Result of FASTA (omim) for
pFN21AE1947
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1947, 501 aa
1>>>pF1KE1947 501 - 501 aa - 501 aa
Library: /omim/omim.rfq.tfa
64440809 residues in 90964 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9065+/-0.000359; mu= 20.5585+/- 0.022
mean_var=67.3780+/-13.601, 0's: 0 Z-trim(113.9): 34 B-trim: 1425 in 1/50
Lambda= 0.156248
statistics sampled from 24200 (24234) to 24200 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.635), E-opt: 0.2 (0.266), width: 16
Scan time: 4.320
The best scores are: opt bits E(90964)
NP_036236 (OMIM: 604252) beta-secretase 1 isoform ( 501) 3417 779.4 0
NP_001193977 (OMIM: 604252) beta-secretase 1 isofo ( 401) 2607 596.8 4.2e-170
NP_620427 (OMIM: 604252) beta-secretase 1 isoform ( 457) 2144 492.4 1.2e-138
NP_001193978 (OMIM: 604252) beta-secretase 1 isofo ( 376) 1960 450.9 3.2e-126
NP_620428 (OMIM: 604252) beta-secretase 1 isoform ( 476) 1960 451.0 3.8e-126
NP_620429 (OMIM: 604252) beta-secretase 1 isoform ( 432) 1959 450.7 4.1e-126
NP_036237 (OMIM: 605668) beta-secretase 2 isoform ( 518) 1535 355.2 2.8e-97
XP_016883803 (OMIM: 605668) beta-secretase 2 isofo ( 423) 1391 322.7 1.4e-87
NP_620477 (OMIM: 605668) beta-secretase 2 isoform ( 396) 1249 290.6 5.8e-78
NP_620476 (OMIM: 605668) beta-secretase 2 isoform ( 468) 1041 243.8 8.6e-64
XP_011507546 (OMIM: 116890) cathepsin E isoform X1 ( 401) 337 85.1 4.5e-16
NP_001901 (OMIM: 116890) cathepsin E isoform a pre ( 396) 321 81.4 5.5e-15
NP_001304260 (OMIM: 116890) cathepsin E isoform c ( 288) 308 78.4 3.3e-14
NP_683865 (OMIM: 116890) cathepsin E isoform b pre ( 363) 308 78.5 3.9e-14
XP_011507547 (OMIM: 116890) cathepsin E isoform X2 ( 368) 298 76.2 1.9e-13
NP_001900 (OMIM: 116840,610127) cathepsin D prepro ( 412) 267 69.3 2.6e-11
NP_000528 (OMIM: 179820,267430,613092) renin prepr ( 406) 258 67.3 1.1e-10
NP_004842 (OMIM: 605631) napsin-A preproprotein [H ( 420) 253 66.1 2.4e-10
XP_011525842 (OMIM: 605631) napsin-A isoform X1 [H ( 420) 253 66.1 2.4e-10
NP_002621 (OMIM: 169740) gastricsin isoform 1 prep ( 388) 240 63.2 1.7e-09
XP_016883001 (OMIM: 605631) napsin-A isoform X2 [H ( 411) 188 51.5 6e-06
NP_055039 (OMIM: 169730) pepsin A-5 preproprotein ( 388) 154 43.8 0.0012
NP_001073275 (OMIM: 169710) pepsin A-3 preproprote ( 388) 153 43.6 0.0014
NP_001073276 (OMIM: 169720) pepsin A-4 preproprote ( 388) 153 43.6 0.0014
NP_001159896 (OMIM: 169740) gastricsin isoform 2 p ( 315) 149 42.6 0.0022
>>NP_036236 (OMIM: 604252) beta-secretase 1 isoform A pr (501 aa)
initn: 3417 init1: 3417 opt: 3417 Z-score: 4160.9 bits: 779.4 E(90964): 0
Smith-Waterman score: 3417; 100.0% identity (100.0% similar) in 501 aa overlap (1-501:1-501)
10 20 30 40 50 60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
430 440 450 460 470 480
490 500
pF1KE1 RCLRCLRQQHDDFADDISLLK
:::::::::::::::::::::
NP_036 RCLRCLRQQHDDFADDISLLK
490 500
>>NP_001193977 (OMIM: 604252) beta-secretase 1 isoform E (401 aa)
initn: 2607 init1: 2607 opt: 2607 Z-score: 3175.4 bits: 596.8 E(90964): 4.2e-170
Smith-Waterman score: 2607; 100.0% identity (100.0% similar) in 384 aa overlap (118-501:18-401)
90 100 110 120 130 140
pF1KE1 LNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
::::::::::::::::::::::::::::::
NP_001 MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
10 20 30 40
150 160 170 180 190 200
pF1KE1 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
50 60 70 80 90 100
210 220 230 240 250 260
pF1KE1 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
110 120 130 140 150 160
270 280 290 300 310 320
pF1KE1 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
170 180 190 200 210 220
330 340 350 360 370 380
pF1KE1 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
230 240 250 260 270 280
390 400 410 420 430 440
