB4 CLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGR
.:::.:.. : :..::..:::::::.::.
NP_001 MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGK
10 20 30 40 50
70 80 90 100 110 120
pF1KB4 DRNTMLAN-----KECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEF
. : ::. ::..:.:.:... ::.:::::::::: .::.::::.. .: .:...
NP_001 ETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSL-QGNDL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB4 YEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYI
: ::::::.::::::::.. ..: .. . :.:.::::::::::.: ::: ::.::
NP_001 LEDSPYEPVNSRLSDIFRVVPFIS---VEHI--PKGNNCLDAAKACNLDDICKKYRSAYI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB4 SICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCS
. :. .: .. :::::::::::::::.::....: ::::::.: ::.:::::::.: ::
NP_001 TPCTTSVS-NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCS
180 190 200 210 220
250 260 270 280 290 300
pF1KB4 YEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIG
::..::::::.:. :.:...:::::::: .::. ..:.:: .:: :: .:.:.::
NP_001 YEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB4 FDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVN
:::::.::: .. :.:::.: .::: ::: ::: : .: ::.:::::::::.::.
NP_001 TVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVT
290 300 310 320 330 340
370 380 390 400 410
pF1KB4 V-SPKGP----SFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKE
: .: : . .: : ::.. : : .. . . : :. :...: : ::.: : .
NP_001 VWQPAFPVQTTTATTTTALRVKNKPLGPA--GSENEIPTHVLPPCANLQAQKLKSNVSGN
350 360 370 380 390 400
420 430 440 450 460
pF1KB4 LSMCFTELT---TNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
.:... . .. .:. . : ..: :: .:. : ::..
NP_001 THLCISNGNYEKEGLGASSHITTKSMAAP----PSCGLSPLLVLVVTALSTLLSLTETS
410 420 430 440 450 460
464 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 05:32:40 2016 done: Sat Nov 5 05:32:41 2016
Total Scan time: 9.450 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]