Result of FASTA (omim) for
pFN21AE4277
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4277, 1280 aa
1>>>pF1KE4277 1280 - 1280 aa - 1280 aa
Library: /omim/omim.rfq.tfa
64092750 residues in 91774 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.5964+/-0.000509; mu= -2.1070+/- 0.031
mean_var=297.9807+/-61.529, 0's: 0 Z-trim(116.6): 80 B-trim: 414 in 1/54
Lambda= 0.074299
statistics sampled from 28911 (28991) to 28911 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.316), width: 16
Scan time: 8.950
The best scores are: opt bits E(91774)
NP_733793 (OMIM: 606136) ras GTPase-activating pro (1280) 8403 916.0 0
XP_011508469 (OMIM: 606136) ras GTPase-activating (1287) 8379 913.4 0
XP_011508468 (OMIM: 606136) ras GTPase-activating (1290) 8042 877.3 0
XP_016858341 (OMIM: 606136) ras GTPase-activating (1409) 7950 867.4 0
XP_016858339 (OMIM: 606136) ras GTPase-activating (1416) 7926 864.9 0
XP_016858340 (OMIM: 606136) ras GTPase-activating (1412) 7613 831.3 0
XP_016858342 (OMIM: 606136) ras GTPase-activating (1234) 7590 828.8 0
XP_016858338 (OMIM: 606136) ras GTPase-activating (1419) 7589 828.7 0
NP_004832 (OMIM: 606136) ras GTPase-activating pro (1139) 7341 802.1 0
XP_016858344 (OMIM: 606136) ras GTPase-activating (1138) 7028 768.5 0
XP_005245679 (OMIM: 606136) ras GTPase-activating (1142) 7004 766.0 0
XP_016858343 (OMIM: 606136) ras GTPase-activating (1145) 7004 766.0 0
NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 3357 375.0 1.7e-102
XP_011516568 (OMIM: 609205) disabled homolog 2-int (1153) 3357 375.0 1.7e-102
XP_005251778 (OMIM: 609205) disabled homolog 2-int (1161) 3357 375.0 1.7e-102
XP_011516566 (OMIM: 609205) disabled homolog 2-int (1182) 3357 375.1 1.7e-102
XP_005251776 (OMIM: 609205) disabled homolog 2-int (1189) 3357 375.1 1.7e-102
XP_024303186 (OMIM: 609205) disabled homolog 2-int (1125) 3296 368.5 1.6e-100
XP_011516569 (OMIM: 609205) disabled homolog 2-int (1131) 3239 362.4 1.1e-98
XP_011516567 (OMIM: 609205) disabled homolog 2-int (1160) 3238 362.3 1.2e-98
XP_024303185 (OMIM: 609205) disabled homolog 2-int (1128) 3125 350.2 5.1e-95
XP_016869788 (OMIM: 609205) disabled homolog 2-int (1141) 3123 350.0 6e-95
XP_016869787 (OMIM: 609205) disabled homolog 2-int (1164) 3118 349.4 8.9e-95
NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 3110 348.5 1.5e-94
XP_016869789 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
XP_011516572 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
XP_011516573 (OMIM: 609205) disabled homolog 2-int (1065) 3110 348.5 1.5e-94
NP_001123538 (OMIM: 603384,612621) ras/Rap GTPase- (1292) 1730 200.7 5.9e-50
NP_006763 (OMIM: 603384,612621) ras/Rap GTPase-act (1343) 1705 198.0 3.9e-49
XP_024307424 (OMIM: 616561) RAS protein activator (1005) 1475 173.3 8.2e-42
NP_075055 (OMIM: 616561) RAS protein activator lik (1011) 1471 172.8 1.1e-41
XP_011526488 (OMIM: 616561) RAS protein activator (1008) 1437 169.2 1.4e-40
XP_011526489 (OMIM: 616561) RAS protein activator ( 949) 1433 168.8 1.8e-40
XP_011526487 (OMIM: 616561) RAS protein activator (1014) 1433 168.8 1.9e-40
NP_001334957 (OMIM: 616561) RAS protein activator ( 568) 952 117.0 3.9e-25
NP_001334956 (OMIM: 616561) RAS protein activator ( 574) 948 116.6 5.3e-25
NP_072179 (OMIM: 139150,605462,608354) ras GTPase- ( 870) 649 84.7 3.3e-15
NP_002881 (OMIM: 139150,605462,608354) ras GTPase- (1047) 649 84.7 3.8e-15
NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 434 61.6 2.7e-08
XP_011533144 (OMIM: 605182) ras GTPase-activating ( 802) 434 61.6 2.7e-08
XP_011533143 (OMIM: 605182) ras GTPase-activating ( 802) 434 61.6 2.7e-08
NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 434 61.6 2.8e-08
XP_016862459 (OMIM: 601589) ras GTPase-activating ( 707) 379 55.7 1.4e-06
XP_024309459 (OMIM: 601589) ras GTPase-activating ( 792) 379 55.7 1.6e-06
NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 379 55.7 1.7e-06
NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 379 55.7 1.7e-06
NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 379 55.7 1.7e-06
XP_011511361 (OMIM: 601589) ras GTPase-activating ( 853) 379 55.7 1.7e-06
XP_016862458 (OMIM: 601589) ras GTPase-activating ( 871) 379 55.7 1.7e-06
XP_016862457 (OMIM: 601589) ras GTPase-activating ( 872) 379 55.7 1.7e-06
>>NP_733793 (OMIM: 606136) ras GTPase-activating protein (1280 aa)