pF1KE1 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
290 300 310 320 330 340
450 460 470 480 490 500
pF1KE1 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
350 360 370 380 390 400
>>NP_620427 (OMIM: 604252) beta-secretase 1 isoform C pr (457 aa)
initn: 3118 init1: 2130 opt: 2144 Z-score: 2610.6 bits: 492.4 E(90964): 1.2e-138
Smith-Waterman score: 3034; 91.2% identity (91.2% similar) in 501 aa overlap (1-501:1-457)
10 20 30 40 50 60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
:::::::::::::::::::::::::
NP_620 YRDLRKGVYVPYTQGKWEGELGTDL-----------------------------------
130 140
190 200 210 220 230 240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ---------PDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
150 160 170 180 190
250 260 270 280 290 300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
380 390 400 410 420 430
490 500
pF1KE1 RCLRCLRQQHDDFADDISLLK
:::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
440 450
>>NP_001193978 (OMIM: 604252) beta-secretase 1 isoform F (376 aa)
initn: 1960 init1: 1960 opt: 1960 Z-score: 2387.6 bits: 450.9 E(90964): 3.2e-126
Smith-Waterman score: 2376; 93.5% identity (93.5% similar) in 384 aa overlap (118-501:18-376)
90 100 110 120 130 140
pF1KE1 LNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
::::::::::::::::::::::::::::::
NP_001 MVPFIYLQAHFTLCSGWSSTYRDLRKGVYVPYTQGKWEGELGTDLVS
10 20 30 40
150 160 170 180 190 200
pF1KE1 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHV
::::::::::::::::::::::::::::::::::::::::::
NP_001 IPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIAR------------------
50 60 70 80
210 220 230 240 250 260
pF1KE1 PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -------LCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV
90 100 110 120 130 140
270 280 290 300 310 320
pF1KE1 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQ
150 160 170 180 190 200
330 340 350 360 370 380
pF1KE1 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQ
210 220 230 240 250 260
390 400 410 420 430 440
pF1KE1 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNI
270 280 290 300 310 320
450 460 470 480 490 500
pF1KE1 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
330 340 350 360 370
>>NP_620428 (OMIM: 604252) beta-secretase 1 isoform B pr (476 aa)
initn: 1960 init1: 1960 opt: 1960 Z-score: 2386.2 bits: 451.0 E(90964): 3.8e-126
Smith-Waterman score: 3186; 95.0% identity (95.0% similar) in 501 aa overlap (1-501:1-476)
10 20 30 40 50 60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
::::::::: ::::::::::::::::::::::::::
NP_620 GLAYAEIAR-------------------------LCGAGFPLNQSEVLASVGGSMIIGGI
190 200 210
250 260 270 280 290 300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
400 410 420 430 440 450
490 500
pF1KE1 RCLRCLRQQHDDFADDISLLK
:::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
460 470
>>NP_620429 (OMIM: 604252) beta-secretase 1 isoform D pr (432 aa)
initn: 1959 init1: 1959 opt: 1959 Z-score: 2385.6 bits: 450.7 E(90964): 4.1e-126
Smith-Waterman score: 2813; 86.2% identity (86.2% similar) in 501 aa overlap (1-501:1-432)
10 20 30 40 50 60
pF1KE1 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
:::::::::::::::::::::::::
NP_620 YRDLRKGVYVPYTQGKWEGELGTDL-----------------------------------
130 140
190 200 210 220 230 240
pF1KE1 GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
::::::::::::::::::::::::::
NP_620 ----------------------------------LCGAGFPLNQSEVLASVGGSMIIGGI
150 160 170
250 260 270 280 290 300
pF1KE1 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE1 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE1 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
300 310 320 330 340 350
430 440 450 460 470 480
pF1KE1 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
360 370 380 390 400 410
490 500
