Result of FASTA (omim) for
pFN21AB9870
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB9870, 477 aa
1>>>pF1KB9870 477 - 477 aa - 477 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8270+/-0.000373; mu= 20.9509+/- 0.023
mean_var=93.0538+/-21.727, 0's: 0 Z-trim(114.7): 499 B-trim: 2586 in 2/49
Lambda= 0.132956
statistics sampled from 24022 (24706) to 24022 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.655), E-opt: 0.2 (0.29), width: 16
Scan time: 9.370
The best scores are: opt bits E(85289)
NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 3285 640.8 2.4e-183
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 1045 211.1 5.1e-54
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 553 116.6 1.2e-25
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 500 106.7 1.8e-22
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 478 102.4 3e-21
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 469 100.5 8.6e-21
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 464 99.6 1.7e-20
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 457 98.2 3.8e-20
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 457 98.3 4.7e-20
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 457 98.3 4.7e-20
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 454 97.6 5.6e-20
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 456 98.2 5.8e-20
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 454 97.6 6.1e-20
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 454 97.7 6.3e-20
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 454 97.7 6.4e-20
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 454 97.8 7.9e-20
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 444 95.6 2e-19
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 444 95.6 2.1e-19
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 444 95.7 2.1e-19
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 444 95.7 2.2e-19
NP_387512 (OMIM: 126451,181500,190300) D(3) dopami ( 367) 444 95.7 2.3e-19
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 444 95.7 2.3e-19
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 444 95.7 2.3e-19
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 444 95.8 2.5e-19
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 444 95.8 2.5e-19
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 444 95.8 2.6e-19
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 444 95.8 2.7e-19
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 444 95.9 2.7e-19
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 444 95.9 2.7e-19
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 444 95.9 2.7e-19
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 444 95.9 2.7e-19
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 417 90.6 9e-18
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 417 90.6 9.1e-18
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 416 90.3 9.4e-18
NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 417 90.6 9.4e-18
XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 417 90.6 9.4e-18
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 416 90.3 9.4e-18
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 417 90.7 9.7e-18
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 416 90.4 1e-17
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 416 90.4 1e-17
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 416 90.4 1e-17
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 416 90.4 1e-17
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 416 90.4 1e-17
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 416 90.4 1e-17
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 414 90.0 1.3e-17
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 404 88.1 5.3e-17
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 400 87.4 9.2e-17
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 396 86.5 1.3e-16
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 396 86.5 1.4e-16
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 396 86.5 1.4e-16
>>NP_000789 (OMIM: 126453,143465,606798) D(1B) dopamine (477 aa)
initn: 3285 init1: 3285 opt: 3285 Z-score: 3412.5 bits: 640.8 E(85289): 2.4e-183
Smith-Waterman score: 3285; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477)
10 20 30 40 50 60
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB9 VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB9 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB9 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB9 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB9 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB9 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTP
370 380 390 400 410 420
430 440 450 460 470
pF1KB9 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
430 440 450 460 470
>>NP_000785 (OMIM: 126449) D(1A) dopamine receptor [Homo (446 aa)
initn: 1627 init1: 784 opt: 1045 Z-score: 1090.7 bits: 211.1 E(85289): 5.1e-54