initn: 8403 init1: 8403 opt: 8403 Z-score: 4884.2 bits: 916.0 E(91774): 0
Smith-Waterman score: 8403; 100.0% identity (100.0% similar) in 1280 aa overlap (1-1280:1-1280)
10 20 30 40 50 60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVS
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 GSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 PQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 DFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQ
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE4 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 QTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKER
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE4 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 LRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE4 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_733 VEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGIS
1210 1220 1230 1240 1250 1260
1270 1280
pF1KE4 PTNPTKLSITENGEFKNSSC
::::::::::::::::::::
NP_733 PTNPTKLSITENGEFKNSSC
1270 1280
>>XP_011508469 (OMIM: 606136) ras GTPase-activating prot (1287 aa)
initn: 5010 init1: 4954 opt: 8379 Z-score: 4870.2 bits: 913.4 E(91774): 0
Smith-Waterman score: 8379; 99.5% identity (99.5% similar) in 1287 aa overlap (1-1280:1-1287)
10 20 30 40 50 60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
670 680 690 700 710 720
730 740 750 760 770
pF1KE4 LSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_011 LSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE4 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE4 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE4 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE4 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE4 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
1210 1220 1230 1240 1250 1260
1260 1270 1280
pF1KE4 QVRNGISPTNPTKLSITENGEFKNSSC
:::::::::::::::::::::::::::
XP_011 QVRNGISPTNPTKLSITENGEFKNSSC
1270 1280
>>XP_011508468 (OMIM: 606136) ras GTPase-activating prot (1290 aa)
initn: 5010 init1: 4954 opt: 8042 Z-score: 4675.0 bits: 877.3 E(91774): 0
Smith-Waterman score: 8042; 99.4% identity (99.4% similar) in 1233 aa overlap (1-1226:1-1233)
10 20 30 40 50 60
pF1KE4 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHES
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRE
670 680 690 700 710 720
730 740 750 760 770
pF1KE4 LSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
::::::::::::::::: ::::::::::::::::::::::::::::::::::::
XP_011 LSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEH
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRET
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE4 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASS
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE4 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPK
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE4 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQE
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE4 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE4 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSM
:::::::::::::::::::::::::::::::::
XP_011 IISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTGKTDRVPGFSQHQTDER
1210 1220 1230 1240 1250 1260
1260 1270 1280
pF1KE4 QVRNGISPTNPTKLSITENGEFKNSSC
XP_011 ADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
1270 1280 1290
>>XP_016858341 (OMIM: 606136) ras GTPase-activating prot (1409 aa)
initn: 7950 init1: 7950 opt: 7950 Z-score: 4621.2 bits: 867.4 E(91774): 0
Smith-Waterman score: 7950; 100.0% identity (100.0% similar) in 1213 aa overlap (68-1280:197-1409)
40 50 60 70 80 90
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
170 180 190 200 210 220
100 110 120 130 140 150
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
290 300 310 320 330 340
220 230 240 250 260 270
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
350 360 370 380 390 400
280 290 300 310 320 330
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
410 420 430 440 450 460
340 350 360 370 380 390
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
470 480 490 500 510 520
400 410 420 430 440 450
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
530 540 550 560 570 580
460 470 480 490 500 510
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
590 600 610 620 630 640
520 530 540 550 560 570
