Result of FASTA (omim) for
pFN21AE0968
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0968, 520 aa
1>>>pF1KE0968 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.3652+/-0.000681; mu= -5.4810+/- 0.041
mean_var=633.3475+/-141.318, 0's: 0 Z-trim(114.1): 1105 B-trim: 33 in 1/55
Lambda= 0.050963
statistics sampled from 22334 (23837) to 22334 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.279), width: 16
Scan time: 9.500
The best scores are: opt bits E(85289)
NP_003836 (OMIM: 609181) dual specificity tyrosine ( 520) 3481 272.3 2.5e-72
NP_001269214 (OMIM: 609181) dual specificity tyros ( 234) 1596 133.2 8.6e-31
NP_001269215 (OMIM: 609181) dual specificity tyros ( 233) 1579 131.9 2e-30
NP_003574 (OMIM: 603496) dual specificity tyrosine ( 528) 1312 112.8 2.5e-24
XP_016875521 (OMIM: 603496) PREDICTED: dual specif ( 528) 1312 112.8 2.5e-24
NP_006473 (OMIM: 603496) dual specificity tyrosine ( 601) 1312 112.9 2.7e-24
XP_011508363 (OMIM: 603497) PREDICTED: dual specif ( 553) 1237 107.3 1.2e-22
XP_005273372 (OMIM: 603497) PREDICTED: dual specif ( 568) 1237 107.4 1.2e-22
NP_001004023 (OMIM: 603497) dual specificity tyros ( 568) 1237 107.4 1.2e-22
NP_003573 (OMIM: 603497) dual specificity tyrosine ( 588) 1237 107.4 1.2e-22
NP_006475 (OMIM: 604556,615812) dual specificity t ( 601) 982 88.7 5.5e-17
NP_006474 (OMIM: 604556,615812) dual specificity t ( 589) 943 85.8 4e-16
XP_005259455 (OMIM: 604556,615812) PREDICTED: dual ( 629) 935 85.2 6.2e-16
NP_004705 (OMIM: 604556,615812) dual specificity t ( 629) 935 85.2 6.2e-16
XP_011527787 (OMIM: 600855,614104) PREDICTED: dual ( 725) 934 85.3 7e-16
XP_016883774 (OMIM: 600855,614104) PREDICTED: dual ( 754) 934 85.3 7.1e-16
XP_016883773 (OMIM: 600855,614104) PREDICTED: dual ( 754) 934 85.3 7.1e-16
NP_569120 (OMIM: 600855,614104) dual specificity t ( 754) 934 85.3 7.1e-16
XP_006724042 (OMIM: 600855,614104) PREDICTED: dual ( 754) 934 85.3 7.1e-16
XP_011527786 (OMIM: 600855,614104) PREDICTED: dual ( 761) 934 85.3 7.2e-16
NP_569122 (OMIM: 600855,614104) dual specificity t ( 529) 927 84.5 8.4e-16
NP_567824 (OMIM: 600855,614104) dual specificity t ( 584) 927 84.6 8.9e-16
XP_016883775 (OMIM: 600855,614104) PREDICTED: dual ( 734) 927 84.7 1e-15
XP_006724041 (OMIM: 600855,614104) PREDICTED: dual ( 763) 927 84.8 1e-15
NP_001387 (OMIM: 600855,614104) dual specificity t ( 763) 927 84.8 1e-15
XP_006724040 (OMIM: 600855,614104) PREDICTED: dual ( 763) 927 84.8 1e-15
XP_006724039 (OMIM: 600855,614104) PREDICTED: dual ( 763) 927 84.8 1e-15
XP_011527785 (OMIM: 600855,614104) PREDICTED: dual ( 763) 927 84.8 1e-15
XP_011527784 (OMIM: 600855,614104) PREDICTED: dual ( 770) 927 84.8 1e-15
XP_016856095 (OMIM: 608003) PREDICTED: homeodomain ( 605) 697 67.7 1.1e-10
NP_689909 (OMIM: 608003) homeodomain-interacting p (1075) 697 68.1 1.5e-10
XP_016856094 (OMIM: 608003) PREDICTED: homeodomain (1209) 697 68.2 1.6e-10
NP_938009 (OMIM: 608003) homeodomain-interacting p (1210) 697 68.2 1.6e-10
XP_005270670 (OMIM: 608003) PREDICTED: homeodomain (1210) 697 68.2 1.6e-10
XP_005270669 (OMIM: 608003) PREDICTED: homeodomain (1210) 697 68.2 1.6e-10
XP_006710506 (OMIM: 608003) PREDICTED: homeodomain (1247) 697 68.2 1.6e-10
XP_005270668 (OMIM: 608003) PREDICTED: homeodomain (1256) 697 68.2 1.6e-10
XP_005270667 (OMIM: 608003) PREDICTED: homeodomain (1280) 697 68.2 1.7e-10
