FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1880, 406 aa 1>>>pF1KE1880 406 - 406 aa - 406 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2422+/-0.000447; mu= 17.5323+/- 0.028 mean_var=84.6354+/-17.354, 0's: 0 Z-trim(111.7): 282 B-trim: 20 in 1/50 Lambda= 0.139411 statistics sampled from 20088 (20419) to 20088 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.239), width: 16 Scan time: 8.190 The best scores are: opt bits E(85289) NP_005134 (OMIM: 140100,614081) haptoglobin isofor ( 406) 2795 572.5 6.3e-163 NP_001119574 (OMIM: 140100,614081) haptoglobin iso ( 347) 2188 450.4 3.2e-126 NP_001305067 (OMIM: 140100,614081) haptoglobin iso ( 347) 2178 448.4 1.3e-125 NP_066275 (OMIM: 140210) haptoglobin-related prote ( 348) 2006 413.8 3.3e-115 NP_001725 (OMIM: 120580,613783) complement C1s sub ( 688) 480 107.1 1.4e-22 XP_005253817 (OMIM: 120580,613783) PREDICTED: comp ( 688) 480 107.1 1.4e-22 NP_958850 (OMIM: 120580,613783) complement C1s sub ( 688) 480 107.1 1.4e-22 NP_006601 (OMIM: 605102,613791) mannan-binding lec ( 686) 453 101.7 5.8e-21 NP_001724 (OMIM: 216950,613785) complement C1r sub ( 705) 447 100.5 1.4e-20 XP_016875404 (OMIM: 216950,613785) PREDICTED: comp ( 719) 447 100.5 1.4e-20 XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 399 90.6 6.8e-18 NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 399 90.6 7.1e-18 XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 399 90.6 7.8e-18 NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 399 90.7 7.9e-18 NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 399 90.7 8.2e-18 XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 399 90.7 8.6e-18 XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 394 89.6 1.5e-17 NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 370 84.7 3.3e-16 NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 362 83.1 1.1e-15 NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 360 82.8 1.9e-15 XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 360 82.8 1.9e-15 XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 360 82.9 2.1e-15 XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 356 82.0 3.4e-15 XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 345 79.6 1e-14 XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 345 79.6 1e-14 NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 345 79.6 1e-14 XP_016862359 (OMIM: 257920,600521) PREDICTED: mann ( 668) 346 80.2 1.7e-14 NP_001870 (OMIM: 257920,600521) mannan-binding lec ( 699) 346 80.2 1.8e-14 XP_011511292 (OMIM: 257920,600521) PREDICTED: mann ( 706) 346 80.2 1.8e-14 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 334 77.6 6.5e-14 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 334 77.6 6.9e-14 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 334 77.6 7e-14 NP_057630 (OMIM: 608974) complement C1r subcompone ( 487) 331 77.0 1.1e-13 XP_016874886 (OMIM: 608974) PREDICTED: complement ( 504) 331 77.0 1.1e-13 NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 317 74.0 5.1e-13 NP_001284569 (OMIM: 608974) complement C1r subcomp ( 445) 314 73.6 1.1e-12 XP_016874887 (OMIM: 608974) PREDICTED: complement ( 462) 314 73.6 1.1e-12 NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 309 72.4 1.6e-12 XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 307 72.3 3.8e-12 XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 307 72.3 3.8e-12 XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 307 72.3 3.8e-12 NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 307 72.4 4.3e-12 XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 307 72.4 4.4e-12 NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 307 72.4 4.7e-12 NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 307 72.4 4.7e-12 XP_016862361 (OMIM: 257920,600521) PREDICTED: mann ( 615) 294 69.7 2.3e-11 XP_016862358 (OMIM: 257920,600521) PREDICTED: mann ( 702) 294 69.7 2.5e-11 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 