FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4006, 126 aa 1>>>pF1KE4006 126 - 126 aa - 126 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4679+/-0.000259; mu= 11.1675+/- 0.016 mean_var=80.3630+/-15.610, 0's: 0 Z-trim(121.8): 31 B-trim: 82 in 1/53 Lambda= 0.143069 statistics sampled from 38856 (38887) to 38856 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.456), width: 16 Scan time: 4.690 The best scores are: opt bits E(85289) NP_001010858 (OMIM: 613754) E3 ubiquitin-protein l ( 235) 842 182.1 3.7e-46 NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 160 41.6 0.0015 XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 148 38.9 0.0054 XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 148 38.9 0.0054 XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 150 39.5 0.0063 NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 148 39.0 0.0066 XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 148 39.1 0.0082 NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 148 39.1 0.0086 NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 148 39.1 0.0086 XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086 XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086 XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086 >>NP_001010858 (OMIM: 613754) E3 ubiquitin-protein ligas (235 aa) initn: 842 init1: 842 opt: 842 Z-score: 949.6 bits: 182.1 E(85289): 3.7e-46 Smith-Waterman score: 842; 100.0% identity (100.0% similar) in 126 aa overlap (1-126:110-235) 10 20 30 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIM :::::::::::::::::::::::::::::: NP_001 AAPARDGPASEAALQLLCRADAGPLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIM 80 90 100 110 120 130 40 50 60 70 80 90 pF1KE4 RKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGL 140 150 160 170 180 190 100 110 120 pF1KE4 PEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ :::::::::::::::::::::::::::::::::::: NP_001 PEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ 200 210 220 230 >>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa) initn: 167 init1: 151 opt: 160 Z-score: 184.6 bits: 41.6 E(85289): 0.0015 Smith-Waterman score: 160; 30.6% identity (71.2% similar) in 111 aa overlap (18-124:135-244) 10 20 30 40 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESA :..: .: :.: .::...:: ...::. . NP_660 DELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEK-SLEHLRKQMQDALLFQAQADET 110 120 130 140 150 160 50 60 70 80 90 100 pF1KE4 AAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEG--LPE--DELADPTERFR ..:. : ..:...: ....:: ...:::...::. :.:: ::. . : .. NP_660 CVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSA 170 180 190 200 210 220 110 120 pF1KE4 SLLQAVSELEKKHRNLGLSMLLQ : . ..::: . . .:..: NP_660 HLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLR 230 240 250 260 270 280 >>XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (262 aa) initn: 132 init1: 132 opt: 148 Z-score: 174.8 bits: 38.9 E(85289): 0.0054 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: XP_016 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... XP_016 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: XP_016 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRTT 230 240 250 260 >>XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (262 aa) initn: 132 init1: 132 opt: 148 Z-score: 174.8 bits: 38.9 E(85289): 0.0054 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: XP_016 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... XP_016 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: XP_016 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRTT 230 240 250 260 >>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa) initn: 156 init1: 89 opt: 150 Z-score: 173.5 bits: 39.5 E(85289): 0.0063 Smith-Waterman score: 150; 30.6% identity (71.2% similar) in 111 aa overlap (18-124:135-243) 10 20 30 40 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESA :..: .: :.: .::...:: ...::. . XP_016 DELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEK-SLEHLRKQMQDALLFQAQADET 110 120 130 140 150 160 50 60 70 80 90 100 pF1KE4 AAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEG--LPE--DELADPTERFR ..:. : ..:...: ....:: ...:::...::. :.:: ::. . : .. XP_016 CVLWQ-MVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSA 170 180 190 200 210 220 110 120 pF1KE4 SLLQAVSELEKKHRNLGLSMLLQ : . ..::: . . .:..: XP_016 HLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLR 230 240 250 260 270 280 >>NP_001128327 (OMIM: 606123) E3 ubiquitin-protein ligas (343 aa) initn: 132 init1: 132 opt: 148 Z-score: 173.2 bits: 39.0 E(85289): 0.0066 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: NP_001 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE 230 240 250 260 270 280 >>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa) initn: 132 init1: 132 opt: 148 Z-score: 171.5 bits: 39.1 E(85289): 0.0082 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:123-211) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 100 110 120 130 140 150 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 160 170 180 190 200 120 pF1KE4 RNLGLSMLLQ ..: : .::: XP_011 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE 210 220 230 240 250 260 >>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa) initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: NP_057 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... NP_057 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: NP_057 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE 230 240 250 260 270 280 >>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa) initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: NP_001 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE 230 240 250 260 270 280 >>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa) initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086 Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238) 10 20 30 40 50 pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM .: .:.... . .:... :.. : :.:.: XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK 120 130 140 150 160 170 60 70 80 90 100 110 pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH .::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :... XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG 180 190 200 210 220 120 pF1KE4 RNLGLSMLLQ ..: : .::: XP_011 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE 230 240 250 260 270 280 126 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:03:10 2016 done: Sun Nov 6 04:03:11 2016 Total Scan time: 4.690 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]