FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1879, 404 aa 1>>>pF1KE1879 404 - 404 aa - 404 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6348+/-0.000358; mu= 15.4227+/- 0.023 mean_var=72.6627+/-14.571, 0's: 0 Z-trim(115.2): 48 B-trim: 238 in 1/54 Lambda= 0.150459 statistics sampled from 25418 (25466) to 25418 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.662), E-opt: 0.2 (0.299), width: 16 Scan time: 7.490 The best scores are: opt bits E(85289) XP_016869448 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 2713 598.1 1.2e-170 XP_016869447 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 2713 598.1 1.2e-170 NP_477097 (OMIM: 603775) G1/S-specific cyclin-E2 [ ( 404) 2713 598.1 1.2e-170 XP_016869446 (OMIM: 603775) PREDICTED: G1/S-specif ( 404) 2713 598.1 1.2e-170 XP_011515668 (OMIM: 603775) PREDICTED: G1/S-specif ( 288) 1864 413.7 2.8e-115 XP_011525742 (OMIM: 123837) PREDICTED: G1/S-specif ( 407) 1233 276.8 6.4e-74 NP_001309191 (OMIM: 123837) G1/S-specific cyclin-E ( 395) 1231 276.4 8.4e-74 NP_001229 (OMIM: 123837) G1/S-specific cyclin-E1 i ( 410) 1231 276.4 8.7e-74 NP_001309190 (OMIM: 123837) G1/S-specific cyclin-E ( 361) 727 167.0 6.7e-41 NP_001309188 (OMIM: 123837) G1/S-specific cyclin-E ( 365) 680 156.8 8e-38 XP_011533598 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 331 81.1 5.7e-15 XP_011533596 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 331 81.1 5.7e-15 XP_011533597 (OMIM: 604036) PREDICTED: cyclin-A1 i ( 421) 331 81.1 5.7e-15 NP_001104517 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 331 81.1 5.7e-15 NP_001104516 (OMIM: 604036) cyclin-A1 isoform c [H ( 421) 331 81.1 5.7e-15 NP_001104515 (OMIM: 604036) cyclin-A1 isoform b [H ( 464) 331 81.1 6.2e-15 NP_003905 (OMIM: 604036) cyclin-A1 isoform a [Homo ( 465) 331 81.1 6.2e-15 NP_001228 (OMIM: 123835) cyclin-A2 [Homo sapiens] ( 432) 320 78.7 3.1e-14 NP_001751 (OMIM: 123834) G1/S-specific cyclin-D3 i ( 292) 306 75.6 1.8e-13 NP_004692 (OMIM: 602755) G2/mitotic-specific cycli ( 398) 307 75.8 2e-13 NP_444284 (OMIM: 168461,193300,254500) G1/S-specif ( 295) 302 74.7 3.3e-13 XP_011513273 (OMIM: 123834) PREDICTED: G1/S-specif ( 276) 297 73.6 6.7e-13 NP_114172 (OMIM: 123836) G2/mitotic-specific cycli ( 433) 299 74.1 7.3e-13 NP_001750 (OMIM: 123833,615938) G1/S-specific cycl ( 289) 295 73.2 9.4e-13 XP_016885407 (OMIM: 300456) PREDICTED: G2/mitotic- (1395) 254 64.6 1.7e-09 NP_149020 (OMIM: 300456) G2/mitotic-specific cycli (1395) 254 64.6 1.7e-09 XP_016885406 (OMIM: 300456) PREDICTED: G2/mitotic- (1396) 254 64.6 1.7e-09 XP_016885405 (OMIM: 300456) PREDICTED: G2/mitotic- (1403) 250 63.7 3.1e-09 XP_016885402 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 250 63.7 3.1e-09 XP_016885404 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 250 63.7 3.1e-09 XP_016885403 (OMIM: 300456) PREDICTED: G2/mitotic- (1404) 250 63.7 3.1e-09 NP_066970 (OMIM: 607752,615872) cyclin-O [Homo sap ( 350) 235 60.2 9.2e-09 NP_001274356 (OMIM: 123834) G1/S-specific cyclin-D ( 242) 202 52.9 9.7e-07 XP_011530701 (OMIM: 603203) PREDICTED: cyclin-G2 i ( 344) 180 48.2 3.6e-05 NP_004345 (OMIM: 603203) cyclin-G2 [Homo sapiens] ( 344) 180 48.2 3.6e-05 XP_011530700 (OMIM: 603203) PREDICTED: cyclin-G2 i ( 344) 180 48.2 3.6e-05 NP_391990 (OMIM: 300456) G2/mitotic-specific cycli ( 291) 177 47.6 4.9e-05 NP_001752 (OMIM: 600227) cyclin-F isoform 1 [Homo ( 786) 175 47.3 0.00015 XP_016879311 (OMIM: 600227) PREDICTED: cyclin-F is ( 867) 175 47.4 0.00017 NP_001129489 (OMIM: 123834) G1/S-specific cyclin-D ( 211) 164 44.7 0.00026 NP_001310467 (OMIM: 600227) cyclin-F isoform 2 [Ho ( 478) 163 44.6 0.00061 NP_004051 (OMIM: 601578) cyclin-G1 [Homo sapiens] ( 295) 160 43.9 0.00063 NP_954854 (OMIM: 601578) cyclin-G1 [Homo sapiens] ( 295) 160 