FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1958, 514 aa 1>>>pF1KE1958 514 - 514 aa - 514 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2859+/-0.000349; mu= 18.8053+/- 0.022 mean_var=78.6225+/-16.060, 0's: 0 Z-trim(115.2): 20 B-trim: 27 in 1/54 Lambda= 0.144644 statistics sampled from 25458 (25477) to 25458 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.299), width: 16 Scan time: 8.990 The best scores are: opt bits E(85289) NP_005856 (OMIM: 607169) thymus-specific serine pr ( 514) 3439 727.4 2.4e-209 XP_016865651 (OMIM: 607169) PREDICTED: thymus-spec ( 454) 2564 544.8 2e-154 XP_016865650 (OMIM: 607169) PREDICTED: thymus-spec ( 488) 1927 411.9 2.2e-114 XP_016865653 (OMIM: 607169) PREDICTED: thymus-spec ( 357) 1605 344.6 2.9e-94 XP_016865652 (OMIM: 607169) PREDICTED: thymus-spec ( 417) 1605 344.6 3.3e-94 XP_016865654 (OMIM: 607169) PREDICTED: thymus-spec ( 257) 1210 262.0 1.5e-69 NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 pr ( 492) 624 140.0 1.6e-32 XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl ( 514) 566 127.9 7.2e-29 XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl ( 484) 557 126.0 2.5e-28 XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl ( 436) 491 112.2 3.2e-24 XP_016870140 (OMIM: 610537) PREDICTED: dipeptidyl ( 458) 433 100.1 1.5e-20 NP_005031 (OMIM: 176785) lysosomal Pro-X carboxype ( 496) 410 95.3 4.4e-19 NP_955450 (OMIM: 176785) lysosomal Pro-X carboxype ( 517) 391 91.4 7.1e-18 XP_005274150 (OMIM: 176785) PREDICTED: lysosomal P ( 391) 302 72.7 2.2e-12 NP_001306143 (OMIM: 176785) lysosomal Pro-X carbox ( 391) 302 72.7 2.2e-12 XP_006717146 (OMIM: 610537) PREDICTED: dipeptidyl ( 509) 254 62.8 2.8e-09 XP_005266132 (OMIM: 610537) PREDICTED: dipeptidyl ( 565) 254 62.8 3.1e-09 >>NP_005856 (OMIM: 607169) thymus-specific serine protea (514 aa) initn: 3439 init1: 3439 opt: 3439 Z-score: 3879.5 bits: 727.4 E(85289): 2.4e-209 Smith-Waterman score: 3439; 100.0% identity (100.0% similar) in 514 aa overlap (1-514:1-514) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER 430 440 450 460 470 480 490 500 510 pF1KE1 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :::::::::::::::::::::::::::::::::: NP_005 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 490 500 510 >>XP_016865651 (OMIM: 607169) PREDICTED: thymus-specific (454 aa) initn: 2584 init1: 2561 opt: 2564 Z-score: 2893.4 bits: 544.8 E(85289): 2e-154 Smith-Waterman score: 2896; 88.1% identity (88.3% similar) in 514 aa overlap (1-514:1-454) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ :::::::::::::::::::::::. XP_016 TEPQLSGVGDRQWLYQTCTEFGFW------------------------------------ 370 380 430 440 450 460 470 480 pF1KE1 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER :::::::::::::::::::::::::::::::::::: XP_016 ------------------------DTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER 390 400 410 420 490 500 510 pF1KE1 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :::::::::::::::::::::::::::::::::: XP_016 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 430 440 450 >>XP_016865650 (OMIM: 607169) PREDICTED: thymus-specific (488 aa) initn: 3257 init1: 1927 opt: 1927 Z-score: 2174.6 bits: 411.9 E(85289): 2.2e-114 Smith-Waterman score: 3209; 94.9% identity (94.9% similar) in 514 aa overlap (1-514:1-488) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC ::::::::::::::::: ::::::::::::::::: XP_016 CFGGSYAGSLAAWARLK--------------------------VVSRSLMSTAIGGSLEC 190 200 210 250 260 270 280 290 300 pF1KE1 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE1 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE1 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE1 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER 400 410 420 430 440 450 490 500 510 pF1KE1 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :::::::::::::::::::::::::::::::::: XP_016 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 460 470 480 >>XP_016865653 (OMIM: 607169) PREDICTED: thymus-specific (357 aa) initn: 2055 init1: 1603 opt: 1605 Z-score: 1813.3 bits: 344.6 E(85289): 2.9e-94 Smith-Waterman score: 2055; 69.3% identity (69.5% similar) in 514 aa overlap (1-514:1-357) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLE- 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG XP_016 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE1 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS :::::::::::::::::::::::: XP_016 ------------------------------------IVLHSLGQKCLSFSRAETVAQLRS 240 250 260 370 380 390 400 410 420 pF1KE1 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ :::::::::::::::::::::::. XP_016 TEPQLSGVGDRQWLYQTCTEFGFW------------------------------------ 270 280 430 440 450 460 470 480 pF1KE1 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER :::::::::::::::::::::::::::::::::::: XP_016 ------------------------DTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER 290 300 310 320 490 500 510 pF1KE1 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :::::::::::::::::::::::::::::::::: XP_016 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 330 340 350 >>XP_016865652 (OMIM: 607169) PREDICTED: thymus-specific (417 aa) initn: 1603 init1: 1603 opt: 1605 Z-score: 1812.3 bits: 344.6 E(85289): 3.3e-94 Smith-Waterman score: 2598; 81.1% identity (81.1% similar) in 514 aa overlap (1-514:1-417) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWGALVISLEHRFYGLSIPAGGLEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLEC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLE- 190 200 210 220 230 250 260 270 280 290 300 pF1KE1 RAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELLGALQALVGGVVQYDG XP_016 ------------------------------------------------------------ 310 320 330 340 350 360 pF1KE1 QTGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRS :::::::::::::::::::::::: XP_016 ------------------------------------IVLHSLGQKCLSFSRAETVAQLRS 240 250 260 370 380 390 400 410 420 pF1KE1 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQ 270 280 290 300 310 320 430 440 450 460 470 480 pF1KE1 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPER 330 340 350 360 370 380 490 500 510 pF1KE1 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :::::::::::::::::::::::::::::::::: XP_016 PSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 390 400 410 >>XP_016865654 (OMIM: 607169) PREDICTED: thymus-specific (257 aa) initn: 1210 init1: 1210 opt: 1210 Z-score: 1369.8 bits: 262.0 E(85289): 1.5e-69 Smith-Waterman score: 1210; 98.4% identity (98.9% similar) in 183 aa overlap (332-514:75-257) 310 320 330 340 350 360 pF1KE1 TGAPLSVRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLGQKCLSFSRAETVAQLRST : .:::::::::::::::::::::::::: XP_016 LGLSLGPGAAALPKVGWLEQLLDPFNVSDRRSFLQIVLHSLGQKCLSFSRAETVAQLRST 50 60 70 80 90 100 370 380 390 400 410 420 pF1KE1 EPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPQLSGVGDRQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSALSVAQA 110 120 130 140 150 160 430 440 450 460 470 480 pF1KE1 VAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLDMAPERP 170 180 190 200 210 220 490 500 510 pF1KE1 SDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV ::::::::::::::::::::::::::::::::: XP_016 SDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV 230 240 250 >-- initn: 502 init1: 502 opt: 502 Z-score: 571.3 bits: 114.3 E(85289): 4.4e-25 Smith-Waterman score: 502; 100.0% identity (100.0% similar) in 74 aa overlap (1-74:1-74) 10 20 30 40 50 60 pF1KE1 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAVWLAQWLGPLLLVSLWGLLAPASLLRRLGEHIQQFQESSAQGLGLSLGPGAAALPKVG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 WLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAP :::::::::::::: XP_016 WLEQLLDPFNVSDRRSFLQIVLHSLGQKCLSFSRAETVAQLRSTEPQLSGVGDRQWLYQT 70 80 90 100 110 120 >>NP_037511 (OMIM: 610537) dipeptidyl peptidase 2 prepro (492 aa) initn: 499 init1: 184 opt: 624 Z-score: 705.0 bits: 140.0 E(85289): 1.6e-32 Smith-Waterman score: 624; 30.5% identity (57.3% similar) in 485 aa overlap (45-509:14-480) 20 30 40 50 60 pF1KE1 VSLWGLLAPASLLRRLGEHIQQFQESSAQGLGL-SLGPGAAALPKVGWLE----QLLDPF ::: .: :: : :. : : :: : NP_037 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHF 10 20 30 40 70 80 90 100 110 120 pF1KE1 NVS--DRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVI : ..: ::. :.:. :: .::::.. :.::.. . . : :: :::.. NP_037 