XP_005270666 (OMIM: 608003) PREDICTED: homeodomain (1281) 697 68.2 1.7e-10
NP_001106710 (OMIM: 606868) homeodomain-interactin (1171) 695 68.0 1.8e-10
XP_016867558 (OMIM: 606868) PREDICTED: homeodomain (1191) 695 68.0 1.8e-10
XP_006715998 (OMIM: 606868) PREDICTED: homeodomain (1191) 695 68.0 1.8e-10
NP_073577 (OMIM: 606868) homeodomain-interacting p (1198) 695 68.0 1.8e-10
XP_011514383 (OMIM: 606868) PREDICTED: homeodomain (1206) 695 68.0 1.8e-10
XP_011514382 (OMIM: 606868) PREDICTED: homeodomain (1349) 695 68.1 1.9e-10
XP_011514381 (OMIM: 606868) PREDICTED: homeodomain (1350) 695 68.1 1.9e-10
XP_011514380 (OMIM: 606868) PREDICTED: homeodomain (1376) 695 68.1 1.9e-10
XP_011514379 (OMIM: 606868) PREDICTED: homeodomain (1377) 695 68.1 1.9e-10
XP_005260990 (OMIM: 600855,614104) PREDICTED: dual ( 535) 683 66.6 2.1e-10
XP_016872566 (OMIM: 604424) PREDICTED: homeodomain (1194) 681 67.0 3.6e-10
>>NP_003836 (OMIM: 609181) dual specificity tyrosine-pho (520 aa)
initn: 3481 init1: 3481 opt: 3481 Z-score: 1419.6 bits: 272.3 E(85289): 2.5e-72
Smith-Waterman score: 3481; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
430 440 450 460 470 480
490 500 510 520
pF1KE0 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
::::::::::::::::::::::::::::::::::::::::
NP_003 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
490 500 510 520
>>NP_001269214 (OMIM: 609181) dual specificity tyrosine- (234 aa)
initn: 1596 init1: 1596 opt: 1596 Z-score: 673.8 bits: 133.2 E(85289): 8.6e-31
Smith-Waterman score: 1596; 100.0% identity (100.0% similar) in 234 aa overlap (287-520:1-234)
260 270 280 290 300 310
pF1KE0 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI
::::::::::::::::::::::::::::::
NP_001 MWSLGCITAELYTGYPLFPGENEVEQLACI
10 20 30
320 330 340 350 360 370
pF1KE0 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE0 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
160 170 180 190 200 210
500 510 520
pF1KE0 VSMTSPGQSKNFSLKNTNVLPPIV
::::::::::::::::::::::::
NP_001 VSMTSPGQSKNFSLKNTNVLPPIV
220 230
>>NP_001269215 (OMIM: 609181) dual specificity tyrosine- (233 aa)
initn: 1075 init1: 1075 opt: 1579 Z-score: 667.1 bits: 131.9 E(85289): 2e-30
Smith-Waterman score: 1579; 99.6% identity (99.6% similar) in 234 aa overlap (287-520:1-233)
260 270 280 290 300 310
pF1KE0 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI
::::::::::::::::::::::::::::::
NP_001 MWSLGCITAELYTGYPLFPGENEVEQLACI
10 20 30
320 330 340 350 360 370
pF1KE0 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDF
40 50 60 70 80 90
380 390 400 410 420 430
pF1KE0 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHH
100 110 120 130 140 150
440 450 460 470 480 490
pF1KE0 SSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
:::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSRK-DEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLPQLVDAPKKSEAAVGAE
160 170 180 190 200
500 510 520
pF1KE0 VSMTSPGQSKNFSLKNTNVLPPIV
::::::::::::::::::::::::
NP_001 VSMTSPGQSKNFSLKNTNVLPPIV
210 220 230
>>NP_003574 (OMIM: 603496) dual specificity tyrosine-pho (528 aa)
initn: 1450 init1: 1307 opt: 1312 Z-score: 557.6 bits: 112.8 E(85289): 2.5e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:68-476)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:. : : . . .: .:.: . ..:. .