43.9 0.00063 XP_011513274 (OMIM: 123834) PREDICTED: G1/S-specif ( 195) 155 42.7 0.00095 >>XP_016869448 (OMIM: 603775) PREDICTED: G1/S-specific c (404 aa) initn: 2713 init1: 2713 opt: 2713 Z-score: 3184.3 bits: 598.1 E(85289): 1.2e-170 Smith-Waterman score: 2713; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 310 320 330 340 350 360 370 380 390 400 pF1KE1 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH :::::::::::::::::::::::::::::::::::::::::::: XP_016 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 370 380 390 400 >>XP_016869447 (OMIM: 603775) PREDICTED: G1/S-specific c (404 aa) initn: 2713 init1: 2713 opt: 2713 Z-score: 3184.3 bits: 598.1 E(85289): 1.2e-170 Smith-Waterman score: 2713; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 310 320 330 340 350 360 370 380 390 400 pF1KE1 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH :::::::::::::::::::::::::::::::::::::::::::: XP_016 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 370 380 390 400 >>NP_477097 (OMIM: 603775) G1/S-specific cyclin-E2 [Homo (404 aa) initn: 2713 init1: 2713 opt: 2713 Z-score: 3184.3 bits: 598.1 E(85289): 1.2e-170 Smith-Waterman score: 2713; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_477 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 310 320 330 340 350 360 370 380 390 400 pF1KE1 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH :::::::::::::::::::::::::::::::::::::::::::: NP_477 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 370 380 390 400 >>XP_016869446 (OMIM: 603775) PREDICTED: G1/S-specific c (404 aa) initn: 2713 init1: 2713 opt: 2713 Z-score: 3184.3 bits: 598.1 E(85289): 1.2e-170 Smith-Waterman score: 2713; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:1-404) 10 20 30 40 50 60 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH 310 320 330 340 350 360 370 380 390 400 pF1KE1 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH :::::::::::::::::::::::::::::::::::::::::::: XP_016 TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH 370 380 390 400 >>XP_011515668 (OMIM: 603775) PREDICTED: G1/S-specific c (288 aa) initn: 1864 init1: 1864 opt: 1864 Z-score: 2190.6 bits: 413.7 E(85289): 2.8e-115 Smith-Waterman score: 1864; 99.6% identity (100.0% similar) in 279 aa overlap (1-279:1-279) 10 20 30 40 50 60 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA ::::::::::::::::::::::::::::::::::::::. XP_011 VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLFSHFSYLLDQ 250 260 270 280 310 320 330 340 350 360 pF1KE1 LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH >>XP_011525742 (OMIM: 123837) PREDICTED: G1/S-specific c (407 aa) initn: 1220 init1: 1198 opt: 1233 Z-score: 1448.1 bits: 276.8 E(85289): 6.4e-74 Smith-Waterman score: 1233; 51.9% identity (75.1% similar) in 378 aa overlap (29-399:27-399) 10 20 30 40 50 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWP- ...:::.. : ::..: . .: XP_011 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVDPD-EEMAKIDRTARDQCGSQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 PVLSGGI--SPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKEVW : .... .:: .: :: :: .: . : : .: :: ::: :::. .::: XP_011 PWDNNAVCADPCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 LNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFM ::.::. :..:.:: : :.:.::.::::::.:::::: :::::::::::::::.: XP_011 KIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYM 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 LTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKAL ::... :..::::::.:::::.:::::: :::..:::::::::: ..:: :::.:.::: XP_011 ATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 KWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYR ::.: :.::.::::...:: :.: .:::::: :. :::::.:::::.: .: ::: : XP_011 KWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 ILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDR ::.:.:: ::.: :...:.:: .: .: .:: :::::. :.. :. ::: :. . :: XP_011 ILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDA 300 310 320 330 340 350 360 370 380 390 400 pF1KE1 HNIQTHTNYLAMLEEVNYINT-FRKGGQLSPVCNGGIMTPPKSTEKPPGKH :::::: . : .:... .. . . .. ::. .:..:::.: .: XP_011 HNIQTHRDSLDLLDKARAKKAMLSEQNRASPL-PSGLLTPPQSGKKQSSGPEMA 360 370 380 390 400 >>NP_001309191 (OMIM: 123837) G1/S-specific cyclin-E1 is (395 aa) initn: 1220 init1: 1198 opt: 1231 Z-score: 1445.9 bits: 276.4 E(85289): 8.4e-74 Smith-Waterman score: 1231; 51.6% identity (75.0% similar) in 380 aa overlap (29-399:12-387) 10 20 30 40 50 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDV--KKRREEVTKKHQYEIRNCW ...:::.. : . ::..: . .: NP_001 MKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCG 10 20 30 40 60 70 80 90 100 110 pF1KE1 P-PVLSGGI--SPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKE : .... .:: .: :: :: .: . : : .: :: ::: :::. .: NP_001 SQPWDNNAVCADPCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREE 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE1 VWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDR :: ::.::. :..:.:: : :.:.::.::::::.:::::: ::::::::::::::: NP_001 VWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE1 FMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILK .: ::... :..::::::.:::::.:::::: :::..:::::::::: ..:: :::.:.: NP_001 YMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMK 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE1 ALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQ ::::.: :.::.::::...:: :.: .:::::: :. :::::.:::::.: .: ::: NP_001 ALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE1 YRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPME : ::.:.:: ::.: :...:.:: .: .: .:: :::::. :.. :. ::: :. . : NP_001 YGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADE 290 300 310 320 330 340 360 370 380 390 400 pF1KE1 DRHNIQTHTNYLAMLEEVNYINT-FRKGGQLSPVCNGGIMTPPKSTEKPPGKH : :::::: . : .:... .. . . .. ::. .:..:::.: .: NP_001 DAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPL-PSGLLTPPQSGKKQSSGPEMA 350 360 370 380 390 >>NP_001229 (OMIM: 123837) G1/S-specific cyclin-E1 isofo (410 aa) initn: 1220 init1: 1198 opt: 1231 Z-score: 1445.7 bits: 276.4 E(85289): 8.7e-74 Smith-Waterman score: 1231; 51.6% identity (75.0% similar) in 380 aa overlap (29-399:27-402) 10 20 30 40 50 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDV--KKRREEVTKKHQYEIRNCW ...:::.. : . ::..: . .: NP_001 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCG 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 P-PVLSGGI--SPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKE : .... .:: .: :: :: .: . : : .: :: ::: :::. .: NP_001 SQPWDNNAVCADPCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDR :: ::.::. :..:.:: : :.:.::.::::::.:::::: ::::::::::::::: NP_001 VWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 FMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILK .: ::... :..::::::.:::::.:::::: :::..:::::::::: ..:: :::.:.: NP_001 YMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 ALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQ ::::.: :.::.::::...:: :.: .:::::: :. :::::.:::::.: .: ::: NP_001 ALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFP 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 YRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPME : ::.:.:: ::.: :...:.:: .: .: .:: :::::. :.. :. ::: :. . : NP_001 YGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADE 300 310 320 330 340 350 360 370 380 390 400 pF1KE1 DRHNIQTHTNYLAMLEEVNYINT-FRKGGQLSPVCNGGIMTPPKSTEKPPGKH : :::::: . : .:... .. . . .. ::. .:..:::.: .: NP_001 DAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPL-PSGLLTPPQSGKKQSSGPEMA 360 370 380 390 400 410 >>NP_001309190 (OMIM: 123837) G1/S-specific cyclin-E1 is (361 aa) initn: 935 init1: 717 opt: 727 Z-score: 855.3 bits: 167.0 E(85289): 6.7e-41 Smith-Waterman score: 865; 41.6% identity (62.9% similar) in 380 aa overlap (29-399:27-353) 10 20 30 40 50 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDV--KKRREEVTKKHQYEIRNCW ...:::.. : . ::..: . .: NP_001 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCG 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 P-PVLSGGI--SPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKE : .... .:: .: :: :: .: . : : .: :: ::: :::. .: NP_001 SQPWDNNAVCADPCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDR :: ::.::. :..:.:: : :.:.::.::::::.: NP_001 VWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLME--------------------- 120 130 140 150 180 190 200 210 220 230 pF1KE1 FMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILK ::: :::..:::::::::: ..:: :::.:.: NP_001 ----------------------------EIYPPKLHQFAYVTDGACSGDEILTMELMIMK 160 170 180 240 250 260 270 280 290 pF1KE1 ALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQ ::::.: :.::.::::...:: :.: .:::::: :. :::::.:::::.: .: ::: NP_001 ALKWRLSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFP 190 200 210 220 230 240 300 310 320 330 340 350 pF1KE1 YRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPME : ::.:.:: ::.: :...:.:: .: .: .:: :::::. :.. :. ::: :. . : NP_001 YGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADE 250 260 270 280 290 300 360 370 380 390 400 pF1KE1 DRHNIQTHTNYLAMLEEVNYINT-FRKGGQLSPVCNGGIMTPPKSTEKPPGKH : :::::: . : .:... .. . . .. ::. .:..:::.: .: NP_001 DAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPL-PSGLLTPPQSGKKQSSGPEMA 310 320 330 340 350 360 >>NP_001309188 (OMIM: 123837) G1/S-specific cyclin-E1 is (365 aa) initn: 990 init1: 646 opt: 680 Z-score: 800.1 bits: 156.8 E(85289): 8e-38 Smith-Waterman score: 934; 44.2% identity (65.0% similar) in 380 aa overlap (29-399:27-357) 10 20 30 40 50 pF1KE1 MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDV--KKRREEVTKKHQYEIRNCW ...:::.. : . ::..: . .: NP_001 MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCG 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 P-PVLSGGI--SPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPS---PLPDLSWGCSKE : .... .:: .: :: :: .: . : : .: :: ::: :::. .: NP_001 SQPWDNNAVCADPCSLIPTPDKE---DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREE 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 VWLNMLKKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDR :: ::.::. :..:.:: : :.:.::.::::::.:::::: ::::::::::::::: NP_001 VWKIMLNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 FMLTQKDINKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILK .: ::... :..::::::.:::::.:::::: :::..:::::::::: ..:: :::.:.: NP_001 YMATQENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 ALKWELCPVTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQ :::::.: .: ::: NP_001 ---------------------------------------------LLDLCVLDVDCLEFP 240 250 300 310 320 330 340 350 pF1KE1 YRILTAAALCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPME : ::.:.:: ::.: :...:.:: .: .: .:: :::::. :.. :. ::: :. . : NP_001 YGILAASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADE 260 270 280 290 300 310 360 370 380 390 400 pF1KE1 DRHNIQTHTNYLAMLEEVNYINT-FRKGGQLSPVCNGGIMTPPKSTEKPPGKH : :::::: . : .:... .. . . .. ::. .:..:::.: .: NP_001 DAHNIQTHRDSLDLLDKARAKKAMLSEQNRASPL-PSGLLTPPQSGKKQSSGPEMA 320 330 340 350 360 404 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 21:51:19 2016 done: Sun Nov 6 21:51:21 2016 Total Scan time: 7.490 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]