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 SLEHRFYGLSIPAGG--LEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGS :::.:: :.: :. . .. ..:. . :::: . :: : .. ....: : :::: NP_037 FAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLG-AQDAPAIAFGGS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE1 YAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVS :.: :.:. :.:.:::. ...:.:::: :: ... :. :.. . : : .: .: NP_037 YGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFF-RDVTADFEGQSPKCTQGVR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE1 VAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELL----GALQALVGGVVQYDGQ :: ... . .: : ..: :...: ::. .. ..:. .:. .:. : . NP_037 EAFRQIKDLFLQG--AYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTD 230 240 250 260 270 310 320 330 340 350 pF1KE1 TGAPLS---VRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLG-QKCLSFSRAETVAQ .:: :. : :: :.. ::: . .: .. : ..: .. : NP_037 FLGPLPANPVKVGCDRLL------SEAQRITGLRALAGLVYNASGSEHCYDIYR----LY 280 290 300 310 320 360 370 380 390 400 410 pF1KE1 LRSTEPQLSGVGD--RQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSA ..: :.: : : ::.:::... . .: : .:: : .: . :.. NP_037 HSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFT----DELRQRYCLDT 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE1 LSV-AQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCL .: . .:..::. .:....: ::. ::: .. . :..: .. :. :.: : NP_037 WGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHL 390 400 410 420 430 440 480 490 500 510 pF1KE1 DMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV :. .: : :. .:. . :.: :.. : NP_037 DLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 450 460 470 480 490 >>XP_011516901 (OMIM: 610537) PREDICTED: dipeptidyl pept (514 aa) initn: 460 init1: 145 opt: 566 Z-score: 639.3 bits: 127.9 E(85289): 7.2e-29 Smith-Waterman score: 566; 29.5% identity (55.7% similar) in 526 aa overlap (6-509:4-502) 10 20 30 40 50 pF1KE1 MAVWLAQWLGPLLLVSLWGL--LAPASLLRRLGEH-------IQQFQESSAQGLGLSLGP : : .:.::..: :: : .. :: : .. . : :: : : : XP_011 MGSAPW-APVLLLAL-GLRGLQAGGEWRRPPAHSPVPAPPLRFASPHSPQGPGPRL-P 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GAAALPKVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVM :: :: .. :: . :.. : . :: .::::.. :.::.. . XP_011 GAL-LPAASGPLQLR-----ALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANN 60 70 80 90 100 120 130 140 150 160 pF1KE1 RGHPAALAPAWGALVISLEHRFYGLSIPAGG--LEMAQLRFLSSRLALADVVSARLALSR . : :: :::.. :::.:: :.: :. . .. ..:. . :::: . :: : XP_011 SAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 LFNISSSSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSL .. ....: : :::::.: :.:. :.:.:::. ...:.:::: :: ... :. :.. XP_011 DLG-AQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFF-RDV 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE1 MSTAIGGSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELL---- . : : .: .: :: ... . .: : ..: :...: ::. .. ..:. XP_011 TADFEGQSPKCTQGVREAFRQIKDLFLQG--AYDTVRWEFGTCQPLSDEKDLTQLFMFAR 230 240 250 260 270 280 290 300 310 320 330 340 pF1KE1 GALQALVGGVVQYDGQTGAPLS---VRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSL .:. .:. : . .:: :. : :: :.. ::: . .: .. XP_011 NAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLL------SEAQRITGLRALAGLVYNAS 290 300 310 320 330 350 360 370 380 390 pF1KE1 G-QKCLSFSRAETVAQLRSTEPQLSGVGD--RQWLYQTCTEFGFYVTCENPRCPFSQLPA : ..: .. : ..: :.: : : ::.:::... . .: : .:: XP_011 GSEHCYDIYRLYH----SCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPF 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE1 LPSQLDLCEQVFGLSALSV-AQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQAL : .: . :.. .: . .:..::. .:....: ::. ::: .. . : XP_011 T----DELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNL 400 410 420 430 440 450 460 470 480 490 500 510 pF1KE1 GSSESTLLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV ..: .. :. :.: ::. .: : :. .:. . :.: :.. : XP_011 SASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPR 460 470 480 490 500 510 XP_011 LSL >>XP_011516902 (OMIM: 610537) PREDICTED: dipeptidyl pept (484 aa) initn: 460 init1: 145 opt: 557 