pF1KE1 RCLRCLRQQHDDFADDISLLK
:::::::::::::::::::::
NP_620 RCLRCLRQQHDDFADDISLLK
420 430
>>NP_036237 (OMIM: 605668) beta-secretase 2 isoform A pr (518 aa)
initn: 1512 init1: 668 opt: 1535 Z-score: 1867.9 bits: 355.2 E(90964): 2.8e-97
Smith-Waterman score: 1535; 49.6% identity (77.0% similar) in 448 aa overlap (54-500:71-512)
30 40 50 60 70 80
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
:. ..:. :::::.: ::.:::.:: .:.
NP_036 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
50 60 70 80 90 100
90 100 110 120 130 140
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
::: :.::::::::::::...:: .. :.. . :::::. : : ::::.: : .:
NP_036 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
110 120 130 140 150 160
150 160 170 180 190 200
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
:::.::.: :.. .:::.: ::..::. : .:.:::::::: .:.:..::: ::::::
NP_036 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
:...::.::.:.::::.:. : .. :::...:::. ::: :..:::::..::::..
NP_036 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
230 240 250 260 270
270 280 290 300 310 320
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
:...::.::.:..::.::: ::.::::::: ::::.:::.:.:... :: .: ::::
NP_036 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFW
280 290 300 310 320 330
330 340 350 360 370 380
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
: ::.:: . :::. :: ::.:: : ...::::::::: :..:. .. . . ::.:
NP_036 TGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYE-CYRF
340 350 360 370 380 390
390 400 410 420 430 440
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC
.:: :... :.::..::::::.::::.::.:::.: : .. . ::: : :. .
NP_036 GISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASN
400 410 420 430 440 450
450 460 470 480 490 500
pF1KE1 GYNIPQTDESTLMTIAYVMAAIC-ALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
. .: : ..:.. ..: :.... . :.. .:: : : . . ..: : :
NP_036 CVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQR--RPRDPEVVNDESSLVR
460 470 480 490 500 510
NP_036 HRWK
>>XP_016883803 (OMIM: 605668) beta-secretase 2 isoform X (423 aa)
initn: 1373 init1: 611 opt: 1391 Z-score: 1693.7 bits: 322.7 E(90964): 1.4e-87
Smith-Waterman score: 1391; 48.8% identity (76.4% similar) in 416 aa overlap (86-500:8-417)
60 70 80 90 100 110
pF1KE1 RRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQR
. :.::::::::::::...:: .. :..
XP_016 MAALHLYKKLQILVDTGSSNFAVAGTPHSYIDTYFDT
10 20 30
120 130 140 150 160 170
pF1KE1 QLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSN
. :::::. : : ::::.: : .: :::.::.: :.. .:::.: ::..::. : .
XP_016 ERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIK
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE1 WEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSM
:.:::::::: .:.:..::: :::::: :...::.::.:.::::.:. : .. :::.
XP_016 WNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGS---GTNGGSL
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE1 IIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNL
..:::. ::: :..:::::..::::.. :...::.::.:..::.::: ::.::::::: :
XP_016 VLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLL
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE1 RLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQ
:::.:::.:.:... :: .: :::: : ::.:: . :::. :: ::.:: : ...
XP_016 RLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSR
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE1 SFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGF
::::::::: :..:. .. . . ::.:.:: :... :.::..::::::.::::.::.::
XP_016 SFRITILPQLYIQPMMGAGLNYE-CYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGF
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE1 AVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAIC-ALFMLPLC
:.: : .. . ::: : :. . . .: : ..:.. ..: :.... .