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
650 660 670 680 690 700
580 590 600 610 620 630
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
710 720 730 740 750 760
640 650 660 670 680 690
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
770 780 790 800 810 820
700 710 720 730 740 750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
830 840 850 860 870 880
760 770 780 790 800 810
pF1KE4 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
890 900 910 920 930 940
820 830 840 850 860 870
pF1KE4 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
950 960 970 980 990 1000
880 890 900 910 920 930
pF1KE4 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
1010 1020 1030 1040 1050 1060
940 950 960 970 980 990
pF1KE4 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
1070 1080 1090 1100 1110 1120
1000 1010 1020 1030 1040 1050
pF1KE4 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
1130 1140 1150 1160 1170 1180
1060 1070 1080 1090 1100 1110
pF1KE4 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
1190 1200 1210 1220 1230 1240
1120 1130 1140 1150 1160 1170
pF1KE4 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
1250 1260 1270 1280 1290 1300
1180 1190 1200 1210 1220 1230
pF1KE4 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
1310 1320 1330 1340 1350 1360
1240 1250 1260 1270 1280
pF1KE4 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
:::::::::::::::::::::::::::::::::::::::::::
XP_016 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
1370 1380 1390 1400
>>XP_016858339 (OMIM: 606136) ras GTPase-activating prot (1416 aa)
initn: 4557 init1: 4501 opt: 7926 Z-score: 4607.2 bits: 864.9 E(91774): 0
Smith-Waterman score: 7926; 99.4% identity (99.4% similar) in 1220 aa overlap (68-1280:197-1416)
40 50 60 70 80 90
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
170 180 190 200 210 220
100 110 120 130 140 150
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
290 300 310 320 330 340
220 230 240 250 260 270
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
350 360 370 380 390 400
280 290 300 310 320 330
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
410 420 430 440 450 460
340 350 360 370 380 390
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
470 480 490 500 510 520
400 410 420 430 440 450
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
530 540 550 560 570 580
460 470 480 490 500 510
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
590 600 610 620 630 640
520 530 540 550 560 570
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
650 660 670 680 690 700
580 590 600 610 620 630
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
710 720 730 740 750 760
640 650 660 670 680 690
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
770 780 790 800 810 820
700 710 720 730 740 750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVL
:::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVL
830 840 850 860 870 880
760 770 780 790 800 810
pF1KE4 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
890 900 910 920 930 940
820 830 840 850 860 870
pF1KE4 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
950 960 970 980 990 1000
880 890 900 910 920 930
pF1KE4 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
1010 1020 1030 1040 1050 1060
940 950 960 970 980 990
pF1KE4 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
1070 1080 1090 1100 1110 1120
1000 1010 1020 1030 1040 1050
pF1KE4 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
1130 1140 1150 1160 1170 1180
1060 1070 1080 1090 1100 1110
pF1KE4 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
1190 1200 1210 1220 1230 1240
1120 1130 1140 1150 1160 1170
pF1KE4 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
1250 1260 1270 1280 1290 1300
1180 1190 1200 1210 1220 1230
pF1KE4 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
1310 1320 1330 1340 1350 1360
1240 1250 1260 1270 1280
pF1KE4 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
1370 1380 1390 1400 1410
>>XP_016858340 (OMIM: 606136) ras GTPase-activating prot (1412 aa)
initn: 7613 init1: 7613 opt: 7613 Z-score: 4425.9 bits: 831.3 E(91774): 0
Smith-Waterman score: 7613; 100.0% identity (100.0% similar) in 1159 aa overlap (68-1226:197-1355)
40 50 60 70 80 90
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
170 180 190 200 210 220
100 110 120 130 140 150