NP_003 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..::::.::: . .. ..::..: :..: :::.:::::::..:::
NP_003 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
::::::.: ::: .. ::::..::.::::.:: :..::: :::.:::::.::.:: .
NP_003 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. : ..:::::::
NP_003 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: :.:....:::::::::::::.:::::::::::.:::::: : . ::::::::
NP_003 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
280 290 300 310 320 330
300 310 320 330 340
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
: ::: :::::.:::.: .::::..:.::.: ......: ..: .:::.:. :
NP_003 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
340 350 360 370 380 390
350 360 370 380 390
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
. ::: : : .:.. .:: : :::::..:: :.:..:::: :::
NP_003 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :.. : : :.: : .:..
NP_003 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
460 470 480 490 500 510
>>XP_016875521 (OMIM: 603496) PREDICTED: dual specificit (528 aa)
initn: 1450 init1: 1307 opt: 1312 Z-score: 557.6 bits: 112.8 E(85289): 2.5e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:68-476)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:. : : . . .: .:.: . ..:. .
XP_016 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..::::.::: . .. ..::..: :..: :::.:::::::..:::
XP_016 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
::::::.: ::: .. ::::..::.::::.:: :..::: :::.:::::.::.:: .
XP_016 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. : ..:::::::
XP_016 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: :.:....:::::::::::::.:::::::::::.:::::: : . ::::::::
XP_016 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
280 290 300 310 320 330
300 310 320 330 340
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
: ::: :::::.:::.: .::::..:.::.: ......: ..: .:::.:. :
XP_016 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
340 350 360 370 380 390
350 360 370 380 390
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
. ::: : : .:.. .:: : :::::..:: :.:..:::: :::
XP_016 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
400 410 420 430 440 450
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :.. : : :.: : .:..
XP_016 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
460 470 480 490 500 510
>>NP_006473 (OMIM: 603496) dual specificity tyrosine-pho (601 aa)
initn: 1450 init1: 1307 opt: 1312 Z-score: 557.1 bits: 112.9 E(85289): 2.7e-24
Smith-Waterman score: 1467; 53.4% identity (77.8% similar) in 414 aa overlap (23-419:141-549)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:. : : . . .: .:.: . ..:. .
NP_006 LTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAF
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..::::.::: . .. ..::..: :..: :::.:::::::..:::
NP_006 EHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGK
180 190 200 210 220 230
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
::::::.: ::: .. ::::..::.::::.:: :..::: :::.:::::.::.:: .
NP_006 GSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLEN
240 250 260 270 280 290
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: ::::.:.:::::..:::::.:.:.:::::: .::.:. :.:.::. : ..:::::::
NP_006 FTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLK
300 310 320 330 340 350
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: :.:....:::::::::::::.:::::::::::.:::::: : . ::::::::
NP_006 PENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGC
360 370 380 390 400 410
300 310 320 330 340
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT----
: ::: :::::.:::.: .::::..:.::.: ......: ..: .:::.:. :
NP_006 ILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTL
420 430 440 450 460 470
350 360 370 380 390
pF1KE0 -----------NNRGKKRYP-DSKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
. ::: : : .:.. .:: : :::::..:: :.:..:::: :::
NP_006 SDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQAL
480 490 500 510 520 530
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :.. : : :.: : .:..
NP_006 RHPWLR--RRL---PKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTD
540 550 560 570 580
>>XP_011508363 (OMIM: 603497) PREDICTED: dual specificit (553 aa)
initn: 1395 init1: 1237 opt: 1237 Z-score: 527.6 bits: 107.3 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:93-496)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:.. .: . : :: .::: .:..:. :
XP_011 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..:.: .::: . .. ..:: : :..: .::.:::::::. :::
XP_011 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
130 140 150 160 170 180
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
:::::::. ::: . ::::..::.::::.:: :..::: :.:.:: ...::.:: .
XP_011 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. : .::::::::
XP_011 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: ..:..:.:::::::::.:.::.::::::::::.::.::: :.. ::.::.::
XP_011 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
: ::: :: ::::::.: .::::.::.::.:: ... ..: . :..:::.:. ..:..