XP_016 AASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIV
340 350 360 370 380 390
480 490 500
pF1KE1 LMVCQWRCLRCLRQQHDDFADDISLLK
:.. .:: : : . . ..: : :
XP_016 LLLLPFRCQR--RPRDPEVVNDESSLVRHRWK
400 410 420
>>NP_620477 (OMIM: 605668) beta-secretase 2 isoform B pr (396 aa)
initn: 1247 init1: 668 opt: 1249 Z-score: 1521.1 bits: 290.6 E(90964): 5.8e-78
Smith-Waterman score: 1249; 56.4% identity (82.1% similar) in 312 aa overlap (54-365:71-379)
30 40 50 60 70 80
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
:. ..:. :::::.: ::.:::.:: .:.
NP_620 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
50 60 70 80 90 100
90 100 110 120 130 140
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
::: :.::::::::::::...:: .. :.. . :::::. : : ::::.: : .:
NP_620 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
110 120 130 140 150 160
150 160 170 180 190 200
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
:::.::.: :.. .:::.: ::..::. : .:.:::::::: .:.:..::: ::::::
NP_620 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
:...::.::.:.::::.:. : .. :::...:::. ::: :..:::::..::::..
NP_620 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
230 240 250 260 270
270 280 290 300 310 320
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
:...::.::.:..::.::: ::.::::::: ::::.:::.:.:... :: .: ::::
NP_620 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFW
280 290 300 310 320 330
330 340 350 360 370 380
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
: ::.:: . :::. :: ::.:: : ...:::::::::.
NP_620 TGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQKLQVLQCLKFPGLSQQRM
340 350 360 370 380 390
390 400 410 420 430 440
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC
>>NP_620476 (OMIM: 605668) beta-secretase 2 isoform C pr (468 aa)
initn: 1276 init1: 668 opt: 1041 Z-score: 1266.7 bits: 243.8 E(90964): 8.6e-64
Smith-Waterman score: 1209; 43.3% identity (69.2% similar) in 448 aa overlap (54-500:71-462)
30 40 50 60 70 80
pF1KE1 HGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGS
:. ..:. :::::.: ::.:::.:: .:.
NP_620 RVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGT
50 60 70 80 90 100
90 100 110 120 130 140
pF1KE1 PPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGT
::: :.::::::::::::...:: .. :.. . :::::. : : ::::.: : .:
NP_620 PPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGE
110 120 130 140 150 160
150 160 170 180 190 200
pF1KE1 DLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVK
:::.::.: :.. .:::.: ::..::. : .:.:::::::: .:.:..::: ::::::
NP_620 DLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVT
170 180 190 200 210 220
210 220 230 240 250 260
pF1KE1 QTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI
:...::.::.:.::::.:. : .. :::...:::. ::: :..:::::..::::..
NP_620 QANIPNVFSMQMCGAGLPVAGS---GTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIE
230 240 250 260 270
270 280 290 300 310 320
pF1KE1 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW
:...::.::.:..::.::: ::.::::::: ::::.:::.:.:... ::
NP_620 ILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARAS----------
280 290 300 310 320
330 340 350 360 370 380
pF1KE1 LGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKF
:. :..:. .. . . ::.:
NP_620 ------------------------LL----------------YIQPMMGAGLNYE-CYRF
330 340
390 400 410 420 430 440
pF1KE1 AISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDC
.:: :... :.::..::::::.::::.::.:::.: : .. . ::: : :. .
NP_620 GISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASN
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE1 GYNIPQTDESTLMTIAYVMAAIC-ALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
. .: : ..:.. ..: :.... . :.. .:: : : . . ..: : :
NP_620 CVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQR--RPRDPEVVNDESSLVR
410 420 430 440 450 460
NP_620 HRWK
501 residues in 1 query sequences
64440809 residues in 90964 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Apr 22 20:29:06 2018 done: Sun Apr 22 20:29:07 2018
Total Scan time: 4.320 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]