Smith-Waterman score: 1647; 58.2% identity (79.1% similar) in 450 aa overlap (40-477:23-444)
10 20 30 40 50 60
pF1KB9 AYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSR
...:::.:.:::. :::::.:::::..: :
NP_000 MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFR
10 20 30 40 50
70 80 90 100 110 120
pF1KB9 HLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASIL
:::...:: :..:::::::.::.::::::::::.::.::::.::..::::::::::::::
NP_000 HLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASIL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB9 NLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWG
:::::::::::::: ::::.:::: . :......:::::.:::::::::.::. . .:
NP_000 NLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTS--
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB9 GLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIY
:.. .: : : . .::::::.::::::::.::::::::::::::::::
NP_000 ----PSD-GNATSLAETI-------DNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIY
180 190 200 210
250 260 270 280 290 300
pF1KB9 RIAQVQIRRISSLERAAEHAQSCRSSAA------CA-PDTSLRASIKKETKVLKTLSVIM
:::: :::::..::::: ::..:..... :. :..:.. :.:.::::::::::::
NP_000 RIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIM
220 230 240 250 260 270
310 320 330 340 350 360
pF1KB9 GVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFN
:::::::::::::::..::: : : : : :.. .:::::::::::::::::.:::::
NP_000 GVFVCCWLPFFILNCILPFC-GSGETQP--F-CIDSNTFDVFVWFGWANSSLNPIIYAFN
280 290 300 310 320 330
370 380 390 400 410
pF1KB9 ADFQKVFAQLLGCSHFCSRT--PVETVNISNE---LISYNQDIVFHKEIAAAYIHMMPNA
:::.:.:. :::: ..: : .:::.:.:. ..: ... ....:.:
NP_000 ADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHA
340 350 360 370 380 390
420 430 440 450 460 470
pF1KB9 VTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
: :. : . :: . . : .. . :: : :: :: . ..::.:: :.: :: :
NP_000 V--GSSEDLKKEEAAGIARPLE--KLSP-----ALSVI-LDYDTDVSLEKIQPITQNGQH
400 410 420 430 440
NP_000 PT
>>NP_000855 (OMIM: 182133) 5-hydroxytryptamine receptor (377 aa)
initn: 608 init1: 239 opt: 553 Z-score: 581.5 bits: 116.6 E(85289): 1.2e-25
Smith-Waterman score: 597; 31.7% identity (59.8% similar) in 410 aa overlap (1-373:1-371)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPP--LGPSQVVTACLLTLLIIWTLLGN
: : .... . : : : ..: ::. : . : : .. : .:... . :.:.:
NP_000 MSPLNQSAEGLP-QEASNRSL---NATETSEAWDPRTLQALKISLAVVLSVITLATVLSN
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 VLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGA-FCDVWV
..: ..:. .:.:.. .: .: :::..::.:..:::: . . .. : :: .::.:.
NP_000 AFVLTTILLTRKLHTP-ANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 AFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQ
. :: : :::::.::::..::::::. ..:... : : .:....:..:: ::. :
NP_000 SSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPP--
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 LNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIP
: :.. .: .. . :.: :.. .:.: :. .::::
NP_000 LFWRQAKAQE----EMSDCLVN------------------TSQI--SYTIYSTCGAFYIP
180 190 200
240 250 260 270
pF1KB9 VAIMIVTYTRIYRIAQVQI--------RRISSLERAAEHAQS--C---------RSSAAC
...:. : :::: :. .: .:... . . : : : .: .:
NP_000 SVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAG
210 220 230 240 250 260
280 290 300 310 320
pF1KB9 AP-----------DTSL---RASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
.: :..: : : .: :. : :..:.:.:. ::::::... ..:.:
NP_000 SPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRD
270 280 290 300 310 320
330 340 350 360 370 380
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
:: :: :.:.:. :: .::.::. :: .:...: ...
NP_000 SCWIHPA--------LFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
330 340 350 360 370
390 400 410 420 430 440
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT
>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa)
initn: 636 init1: 241 opt: 500 Z-score: 524.5 bits: 106.7 E(85289): 1.8e-22
Smith-Waterman score: 678; 34.3% identity (63.9% similar) in 385 aa overlap (24-381:78-423)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSA--GAPPLGPSQVVTACLLTLLI
:. :.:.: :. .. . : .. .:. .:
NP_000 GGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFI
50 60 70 80 90 100
60 70 80 90 100 110
pF1KB9 IWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-
. .. ::.:: ... .:::.. .:: :::.:::.::... :.:..:. :: :.: ::
NP_000 LMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGR
110 120 130 140 150 160
120 130 140 150 160 170
pF1KB9 AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSIL
::::::.: :..: :::::.::.:::::: .. . ..: ::.: : ....: :.....
NP_000 AFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALV
170 180 190 200 210 220
180 190 200 210 220 230
pF1KB9 ISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSS
.: :. :.:.. : .: .: : : . . ::. ::
NP_000 VSVGPL-LGWKE-----------P------VPPDERF---------CGITEEAGYAVFSS
230 240 250
240 250 260 270 280
pF1KB9 LISFYIPVAIMIVTYTRIYRIAQVQIRRI-SSLERAAEHAQS------CRSSAACAPDT-
. :::.:.:...: : :.: .:. : . ....: .:. ::..:. : .