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
290 300 310 320 330 340
220 230 240 250 260 270
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
350 360 370 380 390 400
280 290 300 310 320 330
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
410 420 430 440 450 460
340 350 360 370 380 390
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
470 480 490 500 510 520
400 410 420 430 440 450
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
530 540 550 560 570 580
460 470 480 490 500 510
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
590 600 610 620 630 640
520 530 540 550 560 570
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
650 660 670 680 690 700
580 590 600 610 620 630
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
710 720 730 740 750 760
640 650 660 670 680 690
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
770 780 790 800 810 820
700 710 720 730 740 750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSL
830 840 850 860 870 880
760 770 780 790 800 810
pF1KE4 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGK
890 900 910 920 930 940
820 830 840 850 860 870
pF1KE4 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGS
950 960 970 980 990 1000
880 890 900 910 920 930
pF1KE4 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMP
1010 1020 1030 1040 1050 1060
940 950 960 970 980 990
pF1KE4 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIP
1070 1080 1090 1100 1110 1120
1000 1010 1020 1030 1040 1050
pF1KE4 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGS
1130 1140 1150 1160 1170 1180
1060 1070 1080 1090 1100 1110
pF1KE4 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEET
1190 1200 1210 1220 1230 1240
1120 1130 1140 1150 1160 1170
pF1KE4 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSE
1250 1260 1270 1280 1290 1300
1180 1190 1200 1210 1220 1230
pF1KE4 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSAN
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTG
1310 1320 1330 1340 1350 1360
1240 1250 1260 1270 1280
pF1KE4 TRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
XP_016 KTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
1370 1380 1390 1400 1410
>>XP_016858342 (OMIM: 606136) ras GTPase-activating prot (1234 aa)
initn: 4557 init1: 4501 opt: 7590 Z-score: 4413.4 bits: 828.8 E(91774): 0
Smith-Waterman score: 7590; 99.1% identity (99.1% similar) in 1171 aa overlap (63-1226:9-1177)
40 50 60 70 80 90
pF1KE4 DLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWER
: . :::::::::::::::::::::::::
XP_016 MMENALHLWEK--DVKGPPTHRLSCGQSPYTETTTWER
10 20 30
100 110 120 130 140 150
pF1KE4 KYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVPAERSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNT
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQD
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE4 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPK
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE4 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKN
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE4 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEF
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE4 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE4 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQ
460 470 480 490 500 510
580 590 600 610 620 630
pF1KE4 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCP
520 530 540 550 560 570
640 650 660 670 680 690
pF1KE4 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGM
580 590 600 610 620 630
700 710 720 730 740
pF1KE4 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGP
::::::::::::::::::::::::::::::::::::::::::::: ::::::::
XP_016 KRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGP
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE4 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSP
700 710 720 730 740 750
810 820 830 840 850 860
pF1KE4 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHAS
760 770 780 790 800 810
870 880 890 900 910 920
pF1KE4 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNP
820 830 840 850 860 870
930 940 950 960 970 980
pF1KE4 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDF
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KE4 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVS
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KE4 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVL
1000 1010 1020 1030 1040 1050
1110 1120 1130 1140 1150 1160
pF1KE4 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKL
1060 1070 1080 1090 1100 1110
1170 1180 1190 1200 1210 1220
pF1KE4 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDA
1120 1130 1140 1150 1160 1170
1230 1240 1250 1260 1270 1280
pF1KE4 QEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
:
XP_016 QVINGDEIIQTGKTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
1180 1190 1200 1210 1220 1230
>>XP_016858338 (OMIM: 606136) ras GTPase-activating prot (1419 aa)
initn: 4557 init1: 4501 opt: 7589 Z-score: 4412.0 bits: 828.7 E(91774): 0
Smith-Waterman score: 7589; 99.4% identity (99.4% similar) in 1166 aa overlap (68-1226:197-1362)
40 50 60 70 80 90
pF1KE4 VPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCIL
::::::::::::::::::::::::::::::
XP_016 FIRGIFSTLSNGFSRMLNLKGESTNEPVREDVKGPPTHRLSCGQSPYTETTTWERKYCIL
170 180 190 200 210 220
100 110 120 130 140 150
pF1KE4 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAE
230 240 250 260 270 280
160 170 180 190 200 210
pF1KE4 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSPRRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLP
290 300 310 320 330 340
220 230 240 250 260 270
pF1KE4 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEV
350 360 370 380 390 400
280 290 300 310 320 330
pF1KE4 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFC
410 420 430 440 450 460
340 350 360 370 380 390
pF1KE4 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGL
470 480 490 500 510 520
400 410 420 430 440 450
pF1KE4 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVT
530 540 550 560 570 580
460 470 480 490 500 510
pF1KE4 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNYTMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFR
590 600 610 620 630 640
520 530 540 550 560 570
pF1KE4 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKM
650 660 670 680 690 700
580 590 600 610 620 630
pF1KE4 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSP
710 720 730 740 750 760
640 650 660 670 680 690
pF1KE4 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLL
770 780 790 800 810 820
700 710 720 730 740 750
pF1KE4 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDK-------ATVAKLGPLPRVL
:::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 EISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVL
830 840 850 860 870 880
760 770 780 790 800 810
pF1KE4 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNT
890 900 910 920 930 940
820 830 840 850 860 870
pF1KE4 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDV
950 960 970 980 990 1000
880 890 900 910 920 930
pF1KE4 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
1010 1020 1030 1040 1050 1060
940 950 960 970 980 990
pF1KE4 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHT
1070 1080 1090 1100 1110 1120
1000 1010 1020 1030 1040 1050
pF1KE4 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVA
1130 1140 1150 1160 1170 1180
1060 1070 1080 1090 1100 1110
pF1KE4 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
1190 1200 1210 1220 1230 1240
1120 1130 1140 1150 1160 1170
pF1KE4 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYK
1250 1260 1270 1280 1290 1300
1180 1190 1200 1210 1220 1230
pF1KE4 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQAVIDAKQKIIDAQVING
1310 1320 1330 1340 1350 1360
1240 1250 1260 1270 1280
pF1KE4 VSLDSANTRLMSALTQVKERYSMQVRNGISPTNPTKLSITENGEFKNSSC
XP_016 DEIIQTGKTDRVPGFSQHQTDERADPSEGAVQHAGPQWHLPHQPHQAFHHGEW
1370 1380 1390 1400 1410
>>NP_004832 (OMIM: 606136) ras GTPase-activating protein (1139 aa)
initn: 3972 init1: 3916 opt: 7341 Z-score: 4269.7 bits: 802.1 E(91774): 0
Smith-Waterman score: 7341; 99.4% identity (99.4% similar) in 1135 aa overlap (153-1280:5-1139)
130 140 150 160 170 180
pF1KE4 STKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTANT
::::::::::::::::::::::::::::::
NP_004 MQTPEVPAERSPRRRSISGTSTSEKPNSMDTANT
10 20 30
190 200 210 220 230 240
pF1KE4 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE4 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE4 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE4 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE4 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE4 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE4 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE4 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