Z-score: 629.5 bits: 126.0 E(85289): 2.5e-28 Smith-Waterman score: 557; 29.7% identity (57.9% similar) in 435 aa overlap (88-509:56-472) 60 70 80 90 100 110 pF1KE1 KVGWLEQLLDPFNVSDRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAA :: .::::.. :.::.. . . : XP_011 GALLPAASGPLQLRALRQQDLPSALPGVGFWVRGEGPIFFYTGNEGDVWAFANNSAFVAE 30 40 50 60 70 80 120 130 140 150 160 170 pF1KE1 LAPAWGALVISLEHRFYGLSIPAGG--LEMAQLRFLSSRLALADVVSARLALSRLFNISS :: :::.. :::.:: :.: :. . .. ..:. . :::: . :: : .. .. XP_011 LAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLG-AQ 90 100 110 120 130 140 180 190 200 210 220 230 pF1KE1 SSPWICFGGSYAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIG ..: : :::::.: :.:. :.:.:::. ...:.:::: :: ... :. :.. . : XP_011 DAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFF-RDVTADFEG 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE1 GSLECRAAVSVAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELL----GALQAL : .: .: :: ... . .: : ..: :...: ::. .. ..:. .:. .: XP_011 QSPKCTQGVREAFRQIKDLFLQG--AYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVL 210 220 230 240 250 260 300 310 320 330 340 pF1KE1 VGGVVQYDGQTGAPLS---VRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLG-QKCL . : . .:: :. : :: :.. ::: . .: .. : ..: XP_011 AMMDYPYPTDFLGPLPANPVKVGCDRLL------SEAQRITGLRALAGLVYNASGSEHCY 270 280 290 300 310 350 360 370 380 390 400 pF1KE1 SFSRAETVAQLRSTEPQLSGVGD--RQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLD .. : ..: :.: : : ::.:::... . .: : .:: : XP_011 DIYRL----YHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPF----TD 320 330 340 350 360 410 420 430 440 450 460 pF1KE1 LCEQVFGLSALSV-AQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSEST .: . :.. .: . .:..::. .:....: ::. ::: .. . :..: . XP_011 ELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIA 370 380 390 400 410 420 470 480 490 500 510 pF1KE1 LLIRTGSHCLDMAPERPSDSPSLRLGRQNIFQQLQTWLKLAKESQIKGEV . :. :.: ::. .: : :. .:. . :.: :.. : XP_011 VTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL 430 440 450 460 470 480 >>XP_016870141 (OMIM: 610537) PREDICTED: dipeptidyl pept (436 aa) initn: 372 init1: 184 opt: 491 Z-score: 555.7 bits: 112.2 E(85289): 3.2e-24 Smith-Waterman score: 491; 31.9% identity (57.6% similar) in 373 aa overlap (45-398:14-372) 20 30 40 50 60 pF1KE1 VSLWGLLAPASLLRRLGEHIQQFQESSAQGLGL-SLGPGAAALPKVGWLE----QLLDPF ::: .: :: : :. : : :: : XP_016 MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHF 10 20 30 40 70 80 90 100 110 120 pF1KE1 NVS--DRRSFLQRYWVNDQHWVGQDGPIFLHLGGEGSLGPGSVMRGHPAALAPAWGALVI : ..: ::. :.:. :: .::::.. :.::.. . . : :: :::.. XP_016 NFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE1 SLEHRFYGLSIPAGG--LEMAQLRFLSSRLALADVVSARLALSRLFNISSSSPWICFGGS :::.:: :.: :. . .. ..:. . :::: . :: : .. ....: : :::: XP_016 FAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLG-AQDAPAIAFGGS 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE1 YAGSLAAWARLKFPHLIFASVASSAPVRAVLDFSEYNDVVSRSLMSTAIGGSLECRAAVS :.: :.:. :.:.:::. ...:.:::: :: ... :. :.. . : : .: .: XP_016 YGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFF-RDVTADFEGQSPKCTQGVR 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE1 VAFAEVERRLRSGGAAQAALRTELSACGPLGRAENQAELL----GALQALVGGVVQYDGQ :: ... . .: : ..: :...: ::. .. ..:. .:. .:. : . XP_016 EAFRQIKDLFLQG--AYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTD 230 240 250 260 270 310 320 330 340 350 pF1KE1 TGAPLS---VRQLCGLLLGGGGNRSHSTPYCGLRRAVQIVLHSLG-QKCLSFSRAETVAQ .:: :. : :: :.. ::: . .: .. : ..: .. : XP_016 FLGPLPANPVKVGCDRLL------SEAQRITGLRALAGLVYNASGSEHCYDIYRLYH--- 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE1 LRSTEPQLSGVGD--RQWLYQTCTEFGFYVTCENPRCPFSQLPALPSQLDLCEQVFGLSA ..: :.: : : ::.:::... . .: : .:: XP_016 -SCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRSQSRQQHHL 340 350 360 370 380 420 430 440 450 460 470 pF1KE1 LSVAQAVAQTNSYYGGQTPGANKVLFVNGDTDPWHVLSVTQALGSSESTLLIRTGSHCLD XP_016 LQREPGPLGRGRDSEEPECLSHRRHHPGGSAPPRPQSLPPRRSCFRG 390 400 410 420 430 514 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:19:31 2016 done: Sun Nov 6 21:19:33 2016 Total Scan time: 8.990 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]