FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4108, 478 aa 1>>>pF1KE4108 478 - 478 aa - 478 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4747+/-0.000406; mu= 12.7951+/- 0.025 mean_var=182.4821+/-40.334, 0's: 0 Z-trim(116.7): 126 B-trim: 394 in 2/54 Lambda= 0.094943 statistics sampled from 27881 (28062) to 27881 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.329), width: 16 Scan time: 7.630 The best scores are: opt bits E(85289) NP_742024 (OMIM: 608308) ankyrin repeat and BTB/PO ( 478) 3273 461.3 2.6e-129 XP_006713832 (OMIM: 608308) PREDICTED: ankyrin rep ( 480) 3150 444.5 3.1e-124 NP_115937 (OMIM: 608308) ankyrin repeat and BTB/PO ( 336) 2288 326.2 8.6e-89 XP_016862776 (OMIM: 608308) PREDICTED: ankyrin rep ( 336) 2288 326.2 8.6e-89 XP_011511515 (OMIM: 608308) PREDICTED: ankyrin rep ( 336) 2288 326.2 8.6e-89 XP_016862777 (OMIM: 608308) PREDICTED: ankyrin rep ( 297) 1798 259.0 1.3e-68 XP_016862775 (OMIM: 608308) PREDICTED: ankyrin rep ( 414) 1798 259.2 1.6e-68 XP_016862774 (OMIM: 608308) PREDICTED: ankyrin rep ( 439) 1798 259.2 1.6e-68 NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 214 42.5 0.0041 NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 214 42.5 0.0041 >>NP_742024 (OMIM: 608308) ankyrin repeat and BTB/POZ do (478 aa) initn: 3273 init1: 3273 opt: 3273 Z-score: 2442.5 bits: 461.3 E(85289): 2.6e-129 Smith-Waterman score: 3273; 100.0% identity (100.0% similar) in 478 aa overlap (1-478:1-478) 10 20 30 40 50 60 pF1KE4 MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 RCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 GVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRED 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 MALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 MALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRAL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 LPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 LPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEA 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 VKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_742 VKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 430 440 450 460 470 >>XP_006713832 (OMIM: 608308) PREDICTED: ankyrin repeat (480 aa) initn: 3150 init1: 3150 opt: 3150 Z-score: 2351.5 bits: 444.5 E(85289): 3.1e-124 Smith-Waterman score: 3150; 100.0% identity (100.0% similar) in 460 aa overlap (19-478:21-480) 10 20 30 40 50 pF1KE4 MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLAN :::::::::::::::::::::::::::::::::::::::: XP_006 MWAECDHEPVLTQALTSFLPRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLAN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 GARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE4 FVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE4 DIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE4 EDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFR 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE4 ALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADM 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE4 YLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFV 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE4 EAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 430 440 450 460 470 480 >>NP_115937 (OMIM: 608308) ankyrin repeat and BTB/POZ do (336 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 1715.1 bits: 326.2 E(85289): 8.6e-89 Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 336 aa overlap (143-478:1-336) 120 130 140 150 160 170 pF1KE4 IHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQY :::::::::::::::::::::::::::::: NP_115 MLDTKWKGKSVVVLRHPLINPVAFGALLQY 10 20 30 180 190 200 210 220 230 pF1KE4 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE4 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV 280 290 300 310 320 330 pF1KE4 SIGLDC :::::: NP_115 SIGLDC >>XP_016862776 (OMIM: 608308) PREDICTED: ankyrin repeat (336 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 1715.1 bits: 326.2 E(85289): 8.6e-89 Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 336 aa overlap (143-478:1-336) 120 130 140 150 160 170 pF1KE4 IHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQY :::::::::::::::::::::::::::::: XP_016 MLDTKWKGKSVVVLRHPLINPVAFGALLQY 10 20 30 180 190 200 210 220 230 pF1KE4 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE4 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV 280 290 300 310 320 330 pF1KE4 SIGLDC :::::: XP_016 SIGLDC >>XP_011511515 (OMIM: 608308) PREDICTED: ankyrin repeat (336 aa) initn: 2288 init1: 2288 opt: 2288 Z-score: 1715.1 bits: 326.2 E(85289): 8.6e-89 Smith-Waterman score: 2288; 100.0% identity (100.0% similar) in 336 aa overlap (143-478:1-336) 120 130 140 150 160 170 pF1KE4 IHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQY :::::::::::::::::::::::::::::: XP_011 MLDTKWKGKSVVVLRHPLINPVAFGALLQY 10 20 30 180 190 200 210 220 230 pF1KE4 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV 220 230 240 250 260 270 420 430 440 450 460 470 pF1KE4 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV 280 290 300 310 320 330 pF1KE4 SIGLDC :::::: XP_011 SIGLDC >>XP_016862777 (OMIM: 608308) PREDICTED: ankyrin repeat (297 aa) initn: 2003 init1: 1798 opt: 1798 Z-score: 1352.9 bits: 259.0 E(85289): 1.3e-68 Smith-Waterman score: 1929; 88.4% identity (88.4% similar) in 336 aa overlap (143-478:1-297) 120 130 140 150 160 170 pF1KE4 IHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQY :::::::::::::::::::::::::::::: XP_016 MLDTKWKGKSVVVLRHPLINPVAFGALLQY 10 20 30 180 190 200 210 220 230 pF1KE4 LYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPP ::: :::::::::::::::::: XP_016 LYT---------------------------------------VASKPGTCVKVLTIEPPP 40 50 240 250 260 270 280 290 pF1KE4 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCG 60 70 80 90 100 110 300 310 320 330 340 350 pF1KE4 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDV 120 130 140 150 160 170 360 370 380 390 400 410 pF1KE4 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLV 180 190 200 210 220 230 420 430 440 450 460 470 pF1KE4 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLV 240 250 260 270 280 290 pF1KE4 SIGLDC :::::: XP_016 SIGLDC >>XP_016862775 (OMIM: 608308) PREDICTED: ankyrin repeat (414 aa) initn: 2715 init1: 1798 opt: 1798 Z-score: 1351.3 bits: 259.2 E(85289): 1.6e-68 Smith-Waterman score: 2647; 90.3% identity (90.6% similar) in 445 aa overlap (35-478:9-414) 10 20 30 40 50 60 pF1KE4 DLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDS-TPLYYACLCGHEELVLYLLANGARCE :.: : ::::::::::::::::::::::: XP_016 MWAECGTCWSSETWRYYACLCGHEELVLYLLANGARCE 10 20 30 70 80 90 100 110 120 pF1KE4 ANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 KPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVE :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT-------- 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 HVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMAL ::::::::::::::::::::::::::::: XP_016 -------------------------------VASKPGTCVKVLTIEPPPADPRLREDMAL 160 170 250 260 270 280 290 300 pF1KE4 LADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDD 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE4 HFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPG 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE4 LKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKE 300 310 320 330 340 350 430 440 450 460 470 pF1KE4 EAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 360 370 380 390 400 410 >>XP_016862774 (OMIM: 608308) PREDICTED: ankyrin repeat (439 aa) initn: 2988 init1: 1798 opt: 1798 Z-score: 1351.0 bits: 259.2 E(85289): 1.6e-68 Smith-Waterman score: 2914; 91.8% identity (91.8% similar) in 478 aa overlap (1-478:1-439) 10 20 30 40 50 60 pF1KE4 MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 RCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYT----- 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 GVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRED :::::::::::::::::::::::::: XP_016 ----------------------------------VASKPGTCVKVLTIEPPPADPRLRED 180 190 200 250 260 270 280 290 300 pF1KE4 MALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRAL 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 LDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 LPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEA 330 340 350 360 370 380 430 440 450 460 470 pF1KE4 VKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 390 400 410 420 430 >>NP_001316524 (OMIM: 608778,615081) kelch-like protein (608 aa) initn: 168 init1: 97 opt: 214 Z-score: 176.9 bits: 42.5 E(85289): 0.0041 Smith-Waterman score: 216; 24.0% identity (55.9% similar) in 204 aa overlap (235-435:15-196) 210 220 230 240 250 260 pF1KE4 EAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELR--GDLWELPF :.... :. .: : . ::: : : NP_001 MEMESAAASTRFHQPHMERKMSAMA-CEIFNELRLEGKL----- 10 20 30 270 280 290 300 310 320 pF1KE4 PCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTL : :. ..: : : :: ..:. :.:::::. . . ..:. . . . NP_001 -C--------DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYN-------I 40 50 60 70 80 330 340 350 360 370 380 pF1KE4 HGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVV :::::.. .. : :. . ..:. . .:..::.. . :. : : . : . : :. . NP_001 PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 90 100 110 120 130 140 390 400 410 420 430 440 pF1KE4 GVWRVAKLFRLARLEDQCTEYMAKVIEKLVE-REDFVEAVKEEAAAVAARQETDSIPLVD :. . . . .:... .. . .:..:. .:.: : . ..: . NP_001 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 150 160 170 180 190 200 450 460 470 pF1KE4 DIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC NP_001 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 210 220 230 240 250 260 >>NP_689680 (OMIM: 608778,615081) kelch-like protein 10 (608 aa) initn: 168 init1: 97 opt: 214 Z-score: 176.9 bits: 42.5 E(85289): 0.0041 Smith-Waterman score: 216; 24.0% identity (55.9% similar) in 204 aa overlap (235-435:15-196) 210 220 230 240 250 260 pF1KE4 EAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELR--GDLWELPF :.... :. .: : . ::: : : NP_689 MEMESAAASTRFHQPHMERKMSAMA-CEIFNELRLEGKL----- 10 20 30 270 280 290 300 310 320 pF1KE4 PCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTL : :. ..: : : :: ..:. :.:::::. . . ..:. . . . NP_689 -C--------DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYN-------I 40 50 60 70 80 330 340 350 360 370 380 pF1KE4 HGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVV :::::.. .. : :. . ..:. . .:..::.. . :. : : . : . : :. . NP_689 PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 90 100 110 120 130 140 390 400 410 420 430 440 pF1KE4 GVWRVAKLFRLARLEDQCTEYMAKVIEKLVE-REDFVEAVKEEAAAVAARQETDSIPLVD :. . . . .:... .. . .:..:. .:.: : . ..: . NP_689 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 150 160 170 180 190 200 450 460 470 pF1KE4 DIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC NP_689 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 210 220 230 240 250 260 478 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:54:00 2016 done: Sun Nov 6 01:54:01 2016 Total Scan time: 7.630 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]