292 69.4 3.7e-11 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 292 69.4 3.7e-11 NP_001298186 (OMIM: 176930,188050,601367,613679,61 ( 606) 286 68.0 6.9e-11 >>NP_005134 (OMIM: 140100,614081) haptoglobin isoform 1 (406 aa) initn: 2795 init1: 2795 opt: 2795 Z-score: 3046.0 bits: 572.5 E(85289): 6.3e-163 Smith-Waterman score: 2795; 100.0% identity (100.0% similar) in 406 aa overlap (1-406:1-406) 10 20 30 40 50 60 pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA 310 320 330 340 350 360 370 380 390 400 pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN :::::::::::::::::::::::::::::::::::::::::::::: NP_005 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN 370 380 390 400 >>NP_001119574 (OMIM: 140100,614081) haptoglobin isoform (347 aa) initn: 2188 init1: 2188 opt: 2188 Z-score: 2387.1 bits: 450.4 E(85289): 3.2e-126 Smith-Waterman score: 2237; 85.5% identity (85.5% similar) in 406 aa overlap (1-406:1-347) 10 20 30 40 50 60 pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT :::::::::::::::::::::::::::::::::::::::::: NP_001 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHG------------------ 10 20 30 40 70 80 90 100 110 120 pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE ::::::::::::::::::: NP_001 -----------------------------------------YVEHSVRYQCKNYYKLRTE 50 60 130 140 150 160 170 180 pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA 250 260 270 280 290 300 370 380 390 400 pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN :::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN 310 320 330 340 >>NP_001305067 (OMIM: 140100,614081) haptoglobin isoform (347 aa) initn: 2178 init1: 2178 opt: 2178 Z-score: 2376.2 bits: 448.4 E(85289): 1.3e-125 Smith-Waterman score: 2238; 85.5% identity (85.5% similar) in 406 aa overlap (1-406:1-347) 10 20 30 40 50 60 pF1KE1 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE :::::::::::::::::::::::::::: NP_001 EGDGVYTLNDKKQWINKAVGDKLPECEA-------------------------------- 70 80 130 140 150 160 170 180 pF1KE1 GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV ::::::::::::::::::::::::::::::::: NP_001 ---------------------------VCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV 90 100 110 120 190 200 210 220 230 240 pF1KE1 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE1 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE1 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA 250 260 270 280 290 300 370 380 390 400 pF1KE1 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN :::::::::::::::::::::::::::::::::::::::::::::: NP_001 VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN 310 320 330 340 >>NP_066275 (OMIM: 140210) haptoglobin-related protein p (348 aa) initn: 2070 init1: 2006 opt: 2006 Z-score: 2189.2 bits: 413.8 E(85289): 3.3e-115 Smith-Waterman score: 2028; 78.4% identity (81.8% similar) in 407 aa overlap (1-406:1-348) 10 20 30 40 50 pF1KE1 MSALGAVIALLLWG-QLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLR :: :::::.::::: ::::. ::::::::.:: :::::::.::::: ::::::::.:: NP_066 MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE1 TEGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT ::::::::::::::::::::::::::::: NP_066 TEGDGVYTLNDKKQWINKAVGDKLPECEA------------------------------- 70 80 120 130 140 150 160 170 pF1KE1 EGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKM :::::::::::::::::::::::::::::::: NP_066 ----------------------------VCGKPKNPANPVQRILGGHLDAKGSFPWQAKM 90 100 110 120 180 190 200 210 220 230 pF1KE1 VSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 VSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLH 130 140 150 160 170 180 240 250 260 270 280 290 pF1KE1 PNYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYV ::: ::::::::::::: :::::::::::::.::::::::::::::.. :::.::::::: NP_066 PNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKYV 190 200 210 220 230 240 300 310 320 330 340 350 pF1KE1 MLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAF ::::::: .:: :::::: :. :.:::::::::::::::::.:::::::::::::::::: NP_066 MLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAF 250 260 270 280 290 300 360 370 380 390 400 pF1KE1 AVHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN ::::::::::::.:::::::::::::::::::::::: ::::::::: NP_066 AVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN 310 320 330 340 >>NP_001725 (OMIM: 120580,613783) complement C1s subcomp (688 aa) initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22 Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682) 10 20 30 40 50 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN ::: : : :. . :. : . NP_001 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD 270 280 290 300 310 320 60 70 80 90 100 pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS------- ... .:: :. .. . : .: ..:: .:. : : : : .: :: NP_001 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS 330 340 350 360 370 380 110 120 130 140 150 160 pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG .:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.: NP_001 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG 390 400 410 420 430 440 170 180 190 200 210 220 pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY : .:::: : : .:..:::: :.::.: .. .. : . . . : NP_001 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR 450 460 470 480 490 230 240 250 260 270 pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD ..:.... :.: .::... . ::.:..::. :... : ::::: :.: NP_001 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV : . : .: .:::::. . . .:: . :::: .: : :. : . . NP_001 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA 560 570 580 590 600 340 350 360 370 380 pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV . ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::. NP_001 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL 610 620 630 640 650 660 390 400 pF1KE1 YVKVTSIQDWVQKTIAEN :..: . ::..::. :: NP_001 YTRVKNYVDWIMKTMQENSTPRED 670 680 >>XP_005253817 (OMIM: 120580,613783) PREDICTED: compleme (688 aa) initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22 Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682) 10 20 30 40 50 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN ::: : : :. . :. : . XP_005 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD 270 280 290 300 310 320 60 70 80 90 100 pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS------- ... .:: :. .. . : .: ..:: .:. : : : : .: :: XP_005 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS 330 340 350 360 370 380 110 120 130 140 150 160 pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG .:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.: XP_005 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG 390 400 410 420 430 440 170 180 190 200 210 220 pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY : .:::: : : .:..:::: :.::.: .. .. : . . . : XP_005 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR 450 460 470 480 490 230 240 250 260 270 pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD ..:.... :.: .::... . ::.:..::. :... : ::::: :.: XP_005 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV : . : .: .:::::. . . .:: . :::: .: : :. : . . XP_005 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA 560 570 580 590 600 340 350 360 370 380 pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV . ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::. XP_005 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL 610 620 630 640 650 660 390 400 pF1KE1 YVKVTSIQDWVQKTIAEN :..: . ::..::. :: XP_005 YTRVKNYVDWIMKTMQENSTPRED 670 680 >>NP_958850 (OMIM: 120580,613783) complement C1s subcomp (688 aa) initn: 405 init1: 191 opt: 480 Z-score: 526.6 bits: 107.1 E(85289): 1.4e-22 Smith-Waterman score: 610; 32.1% identity (59.1% similar) in 408 aa overlap (33-406:294-682) 10 20 30 40 50 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPK---P-----PEIAHGYVEHSVRYQCKN ::: : : :. . :. : . NP_958 KSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYVFRDVVQITCLD 270 280 290 300 310 320 60 70 80 90 100 pF1KE1 YYKLRTEGD-GVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS------- ... .:: :. .. . : .: ..:: .:. : : : : .: :: NP_958 GFEV-VEGRVGATSFYSTCQSNGKWSNSKL-KCQPVD-CGIPESIENGKVEDPESTLFGS 330 340 350 360 370 380 110 120 130 140 150 160 pF1KE1 -VRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILG .:: :.. :: ... : : : .. .:.:...: .::.: ::: :..: . :::.: NP_958 VIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEEKQRIIG 390 400 410 420 430 440 170 180 190 200 210 220 pF1KE1 GHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLY : .:::: : : .:..:::: :.::.: .. .. : . . . : NP_958 GSDADIKNFPWQ---VFFDNPWAGGALINEYWVLTAA-HVVEGNREPTMYVGSTSVQTSR 450 460 470 480 490 230 240 250 260 270 pF1KE1 VGKKQLVEIEKVVLHPNYSQV-----------DIGLIKLKQKVSVNERVMPICLP--SKD ..:.... :.: .::... . ::.:..::. :... : ::::: :.: NP_958 LAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPICLPGTSSD 500 510 520 530 540 550 280 290 300 310 320 330 pF1KE1 YAEV-GRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGV : . : .: .:::::. . . .:: . :::: .: : :. : . . NP_958 YNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKC---------KEVKVEKPTADA 560 570 580 590 600 340 350 360 370 380 pF1KE1 QP-ILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDT-WYATGILSFDKSCAVAEYGV . ... . .::: : . :.: ::.:.::::.: .. : .::.:..:. .:.. ::. NP_958 EAYVFTPNMICAGGEKGM-DSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCGT--YGL 610 620 630 640 650 660 390 400 pF1KE1 YVKVTSIQDWVQKTIAEN :..: . ::..::. :: NP_958 YTRVKNYVDWIMKTMQENSTPRED 670 680 >>NP_006601 (OMIM: 605102,613791) mannan-binding lectin (686 aa) initn: 439 init1: 121 opt: 453 Z-score: 497.3 bits: 101.7 E(85289): 5.8e-21 Smith-Waterman score: 538; 29.1% identity (58.1% similar) in 406 aa overlap (33-405:300-685) 10 20 30 40 50 60 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEH-SVRYQCKNYYKLRTE :: : .:.: ...: :. ... : NP_006 KSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKDSFSIFCE 270 280 290 300 310 320 70 80 90 100 pF1KE1 GDGVYTLNDK---KQW--INKAVG--DK-LPECEADDGCPKPPEIAHGYVEH-------- : :. . :.. . . : :. .: : : : : .. : ::. NP_006 -TGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVD-CGPPDDLPSGRVEYITGPGVTT 330 340 350 360 370 380 110 120 130 140 150 160 pF1KE1 ---SVRYQCKN-YYKLRTEGDGVYTLNNEKQWINKAVGDK-LPECEAVCGKPKNPANPVQ ..:.:.. .: .... :: :. . . : .. :.: :: :: ::: .. NP_006 YKAVIQYSCEETFYTMKVN-DGKYVCEADGFWTSSK-GEKSLPVCEPVCGLSARTTG--G 390 400 410 420 430 440 170 180 190 200 210 pF1KE1 RILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDI-AP :: ::. :.::::. ... . :....:. ..:.::.:. .. .....:.: :: NP_006 RIYGGQKAKPGDFPWQVLILG--GTTAAGALLYDNWVLTAAHAVY-EQKHDASALDIRMG 450 460 470 480 490 500 220 230 240 250 260 270 pF1KE1 TLTLYVGKKQLVEIEKVVLHPNYSQ-----VDIGLIKLKQKVSVNERVMPICLPSKD--- :: . . : : .: .:.. ::.::::..:: .: . ::::: :. NP_006 TLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAES 510 520 530 540 550 560 280 290 300 310 320 330 pF1KE1 YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHYEGSTVPEKKTPKSPVGVQ . .. .: .:::: . .. .: :: .:..:...: :: : : : NP_006 FMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYE--------KPPYPRGS- 570 580 590 600 610 340 350 360 370 380 pF1KE1 PILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATGILSFDK-SCAVA-EYGVY .. . .:::. . .:.: ::.:.:.. : : . :.. ::.:. . .:. : .:::: NP_006 --VTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVY 620 630 640 650 660 390 400 pF1KE1 VKVTSIQDWVQKTIAEN .:: . :... :.. NP_006 TKVINYIPWIENIISDF 670 680 >>NP_001724 (OMIM: 216950,613785) complement C1r subcomp (705 aa) initn: 526 init1: 204 opt: 447 Z-score: 490.6 bits: 100.5 E(85289): 1.4e-20 Smith-Waterman score: 658; 31.3% identity (61.4% similar) in 422 aa overlap (33-405:309-703) 10 20 30 40 50 