XP_011 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
370 380 390 400 410 420
360 370 380 390
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
::::: : ::: .:: : :..::.::: :.:: :.:: :::
XP_011 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
430 440 450 460 470 480
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :: .: ::: :
XP_011 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
490 500 510 520 530
>>XP_005273372 (OMIM: 603497) PREDICTED: dual specificit (568 aa)
initn: 1395 init1: 1237 opt: 1237 Z-score: 527.5 bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:108-511)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:.. .: . : :: .::: .:..:. :
XP_005 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
80 90 100 110 120 130
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..:.: .::: . .. ..:: : :..: .::.:::::::. :::
XP_005 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
140 150 160 170 180 190
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
:::::::. ::: . ::::..::.::::.:: :..::: :.:.:: ...::.:: .
XP_005 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. : .::::::::
XP_005 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: ..:..:.:::::::::.:.::.::::::::::.::.::: :.. ::.::.::
XP_005 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
: ::: :: ::::::.: .::::.::.::.:: ... ..: . :..:::.:. ..:..
XP_005 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
380 390 400 410 420 430
360 370 380 390
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
::::: : ::: .:: : :..::.::: :.:: :.:: :::
XP_005 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :: .: ::: :
XP_005 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
500 510 520 530 540 550
>>NP_001004023 (OMIM: 603497) dual specificity tyrosine- (568 aa)
initn: 1395 init1: 1237 opt: 1237 Z-score: 527.5 bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:108-511)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:.. .: . : :: .::: .:..:. :
NP_001 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
80 90 100 110 120 130
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..:.: .::: . .. ..:: : :..: .::.:::::::. :::
NP_001 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
140 150 160 170 180 190
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
:::::::. ::: . ::::..::.::::.:: :..::: :.:.:: ...::.:: .
NP_001 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
200 210 220 230 240 250
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. : .::::::::
NP_001 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
260 270 280 290 300 310
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: ..:..:.:::::::::.:.::.::::::::::.::.::: :.. ::.::.::
NP_001 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
: ::: :: ::::::.: .::::.::.::.:: ... ..: . :..:::.:. ..:..
NP_001 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
380 390 400 410 420 430
360 370 380 390
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
::::: : ::: .:: : :..::.::: :.:: :.:: :::
NP_001 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
440 450 460 470 480 490
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :: .: ::: :
NP_001 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
500 510 520 530 540 550
>>NP_003573 (OMIM: 603497) dual specificity tyrosine-pho (588 aa)
initn: 1395 init1: 1237 opt: 1237 Z-score: 527.4 bits: 107.4 E(85289): 1.2e-22
Smith-Waterman score: 1402; 52.6% identity (76.8% similar) in 409 aa overlap (23-414:128-531)
10 20 30 40 50
pF1KE0 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPY
:.. .: . : :: .::: .:..:. :
NP_003 NTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAY
100 110 120 130 140 150
60 70 80 90 100 110
pF1KE0 EQSEILGYAELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGK
:. ::..: :..:.: .::: . .. ..:: : :..: .::.:::::::. :::
NP_003 EKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGK
160 170 180 190 200 210
120 130 140 150 160 170
pF1KE0 GSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDF
:::::::. ::: . ::::..::.::::.:: :..::: :.:.:: ...::.:: .
NP_003 GSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLES
220 230 240 250 260 270
180 190 200 210 220 230
pF1KE0 FYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLK
: :::: :..::::.:.::::.:.:.:::::...::.:. :.:. :. : .::::::::
NP_003 FTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLK
280 290 300 310 320 330
240 250 260 270 280 290
pF1KE0 PENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGC
::::.: ..:..:.:::::::::.:.::.::::::::::.::.::: :.. ::.::.::
NP_003 PENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGC
340 350 360 370 380 390
300 310 320 330 340 350
pF1KE0 ITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPK--NITNN
: ::: :: ::::::.: .::::.::.::.:: ... ..: . :..:::.:. ..:..
NP_003 ILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQ
400 410 420 430 440 450
360 370 380 390
pF1KE0 -------------RGKKRYPD-SKDLTMVLKTYDTS-FLDFLRRCLVWEPSLRMTPDQAL
::::: : ::: .:: : :..::.::: :.:: :.:: :::
NP_003 ADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQAL
460 470 480 490 500 510
400 410 420 430 440 450
pF1KE0 KHAWIHQSRNLKPQPRPQTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTEKTKDS
.: :: .: ::: :
NP_003 RHPWISKSV-----PRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSE
520 530 540 550 560 570
520 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:45:45 2016 done: Sat Nov 5 04:45:47 2016
Total Scan time: 9.500 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]