520 530 540 550 560 570
730 740 750 760 770
pF1KE4 VLHSLLWEVVSQLDK-------ATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNS
::::::::::::::: ::::::::::::::::::::::::::::::::::::::
NP_004 VLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNS
580 590 600 610 620 630
780 790 800 810 820 830
pF1KE4 SPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEK
640 650 660 670 680 690
840 850 860 870 880 890
pF1KE4 DERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQS
700 710 720 730 740 750
900 910 920 930 940 950
pF1KE4 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRS
760 770 780 790 800 810
960 970 980 990 1000 1010
pF1KE4 QSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVD
820 830 840 850 860 870
1020 1030 1040 1050 1060 1070
pF1KE4 QGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVR
880 890 900 910 920 930
1080 1090 1100 1110 1120 1130
pF1KE4 AIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEIT
940 950 960 970 980 990
1140 1150 1160 1170 1180 1190
pF1KE4 KLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSII
1000 1010 1020 1030 1040 1050
1200 1210 1220 1230 1240 1250
pF1KE4 SRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SRLMAVEEELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQV
1060 1070 1080 1090 1100 1110
1260 1270 1280
pF1KE4 RNGISPTNPTKLSITENGEFKNSSC
:::::::::::::::::::::::::
NP_004 RNGISPTNPTKLSITENGEFKNSSC
1120 1130
>>XP_016858344 (OMIM: 606136) ras GTPase-activating prot (1138 aa)
initn: 7028 init1: 7028 opt: 7028 Z-score: 4088.4 bits: 768.5 E(91774): 0
Smith-Waterman score: 7028; 100.0% identity (100.0% similar) in 1074 aa overlap (153-1226:8-1081)
130 140 150 160 170 180
pF1KE4 STKGRCLRRTVSVPSEGQFPEYPPEGATKLEVPAERSPRRRSISGTSTSEKPNSMDTANT
::::::::::::::::::::::::::::::
XP_016 MGSSCDKEVPAERSPRRRSISGTSTSEKPNSMDTANT
10 20 30
190 200 210 220 230 240
pF1KE4 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTDDRSRGLPKLKESRSHESLL
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE4 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLR
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGE
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE4 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKWYPVSTPTP
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE4 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACA
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE4 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDAL
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE4 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFA
400 410 420 430 440 450
610 620 630 640 650 660
pF1KE4 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVI
460 470 480 490 500 510
670 680 690 700 710 720
pF1KE4 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELS
520 530 540 550 560 570
730 740 750 760 770 780
pF1KE4 VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGS
580 590 600 610 620 630
790 800 810 820 830 840
pF1KE4 LSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSL
640 650 660 670 680 690
850 860 870 880 890 900
pF1KE4 PNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQ
700 710 720 730 740 750
910 920 930 940 950 960
pF1KE4 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDF
760 770 780 790 800 810
970 980 990 1000 1010 1020
pF1KE4 KLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGAR
820 830 840 850 860 870
1030 1040 1050 1060 1070 1080
pF1KE4 AKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQT
880 890 900 910 920 930
1090 1100 1110 1120 1130 1140
pF1KE4 QQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLR
940 950 960 970 980 990
1150 1160 1170 1180 1190 1200
pF1KE4 VSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVE
1000 1010 1020 1030 1040 1050
1210 1220 1230 1240 1250 1260
pF1KE4 EELKKDHAEMQAVIDAKQKIIDAQEKRIVSLDSANTRLMSALTQVKERYSMQVRNGISPT
::::::::::::::::::::::::
XP_016 EELKKDHAEMQAVIDAKQKIIDAQVINGDEIIQTGKTDRVPGFSQHQTDERADPSEGAVQ
1060 1070 1080 1090 1100 1110
1280 residues in 1 query sequences
64092750 residues in 91774 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Jul 16 15:46:51 2019 done: Tue Jul 16 15:46:53 2019
Total Scan time: 8.950 Total Display time: 0.390
Function used was FASTA [36.3.4 Apr, 2011]