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVR--YQ--------C ::.: . . . .... :: : NP_001 SSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATC 280 290 300 310 320 330 60 70 80 90 100 pF1KE1 KNYYKLRTEGDGVY-----TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS- :. :.: ::. : . .: : ..: .:.:. : : .: .. .: ... NP_001 KQGYQL-IEGNQVLHSFTAVCQDDGTW-HRA----MPRCKIKD-CGQPRNLPNGDFRYTT 340 350 360 370 380 390 110 120 130 140 pF1KE1 ----------VRYQCKN-YYKLRTEG------DGVYTLNNEKQWINKAVGDKLPECEAVC ..: :.. :::..:.. .:::: . . : :. :.:.:.: :: NP_001 TMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVC 400 410 420 430 440 450 150 160 170 180 190 200 pF1KE1 GKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHS ::: ::.. :::.::. :.::::. ... :. :: :....:.::.:..:. .. NP_001 GKPVNPVEQRQRIIGGQKAKMGNFPWQV-FTNIHGRGGGA-LLGDRWILTAAHTLYPKEH 460 470 480 490 500 210 220 230 240 250 pF1KE1 ENATAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYSQV-------DIGLIKLKQ : :.. : .: ...:. .. : :..: .::.: : ::.:..:.. NP_001 E---AQSNA-SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN 510 520 530 540 550 560 260 270 280 290 300 310 pF1KE1 KVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY .:... ..:::::..: . ..: .:::::.: . :.. :..: ::::. . : NP_001 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANPQACENWL 570 580 590 600 610 620 320 330 340 350 360 370 pF1KE1 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG .:.. . ..... :::: . ..:.: ::.:..:::.: . : : ::: NP_001 RGKNRMD------------VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATG 630 640 650 660 670 380 390 400 pF1KE1 ILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN :.:. .:. . :: :.:: . ::..: . : NP_001 IVSWGIGCSRG-YGFYTKVLNYVDWIKKEMEEED 680 690 700 >>XP_016875404 (OMIM: 216950,613785) PREDICTED: compleme (719 aa) initn: 526 init1: 204 opt: 447 Z-score: 490.5 bits: 100.5 E(85289): 1.4e-20 Smith-Waterman score: 658; 31.3% identity (61.4% similar) in 422 aa overlap (33-405:323-717) 10 20 30 40 50 pF1KE1 ALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVR--YQ--------C ::.: . . . .... :: : XP_016 SSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATC 300 310 320 330 340 350 60 70 80 90 100 pF1KE1 KNYYKLRTEGDGVY-----TLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHS- :. :.: ::. : . .: : ..: .:.:. : : .: .. .: ... XP_016 KQGYQL-IEGNQVLHSFTAVCQDDGTW-HRA----MPRCKIKD-CGQPRNLPNGDFRYTT 360 370 380 390 400 110 120 130 140 pF1KE1 ----------VRYQCKN-YYKLRTEG------DGVYTLNNEKQWINKAVGDKLPECEAVC ..: :.. :::..:.. .:::: . . : :. :.:.:.: :: XP_016 TMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKGEKIPRCLPVC 410 420 430 440 450 460 150 160 170 180 190 200 pF1KE1 GKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKNLFLNHS ::: ::.. :::.::. :.::::. ... :. :: :....:.::.:..:. .. XP_016 GKPVNPVEQRQRIIGGQKAKMGNFPWQV-FTNIHGRGGGA-LLGDRWILTAAHTLYPKEH 470 480 490 500 510 520 210 220 230 240 250 pF1KE1 ENATAKDIAPTLTLYVGKKQLVE--------IEKVVLHPNYSQV-------DIGLIKLKQ : :.. : .: ...:. .. : :..: .::.: : ::.:..:.. XP_016 E---AQSNA-SLDVFLGHTNVEELMKLGNHPIRRVSVHPDYRQDESYNFEGDIALLELEN 530 540 550 560 570 260 270 280 290 300 310 pF1KE1 KVSVNERVMPICLPSKD-YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIRHY .:... ..:::::..: . ..: .:::::.: . :.. :..: ::::. . : XP_016 SVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVMEE-KIAHDLRFVRLPVANPQACENWL 580 590 600 610 620 630 320 330 340 350 360 370 pF1KE1 EGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYATG .:.. . ..... :::: . ..:.: ::.:..:::.: . : : ::: XP_016 RGKNRMD------------VFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATG 640 650 660 670 680 380 390 400 pF1KE1 ILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN :.:. .:. . :: :.:: . ::..: . : XP_016 IVSWGIGCSRG-YGFYTKVLNYVDWIKKEMEEED 690 700 710 406 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:06:28 2016 done: Sun Nov 6 21:06:29 2016 Total Scan time: 8.190 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]