NP_000 VCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAH
260 270 280 290 300 310
290 300 310 320
pF1KB9 --------SLRASIK-------KETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPE
..:.:.. .: :. :::....:::: ::.:::.. .:. : :.
NP_000 GMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFV---LPLGSLFPQ
320 330 340 350 360 370
330 340 350 360 370 380
pF1KB9 GPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNA-DFQKVFAQLLGCSHFCSRTPVET
: :: .: :. :.:. :: .::.:: .. .:...: .:: :. : :
NP_000 LKP------SEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQ--CRRRRRRR
380 390 400 410 420
390 400 410 420 430 440
pF1KB9 VNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPD
NP_000 PLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRR
430 440 450 460 470 480
>>NP_000675 (OMIM: 109630,607276) beta-1 adrenergic rece (477 aa)
initn: 399 init1: 287 opt: 478 Z-score: 502.6 bits: 102.4 E(85289): 3e-21
Smith-Waterman score: 752; 36.1% identity (59.9% similar) in 421 aa overlap (8-381:9-399)
10 20 30 40
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGS---AGAPP---LGP--------SQVVTA-
:.. ::... : .: :... ..:: : : :: ::
NP_000 MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB9 --CLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAE
:..:... . ::::: .::... .:.. .::.::.::: .:: ..:::.:. :.
NP_000 MGLLMALIVLLIVAGNVLVIVAIAKTPRLQT-LTNLFIMSLASADLVMGLLVVPFGATIV
70 80 90 100 110
110 120 130 140 150 160
pF1KB9 VAGYWPFGAF-CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMV
: : : .:.: :..:.. :..: :::: .::::..::: ::. ::::. .:. : .:
NP_000 VWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 GLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSL
.:..: :.::.:. ..: : .. : : .: . ::
NP_000 CTVWAISALVSFLPILMHWWRAES------DEARRCYN---------DP----KCCDFVT
180 190 200 210 220
230 240 250 260 270
pF1KB9 NRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLER-----AAEHAQSCRS--
::.:::.::..:::.:. :: .: :..: :: :...:.: :: :. . :
NP_000 NRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPV
230 240 250 260 270 280
280 290 300 310
pF1KB9 --------------SAACAPDTSLRASIKK--------ETKVLKTLSVIMGVFVCCWLPF
.:: :: .. ::. .. : :.::::..:::::. :::::
NP_000 PAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPF
290 300 310 320 330 340
320 330 340 350 360 370
pF1KB9 FILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQL
:. : . : : : : . : : :.:.:::..::.:: . ::.:.: :
NP_000 FLANVVKAF---HRELVP-------DRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGL
350 360 370 380 390
380 390 400 410 420 430
pF1KB9 LGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEG
: :.. .:
NP_000 LCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAG
400 410 420 430 440 450
>>NP_000854 (OMIM: 182131) 5-hydroxytryptamine receptor (390 aa)
initn: 572 init1: 240 opt: 469 Z-score: 494.3 bits: 100.5 E(85289): 8.6e-21
Smith-Waterman score: 607; 32.9% identity (59.5% similar) in 410 aa overlap (3-373:12-384)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLG-PSQVVTACLLTLL
::... : : : : . .:. .. .. : .:. . ::.:.
NP_000 MEEPGAQCAPPPPAGSETWVP-QANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALI
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 IIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG
. : :.:..: :.. :.:.:.. .: .:.::::.::.:..:::: ... :.: : .:
NP_000 TLATTLSNAFVIATVYRTRKLHTP-ANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLG
60 70 80 90 100 110
120 130 140 150 160
pF1KB9 -AFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSI
. :: :.. :: : :::::.::::..::::::. .:. : : . : ::..:.:..::
NP_000 QVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSI
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB9 LISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISS
::. : . :.. .: ::. : ::... :.. :
NP_000 SISLPP--FFWRQAKA------------------EEEVSECVVNTDHI------LYTVYS
180 190 200 210
230 240 250 260 270
pF1KB9 SLISFYIPVAIMIVTYTRIY-----RI-AQVQIRRISSLERAAEHAQSCRSSAACA----
.. .::.:. ..:. : ::: :: :. : . : :: ..: :... .
NP_000 TVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINS
220 230 240 250 260 270
280 290 300 310
pF1KB9 --PDT-------------SLRAS----------IKKETKVLKTLSVIMGVFVCCWLPFFI
::. ..:.: .: :. :::..:.:.:. :::::::
NP_000 RVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFI
280 290 300 310 320 330
320 330 340 350 360 370
pF1KB9 LNCMVPFCSGHPEGPPAGFPC-VSETTFDVFVWFGWANSSLNPVIYAF-NADFQKVFAQL
.. ..:.:. : . :: :.:.:. :: .::.::.. : ::...: .:
NP_000 ISLVMPICKD---------ACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKL
340 350 360 370 380
380 390 400 410 420 430
pF1KB9 LGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEG
.
NP_000 IRFKCTS
390
>>NP_000016 (OMIM: 109691,601665) beta-3 adrenergic rece (408 aa)
initn: 377 init1: 269 opt: 464 Z-score: 488.9 bits: 99.6 E(85289): 1.7e-20
Smith-Waterman score: 654; 33.0% identity (60.8% similar) in 400 aa overlap (1-381:1-365)
10 20 30 40 50
pF1KB9 MLP-PGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNV
: : : :.. : . :: ..: ...: : . .... ::.: .. :. ::.
NP_000 MAPWPHENSSLAP--WPDLPTLAPNTA--NTSGLPGVPWEAALAGALLALAVLATVGGNL
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 LVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAF-CDVWVA
:: .::. . .:.. :::::..:::..:: ..:::.: :. ..:.::.:: :..:..
NP_000 LVIVAIAWTPRLQT-MTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 FDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQL
:..: :::: .::...:::: :.. :.:: .:.: : . : :.:..: .:: :..
NP_000 VDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMS
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 NWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPV
.: : : : . . .: . : . : :.. :: .:::.:.
NP_000 QWWRV------GADAEAQRCHSNP------------RCCAFASNMPYVLLSSSVSFYLPL
180 190 200 210
240 250 260 270 280
pF1KB9 AIMIVTYTRIYRIAQVQIR-------RISSLERAAEHAQSCRSS--AACAPDTSLRASIK
.:. .:.:.. .: :.: :. : ..: . ..::: .. : .
NP_000 LVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGR
220 230 240 250 260 270
290 300 310 320 330 340
pF1KB9 K--------ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTF
. : ..: ::..:::.:. ::::::. : . . : :. : .:
NP_000 RPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRAL------GGPSLVPG---PAF
280 290 300 310 320
350 360 370 380 390 400
pF1KB9 DVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIV
.. :.:.:::..::.:: . ::...: .:: : :.:
NP_000 LALNWLGYANSAFNPLIYCRSPDFRSAFRRLL-CR--CGRRLPPEPCAAARPALFPSGVP
330 340 350 360 370 380
410 420 430 440 450 460
pF1KB9 FHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEG
NP_000 AARSSPAQPRLCQRLDGASWGVS
390 400
>>XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B adrene (331 aa)
initn: 550 init1: 236 opt: 457 Z-score: 482.7 bits: 98.2 E(85289): 3.8e-20
Smith-Waterman score: 551; 32.2% identity (62.4% similar) in 351 aa overlap (2-328:5-325)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQ--LAQGNAVGGSAGAPPLGPSQVVTACL-LTLLIIWT
: : : .: :.... .. .. : ..... : : ...... : : .:...
XP_006 MNPDLDTGHNTSA-PAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFA
10 20 30 40 50
60 70 80 90 100 110
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFC
..::.:: ... .::::. :: :::.::..::.... :.:..:. :: ::: .: ::
XP_006 IVGNILVILSVACNRHLRTP-TNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB9 DVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISF
:.:.: :..: :::::.::.::.::: .. ..: .:.: :.. . .:.:: .::.
XP_006 DIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB9 IPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLIS
:. :.: .. : ::. : ..: . . ::. ::: :
XP_006 GPL-LGW-KEPA--------PND---------D--------KECGVTEEPFYALFSSLGS
180 190 200 210
240 250 260 270
pF1KB9 FYIPVAIMIVTYTRIYRIAQVQIRRISS-----LERAAE----------HAQSCRSSAAC
::::.:...: : :.: .:. . . . . . : : .. :. :
XP_006 FYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAK
220 230 240 250 260 270
280 290 300 310 320 330
pF1KB9 A--PDTSLRASI---KKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGF
. : .:. ... ..: :. :::....:.:. ::::::: . : : :.:
XP_006 GHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLELFTST-PKGLEKDW
280 290 300 310 320 330
340 350 360 370 380 390
pF1KB9 PCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNEL
XP_006 K
>>NP_000859 (OMIM: 312861) 5-hydroxytryptamine receptor (458 aa)
initn: 476 init1: 182 opt: 457 Z-score: 481.0 bits: 98.3 E(85289): 4.7e-20
Smith-Waterman score: 511; 29.2% identity (57.4% similar) in 390 aa overlap (25-383:39-393)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWT
:. :. : : : : ....:: :
NP_000 HSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDG-VQNWPALSIVIIIIMT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGY-WPFGAF-
. ::.:: :. ..:. : :: :..:::..:..:.::::: . .: . : ::. .
NP_000 IGGNILVIMAVSMEKKLH-NATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILIS
: ::...:.. :::::..::.::.::: :: :....: .. :.. ....:..:: .:
NP_000 CPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 FIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR-TYAISSSL
.:. . ::. :. : :: .: :: .... .:.
NP_000 -VPIPVIGLRDE-------------------EKVF----VNNTTC--VLNDPNFVLIGSF
190 200 210 220
240 250 260
pF1KB9 ISFYIPVAIMIVTYTRIYRIAQVQI-----------------------RRISSLERAAEH
..:.::..::..:: . . : : . : .:.
NP_000 VAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANP
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB9 AQSC----RSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
:. :.. : ...: :..: :. :.:.... ::. : :::: : . .:
NP_000 NQDQNARRRKKKERRPRGTMQA-INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEK
290 300 310 320 330
330 340 350 360 370 380
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
. . : ..::::.:.. :..::..:. :: ....:.. : :.. . :
NP_000 SCNQK------LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT
NP_000 PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSE
400 410 420 430 440 450
>>NP_001243689 (OMIM: 312861) 5-hydroxytryptamine recept (458 aa)
initn: 476 init1: 182 opt: 457 Z-score: 481.0 bits: 98.3 E(85289): 4.7e-20
Smith-Waterman score: 511; 29.2% identity (57.4% similar) in 390 aa overlap (25-383:39-393)
10 20 30 40 50
pF1KB9 MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWT
:. :. : : : : ....:: :
NP_001 HSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDG-VQNWPALSIVIIIIMT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB9 LLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGY-WPFGAF-
. ::.:: :. ..:. : :: :..:::..:..:.::::: . .: . : ::. .
NP_001 IGGNILVIMAVSMEKKLH-NATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB9 CDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILIS
: ::...:.. :::::..::.::.::: :: :....: .. :.. ....:..:: .:
NP_001 CPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVS
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB9 FIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNR-TYAISSSL
.:. . ::. :. : :: .: :: .... .:.
NP_001 -VPIPVIGLRDE-------------------EKVF----VNNTTC--VLNDPNFVLIGSF
190 200 210 220
240 250 260
pF1KB9 ISFYIPVAIMIVTYTRIYRIAQVQI-----------------------RRISSLERAAEH
..:.::..::..:: . . : : . : .:.
NP_001 VAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANP
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB9 AQSC----RSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSG
:. :.. : ...: :..: :. :.:.... ::. : :::: : . .:
NP_001 NQDQNARRRKKKERRPRGTMQA-INNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEK
290 300 310 320 330
330 340 350 360 370 380
pF1KB9 HPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYA-FNADFQKVFAQLLGCSHFCSRTP
. . : ..::::.:.. :..::..:. :: ....:.. : :.. . :
NP_001 SCNQK------LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKP
340 350 360 370 380 390
390 400 410 420 430 440
pF1KB9 VETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQT
NP_001 PVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSE
400 410 420 430 440 450
477 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 20:57:08 2016 done: Sat Nov 5 20:57:09 2016
Total Scan time: 9.370 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]